Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection

Xiaomin Lin; Chun Lin; Xin Li; Fen Yao; Xiaoling Guo; Meimei Wang; Mi Zeng; Yumeng Yuan; Qingdong Xie; Xudong Huang; Xiaoyang Jiao

doi:10.1007/s12275-024-00190-5

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Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection: Xiaomin Lin¹, Chun Lin², Xin Li³, Fen Yao⁴, Xiaoling Guo³, Meimei Wang³, Mi Zeng³, Yumeng Yuan³, Qingdong Xie³, Xudong Huang¹, Xiaoyang Jiao³; Journal of Microbiology 2024;62(12):1113-1124.
DOI: https://doi.org/10.1007/s12275-024-00190-5
Published online: December 2, 2024

¹Department of Clinical Laboratory, Jieyang People's Hospital, Jieyang, 522000, Guangdong, People's Republic of China
²Department of Clinical Laboratory, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, People's Republic of China
³Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, Guangdong, People's Republic of China
⁴Department of Pharmacology, Shantou University Medical College, Shantou, 515041, Guangdong, People's Republic of China

Corresponding author: Xiaoyang Jiao,
Email: xyjiao@stu.edu.cn

Received: 10 July 2024 • Revised: 10 October 2024 • Accepted: 29 October 2024

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Abstract

To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.

Keywords: Bloodstream infection · Intestinal fora · 16S rRNA gene sequencing · Pathogen

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Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection

J. Microbiol. 2024;62(12):1113-1124. Published online December 2, 2024

DOI: https://doi.org/10.1007/s12275-024-00190-5

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