Cure of tuberculosis using nanotechnology: An overview

Rout George Kerry; Sushanto Gouda; Bikram Sil; Gitishree Das; Han-Seung Shin; Gajanan Ghodake; Jayanta Kumar Patra

doi:10.1007/s12275-018-7414-y

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Review
Cure of tuberculosis using nanotechnology: An overview: Rout George Kerry ¹, Sushanto Gouda ², Bikram Sil ¹, Gitishree Das ³, Han-Seung Shin ⁴, Gajanan Ghodake ⁵, Jayanta Kumar Patra ³; Journal of Microbiology 2018;56(5):287-299.
DOI: https://doi.org/10.1007/s12275-018-7414-y
Published online: May 2, 2018

¹Department of Biotechnology, AMIT College, Khurda 752057, Odisha, India, ²Amity Institute of Wildlife Science, Amity University, Noida 201313, Uttar Pradesh, India, ³Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyang 10326, Republic of Korea, ⁴Department of Food Science and Biotechnology, Dongguk University-Seoul, Goyang 10326, Republic of Korea, ⁵Department of Biological and Environmental Science, College of Life Science and Biotechnology, Dongguk University-Seoul, Goyang 10326, Republic of Korea

Corresponding author: Han-Seung Shin , Tel: +82-31-961-5625,
Jayanta Kumar Patra , Tel: +82-31-961-5625,

Received: 29 September 2017 • Revised: 4 January 2018 • Accepted: 4 January 2018

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Abstract

Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), a major health issue of the present era. The bacterium inhabits the host macrophage and other immune cells where it modulates the lysosome trafficking protein, hinders the formation of phagolysosome, and blocks the TNF receptor- dependent apoptosis of host macrophage/monocytes. Other limitations such as resistance to and low bioavailability and bio-distribution of conventional drugs aid to their high virulence and human mortality. This review highlights the use of nanotechnology-based approaches for drug formulation and delivery which could open new avenues to limit the pathogenicity of tuberculosis. Moreover phytochemicals, such as alkaloids, phenols, saponins, steroids, tannins, and terpenoids, extracted from terrestrial plants and mangroves seem promising against M. tuberculosis through different molecular mechanisms. Further understanding of the genomics and proteomics of this pathogenic microbe could also help overcome various research gaps in the path of developing a suitable therapy against tuberculosis.

Keywords: tuberculosis;Mycobacterium tuberculosis;infectious diseases;proteomics;genomics;nano-medicine

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Cure of tuberculosis using nanotechnology: An overview

J. Microbiol. 2018;56(5):287-299. Published online May 2, 2018

DOI: https://doi.org/10.1007/s12275-018-7414-y

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