Rotavirus-mediated alteration of gut microbiota and its correlation with physiological characteristics in neonatal calves

Ja-Young Jang; Suhee Kim; Min-Sung Kwon; Jieun Lee; Do-Hyeon Yu; Ru-Hui Song; Hak-Jong Choi; Jinho Park

doi:10.1007/s12275-019-8549-1

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Rotavirus-mediated alteration of gut microbiota and its correlation with physiological characteristics in neonatal calves: Ja-Young Jang ¹, Suhee Kim ², Min-Sung Kwon ¹, Jieun Lee ¹, Do-Hyeon Yu ³, Ru-Hui Song ⁴, Hak-Jong Choi ¹, Jinho Park ⁴; Journal of Microbiology 2019;57(2):113-121.
DOI: https://doi.org/10.1007/s12275-019-8549-1
Published online: November 19, 2018

¹Research and Development Division, World Institute of Kimchi, Gwangju 61755, Republic of Korea, ²Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Republic of Korea, ³Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea, ⁴Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Republic of Korea

Corresponding author: Jinho Park , Tel: +82-62-610-1729;,

Received: 1 October 2018 • Revised: 31 October 2018 • Accepted: 1 November 2018

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Abstract

Diarrhea is a fatal disease to neonatal calves, and rotavirus is the main pathogen associated with neonatal calf diarrhea. Although previous studies have reported that the gut microbiota is changed in calves during diarrhea, less is known about whether rotavirus infection alters the structure of the gut microbiota. Here, we characterized fecal microbial communities and identified possible relationships between the gut microbiota profiles and physiological parameters. Five fecal specimens of rotavirus-infected calves from 1 to 30 days after birth and five fecal specimens of age-matched healthy calves were used for the microbial community analysis using the Illumina MiSeq sequencer. Rotavirus infection was associated with reduced rotavirus infection significantly reduced the richness and diversity of the bacterial community. Weighted unique fraction metric analysis exhibited significant differences in community membership and structure between healthy and rotavirus-infected calves. Based on relative abundance analysis and linear discriminant analysis effect size, we found that the representative genera from Lactobacillus, Subdoligranulum, Blautia, and Bacteroides were closely related to healthy calves, while the genera Escherichia and Clostridium were closely affiliated to rotavirus-infected calves. Furthermore, canonical correlation analysis and Pearson correlation coefficient results revealed that the increased relative abundances of Lactobacillus, Subdoligranulum, and Bacteroides were correlated with normal levels of physiological characteristics such as white blood cells, blood urea nitrogen, serum amyloid protein A, and glucose concentration in serum. These
results
suggest that rotavirus infection alters the structure of the gut microbiota, correlating changes in physiological

Keywords: diarrhea;rotavirus;gut microbiota;physiological parameters

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Rotavirus-mediated alteration of gut microbiota and its correlation with physiological characteristics in neonatal calves

J. Microbiol. 2019;57(2):113-121. Published online November 19, 2018

DOI: https://doi.org/10.1007/s12275-019-8549-1

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