RraAS1 inhibits the ribonucleolytic activity of RNase ES by interacting with its catalytic domain in Streptomyces coelicolor

Sojin Seo; Daeyoung Kim; Wooseok Song; Jihune Heo; Minju Joo; Yeri Lim; Ji-Hyun Yeom; Kangseok Lee

doi:10.1007/s12275-017-6518-0

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RraAS1 inhibits the ribonucleolytic activity of RNase ES by interacting with its catalytic domain in Streptomyces coelicolor: Sojin Seo , Daeyoung Kim , Wooseok Song , Jihune Heo , Minju Joo , Yeri Lim , Ji-Hyun Yeom , Kangseok Lee; Journal of Microbiology 2017;55(1):37-43.
DOI: https://doi.org/10.1007/s12275-017-6518-0
Published online: December 30, 2016

Department of Life Science, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea

Corresponding author: Ji-Hyun Yeom , Tel: -,
Kangseok Lee , Tel: -,

Received: 12 October 2016 • Revised: 15 December 2016 • Accepted: 20 December 2016

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Abstract

RraA is a protein inhibitor of RNase E, which degrades and processes numerous RNAs in Escherichia coli. Streptomyces coelicolor also contains homologs of RNase E and RraA, RNase ES and RraAS1/RraAS2, respectively. Here, we report that, unlike other RraA homologs, RraAS1 directly interacts with the catalytic domain of RNase ES to exert its inhibitory effect. We further show that rraAS1 gene deletion in S. coelicolor
results
in a higher growth rate and increased production of actinorhodin and undecylprodigiosin, compared with the wild-type strain, suggesting that RraAS1-mediated regulation of RNase ES activity contributes to modulating the cellular physiology of S. coelicolor.

Keywords: Streptomyces coelicolor;RNase E;RNase ES;RraA;RraAS1

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RraAS1 inhibits the ribonucleolytic activity of RNase ES by interacting with its catalytic domain in Streptomyces coelicolor

J. Microbiol. 2017;55(1):37-43. Published online December 30, 2016

DOI: https://doi.org/10.1007/s12275-017-6518-0

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