Journal of Microbiology

Byeong-Hoon Lee

6 Articles

Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components: Prasanna Weeratunga , Md Bashir Uddin , Myun Soo Kim , Byeong-Hoon Lee , Tae-Hwan Kim , Ji-Eun Yoon , Jin Yeul Ma , Hongik Kim , Jong-Soo Lee; J. Microbiol. 2018;56(9):690-690.; DOI: https://doi.org/10.1007/s12275-018-0579-6

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Abstract PDF: The above article by Weeratunga et al. has been retracted from Journal of Microbiology at the request of the corresponding author. The authors found that they were unable to reproduce Figure 1, Figure 3(A), Figure 4(A) and Figure 7(D) presented in this paper. All of the authors agreed to this retraction. The authors regret any inconvenience that this may cause and apologize sincerely to the readers, reviewers, and editors of Journal of Microbiology.

Dense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivo: Prasanna Weeratunga , Thilina U. B. Herath , Tae-Hwan Kim , Hyun-Cheol Lee , Jae-Hoon Kim , Byeong-Hoon Lee , Eun-Seo Lee , Kiramage Chathuranga , W. A. Gayan Chathuranga , Chul-Su Yang , Jin Yeul Ma , Jong-Soo Lee; J. Microbiol. 2017;55(11):909-917. Published online October 27, 2017; DOI: https://doi.org/10.1007/s12275-017-7392-5

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Dense granule protein-7 (GRA-7) is an excretory protein of Toxoplasma gondii. It is a potential serodiagnostic marker and vaccine candidate for toxoplasmosis. Previous reports demonstrated that GRA-7 induces innate immune responses in macrophages by interacting with TRAF6 via the MyD88- dependent pathway. In the present study, we evaluated the antiviral activity and induction of an antiviral state by GRA-7 both in vitro and in vivo. It was observed that GRA-7 markedly reduced the replication of vesicular stomatitis virus (VSVGFP), influenza A virus (PR8-GFP), coxsackievirus (H3- GFP), herpes simplex virus (HSV-GFP), and adenovirus-GFP in epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. These antiviral activities of GRA-7 were attributed to the induction of type I interferon (IFN) signaling, resulting in the secretion of IFNs and pro-inflammatory cytokines. Additionally, in BALB/c mice, intranasal administration of GRA-7 prevented lethal infection by influenza A virus (H1N1) and exhibited prophylactic effects against respiratory syncytial virus (RSV-GFP). Collectively, these results suggested that GRA-7 exhibits immunostimulatory and broad spectrum antiviral activities via type I IFN signaling. Thus, GRA-7 can be potentially used as a vaccine adjuvant or as a candidate drug with prophylactic potential against viruses.

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Coptidis Rhizoma extract inhibits replication of respiratory syncytial virus in vitro and in vivo by inducing antiviral state: Byeong-Hoon Lee , Kiramage Chathuranga , Md Bashir Uddin , Prasanna Weeratunga , Myun Soo Kim , Won-Kyung Cho , Hong Ik Kim , Jin Yeul Ma , Jong-Soo Lee; J. Microbiol. 2017;55(6):488-498. Published online May 28, 2017; DOI: https://doi.org/10.1007/s12275-017-7088-x

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Abstract PDF

Coptidis Rhizoma is derived from the dried rhizome of Ranun-culaceous plants and is a commonly used traditional Chinese medicine. Although Coptidis Rhizoma is commonly used for its many therapeutic effects, antiviral activity against respi-ratory syncytial virus (RSV) has not been reported in detail. In this study, we evaluated the antiviral activities of Coptidis Rhizoma extract (CRE) against RSV in human respiratory tract cell line (HEp2) and BALB/c mice. An effective dose of CRE significantly reduces the replication of RSV in HEp2 cells and reduces the RSV-induced cell death. This antiviral activity against RSV was through the induction of type I inter-feron-related signaling and the antiviral state in HEp2 cells. More importantly, oral administration of CRE exhibited prophylactic effects in BALB/c mice against RSV. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we confirmed that pal-matine was related to the antiviral properties and immune- modulation effect. Taken together, an extract of Coptidis Rhi-zoma and its components play roles as immunomodulators and could be a potential source as promising natural antivirals that can confer protection to RSV. These outcomes should encourage further allied studies in other natural products.

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Inhibitory effects of bee venom and its components against viruses in vitro and in vivo: Md Bashir Uddin , Byeong-Hoon Lee , Chamilani Nikapitiya , Jae-Hoon Kim , Tae-Hwan Kim , Hyun-Cheol Lee , Choul Goo Kim , Jong-Soo Lee , Chul-Joong Kim; J. Microbiol. 2017;55(2):160-160.; DOI: https://doi.org/10.1007/s12275-017-0668-y

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Abstract PDF: In the article by Uddin et al. published in Journal of Microbiology 2016; 54, 853–866, the Protocol number on page 856 and 865 should be corrected as below.

Inhibitory effects of bee venom and its components against viruses in vitro and in vivo: Md Bashir Uddin , Byeong-Hoon Lee , Chamilani Nikapitiya , Jae-Hoon Kim , Tae-Hwan Kim , Hyun-Cheol Lee , Choul Goo Kim , Jong-Soo Lee , Chul-Joong Kim; J. Microbiol. 2016;54(12):853-866. Published online November 26, 2016; DOI: https://doi.org/10.1007/s12275-016-6376-1

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Abstract PDF

Bee venom (BV) from honey bee (Apis Melifera L.) contains at least 18 pharmacologically active components including melittin (MLT), phospholipase A2 (PLA2), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Nevertheless, antiviral properties of BV have not well investigated. Hence, we identified the potential antiviral properties of BV and its component against a broad panel of viruses. Co-incubation of non-cytotoxic amounts of BV and MLT, the main component of BV, significantly inhibited the replication of enveloped viruses such as Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV), and Herpes Simplex Virus (HSV). Additionally, BV and MLT also inhibited the replication of non-enveloped viruses such as Enterovirus-71 (EV-71) and Coxsackie Virus (H3). Such antiviral properties were mainly explained by virucidal mechanism. Moreover, MLT protected mice which were challenged with lethal doses of pathogenic influenza A H1N1 viruses. Therefore, these results provides the evidence that BV and MLT could be a potential source as a promising antiviral agent, especially to develop as a broad spectrum antiviral agent.

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Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components: Prasanna Weeratunga , Md Bashir Uddin , Myun Soo Kim , Byeong-Hoon Lee , Tae-Hwan Kim , Ji-Eun Yoon , Jin Yeul Ma , Hongik Kim , Jong-Soo Lee; J. Microbiol. 2016;54(1):57-70. Published online January 5, 2016; DOI: https://doi.org/10.1007/s12275-016-5555-4

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Abstract PDF

Angelica tenuissima Nakai is a widely used commodity in traditional medicine. Nevertheless, no study has been conducted on the antiviral and immune-modulatory properties of an aqueous extract of Angelica tenuissima Nakai. In the present study, we evaluated the antiviral activities and the mechanism of action of an aqueous extract of Angelica tenuissima Nakai both in vitro and in vivo. In vitro, an effective dose of Angelica tenuissima Nakai markedly inhibited the replication of Influenza A virus (PR8), Vesicular stomatitis virus (VSV), Herpes simplex virus (HSV), Coxsackie virus, and Enterovirus (EV-71) on epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. Such inhibition can be described by the induction of the antiviral state in cells by antiviral, IFNrelated gene induction and secretion of IFNs and pro-inflammatory cytokines. In vivo, Angelica tenuissima Nakai treated BALB/c mice displayed higher survivability and lower lung viral titers when challenged with lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3, and H9N2). We also found that Angelica tenuissima Nakai can induce the secretion of IL-6, IFN-λ, and local IgA in bronchoalveolar lavage fluid (BALF) of Angelica tenuissima Nakai treated mice, which correlating with the observed prophylactic effects. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we evaluated antiviral properties of ferulic acid. Therefore, an extract of Angelica tenuissima Nakai and its components, including ferulic acid, play roles as immunomodulators and may be potential candidates for novel anti-viral/anti-influenza agents.

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