Abstract
With global expansion of the COVID-19 pandemic and the
emergence of new variants, extensive efforts have been made
to develop highly effective antiviral drugs and vaccines against
SARS-CoV-2. The interactions of coronaviruses with host
antiviral interferon pathways ultimately determine successful
viral replication and SARS-CoV-2-induced pathogenesis.
Innate immune receptors play an essential role in host defense
against SARS-CoV-2 via the induction of IFN production
and signaling. Here, we summarize the recent advances
in innate immune sensing mechanisms of SARS-CoV-2 and
various strategies by which SARS-CoV-2 antagonizes antiviral
innate immune signaling pathways, with a particular
focus on mechanisms utilized by multiple SARS-CoV-2 proteins
to evade interferon induction and signaling in host cell.
Understanding the underlying immune evasion mechanisms
of SARS-CoV-2 is essential for the improvement of vaccines
and therapeutic strategies.
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