Rab27b regulates extracellular vesicle production in cells infected with Kaposi’s sarcoma–associated herpesvirus to promote cell survival and persistent infection

Hyungtaek Jeon; Su-Kyung Kang; Myung-Ju Lee; Changhoon Park; Seung-Min Yoo; Yun Hee Kang; Myung-Shin Lee

doi:10.1007/s12275-021-1108-6

Articles

Page Path: HOME > J. Microbiol > Volume 59(5); 2021 > Article

Article
Rab27b regulates extracellular vesicle production in cells infected with Kaposi’s sarcoma–associated herpesvirus to promote cell survival and persistent infection: Hyungtaek Jeon ¹, Su-Kyung Kang ¹, Myung-Ju Lee ¹, Changhoon Park ¹, Seung-Min Yoo ^1,2, Yun Hee Kang ^1,2, Myung-Shin Lee ^1,2; Journal of Microbiology 2021;59(5):522-529.
DOI: https://doi.org/10.1007/s12275-021-1108-6
Published online: April 20, 2021

¹Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 34824, Republic of Korea, ²Eulji Biomedical Science Research Institute, Eulji University School of Medicine, Daejeon 34824, Republic of Korea

Received: 23 February 2021 • Revised: 16 March 2021 • Accepted: 17 March 2021

prev next

586 Views
1 Download
6 Web of Science
5 Crossref
6 Scopus

Article

Download PDF

Abstract

Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication. EVs and viruses share several properties related to their structure and the biogenesis machinery in cells. EVs from virus-infected cells play a key role in virus spread and suppression using various loading molecules, such as viral proteins, host proteins, and microRNAs. However, it remains unclear how and why viruses regulate EV production inside host cells. The purpose of this study is to investigate the molecular mechanisms underlying EV production and their roles in Kaposi’s sarcoma-associated herpesvirus (KSHV)-infected cells. Here, we found that KSHV induced EV production in human endothelial cells via Rab- 27b upregulation. The suppression of Rab27b expression in KSHV-infected cells enhanced cell death by increasing autophagic flux and autolysosome formation. Our results indicate that Rab27b regulates EV biogenesis to promote cell survival and persistent viral infection during KSHV infection, thereby providing novel insights into the crucial role of Rab- 27b in the KSHV life cycle.

Keywords: extracellular vesicle, Kaposi’s sarcoma-associated herpesvirus, Rab27b, autophagy, cell death

Supplementary Information

References

Citations

Citations to this article as recorded by

Extracellular Vesicles in Sarcoma: Implications for Tumor Progression and Therapy
Yue Wang, Shaozhi Gao, Geng Zhang, Wei Xiao, Baoyiyu Xu, Wengang Li
International Journal of Nanomedicine.2025; Volume 20: 13759. CrossRef
Engineered small extracellular vesicles as a novel platform to suppress human oncovirus-associated cancers
Iman Owliaee, Mehran khaledian, Armin Khaghani Boroujeni, Ali Shojaeian
Infectious Agents and Cancer.2023;[Epub] CrossRef
HMGB1, a potential regulator of tumor microenvironment in KSHV-infected endothelial cells
Myung-Ju Lee, Joohee Park, Seokjoo Choi, Seung-Min Yoo, Changhoon Park, Hong Seok Kim, Myung-Shin Lee
Frontiers in Microbiology.2023;[Epub] CrossRef
Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles
Jisu Lee, Hyun Sik Park, Seung Ro Han, Yun Hee Kang, Ji Young Mun, Dong Wook Shin, Hyun-Woo Oh, Yoon-Kyoung Cho, Myung-Shin Lee, Jinsung Park
Frontiers in Oncology.2022;[Epub] CrossRef
Long non-coding RNAs in Sus scrofa ileum under starvation stress
Shu Wang, Yi Jia Ma, Yong Shi Li, Xu Sheng Ge, Chang Lu, Chun Bo Cai, Yang Yang, Yan Zhao, Guo Ming Liang, Xiao Hong Guo, Guo Qing Cao, Bu Gao Li, Peng Fei Gao
Animal Bioscience.2022; 35(7): 975. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Rab27b regulates extracellular vesicle production in cells infected with Kaposi’s sarcoma–associated herpesvirus to promote cell survival and persistent infection

J. Microbiol. 2021;59(5):522-529. Published online April 20, 2021

DOI: https://doi.org/10.1007/s12275-021-1108-6

Related articles