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- Nucleocapsid Amino Acids 211 to 254, in Particular, Tetrad Glutamines, are Essential for the Interaction Between the Nucleocapsid and Membrane Proteins of SARS-Associated Coronavirus
- Xiaonan Fang , Lin-Bai Ye , Yijuan Zhang , Baozong Li , Shanshan Li , Lingbao Kong , Yuhua Wang , Hong Zheng , Wei Wang , Zhenghui Wu
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Journal of Microbiology 2006;44(5):577-580.
DOI: https://doi.org/2437 [pii]
State Key Laboratory of Virology, College of Life Science, Wuhan University, Wuhan, Hubei 430072, P.R. China
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Corresponding author:
Lin-Bai Ye , Tel: 86-27-6875-2372,
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Abstract
GST pull-down assays were used to characterize the SARS-CoV membrane (M) and nucleocapsid (N) interaction, and it was found that the amino acids 211-254 of N protein were essential for this interaction. When tetrad glutamines (Q) were replaced with glutamic acids (E) at positions of 240-243 of the N protein, the interaction was disrupted.
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