The crosstalk between bacteria and host autophagy: host defense or bacteria offense

Lin Zheng; Fang Wei; Guolin Li

doi:10.1007/s12275-022-2009-z

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The crosstalk between bacteria and host autophagy: host defense or bacteria offense: Lin Zheng ¹, Fang Wei ¹, Guolin Li ²; Journal of Microbiology 2022;60(5):451-460.
DOI: https://doi.org/10.1007/s12275-022-2009-z
Published online: April 29, 2022

¹Center for Biomedical Aging, National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P. R. China, ²Key Laboratory of Hunan Province for Model Animal and Stem Cell Biology, School of Medicine, Hunan Normal University, Changsha, Human 410081, P. R. China

Corresponding author: Fang Wei , Tel: +86-0731-88872786,
Guolin Li , Tel: +86-0731-88872786,

Received: 11 January 2022 • Revised: 18 March 2022 • Accepted: 29 March 2022

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Abstract

Xenophagy is a specific selective autophagy for the elimination of intracellular bacteria. Current evidence suggests that the processes for host autophagy system to recognize and eliminate invading bacteria are complex, and vary according to different pathogens. Although both ubiquitin-dependent and ubiquitin-independent autophagy exist in host to defense invading bacteria, successful pathogens have evolved diverse strategies to escape from or paralyze host autophagy system. In this review, we discuss the mechanisms of host autophagy system to recognize and eliminate intracellular pathogens and the mechanisms of different pathogens to escape from or paralyze host autophagy system, with a particular focus on the most extensively studied bacteria.

Keywords: autophagy, xenophagy, bacteria, infection, bacterial effector

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The crosstalk between bacteria and host autophagy: host defense or bacteria offense

J. Microbiol. 2022;60(5):451-460. Published online April 29, 2022

DOI: https://doi.org/10.1007/s12275-022-2009-z

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