The Anti-influenza Virus Effect of Phellinus igniarius Extract

Sangmoo Lee; Jin Il Kim; Jun Heo; Ilseob Lee; Sehee Park; Min-Woong Hwang; Joon-Yong Bae; Mee Sook Park; Hyoung Jin Park; Man-Seong Park

doi:10.1007/s12275-013-3384-2

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Research Support, Non-U.S. Gov't
The Anti-influenza Virus Effect of Phellinus igniarius Extract: Sangmoo Lee ^1,2, Jin Il Kim ^1,2, Jun Heo ^1,2, Ilseob Lee ^1,2, Sehee Park ^1,2, Min-Woong Hwang ^1,2, Joon-Yong Bae ^1,2, Mee Sook Park ^1,2, Hyoung Jin Park ³, Man-Seong Park ^1,2; Journal of Microbiology 2013;51(5):676-681.
DOI: https://doi.org/10.1007/s12275-013-3384-2
Published online: October 31, 2013

¹Department of Microbiology, Hallym University, Chuncheon 200-702, Republic of Korea, ²Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ³MushMed Co. LTD., Business Incubator, Hallym University, Chuncheon 200-702, Republic of Korea¹Department of Microbiology, Hallym University, Chuncheon 200-702, Republic of Korea, ²Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ³MushMed Co. LTD., Business Incubator, Hallym University, Chuncheon 200-702, Republic of Korea

Corresponding author: Man-Seong Park , Tel: +82-33-248-2632,

Received: 23 July 2013 • Accepted: 22 August 2013

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Abstract

Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multicomponent nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

Keywords: antiviral;herbal;influenza;multi-drug;Phellinus igniarius

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The Anti-influenza Virus Effect of Phellinus igniarius Extract

J. Microbiol. 2013;51(5):676-681. Published online October 31, 2013

DOI: https://doi.org/10.1007/s12275-013-3384-2

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