- Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1, 2-dimethylhydrazine-induced rat model
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Ming Zhang , Xing Fan , Bing Fang , Chengzhen Zhu , Jun Zhu , Fazheng Ren
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J. Microbiol. 2015;53(6):398-405. Published online May 30, 2015
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DOI: https://doi.org/10.1007/s12275-015-5046-z
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Probiotics have been suggested as a prophylactic measure
in colon cancer. The aim of this study was to investigate the
impact of Lactobacillus salivarius Ren (Ren) in modulating
colonic microbiota structure and colon cancer incidence in a
rat model after injection with 1,2-dimethyl hydrazine (DMH).
The results indicated that oral administration of Ren could
effectively suppress DMH-induced colonic carcinogenesis.
A significant decrease in cancer incidence (87.5% to 25%)
was detected in rats fed with a dose of 5 × 1010 CFU/kg
bodyweight per day. Using denaturing gradient gel electrophoresis
and Real-time PCR combined with multivariate
statistical methods, we demonstrated that injection with DMH
significantly altered the rat gut microbiota, while Ren counteracted
these DMH-induced adverse effects and promoted
reversion of the gut microbiota close to the healthy state. Tvalue
biplots followed by band sequencing identified 21 bacterial
strains as critical variables affected by DMH and Ren.
Injection of DMH significantly increased the amount of
Ruminococcus species (sp.) and Clostridiales bacteria, as well
as decreasing the Prevotella sp. Administration of Ren reduced
the amount of Ruminococcus sp., Clostridiales bacteria, and
Bacteroides dorei, and increased the amount of Prevotella.
Real-time PCR results were consistent with the results derived
by t-value biplots. These findings suggested that Ren is a potential
agent for colon cancer prevention. In conclusion, the
results
in the present study suggest a potential therapeutic
approach based on the modulation of intestinal microflora
by probiotics may be beneficial in the prevention of colorectal
carcinogenesis.
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Citations
Citations to this article as recorded by 
- Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults
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Hao Zhang , Jing Sun , Xianting Liu , Chuan Hong , Yuanbo Zhu , Aiping Liu , Siqi Li , Huiyuan Guo , Fazheng Ren
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J. Microbiol. 2013;51(6):777-782. Published online December 19, 2013
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DOI: https://doi.org/10.1007/s12275-013-3279-2
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951
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0
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23
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Abstract
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Lactobacillus paracasei subsp. paracasei LC01 (LC01) can
tolerate intestinal stresses and has antioxidant activity. To
evaluate the effect of the bacterium on human intestinal microflora,
a randomized, double-blind, placebo-controlled
human trial was carried out. Fifty-two healthy adult volunteers
were randomized equally to two groups. One group
consumed 12% (wt/vol) skimmed milk supplemented with
1010 CFU of LC01 each day for the 4-week treatment period,
and then consumed placebo in the next treatment period,
separated by a 2-week washout. The other group followed
the reverse order. Group-specific real-time PCR and biochemical
analyses was used to determine the intestinal bacterial
composition of fecal samples collected at the end of
every period, and the concentration of short-chain fatty acids
and ammonia. A significant inhibition in fecal Escherichia
coli and increase in Lactobacillus, Bifidobacterium, and Roseburia
intestinalis were observed after consumption of LC01.
Acetic acid and butyric acid were significantly higher in the
probiotic stage and fecal ammonia was significantly lower.
The results indicated a modulation effect of LC01 on the
intestinal microflora of young adults, suggesting a beneficial
effect on bowel health. LC01 may have potential value as a
probiotic.
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Citations
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Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1
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- Safety Evaluation of Lactobacillus paracasei subsp. paracasei LC-01, Probiotic Bacterium
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Hao Zhang , Yu Wang , Jing Sun , Zirui Guo , Huiyuan Guo , Fazheng Ren
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J. Microbiol. 2013;51(5):633-638. Published online October 31, 2013
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DOI: https://doi.org/10.1007/s12275-013-3336-x
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1,211
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9
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The safety of Lactobacillus paracasei subsp. paracasei LC-01 was evaluated for its use as a potential probiotic. In our in vitro study, the antibiotic resistance and the ability to produce biogenic amine were determined. The results showed that the strain was sensitive to all tested antibiotics and did not produce biogenic amine except for tyramine. The oral toxicity of this strain was evaluated in Balb/C mice. One hundred mice were divided into 10 groups. Four groups were administered 0, 108, 109, or 1010 CFU/mouse per day dissolved in saline solution respectively, for 28 days. Three groups were injected intraperitoneally with 109 CFU/mouse dissolved in saline solution, and were killed 2, 5, and 10 days after injection. The last 3 groups were injected with the vehicle as controls respectively. The results showed that oral administration of the strain had no adverse effects on mouse body weight and that there was no treatment-associated bacterial translocation. Intraperitoneal administration caused a significant translocation to liver, spleen and kidney. However, this translocation did not cause illness or death throughout the experiment. The results suggest that L. paracasei subsp. paracasei LC-01 is likely to be safe for human consumption.
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Citations
Citations to this article as recorded by - Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89
Ting Chen, Yunjiao Zhao, Yixuan Fan, Yao Dong, Zhonghui Gai
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- Lactobacillus salivarius Strain FDB89 Induced Longevity in Caenorhabditis elegans by Dietary Restriction
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Yang Zhao , Liang Zhao , Xiaonan Zheng , Tianjiao Fu , Huiyuan Guo , Fazheng Ren
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J. Microbiol. 2013;51(2):183-188. Published online April 27, 2013
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DOI: https://doi.org/10.1007/s12275-013-2076-2
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703
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In this study, we utilized the nematode Caenorhabditis elegans to assess potential life-expanding effect of Lactobacillus salivarius strain FDB89 (FDB89) isolated from feces of centenarians in Bama County (Guangxi, China). This study showed that feeding FDB89 extended the mean life span in C. elegans by up to 11.9% compared to that of control nematodes. The reduced reproductive capacities, pharyngeal pumping rate, growth, and increased superoxide dismutase (SOD) activity and XTT reduction capacity were also observed in FDB89 feeding worms. To probe the anti-aging mechanism further, we incorporated a food gradient feeding assay and assayed the life span of eat-2 mutant. The results demonstrated that the maximal life span of C. elegans fed on FDB89 was achieved at the concentration of 1.0 mg bacterial cells/plate, which was 10-fold greater than that of C. elegans fed on E. coli OP50 (0.1 mg bacterial cells/plate). However, feeding FDB89 could not further extend the life span of eat-2 mutant. These results indicated that FDB89 modulated the longevity of C. elegans in a dietary restriction-dependent manner and expanded the understanding of anti-aging effect of probiotics.
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Citations
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- Lactobacillus salivarius REN Counteracted Unfavorable 4-Nitroquinoline-1-Oxide-Induced Changes in Colonic Microflora of Rats
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Ming Zhang , Xuewei Qiao , Liang Zhao , Lu Jiang , Fazheng Ren
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J. Microbiol. 2011;49(6):877-883. Published online December 28, 2011
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DOI: https://doi.org/10.1007/s12275-011-1137-7
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722
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Probiotics and carcinogens both have a significant effect on the microfloral composition of the human intestine. The objective of this study was to investigate the impact of an important carcinogen, 4-Nitroquinoline-1- Oxide on colonic microflora and the efficacy of the probiotic Lactobacillus salivarius REN as an agent of counteracting these effects. Using denaturing gradient gel electrophoresis (DGGE) combined with redundancy analysis, we demonstrated that both 4-Nitroquinoline-1-Oxide and L. salivarius REN significantly altered the bacterial communities of rat colons. A total of 27 bacterial strains were identified as being affected by treatment with 4-Nitroquinoline-1-Oxide or L. salivarius REN using a t-value biplot combined with band sequencing. 4-Nitroquinoline-1-Oxide treatment increased the abundance of two potential pathogens (one Helicobacter strain and one Desulfovibrio strain), as well as reducing the abundance of two potentially beneficial strains (one Ruminococcaceae strain and one Rumen bacteria). The Helicobacter strain was initally detected in carcinogen-treated rat intestinal microflora, but L. salivarius REN treatment effectively suppressed the growth of the Helicobacter strain. These results suggested that L. salivarius REN may be a potential probiotic, efficiently acting against the initial infection with, and the growth of pathogenic bacteria.
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Citations
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Yuanyuan Pan, Fang Wang, Da-Wen Sun, Quanyang Li
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Ming Zhang, Xing Fan, Bing Fang, Chengzhen Zhu, Jun Zhu, Fazheng Ren
Journal of Microbiology.2015; 53(6): 398. CrossRef -
Lactobacillus salivarius
Ren prevent the early colorectal carcinogenesis in 1, 2-dimethylhydrazine-induced rat model
J. Zhu, C. Zhu, S. Ge, M. Zhang, L. Jiang, J. Cui, F. Ren
Journal of Applied Microbiology.2014; 117(1): 208. CrossRef - Safety Assessment of Lactobacillus salivarius REN, a Probiotic Strain Isolated from Centenarian Feces
Hao ZHANG, Jing SUN, Qing-yu WANG, Yu-tong HE, Hui-yong GU, Hui-yuan GUO, Qing-bo DING, Jun-si YANG, Fa-zheng REN
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- Safety Evaluation In Vitro of Enterococcus durans from Tibetan Traditional Fermented Yak Milk
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Jing Li , Fazheng Ren , Huiyong Gu , Xiaopeng Li , Bozhong Gan
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J. Microbiol. 2011;49(5):721-728. Published online November 9, 2011
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DOI: https://doi.org/10.1007/s12275-011-1062-9
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Abstract
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Despite its ubiquity in fermented dairy products, the safety of lactic acid enterococcal bacteria remains controversial. In this study, five Enterococcus durans strains – A1, A2, B1, B2, and C1 – were isolated from traditional fermented yak milk from Tibet. To evaluate the strains’ safety, biogenic amine production, antibiotic resistance and presence of known virulence determinants were investigated. Strain A1 can produce biogenic amines for histamine, spermine, and spermidine (mean values: 8.64, 8.31, and 0.30 mg/L, respectively). Polymerase chain reaction amplification for Strain A1 found genes involved in expression of gelatinase (gleE), cytolysin (cylA, cylB, and cylM), sex pheromones (ccf and cpd) and cell wall adhesion (efaA). Strain A2 showed sensitivity or intermediate resistance to all tested antibiotics, and no virulence determinants except gelE and ccf, but did produce tyramine at a relatively high level (912.02 mg/L). Both strains B1 and B2 could produce histamine (10.43 and 10.56 mg/L, respectively), and showed vancomycin resistance; B1 also produced tyramine (504.02 mg/L). Strain C1 could produce all five biogenic amines tested in the study – putrescine, histamine, tyramine, spermine, and spermidine; concentrations were 6.51, 9.59, 205.85, 5.55, and 5.39 mg/L, respectively. All E. durans strains found in Tibetan traditional fermented yak milk thus offer potential risk.
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faecium
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enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance
Christopher A. Mullally, Marhami Fahriani, Shakeel Mowlaboccus, Geoffrey W. Coombs, Audrey N. Schuetz, Karen Carroll, Vincent Cattoir
Clinical Microbiology Reviews.2024;[Epub] CrossRef - Enterococcus faecalis and Enterococcus faecium in pasteurized milk: Prevalence, genotyping, and characterization of virulence traits
Mina Nasiri, Shahram Hanifian
LWT.2022; 153: 112452. CrossRef - Safety Assessment of Lactiplantibacillus (formerly Lactobacillus) plantarum Q180
Yoo Jin Kwon, Byung Hee Chun, Hye Su Jung, Jaeryang Chu, Hyunchae Joung, Sung Yurb Park, Byoung Kook Kim, Che Ok Jeon
Journal of Microbiology and Biotechnology.2021; 31(10): 1420. CrossRef - Bacterial diversity and community in Qula from the Qinghai–Tibetan Plateau in China
Yan Zhu, Yingying Cao, Min Yang, Pengchen Wen, Lei Cao, Jiang Ma, Zhongmin Zhang, Weibing Zhang
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I. Jaouani, M.S. Abbassi, S.C. Ribeiro, M. Khemiri, R. Mansouri, L. Messadi, C.C.G. Silva
Journal of Applied Microbiology.2015; 119(4): 1089. CrossRef - Biological Characteristics and Safety Examination of Five Enterococcal Strains from Probiotic Products
Ming Lei, Xianjun Dai, Mingqi Liu
Journal of Food Safety.2015; 35(3): 324. CrossRef - Safety evaluation of Lactobacillus paracasei subsp. paracasei LC-01, a probiotic bacterium
Hao Zhang, Yu Wang, Jing Sun, Zirui Guo, Huiyuan Guo, Fazheng Ren
Journal of Microbiology.2013; 51(5): 633. CrossRef
- Correlations of Fecal Bacterial Communities with Age and Living Region for the Elderly Living in Bama, Guangxi, China
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Liang Zhao , Xuewei Qiao , Jun Zhu , Xiaoying Zhang , Jingli Jiang , Yanling Hao , Fazheng Ren
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J. Microbiol. 2011;49(2):186-192. Published online May 3, 2011
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DOI: https://doi.org/10.1007/s12275-011-0405-x
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725
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Bama County (Guangxi, China) is famous for its longevous population. In this study, intestinal microflora of 17 healthy elderly subjects of different ages and from different regions (rural and urban) in Bama, were analyzed by denaturing gradient gel electrophoresis (DGGE). Significant effects of age and living region on the whole intestinal bacterial communities were observed by redundancy analysis (RDA). A total of 11 bacterial strains that were correlated with age and living region were identified using a t-value biplot combined with band sequencing. Four bacterial strains were correlated with both age and living region of the elderly in Bama. Two Bacteroides strains and one Ruminococcaceae strain were abundant in the
rural, younger elderly; conversely, one Desulfovibrio strain was high in the urban, older elderly. Another Bacteroidetes strain was only correlated with the participant’s age, and its abundance increased with the age of the elderly. The richness of one Clostridium sordellii strain, which was only correlated with the elderly living region, was high in the urban elderly. The study also found five other novel bacterial strains that were correlated with the age or living region of the elderly in Bama. These results expand our understanding of age- and region-effects on the intestinal microflora of the elderly and raise the possibility of developing probiotics originating from centenarians.
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Na Wang, Rui Li, Haijiang Lin, Chaowei Fu, Xuecai Wang, Yiming Zhang, Meifang Su, Peixin Huang, Junhua Qian, Feng Jiang, Hexing Wang, Lufang Jiang, Xin Yu, Jianxiang Liu, Yue Chen, Qingwu Jiang, Erwin G. Zoetendal
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