Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling

Praveen Rai; Drista Sharma; Rani Soni; Nazia Khatoon; Bhaskar Sharma; Tarun Kumar Bhatt

doi:10.1007/s12275-017-6525-1

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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling: Praveen Rai , Drista Sharma , Rani Soni , Nazia Khatoon , Bhaskar Sharma , Tarun Kumar Bhatt; Journal of Microbiology 2017;55(4):231-236.
DOI: https://doi.org/10.1007/s12275-017-6525-1
Published online: March 1, 2017

School of Life Science, Department of Biotechnology, Central University of Rajasthan, BandarSindri, Ajmer, Rajasthan, 305817, India

Corresponding author: Tarun Kumar Bhatt , Tel: +919928920412,

Received: 13 October 2016 • Revised: 23 December 2016 • Accepted: 23 December 2016

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Abstract

Malaria has been present since ancient time and remains a major global health problem in developing countries. Plas-modium falciparum belongs to the phylum Apicomplexan, largely contain disease-causing parasites and characterized by the presence of apicoplast. It is a very essential organelle of P. falciparum responsible for the synthesis of key mole-cules required for the growth of the parasite. Indispensable nature of apicoplast makes it a potential drug target. Calcium signaling is important in the establishment of malaria para-site inside the host. It has been involved in invasion and egress of merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. There-fore, in this review, we will focus on the role of apicoplast in malaria biology and its metabolic regulation through Ca++ signaling.

Keywords: malaria;Plasmodium falciparum;apicoplast;cal-cium signaling;transcription regulation

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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling

J. Microbiol. 2017;55(4):231-236. Published online March 1, 2017

DOI: https://doi.org/10.1007/s12275-017-6525-1

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