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Research Support, Non-U.S. Gov't
- Antifungal Activity and Mechanism of Fengycin in the Presence and Absence of Commercial Surfactin Against Rhizopus stolonifer
- Yang Tao , Xiao-mei Bie , Feng-xia Lv , Hai-zhen Zhao , Zhao-xin Lu
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Journal of Microbiology 2011;49(1):146-150.
DOI: https://doi.org/10.1007/s12275-011-0171-9
Published online: March 3, 2011
College of Food Science and Technology, Nanjing Agricultural University, Weigang, Nanjing, 210095, P. R. ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Weigang, Nanjing, 210095, P. R. China
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Corresponding author:
Zhao-xin Lu , Tel: +86-25-8439-6583,
Received: 10 May 2010 • Accepted: 22 October 2010
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Abstract
The antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer were investigated. The MIC (minimal inhibitory concentration) of fengycin without commercial surfactin added was 0.4 mg/ml while the MIC of fengycin with commercial surfactin added was 2.0 mg/ml. Fengycin acted on cell membrane and cellular organs and inhibited DNA synthesis. The antifungal effect of fengycin was reduced after commercial surfactin was added. All these results suggest that the fungal cell membrane may be the primary target of fengycin action and commercial surfactin may reduce the antifungal activity of fengycin.
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