Burkholderia thailandensis outer membrane vesicles exert antimicrobial activity against drug-resistant and competitor microbial species

Yihui Wang; Joseph P. Hoffmann; Chau-Wen Chou; Kerstin Höner zu Bentrup; Joseph A. Fuselier; Jacob P. Bitoun; William C. Wimley; Lisa A. Morici

doi:10.1007/s12275-020-0028-1

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Burkholderia thailandensis outer membrane vesicles exert antimicrobial activity against drug-resistant and competitor microbial species: Yihui Wang ¹, Joseph P. Hoffmann ¹, Chau-Wen Chou ², Kerstin Höner zu Bentrup ¹, Joseph A. Fuselier ³, Jacob P. Bitoun ¹, William C. Wimley ⁴, Lisa A. Morici ¹; Journal of Microbiology 2020;58(7):550-562.
DOI: https://doi.org/10.1007/s12275-020-0028-1
Published online: April 11, 2020

¹Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA, ²Department of Chemistry, University of Georgia Franklin College of Arts and Sciences, Athens, GA, USA, ³Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA, ⁴Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA¹Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA, ²Department of Chemistry, University of Georgia Franklin College of Arts and Sciences, Athens, GA, USA, ³Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA, ⁴Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA

Received: 15 January 2020 • Revised: 3 March 2020 • Accepted: 9 March 2020

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Abstract

Gram-negative bacteria secrete outer membrane vesicles (OMVs) that play critical roles in intraspecies, interspecies, and bacteria-environment interactions. Some OMVs, such as those produced by Pseudomonas aeruginosa, have previously been shown to possess antimicrobial activity against competitor species. In the current study, we demonstrate that OMVs from Burkholderia thailandensis inhibit the growth of drug-sensitive and drug-resistant bacteria and fungi. We show that a number of antimicrobial compounds, including peptidoglycan hydrolases, 4-hydroxy-3-methyl-2-(2-nonenyl)- quinoline (HMNQ) and long-chain rhamnolipid are present in or tightly associate with B. thailandensis OMVs. Furthermore, we demonstrate that HMNQ and rhamnolipid possess antimicrobial and antibiofilm properties against methicillin- resistant Staphylococcus aureus (MRSA). These findings indicate that B. thailandensis secretes antimicrobial OMVs that may impart a survival advantage by eliminating competition. In addition, bacterial OMVs may represent an untapped resource of novel therapeutics effective against biofilm- forming and multidrug-resistant organisms.

Keywords: Catabolism;Host–microbe interaction;N-acetylneuraminic acid;Sialic acid

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Burkholderia thailandensis outer membrane vesicles exert antimicrobial activity against drug-resistant and competitor microbial species

J. Microbiol. 2020;58(7):550-562. Published online April 11, 2020

DOI: https://doi.org/10.1007/s12275-020-0028-1

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