Trans-acting regulators of ribonuclease activity

Jaejin Lee; Minho Lee; Kangseok Lee

doi:10.1007/s12275-021-0650-6

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Trans-acting regulators of ribonuclease activity: Jaejin Lee , Minho Lee , Kangseok Lee; Journal of Microbiology 2021;59(4):341-359.
DOI: https://doi.org/10.1007/s12275-021-0650-6
Published online: March 29, 2021

Department of Life Science, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea

Corresponding author: Minho Lee , Tel: +82-2-820-5241;,
Kangseok Lee , Tel: +82-2-820-5241;,

Received: 11 December 2020 • Revised: 28 December 2020 • Accepted: 28 December 2020

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Abstract

RNA metabolism needs to be tightly regulated in response to changes in cellular physiology. Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism, including processing, degradation, and recycling of RNA molecules. Thus, living systems have evolved to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. In addition, various trans-acting regulators of RNase activity have been discovered in recent years. This review focuses on the physiological roles and underlying mechanisms of trans-acting regulators of RNase activity.

Keywords: Acanthamoeba castellanii;Amoebae;Antimycobacterial drug screening system;Mycobacterium paragordonae (Mpg);Recombinant mycobacteria

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Trans-acting regulators of ribonuclease activity

J. Microbiol. 2021;59(4):341-359. Published online March 29, 2021

DOI: https://doi.org/10.1007/s12275-021-0650-6

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