Journal of Microbiology

Kyoung-Sun Lee

2 Articles

Modulation of Immune Response by Interleukin-10 in Systemic Corynebacterium kutscheri Infection in Mice: Eui-Suk Jeong , Kyoung-Sun Lee , Seung-Ho Heo , Jin-Hee Seo , Yang-Kyu Choi; J. Microbiol. 2012;50(2):301-310. Published online April 27, 2012; DOI: https://doi.org/10.1007/s12275-012-1298-z

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Interleukin (IL)-10 is an anti-inflammatory cytokine that modulates sepsis by decreasing pro-inflammatory cytokine production and chemokine expression. In this study, IL- 10-deficient and wild-type (WT) mice were infected with Corynebacterium kutscheri to determine if the absence of IL-10 altered the protective immunity and pathogenesis. After infection, IL-10 knockout (KO) mice had a higher survival rate than WT mice. The decrease of body weight and the increased weight of organs such as liver and spleen were greater in WT mice. Bacterial counts were significantly increased after inoculation in WT mice over those in IL-10 KO mice. WT mice had more granulomatous inflammation and coagulative necrosis in the liver and spleen, lymphocyte depletion in lymphoid follicles, and apoptosis of immune cells in the spleen. WT mice had significantly higher plasma concentrations of aspartate aminotransferase and alanine aminotransferase. Furthermore, more upregulation of tumor necrosis factor-α and IL-4 in the plasma, macrophage inflammatory protein-2, keratinocyte-derived chemokine, inducible nitric oxide synthase, and interferoninducible protein 10 mRNA in the spleen were observed in WT mice after inoculation. These results suggest that the lack of IL-10 contributes to an increase in the systemic clearance of C. kutscheri, and that IL-10 plays a detrimental role in controlling systemic C. kutscheri infection.

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IL-10 Suppresses Bactericidal Response of Macrophages against Salmonella Typhimurium: Kyoung-Sun Lee , Eui-Suk Jeong , Seung-Ho Heo , Jin-Hee Seo , Dong-Gu Jeong , Yang-Kyu Choi; J. Microbiol. 2011;49(6):1050-1053. Published online December 28, 2011; DOI: https://doi.org/10.1007/s12275-011-1043-z

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Abstract PDF

We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-XL, and COX-2 upon ST infection, which may correlate with Salmonella’s survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication.

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