Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J. Microbiol > Volume 49(6); 2011 > Article
Research Support, Non-U.S. Gov't
NOTE] IL-10 Suppresses Bactericidal Response of Macrophages against Salmonella Typhimurium
Kyoung-Sun Lee 1, Eui-Suk Jeong 1, Seung-Ho Heo 1,2, Jin-Hee Seo 1, Dong-Gu Jeong 1, Yang-Kyu Choi 1
Journal of Microbiology 2011;49(6):1050-1053.
DOI: https://doi.org/10.1007/s12275-011-1043-z
Published online: December 28, 2011
1Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea, 2Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Corresponding author:  Yang-Kyu Choi , Tel: +82-2-2049-, 
Received: 26 January 2011   • Accepted: 20 June 2011
prev next
  • 51 Views
  • 0 Download
  • 24 Crossref
  • 24 Scopus
Full Article

Abstract

We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-XL, and COX-2 upon ST infection, which may correlate with Salmonella’s survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication.

  • Cite this Article
    Cite this Article
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    NOTE] IL-10 Suppresses Bactericidal Response of Macrophages against Salmonella Typhimurium
    J. Microbiol. 2011;49(6):1050-1053.   Published online December 28, 2011
    DOI: https://doi.org/10.1007/s12275-011-1043-z
    Close
Related articles
Journal of Microbiology : Journal of Microbiology
© The Microbiological Society of Korea.
TOP