Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea

Yu Jung Won; Lae Hyung Kang; Sung Geun Lee; Seung Won Park; Jae Ik Han; Soon Young Paik

doi:10.1007/s12275-019-9174-8

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Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea: Yu Jung Won ¹, Lae Hyung Kang ¹, Sung Geun Lee ², Seung Won Park ³, Jae Ik Han ⁴, Soon Young Paik ¹; Journal of Microbiology 2019;57(10):927-937.
DOI: https://doi.org/10.1007/s12275-019-9174-8
Published online: August 3, 2019

¹Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, ²Korea Zoonosis Research Institute, Chonbuk National University, Iksan 54596, Republic of Korea, ³Department of Biotechnology, Daegu Catholic University, Gyeongsan 38430, Republic of Korea, ⁴Laboratory of Wildlife Diseases, College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Republic of Korea

Corresponding author: Soon Young Paik , Tel: +82-2-2258-7342,

Received: 3 April 2019 • Revised: 27 May 2019 • Accepted: 17 June 2019

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Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne emerging infectious disease caused by the SFTS virus (SFTSV) and is a threat to public health due to its high fatality rate. However, details on tick-to-human transmission of SFTSV are limited. In this study, we determined the wholegenome sequence of a South Korean SFTSV strain (CUKJJ01), compared it to those of other recent human SFTSV isolates, and identified the genetic variations and relationships among the SFTSV strains. The genome of CUK-JJ01 was consistent with the genome of other members of the genus Phlebovirus, including the large (L), medium (M), and small (S) segments of 6368, 3378, and 1744 nucleotides, respectively. Based on amino acid sequences of the M and S segments, which are used to distinguish the six SFTSV genotypes, CUK-JJ01 was classified as genotype B. Segment analysis revealed that the L, M, and S segments were 97.49%, 97.18%, and 97.94% similar to those of KAJNH2/2013/ Korea, ZJZHSH-FDE/2012/China, and KADGH/2013/Korea, respectively. Currently, only few studies on SFTSV have been conducted in Korean population and most were limited to serological analysis. Although the present study has limitations in terms of number of sample analyzed, the findings may serve as basis to understand the transmission and spread of SFTSV, as well as for the development of diagnostic and detection methods for viral recombinants by comparing the whole genome sequence of SFTSV isolates from South Korea and that of foreign isolates.

Keywords: SFTS;SFTSV;whole-genome sequencing;Phlebovirus;South Korea;phylogeny

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Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea

J. Microbiol. 2019;57(10):927-937. Published online August 3, 2019

DOI: https://doi.org/10.1007/s12275-019-9174-8

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