Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model

Woon-ki Kim; You Jin Jang; SungJun Park; Sung-gyu Min; Heeun Kwon; Min Jung Jo; GwangPyo Ko

doi:10.1007/s12275-024-00104-5

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Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model: Woon-ki Kim ^1,2, You Jin Jang ¹, SungJun Park ^1,3,4, Sung-gyu Min ¹, Heeun Kwon ¹, Min Jung Jo ¹, GwangPyo Ko ^1,2,3; Journal of Microbiology 2024;62(2):91-99.
DOI: https://doi.org/10.1007/s12275-024-00104-5
Published online: February 22, 2024

¹Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea, ²Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea, ³N-Bio, Seoul National University, Seoul 08826, Republic of Korea, ⁴KoBioLabs, Inc, Seoul 08826, Republic of Korea

Corresponding author: Woon-ki Kim ,
GwangPyo Ko ,

Received: 20 August 2023 • Revised: 11 December 2023 • Accepted: 27 December 2023

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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease with repeated exacerbations of eczema and pruritus. Probiotics can prevent or treat AD appropriately via modulation of immune responses and gut microbiota. In this study, we evaluated effects of Lactobacillus acidophilus (L. acidophilus) KBL409 using a house dust mite (Dermatophagoides farinae)-induced in vivo AD model. Oral administration of L. acidophilus KBL409 significantly reduced dermatitis scores and decreased infiltration of immune cells in skin tissues. L. acidophilus KBL409 reduced in serum immunoglobulin E and mRNA levels of T helper (Th)1 (Interferon-γ), Th2 (Interleukin [IL]-4, IL-5, IL-13, and IL-31), and Th17 (IL-17A) cytokines in skin tissues. The anti-inflammatory cytokine IL-10 was increased and Foxp3 expression was up-regulated in AD-induced mice with L. acidophilus KBL409. Furthermore, L. acidophilus KBL409 significantly modulated gut microbiota and concentrations of short-chain fatty acids and amino acids, which could explain its effects on AD. Our results suggest that L. acidophilus KBL409 is the potential probiotic for AD treatment by modulating of immune responses and gut microbiota of host.

Keywords: Atopic dermatitis · Gut-skin axis · Immune response · Lactobacillus acidophilus · Microbiota · Probiotic

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Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model

J. Microbiol. 2024;62(2):91-99. Published online February 22, 2024

DOI: https://doi.org/10.1007/s12275-024-00104-5

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