The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection

Mei Ling Xu; Hyoung Jin Kim; Don Yong Chang; Hong-Jin Kim

doi:10.1007/s12275-013-2683-y

Articles

Page Path: HOME > J. Microbiol > Volume 51(3); 2013 > Article

Journal Article
The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection: Mei Ling Xu , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim; Journal of Microbiology 2013;51(3):389-393.
DOI: https://doi.org/10.1007/s12275-013-2683-y
Published online: April 26, 2013

College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea

Corresponding author: Hong-Jin Kim , Tel: +82-2-820-5613,

Received: 12 December 2012 • Accepted: 2 January 2013

prev next

208 Views
0 Download
6 Crossref
6 Scopus

Full Article

Download PDF

Abstract

Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

Keywords: bovine colostrums;acidic protein;dietary intake;influenza A virus

Figure & Data

References

Citations

Citations to this article as recorded by

The Toxic Effects of Low Molecular Weight Components of Cow Colostrums: The Short-Term and Long-Term Effects
A.I. Bozhkov, E.G. Ivanov, N.I. Kurguzova, Muhammad M.A. Alsardia, R.A. Akzhigitov, S.Ya. Baranikova, V.I. Potapova, A.S. Chuprikova
Journal of Nutritional Therapeutics.2021; 6(4): 84. CrossRef
Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of COVID-19
Alyne Batista da Silva Galdino, Adriano Henrique do Nascimento Rangel, Harpal Singh Buttar, Manuela Sales Lima Nascimento, Elaine Cristina Gavioli, Riva de Paula Oliveira, Danielle Cavalcanti Sales, Stela Antas Urbano, Katya Anaya
Food and Agricultural Immunology.2021; 32(1): 143. CrossRef
Influenza A in Bovine Species: A Narrative Literature Review
Chithra C. Sreenivasan, Milton Thomas, Radhey S. Kaushik, Dan Wang, Feng Li
Viruses.2019; 11(6): 561. CrossRef
Effective Components of Bovine Colostrum and Its Applications
Sang-Ah Seo, Hye-Ryoung Seo, Young-Tae Heo
Journal of Animal Reproduction and Biotechnology.2018; 33(3): 159. CrossRef
The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
Mei Ling Xu, Hyoung Jin Kim, Ga Ram Wi, Hong-Jin Kim
Journal of Microbiology.2015; 53(9): 661. CrossRef
Effect of dietary bovine colostrum on the responses of immune cells to stimulation with bacterial lipopolysaccharide
Mei Ling Xu, Hyoung Jin Kim, Hong-Jin Kim
Archives of Pharmacal Research.2014; 37(4): 494. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection

J. Microbiol. 2013;51(3):389-393. Published online April 26, 2013

DOI: https://doi.org/10.1007/s12275-013-2683-y

Related articles