Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale

Allan de Carvalho; Marcia Giambiagi-deMarval; Ciro César Rossi

doi:10.1007/s12275-024-00156-7

Articles

Page Path: HOME > J. Microbiol > Volume 62(9); 2024 > Article

Journal Article
Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale: Allan de Carvalho¹, Marcia Giambiagi-deMarval², Ciro César Rossi¹; Journal of Microbiology 2024;62(9):775-784.
DOI: https://doi.org/10.1007/s12275-024-00156-7
Published online: July 22, 2024

¹Department of Biochemistry and Molecular Biology, Federal University of Vicosa, Minas Gerais, 36570-000, Brazil
²Paulo de Góes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil

Corresponding author: Ciro César Rossi,
Email: ciro.rossi@ufv.br

Received: 14 May 2024 • Revised: 12 June 2024 • Accepted: 21 June 2024

prev next

111 Views
0 Download
4 Web of Science
6 Crossref
4 Scopus

Full Article

Abstract

Recently emancipated from the Staphylococcus genus due to genomic differences, Mammaliicoccus sciuri, previously classified as an occasional pathogen, emerges as a significant player in the landscape of resistance gene dissemination among Staphylococcaceae. Despite its classification, its role remained enigmatic. In this study, we delved into the genomic repertoire of M. sciuri to unravel its contribution to resistance and virulence gene transfer in the context of One Health. Through comprehensive analysis of publicly available genomes, we unveiled a diverse pan-immune system adept at defending against exogenous genetic elements, yet concurrently fostering horizontal gene transfer (HGT). Specifically, exploration of CRISPR-Cas systems, with spacer sequences as molecular signatures, elucidated a global dissemination pattern spanning environmental, animal, and human hosts. Notably, we identified the integration of CRISPR-Cas systems within SCCmecs (Staphylococcal Cassette Chromosome mec), harboring key genes associated with pathogenicity and resistance, especially the methicillin resistance gene mecA, suggesting a strategic adaptation to outcompete other mobile genetic elements. Our findings underscored M. sciuri's active engagement in HGT dynamics and evolutionary trajectories within Staphylococcaceae, emphasizing its central role in shaping microbial communities and highlighting the significance of understanding its implications in the One Health framework, an interdisciplinary approach that recognizes the interconnectedness of human, animal, and environmental health to address global health challenges.

Keywords: Staphylococcaceae;mecA;Antimicrobial resistance;CRISPR-Cas;One health;SCCmec

Figure & Data

References

Citations

Citations to this article as recorded by

From Farm to Community: Dispersal of Potentially Pathogenic Staphylococcus and Mammaliicoccus Species and Antimicrobial Resistance Across Shared Environments
Faizan Ahmad, Samuel Sathler Martuchelle, Ana Luisa Andrade-Oliveira, Vitor Emanuel Lanes Viana, Maria Antônia Silva Melo Sousa, Felipe Sicchierolli da Silveira, Marisa Alves Nogueira-Diaz, Monalessa Fábia Pereira, Marcia Giambiagi-deMarval, Ciro César Ro
Current Microbiology.2025;[Epub] CrossRef
Genomic insights into multidrug and heavy metal resistance in Chryseobacterium sp. BI5 isolated from sewage sludge
Mrinmoy Patra, Anand Kumar Pandey, Suresh Kumar Dubey
Total Environment Microbiology.2025; 1(1): 100005. CrossRef
The Arms Race Between Actinobacillus pleuropneumoniae and Its Genetic Environment: A Comprehensive Analysis of Its Defensome and Mobile Genetic Elements
Giarlã Cunha da Silva, Ciro César Rossi
Molecular Microbiology.2025;[Epub] CrossRef
Defense systems and mobile elements in Staphylococcus haemolyticus: a genomic view of resistance dissemination
Giarlã Cunha da Silva, Ciro César Rossi
Microbial Pathogenesis.2025; 206: 107808. CrossRef
Frequency, Distribution, and Antimicrobial Resistance of Methicillin-Resistant Staphylococci and Mammaliicoccus sciuri Isolated from Dogs and Their Owners in Rio de Janeiro
Fernanda Cruz Bonnard, Luciana Guimarães, Izabel Mello Teixeira, Sandryelle Mercês Freire, Alessandra Maia, Patrícia Câmara de Castro Abreu Pinto, Thais Veiga Blanchart, Bruno Penna
Antibiotics.2025; 14(4): 409. CrossRef
From farm effluent to biotechnological potential: pGLS, a novel and resilient temperate bacteriophage with synergistic activity and broad antibiofilm properties against Staphylococcus and Mammaliicoccus
Vitor Emanuel Lanes Viana, Faizan Ahmad, Samuel Sathler Martuchelle, Sandy de Almada Estanislau, Nohman Rasheed, Marinella Silva Laport, Monalessa Fábia Pereira, Marcia Giambiagi-deMarval, Ciro César Rossi
Journal of Applied Microbiology.2025;[Epub] CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale

J. Microbiol. 2024;62(9):775-784. Published online July 22, 2024

DOI: https://doi.org/10.1007/s12275-024-00156-7

Related articles