A newly characterized exopolysaccharide from Sanghuangporus sanghuang

Xiao-kui Ma; Xu She; Eric Charles Peterson; Yu Zhen Wang; Peng Zheng; Hongyan Ma; Kexin Zhang; Jian Liang

doi:10.1007/s12275-019-9036-4

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A newly characterized exopolysaccharide from Sanghuangporus sanghuang: Xiao-kui Ma ¹, Xu She ¹, Eric Charles Peterson ², Yu Zhen Wang ¹, Peng Zheng ¹, Hongyan Ma ¹, Kexin Zhang ¹, Jian Liang ¹; Journal of Microbiology 2019;57(9):812-820.
DOI: https://doi.org/10.1007/s12275-019-9036-4
Published online: June 14, 2019

¹Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Science, Shaanxi Normal University, Xi’an 710055, Shaanxi, P. R. China, ²Agency for Science, Technology, and Research (A*STAR), 138673, Singapore

Corresponding author: Xiao-kui Ma , Tel: +86-29-85310266,
Jian Liang , Tel: +86-29-85310266,

Received: 23 January 2019 • Revised: 15 April 2019 • Accepted: 17 April 2019

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Abstract

Sanghuangporus sanghuang is a well-known pharmacodynamic and economically important edible fungus associated with mulberry (Morus spp.). A distinctly new exopolysaccharide (EPS), designated SHP-2 was obtained from S. sanghuang P0988 broth, and its structure and anti-aging prosperity were characterized. SHP-2 was found to be composed of a backbone of 􎵔4)-β-Manp-(1􎵔4)-α-Araf-(1􎵔3,4)-α-Glcp(1􎵔􀁇 3,4)-α-Glcp-(1􎵔3,4)-α-Glcp-(1􎵔3,4)-α-Glcp-(1􎵔3,4)-α- Glcp-(1􎵔6)-α-Galp-(1􎵔4)-β-Manp-(1􎵔􀁇and five branches, including four α-D-Glcp-(1􎵔􀁇and one α-D-Manp-(1􎵔􀁇 SHP-2 was shown to increase antioxidant enzyme activities including catalase (CAT) and superoxide dismutase (SOD) activities, as well as trolox equivalent antioxidant (TEAC) capacity in serum of mice pre-treated with D-Gal, while reducing lipofuscin levels. SHP-2 exerted a favorable influence on immune organ coefficients and ameliorated the histopathological hepatic lesions and apoptosis in hepatocytes of Dgalactose- aged mice almost in a dose-dependent manner. Using the same analytical methods, on comparison with previously studied EPS compounds (i.e. SHP-1), SHP-2 was found to have more complex structure, larger molecule weight, and different anti-aging properties. The results presented here suggest that not only does EPS bioactivity vary with respect to molecular structures and molecule weight, but that multiple structures with different activity can be expressed by a single fungal strain. These results may help understanding the antiaging prosperity of these polysaccharides for use in health foods or dietary supplements.

Keywords: Sanghuangporus sanghuang;biomacromolecule;exopolysaccharide;antioxidant;mammalian system

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A newly characterized exopolysaccharide from Sanghuangporus sanghuang

J. Microbiol. 2019;57(9):812-820. Published online June 14, 2019

DOI: https://doi.org/10.1007/s12275-019-9036-4

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