- Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway
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Taehwan Park , Jintaek Im , A Reum Kim , Dongwook Lee , Sungho Jeong , Cheol-Heui Yun , Seung Hyun Han
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J. Microbiol. 2021;59(12):1142-1149. Published online December 4, 2021
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DOI: https://doi.org/10.1007/s12275-021-1576-8
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102
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17
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 Abstract
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Streptococcus gordonii, a Gram-positive commensal bacterium,
is an opportunistic pathogen closely related to initiation
and progression of various oral diseases, such as periodontitis
and dental caries. Its biofilm formation is linked
with the development of such diseases by enhanced resistance
against antimicrobial treatment or host immunity. In the
present study, we investigated the effect of short-chain fatty
acids (SCFAs) on the biofilm formation of S. gordonii. SCFAs,
including sodium acetate (NaA), sodium propionate (NaP),
and sodium butyrate (NaB), showed an effective inhibitory
activity on the biofilm formation of S. gordonii without reduction
in bacterial growth. SCFAs suppressed S. gordonii
biofilm formation at early time points whereas SCFAs did
not affect its preformed biofilm. A quorum-sensing system
mediated by competence-stimulating peptide (CSP) is known
to regulate biofilm formation of streptococci. Interestingly,
SCFAs substantially decreased mRNA expression of comD
and comE, which are CSP-sensor and its response regulator
responsible for CSP pathway, respectively. Although S. gordonii
biofilm formation was enhanced by exogenous synthetic
CSP treatment, such effect was not observed in the
presence of SCFAs. Collectively, these results suggest that
SCFAs have an anti-biofilm activity on S. gordonii through
inhibiting comD and comE expression which results in negative
regulation of CSP quorum-sensing system. SCFAs could
be an effective anti-biofilm agent against S. gordonii for the
prevention of oral diseases.
-
Citations
Citations to this article as recorded by  - Potential effects of prebiotic fibers on dental caries: a systematic review
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Suwon Lim, Dongwook Lee, Sungho Jeong, Jeong Woo Park, Jintaek Im, Bokeum Choi, Donghyun Gwak, Cheol-Heui Yun, Ho Seong Seo, Seung Hyun Han
Journal of Microbiology and Biotechnology.2024; 34(1): 47. CrossRef - Comprehensive Multi-Omic Evaluation of the Microbiota and Metabolites in the Colons of Diverse Swine Breeds
Yanbin Zhu, Guangming Sun, Yangji Cidan, Bin Shi, Zhankun Tan, Jian Zhang, Wangdui Basang
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Critical Reviews in Microbiology.2024; : 1. CrossRef - Effects of Epigallocatechin gallate on Biofilm adherence and Glycolytic pH in Streptococcus gordonii
Prawati Nuraini, Dimas Prasetianto Wicaksono, Ardianti Maartrina Dewi, Adinda Ayu Fitriana, Sili Han
Research Journal of Pharmacy and Technology.2024; : 4711. CrossRef - Oral Pathogens and Their Antibiotics from Marine Organisms: A Systematic Review of New Drugs for Novel Drug Targets
Sehyeok Im, Jun Hyuck Lee, Youn-Soo Shim
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Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition
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Leli Wang, Yiru Zhang, Juan Xu, Qingqing Shi, Yao Peng, Cimin Long, Lan Li, Yulong Yin
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- Lactobacillus plantarum lipoteichoic acid disrupts mature Enterococcus faecalis biofilm
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A Reum Kim , Minji Kang , Yeon-Jee Yoo , Cheol-Heui Yun , Hiran Perinpanayagam , Kee-Yeon Kum , Seung Hyun Han
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J. Microbiol. 2020;58(4):314-319. Published online January 28, 2020
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DOI: https://doi.org/10.1007/s12275-020-9518-4
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73
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20
Web of Science
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19
Crossref
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Abstract
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Apical periodontitis is caused by biofilm-mediated root canal
infection. Early phase oral bacterial biofilms are inhibited by
Lactobacillus plantarum lipoteichoic acid (Lp.LTA). However,
mature biofilms that develop over 3 weeks are more resistant
to traditional endodontic medicaments. Therefore, this study
examined the effectiveness of Lp.LTA on disrupting mature
Enterococcus faecalis biofilms, and on enhancing the effects
of endodontic medicaments. LTA was purified from L. plantarum
through butanol extraction followed by hydrophobic
and ion-exchange chromatography. E. faecalis biofilms were
formed over 3 weeks on glass bottom dishes and in dentin
blocks obtained from human single-rooted premolars. These
mature biofilms were treated with or without Lp.LTA for 1 h,
followed by additional treatment with either chlorhexidine
digluconate (CHX), calcium hydroxide (CH), or triple antibiotics
for 24 h. Biofilms on glass were live/dead stained and
quantified by ZEN through confocal laser microscopy. Biofilms
in dentin were fixed, sputter coated and analyzed by
ImageJ with scanning electron microscopy. Preformed E. faecalis
mature biofilms on the culture dishes were dose-dependently
disrupted by Lp.LTA. Lp.LTA potentiated the effects
of CHX or CH on the disruption of mature biofilm. Interestingly,
CHX-induced disruption of preformed E. faecalis
mature biofilms was synergistically enhanced only when pretreated
with Lp.LTA. Furthermore, in the dentin block model,
Lp.LTA alone reduced E. faecalis mature biofilm and
pre-treatment with Lp.LTA promoted the anti-biofilm activity
of CHX. Lp.LTA could be an anti-biofilm or supplementary
agent that can be effective for E. faecalis-biofilminduced
diseases.
-
Citations
Citations to this article as recorded by - A Systematic Review of the Comparative Efficacy of Lactobacillus Probiotics and Sodium Hypochlorite as Intracanal Irrigants Against Enterococcus faecalis
Mrinalini Mrinalini, Alpa Gupta, Dax Abraham, Arun Kumar Duraisamy, Rajat Sharma
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The role of
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in oral health: a review of current studies
Xinyan Huang, Jianhang Bao, Mingzhen Yang, Yingying Li, Youwen Liu, Yuankun Zhai
Journal of Oral Microbiology.2024;[Epub] CrossRef - Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG as a Novel Intracanal Medicament Targeting Enterococcus faecalis Biofilm Formation
Ji-Young Yoon, Somin Park, Dongwook Lee, Ok-Jin Park, WooCheol Lee, Seung Hyun Han
Journal of Microbiology.2024; 62(10): 897. CrossRef - Isolation, Identification and Antibacterial Characteristics of Lacticaseibacillus rhamnosus YT
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Dongwook Lee, Jintaek Im, A Reum Kim, Woohyung Jun, Cheol-Heui Yun, Seung Hyun Han
Journal of Microbiology.2024; 62(8): 683. CrossRef - Antibacterial effectiveness of multi-strain probiotics supernatants intracanal medication on Enterococcus faecalis biofilm in a tooth model
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Microorganisms.2020; 8(12): 1852. CrossRef
- Lipoteichoic acids of lactobacilli inhibit Enterococcus faecalis biofilm formation and disrupt the preformed biofilm
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Solmin Jung , Ok-Jin Park , A Reum Kim , Ki Bum Ahn , Dongwook Lee , Kee-Yeon Kum , Cheol-Heui Yun , Seung Hyun Han
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J. Microbiol. 2019;57(4):310-315. Published online January 22, 2019
-
DOI: https://doi.org/10.1007/s12275-019-8538-4
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99
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52
Web of Science
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49
Crossref
-
Abstract
-
Enterococcus faecalis, a Gram-positive bacterium commonly
isolated in patients with refractory apical periodontitis, invades
dentin tubules easily and forms biofilms. Bacteria in biofilms,
which contribute to recurrent and/or chronic inflammatory
diseases, are more resistant to antimicrobial agents
than planktonic cells and easily avoid phagocytosis. Although
Lactobacillus plantarum lipoteichoic acid (Lp.LTA) is associated
with biofilm formation, the effect of Lp.LTA on biofilm
formation by E. faecalis is not clearly understood. In this
study, we investigated whether Lp.LTA inhibits E. faecalis
biofilm formation. The degree of biofilm formation was determined
by using crystal violet assay and LIVE/DEAD bacteria
staining. The quantification of bacterial growth was determined
by measuring the optical density at 600 nm with a
spectrophotometer. Formation of biofilms on human dentin
slices was observed under a scanning electron microscope.
E. faecalis biofilm formation was reduced by Lp.LTA treatment
in a dose-dependent manner. Lp.LTA inhibited biofilm
development of E. faecalis at the early stage without affecting
bacterial growth. LTA from other Lactobacillus species
such as Lactobacillus acidophilus, Lactobacillus casei, or
Lactobacillus rhamnosus GG also inhibited E. faecalis biofilm
formation. In particular, among LTAs from various lactobacilli,
Lp.LTA showed the highest inhibitory effect on biofilms
formed by E. faecalis. Interestingly, LTAs from lactobacilli
could remove the biofilm preformed by E. faecalis.
These inhibitory effects were also observed on the surface of human dentin slices. In conclusion, Lactobacillus species LTA
inhibits biofilm formation caused by E. faecalis and it could
be used as an anti-biofilm agent for prevention or treatment
against E. faecalis-associated diseases.
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Gaurav Kumar, Sanjay Tewari, John Tagg, Michael Leonidas Chikindas, Igor V Popov, Santosh Kumar Tiwari
Probiotics and Antimicrobial Proteins.2021; 13(2): 299. CrossRef - Lactobacilli as Anti-biofilm Strategy in Oral Infectious Diseases: A Mini-Review
Barbara Giordani, Carola Parolin, Beatrice Vitali
Frontiers in Medical Technology.2021;[Epub] CrossRef - Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity
Karen D. Zeise, Robert J. Woods, Gary B. Huffnagle
Clinical Microbiology Reviews.2021;[Epub] CrossRef - Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods
Basavaprabhu H. Nataraj, Syed Azmal Ali, Pradip V. Behare, Hariom Yadav
Microbial Cell Factories.2020;[Epub] CrossRef - Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health
Wallace Jeng Yang Chee, Shu Yih Chew, Leslie Thian Lung Than
Microbial Cell Factories.2020;[Epub] CrossRef - Enhanced biofilm formation of Streptococcus gordonii with lipoprotein deficiency
Ok‐Jin Park, Solmin Jung, Taehwan Park, A Reum Kim, Dongwook Lee, Hyun Jung Ji, Ho Seong Seo, Cheol‐Heui Yun, Seung Hyun Han
Molecular Oral Microbiology.2020; 35(6): 271. CrossRef - Lactobacillus plantarum lipoteichoic acid disrupts mature Enterococcus faecalis biofilm
A. Reum Kim, Minji Kang, Yeon-Jee Yoo, Cheol-Heui Yun, Hiran Perinpanayagam, Kee-Yeon Kum, Seung Hyun Han
Journal of Microbiology.2020; 58(4): 314. CrossRef - Streptococcus gordonii: Pathogenesis and Host Response to Its Cell Wall Components
Ok-Jin Park, Yeongkag Kwon, Chaeyeon Park, Yoon Ju So, Tae Hwan Park, Sungho Jeong, Jintaek Im, Cheol-Heui Yun, Seung Hyun Han
Microorganisms.2020; 8(12): 1852. CrossRef - Using Probiotics as Supplementation for Helicobacter pylori Antibiotic Therapy
Jianfu Ji, Hong Yang
International Journal of Molecular Sciences.2020; 21(3): 1136. CrossRef - In-vitro effect of vaginal lactobacilli against group B Streptococcus
Giacomo Marziali, Claudio Foschi, Carola Parolin, Beatrice Vitali, Antonella Marangoni
Microbial Pathogenesis.2019; 136: 103692. CrossRef
- Gamma-irradiation of Streptococcus pneumoniae for the use as an immunogenic whole cell vaccine
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Min Yong Jwa , Soyoung Jeong , Eun Byeol Ko , A Reum Kim , Hyun Young Kim , Sun Kyung Kim , Ho Seong Seo , Cheol-Heui Yun , Seung Hyun Han
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J. Microbiol. 2018;56(8):579-585. Published online July 25, 2018
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DOI: https://doi.org/10.1007/s12275-018-8347-1
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81
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15
Crossref
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Abstract
-
Streptococcus pneumoniae is a major respiratory pathogen
that causes millions of deaths worldwide. Although subunit
vaccines formulated with the capsular polysaccharides or
their protein conjugates are currently-available, low-cost
vaccines with wide serotype coverage still remain to be developed,
especially for developing countries. Recently, gamma-
irradiation has been considered as an effective inactivation
method
to prepare S. pneumoniae vaccine candidate.
In this study, we investigated the immunogenicity and protective
immunity of gamma-irradiated S. pneumoniae (r-SP),
by comparing with heat-inactivated S. pneumoniae (h-SP)
and formalin-inactivated S. pneumoniae (f-SP), both of which
were made by traditional inactivation methods. Intranasal
immunization of C57BL/6 mice with r-SP in combination
with cholera toxin as an adjuvant enhanced S. pneumoniaespecific
antibodies on the airway mucosal surface and in sera
more potently than that with h-SP or f-SP under the same
conditions. In addition, sera from mice immunized with r-
SP potently induced opsonophagocytic killing activity more
effectively than those of h-SP or f-SP, implying that r-SP
could induce protective antibodies. Above all, immunization
with r-SP effectively protected mice against S. pneumoniae
infection. Collectively, these results suggest that gamma-
irradiation is an effective method for the development
of a killed whole cell pneumococcal vaccine that elicits robust
mucosal and systemic immune responses.
-
Citations
Citations to this article as recorded by - Acute otitis media pneumococcal disease burden and nasopharyngeal colonization in children due to serotypes included and not included in current and new pneumococcal conjugate vaccines
Michael Pichichero, Richard Malley, Ravinder Kaur, Robert Zagursky, Porter Anderson
Expert Review of Vaccines.2023; 22(1): 118. CrossRef - Knock-down of IGFBP2 ameliorates lung fibrosis and inflammation in rats with severe pneumonia through STAT3 pathway
Yuyu Wang, Jianjiang Huang, Fang Zhang, Keli Shen, Bin Qiu
Growth Factors.2023; 41(4): 210. CrossRef - Occurrence of influenza and bacterial infections in cancer patients receiving radiotherapy in Ghana
Augustina K. Arjarquah, Evangeline Obodai, Hannah Ayettey Anie, Michael Aning Osei, John Kofi Odoom, Joseph H. K. Bonney, Eric Behene, Erasmus N. Kotey, James Aboagye, Stephen O. Nyarko, Jeannette Bentum, Clara Yeboah, Selassie Kumordjie, Bright Agbodzi,
PLOS ONE.2022; 17(7): e0271877. CrossRef - Low-Energy Electron Irradiation of Tick-Borne Encephalitis Virus Provides a Protective Inactivated Vaccine
Julia Finkensieper, Leila Issmail, Jasmin Fertey, Alexandra Rockstroh, Simone Schopf, Bastian Standfest, Martin Thoma, Thomas Grunwald, Sebastian Ulbert
Frontiers in Immunology.2022;[Epub] CrossRef - Non-capsular based immunization approaches to prevent Streptococcus pneumoniae infection
Pedro H. Silva, Yaneisi Vázquez, Camilo Campusano, Angello Retamal-Díaz, Margarita K. Lay, Christian A. Muñoz, Pablo A. González, Alexis M. Kalergis, Susan M. Bueno
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef - A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies
Shannon C. David, Erin B. Brazel, Eve V. Singleton, Vikrant Minhas, Zoe Laan, Catherine Scougall, Austen Y. Chen, Hui Wang, Chloe J. Gates, Kimberley T. McLean, Jeremy S. Brown, Giuseppe Ercoli, Rachel A. Higgins, Paul V. Licciardi, Kim Mulholland, Justin
mBio.2022;[Epub] CrossRef - Developing green and sustainable concrete in integrating with different urban wastes
Huaguo Chen, Cheuk Lun Chow, Denvid Lau
Journal of Cleaner Production.2022; 368: 133057. CrossRef - Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease
William Walkowski, Justin Bassett, Manmeet Bhalla, Blaine A. Pfeifer, Elsa N. Bou Ghanem
Vaccines.2021; 9(6): 589. CrossRef - Immune Responses to Irradiated Pneumococcal Whole Cell Vaccine
Eunbyeol Ko, Soyoung Jeong, Min Yong Jwa, A Reum Kim, Ye-Eun Ha, Sun Kyung Kim, Sungho Jeong, Ki Bum Ahn, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Vaccines.2021; 9(4): 405. CrossRef - Controlling the Colonization of Clostridium perfringens in Broiler Chickens by an Electron-Beam-Killed Vaccine
Palmy R. Jesudhasan, Sohini S. Bhatia, Kirthiram K. Sivakumar, Chandni Praveen, Kenneth J. Genovese, Haiqi L. He, Robert Droleskey, Jack L. McReynolds, James A. Byrd, Christina L. Swaggerty, Michael H. Kogut, David J. Nisbet, Suresh D. Pillai
Animals.2021; 11(3): 671. CrossRef - Automated application of low energy electron irradiation enables inactivation of pathogen- and cell-containing liquids in biomedical research and production facilities
Jasmin Fertey, Martin Thoma, Jana Beckmann, Lea Bayer, Julia Finkensieper, Susann Reißhauer, Beatrice Sarah Berneck, Leila Issmail, Jessy Schönfelder, Javier Portillo Casado, Andre Poremba, Frank-Holm Rögner, Bastian Standfest, Gustavo R. Makert, Lia Walc
Scientific Reports.2020;[Epub] CrossRef - Innate and Adaptive Immune Responses against Bordetella pertussis and Pseudomonas aeruginosa in a Murine Model of Mucosal Vaccination against Respiratory Infection
Catherine B. Blackwood, Emel Sen-Kilic, Dylan T. Boehm, Jesse M. Hall, Melinda E. Varney, Ting Y. Wong, Shelby D. Bradford, Justin R. Bevere, William T. Witt, F. Heath Damron, Mariette Barbier
Vaccines.2020; 8(4): 647. CrossRef - Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen Rodentibacter pneumotropicus—A New Method for the Generation of Bacterial Vaccines with Increased Efficacy
Jasmin Fertey, Lea Bayer, Sophie Kähl, Rukiya M. Haji, Anke Burger-Kentischer, Martin Thoma, Bastian Standfest, Jessy Schönfelder, Javier Portillo Casado, Frank-Holm Rögner, Christoph Georg Baums, Thomas Grunwald, Sebastian Ulbert
Vaccines.2020; 8(1): 113. CrossRef - Next-Generation Whole-Cell Pneumococcal Vaccine
Victor Morais, Esther Texeira, Norma Suarez
Vaccines.2019; 7(4): 151. CrossRef - Gamma-irradiation-killed Streptococcus pneumoniae potently induces the expression of IL-6 and IL-8 in human bronchial epithelial cells
Min Yong Jwa, Eun Byeol Ko, Hyun Young Kim, Sun Kyung Kim, Soyoung Jeong, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Microbial Pathogenesis.2018; 124: 38. CrossRef
- The synthetic human beta-defensin-3 C15 peptide exhibits antimicrobial activity against Streptococcus mutans, both alone and in combination with dental disinfectants
-
Ki Bum Ahn , A Reum Kim , Kee-Yeon Kum , Cheol-Heui Yun , Seung Hyun Han
-
J. Microbiol. 2017;55(10):830-836. Published online September 28, 2017
-
DOI: https://doi.org/10.1007/s12275-017-7362-y
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77
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0
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27
Crossref
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Abstract
-
Streptococcus mutans is a major etiologic agent of human
dental caries that forms biofilms on hard tissues in the human
oral cavity, such as tooth and dentinal surfaces. Human
β-defensin-3 (HBD3) is a 45-amino-acid natural antimicrobial
peptide that has broad spectrum antimicrobial activity
against bacteria and fungi. A synthetic peptide consisting of
the C-terminal 15 amino acids of HBD3 (HBD3-C15) was
recently shown to be sufficient for its antimicrobial activity.
Thus, clinical applications of this peptide have garnered
attention. In this study, we investigated whether HBD3-C15
inhibits the growth of the representative cariogenic pathogen
Streptococcus mutans and its biofilm formation. HBD3-C15
inhibited bacterial growth, exhibited bactericidal activity,
and attenuated bacterial biofilm formation in a dose-dependent
manner. HBD3-C15 potentiated the bactericidal and
anti-biofilm activity of calcium hydroxide (CH) and chlorhexidine
digluconate (CHX), which are representative disinfectants
used in dental clinics, against S. mutans. Moreover,
HBD3-C15 showed antimicrobial activity by inhibiting biofilm
formation by S. mutans and other dentinophilic bacteria
such as Enterococcus faecalis and Streptococcus gordonii,
which are associated with dental caries and endodontic
infection, on human dentin slices. These effects were observed
for HBD3-C15 alone and for HBD3-C15 in combination with
CH or CHX. Therefore, we suggest that HBD3-C15 is a potential
alternative or additive disinfectant that can be used
for the treatment of oral infectious diseases, including dental
caries and endodontic infections.
-
Citations
Citations to this article as recorded by - Human β-defensins and their synthetic analogs: Natural defenders and prospective new drugs of oral health
Mumian Chen, Zihe Hu, Jue Shi, Zhijian Xie
Life Sciences.2024; 346: 122591. CrossRef - Addressing Antimicrobial Properties in Guided Tissue/Bone Regeneration Membrane: Enhancing Effectiveness in Periodontitis Treatment
Sara Takallu, Esmaeil Mirzaei, Abbas Zakeri Bazmandeh, Hamid Reza Ghaderi Jafarbeigloo, Hooman Khorshidi
ACS Infectious Diseases.2024; 10(3): 779. CrossRef - Novel Nano Drug‐Loaded Hydrogel Coatings for the Prevention and Treatment of CAUTI
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Xinzi Kong, Vijetha Vishwanath, Prasanna Neelakantan, Zhou Ye
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Karthikeyan Kandaswamy, Raghunandhakumar Subramanian, Jayant Giri, Ajay Guru, Jesu Arockiaraj
International Journal of Peptide Research and Therapeutics.2024;[Epub] CrossRef - A Novel Beta-Defensin Isoform from Malabar Trevally, Carangoides malabaricus (Bloch & Schneider, 1801), an Arsenal Against Fish Bacterial Pathogens: Molecular Characterization, Recombinant Production, and Mechanism of Action
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Sehyeok Im, Jun Hyuck Lee, Youn-Soo Shim
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Mayron Alves Vasconcelos, Bruno Rocha da Silva, Alexandre Lopes Andrade, Aryane de Azevedo Pinheiro, Francisco Flávio Vasconcelos Evaristo, Francisco Vassiliepe Sousa Arruda, Esteban Nicolás Lorenzón, Eduardo Maffud Cilli, Edson Holanda Teixeira
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Olivia Lili Zhang, John Yun Niu, Ollie Yiru Yu, May Lei Mei, Nicholas Stephen Jakubovics, Chun Hung Chu
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Journal of Functional Biomaterials.2022; 13(4): 210. CrossRef - Important Roles and Potential Uses of Natural and Synthetic Antimicrobial Peptides (AMPs) in Oral Diseases: Cavity, Periodontal Disease, and Thrush
Albert Donald Luong, Alyah Buzid, John H. T. Luong
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Xuelian Jiang, Yufei Wang, Xinwei Li, Zening Feng, Yuhao Zeng, Sili Han, Nobuhiro Takahashi, Linglin Zhang
European Journal of Oral Sciences.2022;[Epub] CrossRef - Effect of Bacteriocin-Like Inhibitory Substance (BLIS) from
Enterococcus faecium DB1 on Cariogenic
Streptococcus mutans Biofilm Formation
Ni-Na Kim, Bong Sun Kim, Han Bin Lee, Sunghyun An, Donghan Kim, Seok-Seong Kang
Food Science of Animal Resources.2022; 42(6): 1020. CrossRef - In Vitro Pharmacodynamics and Bactericidal Mechanism of Fungal Defensin-Derived Peptides NZX and P2 against Streptococcus agalactiae
Yankang Wu, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Jianhua Wang
Microorganisms.2022; 10(5): 881. CrossRef - Characterization of Histopathology and Microbiota in Contemporary Regenerative Endodontic Procedures: Still Coming up Short
Yeon-Jee Yoo, Hiran Perinpanayagam, Youngnim Choi, Yu Gu, Seok-Woo Chang, Seung-Ho Baek, Qiang Zhu, Ashraf F. Fouad, Kee-Yeon Kum
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Qi-Yu Zhang, Zhi-Bin Yan, Yue-Ming Meng, Xiang-Yu Hong, Gang Shao, Jun-Jie Ma, Xu-Rui Cheng, Jun Liu, Jian Kang, Cai-Yun Fu
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John Yun Niu, Iris Xiaoxue Yin, William Ka Kei Wu, Quan-Li Li, May Lei Mei, Chun Hung Chu
Archives of Oral Biology.2021; 122: 105022. CrossRef - Suppressive effects of gecko cathelicidin on biofilm formation and cariogenic virulence factors of Streptococcus mutans
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Archives of Oral Biology.2021; 129: 105205. CrossRef - A Chimeric Cationic Peptide Composed of Human β-Defensin 3 and Human β-Defensin 4 Exhibits Improved Antibacterial Activity and Salt Resistance
Wenjing Yu, Nianzhi Ning, Ying Xue, Yanyu Huang, Feng Guo, Tao Li, Boning Yang, Deyan Luo, Yakun Sun, Zhan Li, Jianxin Wang, Zhili He, Shiwei Cheng, Xingxiao Zhang, Hui Wang
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