Abstract
Histoplasma capsulatum is a dimorphic pathogenic fungus
and causative agent of histoplasmosis, which is a respiratory
and systemic infection that is particularly severe in immunocompromised
hosts and represents the fungal homolog of
tuberculosis. In highly endemic regions, the majority of individuals
have been infected and carry the organism in a persistent
latent form that is a danger for reactivation if host
defenses are suppressed. H. capsulatum has been a model
organism for intracellular pathogenesis and fungal morphogenesis
for decades. New genomic information and application
of approaches for molecular genetic manipulation are
shedding new light on virulence mechanisms.
Citations
Citations to this article as recorded by

- Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report
Ruth C. Angrand, Lauren Telesca, Muhammad Aslam
IDCases.2025; 39: e02175. CrossRef - Histoplasmosis in Non-HIV Infected Patients: Another Neglected Infection in French Guiana
Houari Aissaoui, Morgane Bourne-Watrin, Benoit Lemarie, Genevieve Guillot, Alolia Aboikoni, Piseth Chhorn, Dana Gaudard, Ghazi Hadj-Amara, Ricardo Manasse, Mahamado Ouedraogo, Charles Salloum, Magalie Demar, Loïc Epelboin, Hatem Kallel, Antoine Adenis, Ma
Journal of Fungi.2024; 10(6): 400. CrossRef - “We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes
Johannes Sonnberger, Lydia Kasper, Theresa Lange, Sascha Brunke, Bernhard Hube
Molecular Microbiology.2024; 121(3): 341. CrossRef - The influence of a copper efflux pump in Histoplasma capsulatum virulence
Dayane Moraes, Gabriel Brum Tristão, Chad A. Rappleye, Stephanie C. Ray, Fátima Ribeiro‐Dias, Rodrigo Saar Gomes, Leandro do Prado Assunção, Juliano Domiraci Paccez, Rosely Maria Zancopé‐Oliveira, Mirelle Garcia Silva‐Bailão, Célia Maria de Almeida Soares
The FEBS Journal.2024; 291(4): 744. CrossRef - Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis
Anastasia Wasylyshyn, Gina Maki, Kathleen A. Linder, Erica S. Herc
Infectious Diseases in Clinical Practice.2022;[Epub] CrossRef - Important Mycoses of Wildlife: Emphasis on Etiology, Epidemiology, Diagnosis, and Pathology—A Review: PART 1
Iniobong Chukwuebuka Ikenna Ugochukwu, Chioma Inyang Aneke, Nuhu Abdulazeez Sani, Jacinta Ngozi Omeke, Madubuike Umunna Anyanwu, Amienwanlen Eugene Odigie, Remigius Ibe Onoja, Ohiemi Benjamin Ocheja, Miracle Oluchukwu Ugochukwu, Iasmina Luca, Olabisi Amin
Animals.2022; 12(15): 1874. CrossRef - Key thermally dimorphic fungal pathogens: shaping host immunity
Maxine A. Höft, Lucian Duvenage, J. Claire Hoving
Open Biology.2022;[Epub] CrossRef - Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages
Allison Cohen, Edwin E. Jeng, Mark Voorhies, Jane Symington, Nebat Ali, Rosa A. Rodriguez, Michael C. Bassik, Anita Sil, Alex Andrianopoulos
PLOS Pathogens.2022; 18(9): e1010237. CrossRef - Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis
Dinara Azimova, Nadia Herrera, Lucian Duvenage, Mark Voorhies, Rosa A. Rodriguez, Bevin C. English, Jennifer C. Hoving, Oren Rosenberg, Anita Sil, Mairi C. Noverr
PLOS Pathogens.2022; 18(6): e1010417. CrossRef - Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis
Alfredo G. Puing, Shyam S. Raghavan, Maria A. Aleshin, Dora Y. Ho
Medical Mycology Case Reports.2021; 33: 18. CrossRef - Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella
Sylwia Stączek, Agnieszka Zdybicka-Barabas, Iwona Wojda, Adrian Wiater, Paweł Mak, Piotr Suder, Krzysztof Skrzypiec, Małgorzata Cytryńska
Molecules.2021; 26(16): 5097. CrossRef - Comparative Proteomic Analysis of Histoplasma capsulatum Yeast and Mycelium Reveals Differential Metabolic Shifts and Cell Wall Remodeling Processes in the Different Morphotypes
Marcos Abreu Almeida, Lilian Cristiane Baeza, Rodrigo Almeida-Paes, Alexandre Melo Bailão, Clayton Luiz Borges, Allan Jefferson Guimarães, Célia Maria Almeida Soares, Rosely Maria Zancopé-Oliveira
Frontiers in Microbiology.2021;[Epub] CrossRef - Neutrophil and Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi
Juliana da Costa Silva, Glaucia de Azevedo Thompson-Souza, Marina Valente Barroso, Josiane Sabbadini Neves, Rodrigo Tinoco Figueiredo
Frontiers in Microbiology.2021;[Epub] CrossRef - Aspergillus niger α-1,3-glucan acts as a virulence factor by inhibiting the insect phenoloxidase system
Sylwia Stączek, Agnieszka Zdybicka-Barabas, Małgorzata Pleszczyńska, Adrian Wiater, Małgorzata Cytryńska
Journal of Invertebrate Pathology.2020; 171: 107341. CrossRef - Fungal Pathogens: Shape-Shifting Invaders
Kyunghun Min, Aaron M. Neiman, James B. Konopka
Trends in Microbiology.2020; 28(11): 922. CrossRef - Crohn's disease or histoplasmosis? A case of severe disseminated histoplasmosis mimicking Crohn's disease and literature review
Ahmed Ahmed, Nora Homsi, Rajendra Kapila
Medical Mycology Case Reports.2020; 30: 8. CrossRef - Capacity ofHistoplasma capsulatumto Survive the Composting Process
Luisa Fernanda Gómez Londoño, Laura Carolina Pérez León, Juan Guillermo McEwen Ochoa, Alejandra Zuluaga Rodriguez, Carlos Alberto Peláez Jaramillo, Jose Miguel Acevedo Ruiz, María Lucia Taylor, Myrtha Arango Arteaga, María del Pilar Jiménez Alzate
Applied and Environmental Soil Science.2019; 2019: 1. CrossRef - Sensing the heat and the host: Virulence determinants ofHistoplasma capsulatum
Sinem Beyhan, Anita Sil
Virulence.2019; 10(1): 793. CrossRef - Fungal Extracellular Vesicles as Potential Targets for Immune Interventions
Mateus Silveira Freitas, Vânia Luiza Deperon Bonato, Andre Moreira Pessoni, Marcio L. Rodrigues, Arturo Casadevall, Fausto Almeida, Aaron P. Mitchell
mSphere.2019;[Epub] CrossRef - Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents.
Leila M Lopes-Bezerra, Hector M Mora-Montes, Yu Zhang, Gustavo Nino-Vega, Anderson Messias Rodrigues, Zoilo Pires de Camargo, Sybren de Hoog
Medical Mycology.2018; 56(suppl_1): S126. CrossRef - Reactivation of dormant/latent fungal infection
Kevin Brunet, Alexandre Alanio, Olivier Lortholary, Blandine Rammaert
Journal of Infection.2018; 77(6): 463. CrossRef - Disseminated histoplasmosis mimicking relapsed chronic lymphocytic leukaemia
Lokesh Shahani
BMJ Case Reports.2018; : bcr-2018-224498. CrossRef - The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum
Bevin C. English, Nancy Van Prooyen, Tiit Örd, Tõnis Örd, Anita Sil, Robert A. Cramer
PLOS Pathogens.2017; 13(9): e1006589. CrossRef - Histoplasmosis hepatitis after orthotopic liver transplantation
Laura Washburn, N Thao Galván, Sadhna Dhingra, Abbas Rana, John A Goss
Journal of Surgical Case Reports.2017;[Epub] CrossRef - Fungal infections in HIV/AIDS
Andrew H Limper, Antoine Adenis, Thuy Le, Thomas S Harrison
The Lancet Infectious Diseases.2017; 17(11): e334. CrossRef - Use of Fungal Diagnostics and Therapy in Pediatric Cancer Patients in Resource-Limited Settings
Sheena Mukkada, Jeannette Kirby, Nopporn Apiwattanakul, Randall T. Hayden, Miguela A. Caniza
Current Clinical Microbiology Reports.2016; 3(3): 120. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef