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Research Support, Non-U.S. Gov't
- Analysis of Substitution Events in HIV-1 vif Gene of the Korean Clade
- Chan Seung Park 1, Mi Sook Kim 1, Hyun Ah Yi 1, Dong Hun Lee 1, Keon Myung Lee 2, Chan Hee Lee 1
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Journal of Microbiology 2007;45(1):75-78.
DOI: https://doi.org/2487 [pii]
1School of Life Sciences Chungbuk National University, Cheongju, Republic of Korea, 2School of Electrical and Computer Engineering, Chungbuk National University, Cheongju, Republic of Korea
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Corresponding author:
Chan Hee Lee , Tel: 82-43-261-2304,
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Abstract
Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent
evolution in the Korean clade. At amino acid level, there were 17 substitutions and G→E substitution at position 37 may be responsible for change in predicted secondary structure.
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