Abstract
An 80% methanolic extract of Rhus verniciflua Stokes bark
showed significant anti-viral activity against fish pathogenic
infectious hematopoietic necrosis virus (IHNV) and
viral hemorrhagic septicemia virus (VHSV) in a cell-based
assay measuring virus-induced cytopathic effect (CPE).
Activity-guided fractionation and isolation for the 80%
methanolic extract of R. verniciflua yielded the most active
ethyl acetate fraction, and methyl gallate (1) and four flavonoids:
fustin (2), fisetin (3), butin (4) and sulfuretin (5).
Among them, fisetin (3) exhibited high antiviral activities
against both IHNV and VHSV showing EC50 values of 27.1
and 33.3 μM with selective indices (SI = CC50/EC50) more
than 15, respectively. Fustin (2) and sulfuretin (5) displayed
significant antiviral activities showing EC50 values of 91.2–
197.3 μM against IHNV and VHSV. In addition, the antiviral
activity of fisetin against IHNV and VHSV occurred
up to 5 hr post-infection and was not associated with direct
virucidal effects in a timed addition study using a plaque
reduction assay. These results suggested that the bark of R.
verniciflua and isolated flavonoids have significant anti-viral
activity against IHNV and VHSV, and also have potential
to be used as anti-viral therapeutics against fish viral diseases.
Citations
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