Asc1p, a Ribosomal Protein, Plays a Pivotal Role in Cellular Adhesion and Virulence in Candida albicans

Se Woong Kim; Yoo Jin Joo; Joon Kim

doi:10.1007/s12275-010-0422-1

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Asc1p, a Ribosomal Protein, Plays a Pivotal Role in Cellular Adhesion and Virulence in Candida albicans: Se Woong Kim , Yoo Jin Joo , Joon Kim; Journal of Microbiology 2010;48(6):842-848.
DOI: https://doi.org/10.1007/s12275-010-0422-1
Published online: January 9, 2011

Laboratory of Biochemistry, School of Life Sciences and Biotechnology, and BioInstitute, Korea University, Seoul 136-701, Republic of Korea

Corresponding author: Joon Kim , Tel: +82-2-3290-3442,

Received: 30 September 2010 • Accepted: 16 November 2010

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Abstract

Candida albicans, the common human fungal pathogen, can switch morphology from yeast to pseudohyphal or hyphal form upon various environmental cues. It is well-known that the ability of morphological conversion and adhesive growth renders C. albicans virulent. It is noteworthy that every factor involved in the morphogenesis is known to be important for the virulence of this pathogen. To examine a functional relevance of Asc1p, a ribosomal protein, in morphogenesis and virulence, an asc1 homozygous null mutant was generated. Although a normal morphological transition of the asc1 deletion strain in liquid media was found, it did not change its morphology on solid media. Moreover, the adhesion activity and hyphal-specific gene expression were defective due to ASC1 deletion. Finally, it was found that the asc1 null mutant was avirulent in a mouse model. These results strongly suggested that Asc1p a component of the 40S ribosomal subunit and a signal transducer, plays a pivotal role in cellular adhesion and virulence through regulation of specific gene expression in C. albicans.

Keywords: C. albicans;Asc1p;ribosomal protein;virulence;adhesion

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Asc1p, a Ribosomal Protein, Plays a Pivotal Role in Cellular Adhesion and Virulence in Candida albicans

J. Microbiol. 2010;48(6):842-848. Published online January 9, 2011

DOI: https://doi.org/10.1007/s12275-010-0422-1

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