Journal of Microbiology

Kiramage Chathuranga

3 Articles

CA-CAS-01-A: A Permissive Cell Line for Isolation and Live Attenuated Vaccine Development against African Swine Fever Virus: Seung-Chul Lee , Yongkwan Kim , Ji-Won Cha , Kiramage Chathuranga , Niranjan Dodantenna , Hyeok-Il Kwon , Min Ho Kim , Weonhwa Jheong , In-Joong Yoon , Joo Young Lee , Sung-Sik Yoo , Jong-Soo Lee; J. Microbiol. 2024;62(2):125-134. Published online March 13, 2024; DOI: https://doi.org/10.1007/s12275-024-00116-1

1,519 View
17 Download
9 Web of Science
9 Crossref

African swine fever virus (ASFV) is the causative agent of the highly lethal African swine fever disease that affects domestic pigs and wild boars. In spite of the rapid spread of the virus worldwide, there is no licensed vaccine available. The lack of a suitable cell line for ASFV propagation hinders the development of a safe and effective vaccine. For ASFV propagation, primary swine macrophages and monocytes have been widely studied. However, obtaining these cells can be time-consuming and expensive, making them unsuitable for mass vaccine production. The goal of this study was to validate the suitability of novel CA-CAS-01-A (CAS-01) cells, which was identified as a highly permissive cell clone for ASFV replication in the MA-104 parental cell line for live attenuated vaccine development. Through a screening experiment, maximum ASFV replication was observed in the CAS-01 cell compared to other sub-clones of MA-104 with 14.89 and log10 7.5 ± 0.15 Ct value and TCID50/ ml value respectively. When CAS-01 cells are inoculated with ASFV, replication of ASFV was confirmed by Ct value for ASFV DNA, HAD50/ ml assay, TCID50/ ml assay, and cytopathic effects and hemadsoption were observed similar to those in primary porcine alveolar macrophages after 5th passage. Additionally, we demonstrated stable replication and adaptation of ASFV over the serial passage. These results suggest that CAS-01 cells will be a valuable and promising cell line for ASFV isolation, replication, and development of live attenuated vaccines.

Citations

Citations to this article as recorded by

Evaluation of the vaccine candidate ASFV-MEC-01: safety, efficacy, transmission dynamics, and assessment of reversion to virulence
Long Hoang Tran, Anh Ngoc Bui, Hyeok-Il Kwon, Tung Duy Dao, Asela Weerawardhana, Trang Mai Tran, Hoa Thi Vu, Quy Duy Nguyen, Nuwan Gamage, Min Ho Kim, Ji-Yoon Moon, Ji-Hyeon Hong, Jin Kim, Yongkwan Kim, Yeonji Kim, Wonjun Kim, Garam Kim, Song-I Lee, Young
Emerging Microbes & Infections.2026;[Epub] CrossRef
Establishment of a highly sensitive porcine alveolar macrophage cell line for African swine fever virus
Xiangwan Lu, Xiadan Gong, Yingshuo Sun, Lang Gong, Yan Zhang
In Vitro Cellular & Developmental Biology - Animal.2025; 61(4): 425. CrossRef
Genetic and Pathogenic Characteristic of High Pathogenic Korean NADC34‐Like Porcine Reproductive and Respiratory Syndrome Virus
Sehyeong Ham, Chanhee Chae, Nan-hua Chen
Transboundary and Emerging Diseases.2025;[Epub] CrossRef
Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef
Progress in the in vitro propagation of African swine fever virus and implications for vaccine development
Thanathom Chailangkarn, Theeradej Thaweerattanasinp, Asawin Wanitchang, Janya Saenboonrueng, Challika Kaewborisuth, Anan Jongkaewwattana
Animal Diseases.2025;[Epub] CrossRef
Analysis of novel African swine fever variants circulating in wild boars in South Korea isolated in 2021 by deep sequencing
Van Dam Lai, Yong-kwan Kim, Min-Ho Kim, Yeeun Moon, Hyeok-Il Kwon, Weon-hwa Jheong, Jong-Soo Lee, Sung-Sik Yoo, In Pil Mo
Infection, Genetics and Evolution.2025; 135: 105833. CrossRef
Domain-Specific Impacts of Spike Protein Mutations on Infectivity and Antibody Escape in SARS-CoV-2 Omicron BA.1
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef
Current status of African swine fevervaccine research and thoughts
Jiarong Yu, Shengbin Gao, Jiao Xu, Yonggang Zhao, Linlin Fang, Xiaozhen Wang, Yingli Wang, Jingyue Bao, Zhiliang Wang
Journal of Integrative Agriculture.2025;[Epub] CrossRef
Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever
Min Ho Kim, Ashan Subasinghe, Yongkwan Kim, Hyeok-Il Kwon, Yehjin Cho, Kiramage Chathuranga, Ji-Won Cha, Ji-Yoon Moon, Ji-Hyeon Hong, Jin Kim, Seung-Chul Lee, Niranjan Dodantenna, Nuwan Gamage, W. A. Gayan Chathuranga, Yeonji Kim, In-Joong Yoon, Joo Young
Emerging Microbes & Infections.2024;[Epub] CrossRef

Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivo: Prasanna Weeratunga , Thilina U. B. Herath , Tae-Hwan Kim , Hyun-Cheol Lee , Jae-Hoon Kim , Byeong-Hoon Lee , Eun-Seo Lee , Kiramage Chathuranga , W. A. Gayan Chathuranga , Chul-Su Yang , Jin Yeul Ma , Jong-Soo Lee; J. Microbiol. 2017;55(11):909-917. Published online October 27, 2017; DOI: https://doi.org/10.1007/s12275-017-7392-5

1,106 View
10 Download
17 Crossref

Abstract PDF

Dense granule protein-7 (GRA-7) is an excretory protein of Toxoplasma gondii. It is a potential serodiagnostic marker and vaccine candidate for toxoplasmosis. Previous reports demonstrated that GRA-7 induces innate immune responses in macrophages by interacting with TRAF6 via the MyD88- dependent pathway. In the present study, we evaluated the antiviral activity and induction of an antiviral state by GRA-7 both in vitro and in vivo. It was observed that GRA-7 markedly reduced the replication of vesicular stomatitis virus (VSVGFP), influenza A virus (PR8-GFP), coxsackievirus (H3- GFP), herpes simplex virus (HSV-GFP), and adenovirus-GFP in epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. These antiviral activities of GRA-7 were attributed to the induction of type I interferon (IFN) signaling, resulting in the secretion of IFNs and pro-inflammatory cytokines. Additionally, in BALB/c mice, intranasal administration of GRA-7 prevented lethal infection by influenza A virus (H1N1) and exhibited prophylactic effects against respiratory syncytial virus (RSV-GFP). Collectively, these results suggested that GRA-7 exhibits immunostimulatory and broad spectrum antiviral activities via type I IFN signaling. Thus, GRA-7 can be potentially used as a vaccine adjuvant or as a candidate drug with prophylactic potential against viruses.

Citations

Citations to this article as recorded by

Global research landscape and trends in Toxoplasma gondii from 2003 to 2022: A bibliometric analysis
Shi-Jie Fan, Ming Pan, Chen-Yang Xia, Pin Yang, Si-Yang Huang
Veterinary Parasitology.2025; 335: 110438. CrossRef
Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates
Gonzalo Sanchez-Arsuaga, Damer P. Blake, Fiona M. Tomley, Virginia Marugan-Hernandez
Frontiers in Immunology.2025;[Epub] CrossRef
Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity
Magda S.A. Abdeltawab, Mohamed Fateen, Shimaa Saad El-Din, Riem M. Elmessiery, Osama Mohammady Mohamed, Khaled Marzouk Sadek, Engy Medhat, Alshaimaa M.R. Hamed
Cytokine.2024; 177: 156545. CrossRef
Impact of latent toxoplasmosis on pneumonic and non-pneumonic COVID-19 patients with estimation of relevant oxidative stress biomarkers
Doaa A. Hamdy, Ragaey A. Eid, Heba Abdel-Tawab, Mohamed A. El-Badry, Abdelrahman M. Abdallah, Wegdan M. Abd El Wahab
Folia Parasitologica.2024;[Epub] CrossRef
IFNs in host defence and parasite immune evasion during Toxoplasma gondii infections
Carsten G. K. Lüder
Frontiers in Immunology.2024;[Epub] CrossRef
Current vaccine candidate of toxoplasmosis
Eden WOLDEGERIMA, Fasika GETACHEW, Meseret MISGANAW, Yohannes MESFIN, Debaka BELETE, Tekeba SISAY, Nega BERHANE
Journal of Life Science and Biomedicine.2024; : 54. CrossRef
Prevalence of Toxoplasma gondii infection in COVID-19 patients: A systematic review and meta-analysis
Mahdi Fakhar, Khadijeh Najafi Ghobadi, Nastaran Barati, Salman Zafari, Seyed Ali Hosseini, Eissa Soleymani, Seyedmousa Motavallihaghi
Microbial Pathogenesis.2024; 197: 107064. CrossRef
Clinical and Immunological Impacts of Latent Toxoplasmosis on COVID-19 Patients
Samar Habib, Eman Hamza, Randa El-Gamal, Nessma A Nosser, Wafaa A Aboukamar, Sherehan Abdelsalam, Ali Sobh, Mohamed Elegezy, Mohamed Elbayoumy, Waleed Eldars, Khaled Elmasry, Marwa H Elnagdy
Cureus.2023;[Epub] CrossRef
Association between breakthrough infection with COVID-19 and Toxoplasma gondii: a cross-sectional study
Marwa A. Gouda, Hind S. AboShabaan, Ahmed S. Abdelgawad, Aliaa Sabry Abdel Wahed, Khaled A. Abd El-Razik, Yara Elsaadawy, Ayman. A. Abdel-Wahab, Yousry Hawash
Scientific Reports.2023;[Epub] CrossRef
Toxoplasmosis and symptoms severity in patients with COVID-19 in referral centers in Northern Iran
Ali Geraili, Alireza Badirzadeh, Maryam Sadeghi, Seyed Mahmoud Mousavi, Parisa Mousavi, Zabihollah Shahmoradi, Sayed-Mohsen Hosseini, Seyed Hossein Hejazi, Raheleh Rafiei-Sefiddashti
Journal of Parasitic Diseases.2023; 47(1): 185. CrossRef
Synergistic effect of GRA7 and profilin proteins in vaccination against chronic Toxoplasma gondii infection
Nadia Arcon, Mariano S. Picchio, Ignacio M. Fenoy, Rosalía E. Moretta, Ariadna S. Soto, Matías D. Perrone Sibilia, Vanesa R. Sánchez, Cecilia A. Prato, María Virginia Tribulatti, Alejandra Goldman, Valentina Martin
Vaccine.2021; 39(6): 933. CrossRef
GRA8 DNA vaccine formulations protect against chronic toxoplasmosis
Muhammet Karakavuk, Hüseyin Can, Aytül Gül, Aysu Değirmenci Döşkaya, Sedef Erkunt Alak, Cemal Ün, Adnan Yüksel Gürüz, Mert Döşkaya
Microbial Pathogenesis.2021; 158: 105016. CrossRef
Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
Enas Fakhry Abdel-Hamed, Mohamed N. Ibrahim, Nahed E. Mostafa, Howayda S. F. Moawad, Nahla E. Elgammal, Ehab M. Darwiesh, Dina S. El-rafey, Nissreen E. ElBadawy, Emad Ali Al-Khoufi, Salwa I. Hindawi
Gut Pathogens.2021;[Epub] CrossRef
The role of polyspecific T-cell exhaustion in severe outcomes for COVID-19 patients having latent pathogen infections such as Toxoplasma gondii
Kevin Roe
Microbial Pathogenesis.2021; 161: 105299. CrossRef
Preparation of colloidal gold immunochromatographic test strips for the diagnosis of Toxoplasma gondii
Yuanxi Shen, Zhaozhe Wang, Jiajing Li, Rui Xu, Rongyi Ji, Jiaojiao Lin, Chuangang Zhu
Food and Agricultural Immunology.2020; 31(1): 630. CrossRef
A negative covariation between toxoplasmosis and CoVID-19 with alternative interpretations
Łukasz Jankowiak, Lajos Rozsa, Piotr Tryjanowski, Anders Pape Møller
Scientific Reports.2020;[Epub] CrossRef
Characterization of a novel secretory spherical body protein in Babesia orientalis and Babesia orientalis-infected erythrocytes
Jiaying Guo, Muxiao Li, Yali Sun, Long Yu, Pei He, Zheng Nie, Xueyan Zhan, Yangnan Zhao, Xiaoying Luo, Sen Wang, Siqi Aoyang, Qin Liu, Cuiqin Huang, Lan He, Junlong Zhao
Parasites & Vectors.2018;[Epub] CrossRef

Coptidis Rhizoma extract inhibits replication of respiratory syncytial virus in vitro and in vivo by inducing antiviral state: Byeong-Hoon Lee , Kiramage Chathuranga , Md Bashir Uddin , Prasanna Weeratunga , Myun Soo Kim , Won-Kyung Cho , Hong Ik Kim , Jin Yeul Ma , Jong-Soo Lee; J. Microbiol. 2017;55(6):488-498. Published online May 28, 2017; DOI: https://doi.org/10.1007/s12275-017-7088-x

1,164 View
1 Download
27 Crossref

Abstract PDF

Coptidis Rhizoma is derived from the dried rhizome of Ranun-culaceous plants and is a commonly used traditional Chinese medicine. Although Coptidis Rhizoma is commonly used for its many therapeutic effects, antiviral activity against respi-ratory syncytial virus (RSV) has not been reported in detail. In this study, we evaluated the antiviral activities of Coptidis Rhizoma extract (CRE) against RSV in human respiratory tract cell line (HEp2) and BALB/c mice. An effective dose of CRE significantly reduces the replication of RSV in HEp2 cells and reduces the RSV-induced cell death. This antiviral activity against RSV was through the induction of type I inter-feron-related signaling and the antiviral state in HEp2 cells. More importantly, oral administration of CRE exhibited prophylactic effects in BALB/c mice against RSV. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we confirmed that pal-matine was related to the antiviral properties and immune- modulation effect. Taken together, an extract of Coptidis Rhi-zoma and its components play roles as immunomodulators and could be a potential source as promising natural antivirals that can confer protection to RSV. These outcomes should encourage further allied studies in other natural products.

Citations

Citations to this article as recorded by

Systems analysis of Berberis vulgaris alkaloids unveils their functional synergy and drug-like potential
Chinenyenwa Fortune Chukwuneme, Samantha Gildenhuys
Computational Biology and Chemistry.2026; 120: 108698. CrossRef
Integratively screening SARS-CoV-2 3CLpro inhibitors from Coptidis Rhizoma applying activity fingerprinting and molecular docking program
Bihe Zhu, Xiaoyan Wang, Min Han, Han Qin, Jin Li, Shujing Chen, Kunze Du, Yanxu Chang
Journal of Chromatography B.2026; 1277: 125054. CrossRef
In Vitro Inhibitory Effect of Berberine Against Rotavirus
Hue Thi Nguyen, Thi Nguyen Hoa‐Tran, Huy Quang Tran, Thuy Thi Thu Nguyen
Chemistry & Biodiversity.2025;[Epub] CrossRef
Aster tataricus extract and its active compounds display a broad spectrum of antiviral activity in vitro and in vivo
Nuwan Gamage, Ji-Won Cha, Ji-Soo Jeong, Yebin Seong, Kiramage Chathuranga, Asela Weerawardhana, Jin Yeul Ma, Tae-Won Kim, Jong-Soo Lee
Chinese Medicine.2025;[Epub] CrossRef
A Comprehensive Review on Botany, Ethnopharmacology, Phytochemistry, Biosynthesis, Pharmacology, Toxicity, Quality Control and Metabolomics of Coptidis Rhizome
Anlu Liao, Min Han, Shujing Chen, Chuanyuan Gao, Wei Wei, Jin Li, Kunze Du, Yanxu Chang
The American Journal of Chinese Medicine.2025; 53(06): 1711. CrossRef
Topoisomerase inhibitory activity of ethanolic extracts from botanicals Coptis chinensis and Salvia officinalis
Wade Ingersoll, Susan Trapp, Tiffany Turner, Guillermo Ruiz, Jeffrey Langland
Journal of Medical Microbiology .2025;[Epub] CrossRef
Antiviral effect of palmatine against infectious bronchitis virus through regulation of NF-κB/IRF7/JAK-STAT signalling pathway and apoptosis
W. Zhang, Y. Chen, F. Yang, H. Zhang, T. Su, J. Wang, Y. Zhang, X. Song
British Poultry Science.2024; 65(2): 119. CrossRef
Network Pharmacology and Experimental Validation of Qingwen Baidu Decoction Therapeutic Potential in COVID-19-related Lung Injury
Ju Yang, Zhao Zhang, Honghong Liu, Jiawei Wang, Shuying Xie, Pengyan Li, Jianxia Wen, Shizhang Wei, Ruisheng Li, Xiao Ma, Yanling Zhao
Combinatorial Chemistry & High Throughput Screening.2024; 27(9): 1286. CrossRef
Effect of miR-17 on Polygonum Cillinerve polysaccharide against transmissible gastroenteritis virus
Xueqin Duan, Mengxin Xu, Yunying Wang, Nishang Liu, Xingchen Wang, Yingqiu Liu, Weimin Zhang, Wuren Ma, Lin Ma, Yunpeng Fan
Frontiers in Veterinary Science.2024;[Epub] CrossRef
The novel immunobiotic Clostridium butyricum S-45-5 displays broad-spectrum antiviral activity in vitro and in vivo by inducing immune modulation
Kiramage Chathuranga, Yeseul Shin, Md Bashir Uddin, Jayoung Paek, W. A. Gayan Chathuranga, Yebin Seong, Lu Bai, Hongik Kim, Jeong Hwan Shin, Young-Hyo Chang, Jong-Soo Lee
Frontiers in Immunology.2023;[Epub] CrossRef
Interventional effect of processing temperature on anti-angiogenesis of Coptis chinensis and screening of active components by UPLC-MS/MS on quail chick chorioallantoic membrane model
Dan Wang, Miao Qi, Hedi Zhao, Haozhong Wu, Han Chen, Yanan Lan, Yanmin Wang, Yani Jiang, Jingjuan Wang
Journal of Ethnopharmacology.2023; 305: 116014. CrossRef
Coptisine Inhibits Influenza Virus Replication by Upregulating p21
Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Chao-Wei Zhang, Kuang-Yang Yang, Li-Chu Liu, Qian Xie, Chun Hu, Xun Song, Yan Wang
Molecules.2023; 28(14): 5398. CrossRef
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus
Anna A. Shtro, Elizaveta D. Gladkova, Anastasia V. Galochkina, Yulia V. Nikolaeva, Angelika V. Garshinina, Darya N. Razgulyaeva, Evgeniy V. Sorokin, Tatyana R. Tsareva, Olga A. Luzina, Nariman F. Salakhutdinov
Medicinal Chemistry Research.2023; 32(11): 2325. CrossRef
A Global Perspective on Medicinal Plants and Phytochemicals with Antiviral Potentials in the Respiratory System
Neda Mohamadi, Fariba Sharififar, Maryam Rameshk, Shahram Kalantari Khandani
Anti-Infective Agents.2023;[Epub] CrossRef
Giloy: a potential anti-COVID-19 herb with propitious pharmacological attributes: a short review
Shefali Arora, Anjali Goyal, Devendra Singh Rawat, Krishna Samantha
Journal of Biomolecular Structure and Dynamics.2023; 41(14): 7001. CrossRef
Refractory Chest Pain in Mild to Moderate Coronavirus Disease 2019 Successfully Treated with Saikanto, a Japanese Traditional Medicine
Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Takeshi Kanno, Michiaki Abe, Ko Onodera, Shin Takayama, Tadashi Ishii
The Tohoku Journal of Experimental Medicine.2022; 257(3): 241. CrossRef
Pine Needle Extract Applicable to Topical Treatment for the Prevention of Human Papillomavirus Infection
Hee-Jung Lee, Mina Park, HeeJae Choi, Aleksandra Nowakowska, Chiung Moon, Jong Hwan Kwak, Young Bong Kim
Journal of Microbiology and Biotechnology.2021; 31(1): 137. CrossRef
In Silico Target Analysis of Treatment for COVID-19 Using Huang-Lian-Shang-Qing-Wan, a Traditional Chinese Medicine Formula
Ching-Wen Huang, Hai-Anh Ha, Shih-Chang Tsai, Chi-Cheng Lu, Chao-Ying Lee, Yuh-Feng Tsai, Fuu-Jen Tsai, Yu-Jen Chiu, Guo-Kai Wang, Chung-Hua Hsu, Jai-Sing Yang
Natural Product Communications.2021;[Epub] CrossRef
Exploring the Potential Targets and Mechanisms of Huang Lian Jie Du Decoction in the Treatment of Coronavirus Disease 2019 Based on Network Pharmacology
Wang Liu, Yu Zeng, Yanda Li, Nanhong Li, Min Peng, Junfen Cheng, Binbin Tian, Mingdi Chen
International Journal of General Medicine.2021; Volume 14: 9873. CrossRef
Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo
Kiramage Chathuranga, Asela Weerawardhana, Niranjan Dodantenna, Lakmal Ranathunga, Won-Kyung Cho, Jin Yeul Ma, Jong-Soo Lee
Viruses.2021; 13(4): 548. CrossRef
Giloy Ghanvati (Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish
Acharya Balkrishna, Lakshmipathi Khandrika, Anurag Varshney
Frontiers in Pharmacology.2021;[Epub] CrossRef
Systematic screening and characterization of absorbed constituents and in vivo metabolites in rats after oral administration of Rhizoma coptidis using UPLC‐Q‐TOF/MS
Xinchi Feng, Kun Wang, Xintong Hu, Liwei Chai, Shijie Cao, Liqin Ding, Feng Qiu
Biomedical Chromatography.2020;[Epub] CrossRef
Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation
Acharya Balkrishna, Siva Kumar Solleti, Sudeep Verma, Anurag Varshney
Molecules.2020; 25(21): 5091. CrossRef
Palmatine: A review of pharmacological properties and pharmacokinetics
Dominik Tarabasz, Wirginia Kukula‐Koch
Phytotherapy Research.2020; 34(1): 33. CrossRef
Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo
Kiramage Chathuranga, Myun Soo Kim, Hyun-Cheol Lee, Tae-Hwan Kim, Jae-Hoon Kim, W. A. Gayan Chathuranga, Pathum Ekanayaka, H. M. S. M. Wijerathne, Won-Kyung Cho, Hong Ik Kim, Jin Yeul Ma, Jong-Soo Lee
Viruses.2019; 11(7): 604. CrossRef
Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection
Ting-Chun Hung, Alagie Jassey, Chien-Ju Lin, Ching-Hsuan Liu, Chun-Ching Lin, Ming-Hong Yen, Liang-Tzung Lin
Viruses.2018; 10(12): 669. CrossRef
Metabolism of Rhizoma coptidis in Human Urine by Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry
Qingshan Zhang, Gaowa Wang, Xi Chen, Zhiqiang Han, Xiangmei Chen, Risu Na, Haburi Jin, Ping Li, Renbatu Bu
European Journal of Drug Metabolism and Pharmacokinetics.2018; 43(4): 441. CrossRef

Author index