REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins

Megan E. Schmidt; Steven M. Varga

doi:10.1007/s12275-017-7045-8

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REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins: Megan E. Schmidt ¹, Steven M. Varga ^1,2,3; Journal of Microbiology 2017;55(3):161-171.
DOI: https://doi.org/10.1007/s12275-017-7045-8
Published online: February 28, 2017

¹Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA, ²Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA, ³Department of Pathology, University of Iowa, Iowa City, IA 52242, USA

Corresponding author: Steven M. Varga , Tel: +1-319-335-7784,

Received: 31 January 2017 • Accepted: 17 February 2017

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Abstract

Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early childhood, and reinfections with the virus are common throughout life. Despite its clinical impact, there remains no licensed RSV vaccine. RSV infection in the respiratory tract induces an inflammatory response by the host to facilitate efficient clearance of the virus. However, the host immune response also contributes to the respiratory disease observed following an RSV infection. RSV has evolved several mechanisms to evade the host immune response and promote virus replication through interactions between RSV proteins and immune components. In contrast, some RSV proteins also play critical roles in activating, rather than suppressing, host immunity. In this review, we discuss the interactions between individual RSV proteins and host factors that modulate the immune response and the implications of these interactions for the course of an RSV infection.

Keywords: RSV;virus;T cell;lung;vaccine

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REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins

J. Microbiol. 2017;55(3):161-171. Published online February 28, 2017

DOI: https://doi.org/10.1007/s12275-017-7045-8

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