Caspase-3 inhibitor inhibits enterovirus D68 production

Wenbo Huo; Jinghua Yu; Chunyu Liu; Ting Wu; Yue Wang; Xiangling Meng; Fengmei Song; Shuxia Zhang; Ying Su; Yumeng Liu; Jinming Liu; Xiaoyan Yu; Shucheng Hua

doi:10.1007/s12275-020-0241-y

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Caspase-3 inhibitor inhibits enterovirus D68 production: Wenbo Huo ^1,2, Jinghua Yu ¹, Chunyu Liu ³, Ting Wu ⁴, Yue Wang ⁵, Xiangling Meng ², Fengmei Song ², Shuxia Zhang ², Ying Su ², Yumeng Liu ², Jinming Liu ², Xiaoyan Yu ², Shucheng Hua ⁶; Journal of Microbiology 2020;58(9):812-820.
DOI: https://doi.org/10.1007/s12275-020-0241-y
Published online: September 1, 2020

¹Institute of Virology and AIDS Research, The First Hospital of Jilin University, Jilin University, Changchun 130000, P. R. China, ²Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changhun 130000, P. R. China, ³Acupuncture Department, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130000, P. R. China, ⁴Neonatal Intensive Care Unit, The First Hospital of Jilin University, Jilin University, Changchun 130000, P. R. China, ⁵Department of Chemistry of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130000, P. R. China, ⁶Department of Internal Medicine, The First Hospital of Jilin University, Jilin University, Changchun 130000, P. R. China

Received: 8 May 2020 • Revised: 19 June 2020 • Accepted: 22 June 2020

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Abstract

Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.

Keywords: EVD68, caspase-3, apoptosis, viral production, host-pathogen interaction

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Caspase-3 inhibitor inhibits enterovirus D68 production

J. Microbiol. 2020;58(9):812-820. Published online September 1, 2020

DOI: https://doi.org/10.1007/s12275-020-0241-y

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