Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway

Taehwan Park; Jintaek Im; A Reum Kim; Dongwook Lee; Sungho Jeong; Cheol-Heui Yun; Seung Hyun Han

doi:10.1007/s12275-021-1576-8

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Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway: Taehwan Park ¹, Jintaek Im ¹, A Reum Kim ¹, Dongwook Lee ¹, Sungho Jeong ¹, Cheol-Heui Yun ^2,3, Seung Hyun Han ¹; Journal of Microbiology 2021;59(12):1142-1149.
DOI: https://doi.org/10.1007/s12275-021-1576-8
Published online: December 4, 2021

¹Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Republic of Korea, ²Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea, ³Institutes of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea

Corresponding author: Seung Hyun Han , Tel: +82-2-880-2310,

Received: 3 November 2021 • Revised: 12 November 2021 • Accepted: 12 November 2021

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Abstract

Streptococcus gordonii, a Gram-positive commensal bacterium, is an opportunistic pathogen closely related to initiation and progression of various oral diseases, such as periodontitis and dental caries. Its biofilm formation is linked with the development of such diseases by enhanced resistance against antimicrobial treatment or host immunity. In the present study, we investigated the effect of short-chain fatty acids (SCFAs) on the biofilm formation of S. gordonii. SCFAs, including sodium acetate (NaA), sodium propionate (NaP), and sodium butyrate (NaB), showed an effective inhibitory activity on the biofilm formation of S. gordonii without reduction in bacterial growth. SCFAs suppressed S. gordonii biofilm formation at early time points whereas SCFAs did not affect its preformed biofilm. A quorum-sensing system mediated by competence-stimulating peptide (CSP) is known to regulate biofilm formation of streptococci. Interestingly, SCFAs substantially decreased mRNA expression of comD and comE, which are CSP-sensor and its response regulator responsible for CSP pathway, respectively. Although S. gordonii biofilm formation was enhanced by exogenous synthetic CSP treatment, such effect was not observed in the presence of SCFAs. Collectively, these results suggest that SCFAs have an anti-biofilm activity on S. gordonii through inhibiting comD and comE expression which results in negative regulation of CSP quorum-sensing system. SCFAs could be an effective anti-biofilm agent against S. gordonii for the prevention of oral diseases.

Keywords: Streptococcus gordonii, biofilm, short-chain fatty acids, quorum-sensing, competence-stimulating peptide

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Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway

J. Microbiol. 2021;59(12):1142-1149. Published online December 4, 2021

DOI: https://doi.org/10.1007/s12275-021-1576-8

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