NOTE] Envelope Diversity, Characteristics of V3 Region and Predicted Co-Receptor Usage of Human Immunodeficiency Viruses Infecting North Indians

Raiees Andrabi; Rajesh Kumar; Manju Bala; Ambili Nair; Prakash SS; Vandana Kushwaha; Kalpana Luthra

doi:10.1007/s12275-012-2136-z

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NOTE] Envelope Diversity, Characteristics of V3 Region and Predicted Co-Receptor Usage of Human Immunodeficiency Viruses Infecting North Indians: Raiees Andrabi ¹, Rajesh Kumar ¹, Manju Bala ², Ambili Nair ¹, Prakash SS ¹, Vandana Kushwaha ¹, Kalpana Luthra ¹; Journal of Microbiology 2012;50(5):869-873.
DOI: https://doi.org/10.1007/s12275-012-2136-z
Published online: November 4, 2012

¹Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, ²Regional STD Teaching Training & Research Centre, Safdarjung Hospital, New Delhi, India

Corresponding author: Kalpana Luthra , Tel: +91-11-26546431,

Received: 12 March 2012 • Accepted: 12 June 2012

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Abstract

Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.

Keywords: HIV-1;subtypes;envelope glycoprotein;variable regions;co-receptor usage

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NOTE] Envelope Diversity, Characteristics of V3 Region and Predicted Co-Receptor Usage of Human Immunodeficiency Viruses Infecting North Indians

J. Microbiol. 2012;50(5):869-873. Published online November 4, 2012

DOI: https://doi.org/10.1007/s12275-012-2136-z

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