Clonal Spread of Carbapenem Resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-Year Period

Lei Huang; Liying Sun; Yan Yan

doi:10.1007/s12275-013-2341-4

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Research Support, Non-U.S. Gov't
Clonal Spread of Carbapenem Resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-Year Period: Lei Huang , Liying Sun , Yan Yan; Journal of Microbiology 2013;51(1):113-117.
DOI: https://doi.org/10.1007/s12275-013-2341-4
Published online: March 2, 2013

Department of Clinical Laboratory, Peking University First Hospital, Beijing 100034, P. R. China

Corresponding author: Lei Huang , Tel: +86-10-83572485,

Received: 4 July 2012 • Accepted: 8 September 2012

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Abstract

The carbapenem resistance rate of Acinetobacter baumannii in our hospital has increased steadily since 2004. The molecular epidemiology of carbapenem resistant A. baumannii (CRAB) clinical isolates was characterized by multilocus sequence typing (MLST) and rep-PCR in parallel, with pandrug susceptible A. baumannii (PSAB) used as control. MLST was performed to determine the sequence types (STs), and eBURST algorithm was used to analyze their relatedness. Carbapenem resistance related genes (oxa-23, oxa-24, oxa-51, oxa-58, imp, vim, and adeB) were screened using Polymerase Chain Reaction (PCR) method. 23 STs were identified in the 65 included isolates, with ST92 being the predominant clone. PSAB clustered into more singletons than CRAB. The positivity of oxa-23 and adeB correlated with high level carbapenem resistance (MICIPM>32 mg/L, MICMEM>32 mg/L) of CRAB ST92 isolates in 2009, which was different from the resistance pattern (MICIPM≤4 mg/L, 8 mg/L ≤MICMEM≤16 mg/L) of CRAB ST92 isolates in 2004. These observations suggest that clonal spread of CRAB ST92 isolates longitudinally is the possible reason for carbapenem resistance rate increase and correlate with high level carbapenem resistance in our hospital.

Keywords: Acinetobacter baumannii;carbapenem resistance;Multilocus Sequence Typing (MLST);clonal spread

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Clonal Spread of Carbapenem Resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-Year Period

J. Microbiol. 2013;51(1):113-117. Published online March 2, 2013

DOI: https://doi.org/10.1007/s12275-013-2341-4

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