Metabolic Interaction Between Host and the Gut Microbiota During High‑Fat Diet‑Induced Colorectal Cancer

Chaeeun Lee; Seungrin Lee; Woongjae Yoo

doi:10.1007/s12275-024-00123-2

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Metabolic Interaction Between Host and the Gut Microbiota During High‑Fat Diet‑Induced Colorectal Cancer: Chaeeun Lee, Seungrin Lee, Woongjae Yoo; Journal of Microbiology 2024;62(3):153-165.
DOI: https://doi.org/10.1007/s12275-024-00123-2
Published online: April 16, 2024

Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea

Corresponding author: Woongjae Yoo,
Email: wjyoo@postech.ac.kr

Received: 2 January 2024 • Revised: 7 February 2024 • Accepted: 16 February 2024

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Abstract

Colorectal cancer (CRC) is the second-highest cause of cancer-associated mortality among both men and women worldwide. One of the risk factors for CRC is obesity, which is correlated with a high-fat diet prevalent in Western dietary habits. The association between an obesogenic high-fat diet and CRC has been established for several decades; however, the mechanisms by which a high-fat diet increases the risk of CRC remain unclear. Recent studies indicate that gut microbiota strongly infuence the pathogenesis of both high-fat diet-induced obesity and CRC. The gut microbiota is composed of hundreds of bacterial species, some of which are implicated in CRC. In particular, the expansion of facultative anaerobic Enterobacteriaceae, which is considered a microbial signature of intestinal microbiota functional imbalance (dysbiosis), is associated with both high-fat diet-induced obesity and CRC. Here, we review the interaction between the gut microbiome and its metabolic byproducts in the context of colorectal cancer (CRC) during high-fat diet-induced obesity. In addition, we will cover how a high-fat diet can drive the expansion of genotoxin-producing Escherichia coli by altering intestinal epithelial cell metabolism during gut infammation conditions.

Keywords: High-fat diet-induced obesity;Host-microbe interaction;Gut dysbiosis;Colibactin;Colorectal Cancer

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Metabolic Interaction Between Host and the Gut Microbiota During High‑Fat Diet‑Induced Colorectal Cancer

J. Microbiol. 2024;62(3):153-165. Published online April 16, 2024

DOI: https://doi.org/10.1007/s12275-024-00123-2

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