Abstract
Reactive oxygen species (ROS) produced by NADPH oxidases
can serve as signaling molecules to regulate a variety of
physiological processes in multi-cellular organisms. In the
nematophagous fungus Arthrobotrys oligospora, we found
that ROS were produced during conidial germination, hyphal
extension, and trap formation in the presence of nematodes.
Generation of an AoNoxA knockout strain demonstrated
the crucial role of NADPH oxidase in the production
of ROS in A. oligospora, with trap formation impaired in
the AoNoxA mutant, even in the presence of the nematode
host. In addition, the expression of virulence factor serine
protease P186 was up-regulated in the wild-type strain, but
not in the mutant strain, in the presence of Caenorhabditis
elegans. These results indicate that ROS derived from AoNoxA
are essential for full virulence of A. oligospora in nematodes.
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