Lactobacillus salivarius REN Counteracted Unfavorable 4-Nitroquinoline-1-Oxide-Induced Changes in Colonic Microflora of Rats

Ming Zhang; Xuewei Qiao; Liang Zhao; Lu Jiang; Fazheng Ren

doi:10.1007/s12275-011-1137-7

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Lactobacillus salivarius REN Counteracted Unfavorable 4-Nitroquinoline-1-Oxide-Induced Changes in Colonic Microflora of Rats: Ming Zhang ¹, Xuewei Qiao ¹, Liang Zhao ¹, Lu Jiang ², Fazheng Ren ^1,2; Journal of Microbiology 2011;49(6):877-883.
DOI: https://doi.org/10.1007/s12275-011-1137-7
Published online: December 28, 2011

¹Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, P. R. China, ²Beijing Higher Institution Engineering Research Center of Animal Product, P. R. China Agricultural University, Beijing 100083, P. R. China

Corresponding author: Fazheng Ren , Tel: +86-10-6273-6344,

Received: 17 March 2011 • Accepted: 20 July 2011

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Abstract

Probiotics and carcinogens both have a significant effect on the microfloral composition of the human intestine. The objective of this study was to investigate the impact of an important carcinogen, 4-Nitroquinoline-1- Oxide on colonic microflora and the efficacy of the probiotic Lactobacillus salivarius REN as an agent of counteracting these effects. Using denaturing gradient gel electrophoresis (DGGE) combined with redundancy analysis, we demonstrated that both 4-Nitroquinoline-1-Oxide and L. salivarius REN significantly altered the bacterial communities of rat colons. A total of 27 bacterial strains were identified as being affected by treatment with 4-Nitroquinoline-1-Oxide or L. salivarius REN using a t-value biplot combined with band sequencing. 4-Nitroquinoline-1-Oxide treatment increased the abundance of two potential pathogens (one Helicobacter strain and one Desulfovibrio strain), as well as reducing the abundance of two potentially beneficial strains (one Ruminococcaceae strain and one Rumen bacteria). The Helicobacter strain was initally detected in carcinogen-treated rat intestinal microflora, but L. salivarius REN treatment effectively suppressed the growth of the Helicobacter strain. These results suggested that L. salivarius REN may be a potential probiotic, efficiently acting against the initial infection with, and the growth of pathogenic bacteria.

Keywords: colonic microflora;4-nitroquinoline-1-oxide;Lactobacillus salivarius REN;DGGE

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Lactobacillus salivarius REN Counteracted Unfavorable 4-Nitroquinoline-1-Oxide-Induced Changes in Colonic Microflora of Rats

J. Microbiol. 2011;49(6):877-883. Published online December 28, 2011

DOI: https://doi.org/10.1007/s12275-011-1137-7

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