Journal of Microbiology

Reviews

Integrative perspectives on glycosylation networks in fungi and oomycetes: Heeji Moon, Hokyoung Son; J. Microbiol. 2025;63(12):e2510003. Published online December 31, 2025; DOI: https://doi.org/10.71150/jm.2510003

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Abstract PDF: Pathogenic fungi pose major threats to both global food security and human health, yet the molecular basis of their virulence remains only partially understood. Beyond genetic and transcriptional control, emerging evidence highlights protein glycosylation as a key post-translational modification that governs fungal development, stress adaptation, and host interactions. Glycosylation regulates protein folding, stability, trafficking, and immune evasion, thereby shaping infection processes across diverse pathogens. While extensively studied in model organisms, our understanding of glycosylation in pathogenic fungi remains fragmented and lacks a coherent framework linking glycosylation dynamics to fungal development and pathogenicity. This review synthesizes recent advances from proteomic, transcriptomic, and glycomic studies in pathogenic fungi, focusing on interspecific variation in glycogenes and enzymes, hierarchical regulatory networks, and glycoprotein-mediated mechanisms of virulence. Finally, we outline current challenges and highlight glycosylation-targeted strategies as promising avenues for antifungal intervention.

Extracellular vesicles of Gram-negative and Gram-positive probiotics: Yangyunqi Wang, Chongxu Duan, Xiaomin Yu; J. Microbiol. 2025;63(7):e2506005. Published online July 31, 2025; DOI: https://doi.org/10.71150/jm.2506005

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Extracellular vesicles derived from probiotics have received considerable attention for their pivotal role in bacterial‒host communication. These nanosized, bilayer-encapsulated vesicles carry diverse bioactive molecules, such as proteins, lipids, nucleic acids, and metabolites. Currently, ample evidence has emerged that probiotic extracellular vesicles may modulate several processes of host physiological hemostasis and offer therapeutic benefits. This review examines the biogenesis, composition, and immunomodulatory functions of probiotic-derived extracellular vesicles in probiotic–host interactions, highlighting the therapeutic potential of probiotic extracellular vesicles in the diagnosis and treatment of conditions such as cancer and inflammatory bowel disease. We further summarize the techniques for the separation and purification of extracellular vesicles, providing a methodological foundation for future research and applications. Although the field of probiotic extracellular vesicle research is still in its infancy, the prospects for their application in the biomedical field are broad, potentially emerging as a novel therapeutic approach.

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Decoding bacterial extracellular vesicles: A review on isolation and characterization techniques
Malatesh S. Devati, Apoorva Jnana, Stephen P. Kidd, Slade O. Jensen, T. G. Satheesh Babu, Dinesh Upadhya, Thokur S. Murali
Archives of Microbiology.2026;[Epub] CrossRef
Standardizing Bacterial Extracellular Vesicle Purification: A Call for Consensus
Dongsic Choi, Eun-Young Lee
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef
Advances in Biological Functions and Applications of Feeding Microorganism-derived Extracellular Vesicles
Yuanyuan Zhu, Xiaofang Zhang, Xin Feng, Yanyan Huang, Langhong Wang, Huihua Zhang, Xinan Zeng, Zhonglin Tang, Qien Qi
Probiotics and Antimicrobial Proteins.2025;[Epub] CrossRef

Full article

Phycobium rhodophyticola gen. nov., sp. nov. and Aliiphycobium algicola gen. nov., sp. nov., isolated from the phycosphere of marine red algae: Jeong Min Kim, Woonhee Baek, Byeong Jun Choi, Hülya Bayburt, Jae Kyeong Lee, Sung Chul Lee, Che Ok Jeon; J. Microbiol. 2025;63(6):e2503014. Published online June 30, 2025; DOI: https://doi.org/10.71150/jm.2503014

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Abstract PDF Supplementary Material

Two Gram-stain-negative, strictly aerobic, non-motile, rod-shaped bacteria, designated D3-12ᵀ and G2-2ᵀ, were isolated from the phycosphere of marine red algae. Both strains exhibited catalase- and oxidase-positive activities. Strain D3-12ᵀ grew optimally at 30°C, pH 7.0, and 2.0–3.0% (w/v) NaCl, while strain G2-2ᵀ showed optimal growth at 30°C, pH 7.0, and 2.0% NaCl. Ubiquinone-10 was the sole respiratory quinone in both strains. The major fatty acids (> 5%) in strain D3-12ᵀ were feature 8 (C_18:1 ω7c and/or C_18:1 ω6c), 11-methyl-C_18:1 ω7c, and C_16:0, while strain G2-2ᵀ contained summed feature 8 and C_16:0. The predominant polar lipids in strain D3-12ᵀ were phosphatidylcholine, phosphatidylglycerol, and phosphatidylethanolamine, whereas strain G2-2ᵀ contained phosphatidylglycerol and diphosphatidylglycerol. The genomic DNA G + C content was 59.9% for strain D3-12ᵀ and 60.2% for strain G2-2ᵀ. Phylogenetic analyses based on 16S rRNA and whole-genome sequences placed both strains into distinct lineages within the family Roseobacteraceae, separate from previously described genera. Genome-based relatedness metrics, including average nucleotide identity, digital DNA-DNA hybridization, average amino acid identity, and percentage of conserved proteins, further confirmed that these strains represent novel genera. Based on phenotypic, chemotaxonomic, and molecular characteristics, strains D3-12ᵀ and G2-2ᵀ are proposed as novel genera: Phycobium rhodophyticola gen. nov., sp. nov. (D3-12ᵀ = KACC 22712ᵀ = JCM 35528ᵀ) and Aliiphycobium algicola gen. nov., sp. nov. (G2-2ᵀ = KACC 22602ᵀ = JCM 35752ᵀ). Additionally, metabolic features relevant to interactions with marine algae, including genes associated with carbohydrate-active enzymes, vitamin biosynthesis, phenylacetic acid production, and bacterioferritin synthesis, were bioinformatically investigated.

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Ningiella algicola sp. nov. and Marinicella algicola sp. nov., proposal of Paralteromonas gen. Nov. and Neoalteromonas gen. Nov. with reclassification of Alteromonas species, and reclassification of Methylophaga aminisulfidivorans as a later heterotypic s
Hülya Bayburt, Jeong Min Kim, Byeong Jun Choi, Jae Kyeong Lee, Che Ok Jeon
Systematic and Applied Microbiology.2026; 49(1): 126685. CrossRef
Aquimarina rhodophyticola sp. nov. and Aquimarina besae sp. nov., Isolated from Marine Red Algae
Jeong Min Kim, Byeong Jun Choi, Hülya Bayburt, Dong Min Han, Che Ok Jeon
Current Microbiology.2025;[Epub] CrossRef
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Jae Kyeong Lee, Min Woo Lee, Chae Yeong Moon, Jeong Min Kim, Hülya Bayburt, Byeong Jun Choi, Che Ok Jeon
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef
Flagellimonas ulvae sp. nov. and Flagellimonas rhodophyticola sp. nov., isolated from marine algae
Hui Seong Won, Dong Min Han, Jeong Min Kim, Hülya Bayburt, Byeong Jun Choi, Zhe-Xue Quan, Che Ok Jeon
International Journal of Systematic and Evolutionary Microbiology .2025;[Epub] CrossRef
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Minireview

Advances in functional analysis of the microbiome: Integrating metabolic modeling, metabolite prediction, and pathway inference with Next-Generation Sequencing data: Sungwon Jung; J. Microbiol. 2025;63(1):e.2411006. Published online January 24, 2025; DOI: https://doi.org/10.71150/jm.2411006

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