Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus

Mohammed Kawser Hossain; Hye Yeon Choi; Jae-Seon Hwang; Ahmed Abdal Dayem; Jung-Hyun Kim; Young Bong Kim; Haryoung Poo; Ssang-Goo Cho

doi:10.1007/s12275-014-4212-z

Articles

Page Path: HOME > J. Microbiol > Volume 52(6); 2014 > Article

Research Support, Non-U.S. Gov't
Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus: Mohammed Kawser Hossain ¹, Hye Yeon Choi ¹, Jae-Seon Hwang ², Ahmed Abdal Dayem ¹, Jung-Hyun Kim ¹, Young Bong Kim ³, Haryoung Poo ², Ssang-Goo Cho ¹; Journal of Microbiology 2014;52(6):521-526.
DOI: https://doi.org/10.1007/s12275-014-4212-z
Published online: May 29, 2014

¹Department of Animal Biotechnology, Animal Resources Research Center, and Incurable Disease Animal model and Stem cell Institute (IDASI), Konkuk University, Seoul 143-701, Republic of Korea, ²Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea, ³Department of Bioindustrial Technologies, Konkuk University, Seoul 143-701, Republic of Korea

Corresponding author: Ssang-Goo Cho , Tel: +82-2-450-4207,

Received: 3 April 2014 • Revised: 21 April 2014 • Accepted: 21 April 2014

prev next

114 Views
0 Download
17 Crossref
20 Scopus

Full Article

Abstract

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2'-dihydroxyflavone (3,2'-DHF) and 3,4'-dihydroxyflavone (3,4'-DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4'-DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4'-DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.

Keywords: flavonoid, 3-hydroxyl group flavonoids, 3,4'-dihydroxyflavone, influenza virus

Figure & Data

References

Citations

Citations to this article as recorded by

Antifungal and antibiofilm activities of flavonoids against Candida albicans: Focus on 3,2′-dihydroxyflavone as a potential therapeutic agent
Jin-Hyung Lee, Yong-Guy Kim, Inji Park, Jintae Lee
Biofilm.2024; 8: 100218. CrossRef
Selected flavonoids exhibit antibiofilm and antibacterial effects against Vibrio by disrupting membrane integrity, virulence and metabolic activities
Olajide Sunday Faleye, Jin-Hyung Lee, Jintae Lee
Biofilm.2023; 6: 100165. CrossRef
Specialized metabolites from plants as a source of new multi-target antiviral drugs: a systematic review
Maria Ponticelli, Maria Laura Bellone, Valentina Parisi, Annamaria Iannuzzi, Alessandra Braca, Nunziatina de Tommasi, Daniela Russo, Annalisa Sileo, Paola Quaranta, Giulia Freer, Mauro Pistello, Luigi Milella
Phytochemistry Reviews.2023; 22(3): 615. CrossRef
Technological Maturity and Systematic Review of Medicinal Plants with Pharmacological Activity in the Central Nervous System
Eduardo M.S. Bastos, Victor D.A. da Silva, Silvia L. Costa, Samira A. Hanna
Recent Patents on Biotechnology.2021; 15(2): 89. CrossRef
Hypoglycemic Effects of Plant Flavonoids: A Review
Foo Sok Yen, Chan Shu Qin, Sharryl Tan Shi Xuan, Puah Jia Ying, Hong Yi Le, Thiviya Darmarajan, Baskaran Gunasekaran, Shamala Salvamani, Huijun Wang
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
3,2′-Dihydroxyflavone Improves the Proliferation and Survival of Human Pluripotent Stem Cells and Their Differentiation into Hematopoietic Progenitor Cells
Kyeongseok Kim, Ahmed Abdal Dayem, Minchan Gil, Gwang-Mo Yang, Soo Bin Lee, Oh-Hyung Kwon, Sangbaek Choi, Geun-Ho Kang, Kyung Min Lim, Dongho Kim, Ssang-Goo Cho
Journal of Clinical Medicine.2020; 9(3): 669. CrossRef
pH dependency of the structural and photophysical properties of the atypical 2′,3-dihydroxyflavone
Luc Labarrière, Aurélien Moncomble, Jean-Paul Cornard
RSC Advances.2020; 10(58): 35017. CrossRef
Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells
Kyeongseok Kim, Minchan Gil, Ahmed Dayem, Sangbaek Choi, Geun-Ho Kang, Gwang-Mo Yang, Sungha Cho, Yeojin Jeong, Se Kim, Jaekwon Seok, Hee Kwak, Subbroto Kumar Saha, Aram Kim, Ssang-Goo Cho
Journal of Clinical Medicine.2020; 9(3): 827. CrossRef
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2–HMOX1 axis
Xuewei Liu, Zhongbao Song, Juan Bai, Hans Nauwynck, Yongxiang Zhao, Ping Jiang
Veterinary Research.2019;[Epub] CrossRef
Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
Raghad Khalid AL-Ishaq, Mariam Abotaleb, Peter Kubatka, Karol Kajo, Dietrich Büsselberg
Biomolecules.2019; 9(9): 430. CrossRef
Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos
Parvaneh Mehrbod, Samad Nejad Ebrahimi, Fatemeh Fotouhi, Fatemeh Eskandari, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina
BMC Complementary and Alternative Medicine.2019;[Epub] CrossRef
Bax Inhibitor-1 Acts as an Anti-Influenza Factor by Inhibiting ROS Mediated Cell Death and Augmenting Heme-Oxygenase 1 Expression in Influenza Virus Infected Cells
Mohammed Hossain, Subbroto Saha, Ahmed Abdal Dayem, Jung-Hyun Kim, Kyeongseok Kim, Gwang-Mo Yang, Hye Choi, Ssang-Goo Cho
International Journal of Molecular Sciences.2018; 19(3): 712. CrossRef
Antiviral activity of Poncirus trifoliata seed extract against oseltamivir-resistant influenza virus
Yoonki Heo, Yeondong Cho, Kwon sung Ju, Hansam Cho, Ki Hoon Park, Hanul Choi, Jong Kwang Yoon, Chiung Moon, Young Bong Kim
Journal of Microbiology.2018; 56(8): 586. CrossRef
Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O. Aro, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina
BMC Complementary and Alternative Medicine.2018;[Epub] CrossRef
Seasonal variation of pheophorbide a and flavonoid in different organs of two Carpinus species and its correlation with immunosuppressive activity
Qianqian Sheng, Xianying Fang, Zunling Zhu, Wei Xiao, Zhenzhong Wang, Gang Ding, Linguo Zhao, Yujian Li, Ping Yu, Zhibin Ding, Qinru Sun
In Vitro Cellular & Developmental Biology - Animal.2016; 52(6): 654. CrossRef
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Mohammed Kawser Hossain, Ahmed Abdal Dayem, Jihae Han, Yingfu Yin, Kyeongseok Kim, Subbroto Kumar Saha, Gwang-Mo Yang, Hye Choi, Ssang-Goo Cho
International Journal of Molecular Sciences.2016; 17(4): 569. CrossRef
Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza
Ahmed Abdal Dayem, Hye Yeon Choi, Young Bong Kim, Ssang-Goo Cho, Luis Menéndez-Arias
PLOS ONE.2015; 10(3): e0121610. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus

J. Microbiol. 2014;52(6):521-526. Published online May 29, 2014

DOI: https://doi.org/10.1007/s12275-014-4212-z

Related articles