Production of Cephalosporin C Using Crude Glycerol in Fed-Batch Culture of Acremonium chrysogenum M35

Hyun Yong Shin; Jin Young Lee; Han Suk Choi; Ja Hyun Lee; Seung Wook Kim

doi:10.1007/s12275-011-1155-5

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Research Support, Non-U.S. Gov't
Production of Cephalosporin C Using Crude Glycerol in Fed-Batch Culture of Acremonium chrysogenum M35: Hyun Yong Shin , Jin Young Lee , Han Suk Choi , Ja Hyun Lee , Seung Wook Kim; Journal of Microbiology 2011;49(5):753-758.
DOI: https://doi.org/10.1007/s12275-011-1155-5
Published online: November 9, 2011

Department of Chemical and Biological Engineering, Korea University, Seoul 136-701, Republic of Korea

Corresponding author: Seung Wook Kim , Tel: +82-2-3290-3300,

Received: 28 March 2011 • Accepted: 17 June 2011

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Abstract

In this study, cephalosporin C production by Acremonium chrysogenum M35 cultured with crude glycerol instead of rice oil and methionine was investigated. The addition of crude glycerol increased cephalosporin C production by 6-fold in shake-flask culture, and also the amount of cysteine. In fed-batch culture without methionine, crude glycerol resulted only in overall improvement in cephalosporin C production (about 700%). In addition, A. chrysogenum M35 became highly differentiated in fed-batch culture with crude glycerol, compared with the differentiation in batch culture. The results presented here suggest that crude glycerol can replace methionine and plant oil as cysteine and carbon sources during cephalosporin C production by A. chrysogenum M35.

Keywords: cysteine;cystathionine-γ-lyase activity;Acremonium chrysogenum M35;methionine;cephalosporin C;crude glycerol

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Production of Cephalosporin C Using Crude Glycerol in Fed-Batch Culture of Acremonium chrysogenum M35

J. Microbiol. 2011;49(5):753-758. Published online November 9, 2011

DOI: https://doi.org/10.1007/s12275-011-1155-5

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