Journal of Microbiology

Full articles

Pycnogenol reduces the expression of P. aeruginosa T3SS and inflammatory response in NCI-H292 cells: Seung-Ho Kim, Da Yun Seo, Sang-Bae Han, Un-Hwan Ha, Ji-Won Park, Kyung-Seop Ahn; J. Microbiol. 2025;63(10):2503004. Published online September 19, 2025; DOI: https://doi.org/10.71150/jm.2503004

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Abstract PDF Supplementary Material: Nosocomial infections caused by Pseudomonas aeruginosa (P. aeruginosa) have become increasingly common, particularly among immunocompromised individuals, who experience high mortality rates and prolonged treatment durations due to the limited availability of effective therapies. In this study, we screened for anti-ExoS compounds targeting P. aeruginosa and identified pycnogenol (PYC) as a potent inhibitor of the type III secretion system (T3SS), a major virulence mechanism responsible for the translocation of effectors such as ExoS. Using ELISA, western blotting, and real-time PCR analyses in both P. aeruginosa and infected H292 cells, we found that PYC significantly reduced T3SS activity. Mechanistically, PYC suppressed the transcription of T3SS-related genes by downregulating exsA expression in P. aeruginosa. Furthermore, pretreatment with PYC attenuated the cytotoxic effects and reduced the expression of proinflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18), in P. aeruginosa-infected H292 cells. These effects were associated with the inhibition of NF-κB signaling and inflammasome activation. Taken together, our findings suggest that PYC may serve as a promising therapeutic candidate against P. aeruginosa infections by targeting T3SS-mediated virulence and modulating host inflammatory responses.

Multi-omics to evaluate the protective mechanisms during Akkermansia muciniphila treatment of Candida albicans colonization and subsequent infection: Qiulin Luo, Huan Zhang, Youming Pu, Yingpu Wei, Jiangkun Yu, Xiaoshen Wang, Qin Cai, Ying Hu, Wenli Yuan; J. Microbiol. 2025;63(8):e2502007. Published online August 31, 2025; DOI: https://doi.org/10.71150/jm.2502007

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Abstract PDF Supplementary Material: Akkermansia muciniphila (AKK, A. muciniphila) fortifies the intestinal barrier, inhibits the colonization of pathogenic bacteria, and protects the host’s health. Nevertheless, the existing literature offers inadequate evidence to ascertain whether A. muciniphila can effectively treat Candida albicans (C. albicans) infections in vitro, and the underlying mechanisms remain ambiguous. This study, animal models were established through gavage with clinical isolates of C. albicans to induce gastrointestinal tract colonization and subsequent translocation infection. The models were subsequently administered A. muciniphila. We examined the analysis of 16S rRNA gene sequencing, metabolomics of colonic contents, and transcriptomics of colonic tissue. The intestinal barrier, inflammatory responses, and immune cell infiltration are analyzed. This study revealed that A. muciniphila markedly mitigated C. albicans translocation infection and modified the intestinal microbial community structure and metabolic attributes in model mice. After administering A. muciniphila to the translocation infection group, there was a notable increase in the prevalence of bacteria that produce short-chain fatty acids, including Eubacterium_F. Moreover, there was a significant increase in the levels of specific pathogens, including Faecalibaculum, Turicibacter, and Turicimonas. The study demonstrated that A. muciniphila treatment can improve the composition of intestinal microbiota and metabolites, augment the tight junctions of colonic tissue and diminish systemic inflammatory response. This presents an innovative therapeutic approach for the potential treatment of intestinal C. albicans infection using A. muciniphila.

Review

Targeting innate immune sensors for therapeutic strategies in infectious diseases: Seyun Shin, Young Ki Choi, SangJoon Lee; J. Microbiol. 2025;63(6):e2503009. Published online June 30, 2025; DOI: https://doi.org/10.71150/jm.2503009

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Abstract PDF: The innate immune system relies on innate immune sensors, such as pattern recognition receptors (PRRs), to detect pathogens and initiate immune responses, crucial for controlling infections but also implicated in inflammatory diseases. These innate immune sensors, including Toll-like receptors (TLRs), nod-like receptors (NLRs), RIG-I-like receptors (RLRs), absent in melanoma 2 (AIM2), and Z-DNA binding protein 1 (ZBP1) trigger signaling pathways that produce cytokines, modulating inflammation and cell death. Traditional therapies focus on directly targeting pathogens; however, host-targeting therapeutic strategies have emerged as innovative approaches to modulate innate immune sensor activity. These strategies aim to fine-tune the immune response, either enhancing antiviral defenses or mitigating hyperinflammation to prevent tissue damage. This review explores innate immune sensor-based therapeutic approaches, including inhibitors, agonists, and antagonists, that enhance antiviral defense or suppress harmful inflammation, highlighting innate immune sensors as promising targets in infectious and inflammatory disease treatment.

Full article

Alizarin, which reduces ExoS, attenuates inflammation by P. aeruginosa in H292 cells: Seung-Ho Kim, Hye In Ahn, Jae-Hoon Oh, Da Yun Seo, Jung-Hee Kim, Ok-kyoung Kwon, Ji-Won Park, Kyung-Seop Ahn; J. Microbiol. 2025;63(5):e2411012. Published online May 27, 2025; DOI: https://doi.org/10.71150/jm.2411012

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Abstract PDF

Pseudomonas aeruginosa (P. aeruginosa) is resistant to several drugs as well as antibiotics and is thus classified as multidrug resistant and extensively drug resistant. These bacteria have a secretion system called the "type 3 secretion system (T3SS)", which facilitates infection by delivering an effector protein. ExoenzymeS (ExoS) is known to induce cell death and activate caspase-1. In particular, patients infected with P. aeruginosa develop diseases associated with high mortality, such as pneumonia, because no drug targets an ExoS or T3SS. We selected natural compounds to treat T3SS-mediated pneumonia and chose alizarin, a red dye. We confirmed the effects of alizarin on T3SS by bacterial PCR and ELISA. It was confirmed that alizarin regulates ExoS by inhibiting exsA but also popD and pscF. Furthermore, in infected H292 cells, it not only attenuates inflammation by inhibiting lipopolysaccharide (LPS)-induced phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65 but also interferes with the level of ExoS delivered into the host and modulates caspase-1. We confirmed this result and determined that it led to decreases in proinflammatory cytokines such as Interleukin-1beta (IL-1β), Interleukin-6 (IL-6), and Interleukin-18 (IL-18). Therefore, we suggest that alizarin is a suitable drug for treating pneumonia caused by P. aeruginosa because it helps to attenuate inflammation by regulating T3SS and NF-κB signaling.

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Beyond pathogenicity: applications of the type III secretion system (T3SS) of Pseudomonas aeruginosa
Tianqi Su, Lin Zhang, Jie Shen, Danyu Qian, Yulei Guo, Zhenpeng Li
Frontiers in Microbiology.2025;[Epub] CrossRef

Journal Article

Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection: Xiaomin Lin, Chun Lin, Xin Li, Fen Yao, Xiaoling Guo, Meimei Wang, Mi Zeng, Yumeng Yuan, Qingdong Xie, Xudong Huang, Xiaoyang Jiao; J. Microbiol. 2024;62(12):1113-1124. Published online December 2, 2024; DOI: https://doi.org/10.1007/s12275-024-00190-5

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Abstract PDF

To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.

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Targeting gut microbiotasu-derived butyrate for Ferroptosis inhibition in Sepsis-induced myocardial dysfunction
Jianfei Xiong, Guoxiang Liu, Tianyuan Jia, Qian Yang, Changqing Zhu, Shiwei Wang
Journal of Molecular and Cellular Cardiology.2025;[Epub] CrossRef

Review

Fecal Microbiota Transplantation: Indications, Methods, and Challenges.: Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim; J. Microbiol. 2024;62(12):1057-1074. Published online November 18, 2024; DOI: https://doi.org/10.1007/s12275-024-00184-3

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Abstract PDF

Over the past two decades, as the importance of gut microbiota to human health has become widely known, attempts have been made to treat diseases by correcting dysbiosis of gut microbiota through fecal microbiota transplantation (FMT). Apart from current knowledge of gut microbiota, FMT to treat disease has a long history, from the treatment of food poisoning in the fourth century to the treatment of Clostridioides difficile infections in the twentieth century. In 2013, FMT was recognized as a standard treatment for recurrent C. difficile because it consistently showed high efficacy. Though recurrent C. difficile is the only disease internationally recognized for FMT efficacy, FMT has been tested for other diseases and shown some promising preliminary results. Different FMT methods have been developed using various formulations and administration routes. Despite advances in FMT, some issues remain to be resolved, such as donor screening, manufacturing protocols, and unknown components in the fecal microbiota. In this review, we discuss the mechanisms, clinical indications, methods, and challenges of current FMT. We also discuss the development of alternative therapies to overcome the challenges of FMT.

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Transplantation of Fecal Flora from Patients with Atherosclerosis to Mice Can Increase Serum Low-Density Lipoprotein Cholesterol and Affect Intestinal Flora and Its Metabolites
Liang Feng, Jianting Feng, Li He, Fu Chen, Xin Feng, Suwen Wang
Applied Microbiology.2025; 5(1): 29. CrossRef
Management of refractory checkpoint inhibitor-induced colitis
Anas Zaher, Maria Julia Moura Nascimento Santos, Hassan Elsaygh, Stephen J. Peterson, Carolina Colli Cruz, Anusha Shirwaikar Thomas, Yinghong Wang
Expert Opinion on Drug Safety.2025; : 1. CrossRef
Fecal Microbiota Transplantation (FMT) in Clostridium difficile Infection: A Paradigm Shift in Gastrointestinal Microbiome Modulation
Muhammad Hamza Saeed, Sundas Qamar, Ayesha Ishtiaq, Qudsia Umaira khan, Asma Atta, Maryam Atta, Hifza Ishtiaq, Marriam Khan, Muhammad Rawal Saeed, Ayesha Iqbal
Cureus.2025;[Epub] CrossRef
Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies
Ayrton Bangolo, Behzad Amoozgar, Maryam Habibi, Elizabeth Simms, Vignesh K Nagesh, Shruti Wadhwani, Nikita Wadhwani, Auda Auda, Daniel Elias, Charlene Mansour, Robert Abbott, Nisrene Jebara, Lili Zhang, Sarvarinder Gill, Kareem Ahmed, Andrew Ip, Andre Goy
World Journal of Gastrointestinal Pharmacology and Therapeutics.2025;[Epub] CrossRef
Microbiome Therapeutics for Clostridioides difficile Infection
Christine W. Lucky, Rachel L. Medernach, Brendan J. Kelly, Jennie H. Kwon, Michael H. Woodworth
Infectious Disease Clinics of North America.2025; 39(4): 663. CrossRef
Laboratory preparation methods for human-derived fecal microbial suspensions for fecal microbiota transplantation: a review and standardization perspectives
Jinhua Gong, Yuchi Liu, Liuye Huang
Frontiers in Microbiology.2025;[Epub] CrossRef
Improving fecal transplantation precision for enhanced maturation of intestinal function in germ-free mice through microencapsulation and probiotic intervention
Furong Ba, Wei Wang, Yilun Huang, Shuobo Zhang, Bo Qiu, Siyuan Xie, Lvwan Xu, Wang Gao, Xiaoqin Zhang, Zhenyu Wen, Qifan Wang, Hainv Gao, Guoping Sheng, Björn Berglund, Ping Li, Lanjuan Li, Mingfei Yao
Microbiome.2025;[Epub] CrossRef
Fecal microbiota transplantation as salvage therapy for disseminated strongyloidiasis in an immunosuppressed patient: a case report
Wei Fu, Na Peng, Yan Geng
Frontiers in Immunology.2025;[Epub] CrossRef

Journal Articles

Infection Dynamics of Dengue Virus in Caco-2 Cells Depending on Its Differentiation Status: Jayoung Nam, Jisu Lee, Geon A Kim, Seung-Min Yoo, Changhoon Park, Myung-Shin Lee; J. Microbiol. 2024;62(9):799-809. Published online August 30, 2024; DOI: https://doi.org/10.1007/s12275-024-00161-w

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Abstract PDF

Dengue virus (DENV), from the Flaviviridae family, is the causative agent of dengue fever and poses a significant global health challenge. The virus primarily affects the vascular system and liver; however, a growing body of evidence suggests its involvement in the gastrointestinal (GI) tract, contributing to clinical symptoms such as abdominal pain, vomiting, and diarrhea. However, the mechanisms underlying DENV infection in the digestive system remain largely unexplored. Prior research has detected viral RNA in the GI tissue of infected animals; however, whether the dengue virus can directly infect human enterocytes remains unclear. In this study, we examine the infectivity of human intestinal cell lines to the dengue virus and their subsequent response. We report that the Caco-2 cell line, a model of human enterocytes, is susceptible to infection and capable of producing viruses. Notably, differentiated Caco-2 cells exhibited a lower infection rate yet a higher level of virus production than their undifferentiated counterparts. These findings suggest that human intestinal cells are a viable target for the dengue virus, potentially elucidating the GI symptoms observed in dengue fever and offering a new perspective on the pathogenetic mechanisms of the virus.

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Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef
Domain-Specific Impacts of Spike Protein Mutations on Infectivity and Antibody Escape in SARS-CoV-2 Omicron BA.1
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2025;[Epub] CrossRef

Yeast polyubiquitin unit regulates synaptonemal complex formation and recombination during meiosis: Min-Kyung Jo , Kiwon Rhee , Keun Pil Kim , Soogil Hong; J. Microbiol. 2022;60(7):705-714. Published online July 4, 2022; DOI: https://doi.org/10.1007/s12275-022-2204-y

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Abstract PDF

Ubiquitin is highly conserved in most eukaryotes and involved in diverse physiological processes, including cell division, protein quality control, and protein degradation mediated by the ubiquitin-proteasome system after heat shock, glucose-starvation, and oxidative stress. However, the role of the ubiquitin gene UBI4, which contains five consecutive head-to-tail ubiquitin repeats, in meiosis has not been investigated. In this study, we show that the Saccharomyces cerevisiae polyubiquitin precursor gene, UBI4, is required to promote synaptonemal complex (SC) formation and suppress excess doublestrand break formation. Moreover, the proportion of Zip1 polycomplexes, which indicate abnormal SC formation, in cells with a mutation in UBI4 (i.e., ubi4Δ cells) is higher than that of wild-type cells, implying that the UBI4 plays an important role in the early meiotic prophase I. Interestingly, although ubi4Δ cells rarely form full-length SCs in the pachytene stage of prophase I, the Zip3 foci are still seen, as in wild-type cells. Moreover, ubi4Δ cells proficiently form crossover and noncrossover products with a slight delay compared to wild-type cells, suggesting that UBI4 is dispensable in SCcoupled recombination. Our findings demonstrate that UBI4 exhibits dual functions that are associated with both positive and negative roles in SC formation and recombination during meiosis.

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The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance
Cathleen M. Lake, Jennifer Gardner, Salam Briggs, Zulin Yu, Grace McKown, R. Scott Hawley
Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef

Activity of Lactobacillus crispatus isolated from vaginal microbiota against Mycobacterium tuberculosis: Youngkyoung Lee , Hoonhee Seo , Sukyung Kim Abdur Rahim , Youjin Yoon , Jehee Jung , Saebim Lee , Chang Beom Ryu , Ho-Yeon Song; J. Microbiol. 2021;59(11):1019-1030. Published online November 1, 2021; DOI: https://doi.org/10.1007/s12275-021-1332-0

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Abstract PDF

Tuberculosis, an infectious disease, is caused by Mycobacterium tuberculosis. It remains a significant public health issue around the globe, causing about 1.8 million deaths every year. Drug-resistant M. tuberculosis, including multi-drug-resistant (MDR), extremely-drug-resistant (XDR), and totally drugresistant (TDR) M. tuberculosis, continues to be a threat to public health. In the case of antibiotic-resistant tuberculosis, the treatment effect of conventional antibiotics is low. Side effects caused by high doses over a long period are causing severe problems. To overcome these problems, there is an urgent need to develop a new anti-tuberculosis drug that is different from the existing compound-based antibiotics. Probiotics are defined as live microorganisms conferring health benefits. They can be potential therapeutic agents in this context as the effectiveness of probiotics against different infectious diseases has been well established. Here, we report that Lactobacillus crispatus PMC201 shows a promising effect on tuberculosis isolated from vaginal fluids of healthy Korean women. Lactobacillus crispatus PMC201 reduced M. tuberculosis H37Rv under co-culture conditions in broth and reduced M. tuberculosis H37Rv and XDR M. tuberculosis in macrophages. Lactobacillus crispatus PMC201 was not toxic to a guinea pig model and did not induce dysbiosis in a human intestinal microbial ecosystem simulator. Taken together, these
results
indicate that L. crispatus PMC201 can be a promising alternative drug candidate in the current tuberculosis drug regime. Further study is warranted to assess the in vivo efficacy and confirm the mode of action of L. crispatus PMC201.

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Insights into Autophagy in Microbiome Therapeutic Approaches for Drug-Resistant Tuberculosis
Md Abdur Rahim, Hoonhee Seo, Indrajeet Barman, Mohammed Solayman Hossain, Md Sarower Hossen Shuvo, Ho-Yeon Song
Cells.2025; 14(7): 540. CrossRef
The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis
Hamed Memariani, Mojtaba Memariani, Seyed Ebrahim Eskandari, Abdolmajid Ghasemian, Ali Nour Neamatollahi
Journal of Infection and Public Health.2025; : 102840. CrossRef
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Md Abdur Rahim, Hoonhee Seo, Sukyung Kim, Indrajeet Barman, Fatemeh Ghorbanian, Mohammed Solayman Hossain, Md Sarower Hossen Shuvo, Saebim Lee, Ho-Yeon Song
Medical Microbiology and Immunology.2024;[Epub] CrossRef
Efficacy of lyophilized Lactobacillus sakei as a potential candidate for preventing carbapenem-resistant Klebsiella infection
Hanieh Tajdozian, Hoonhee Seo, Yoonkyoung Jeong, Fatemeh Ghorbanian, Chae-eun Park, Faezeh Sarafraz, Md Abdur Rahim, Youngkyoung Lee, Sukyung Kim, Saebim Lee, Jung-Hyun Ju, Chul-Ho Kim, Ho-Yeon Song
Annals of Microbiology.2024;[Epub] CrossRef
Identification of Probiotic Strains with Anti-Tuberculosis Activity and Their Characterization as Potential Therapeutic Agents
Mohammed Solayman Hossain, Hoonhee Seo, Md Abdur Rahim, Md Sarower Hossen Shuvo, Indrajeet Barman, Hokyoung Kim, Jinhyeon An, Sukyung Kim, Ho-Yeon Song
Journal of Bacteriology and Virology.2024; 54(4): 325. CrossRef
The gut and lung microbiota in pulmonary tuberculosis: susceptibility, function, and new insights into treatment
Qiqi Zhuo, Xianyi Zhang, Kehong Zhang, Chan Chen, Zhen Huang, Yuzhong Xu
Expert Review of Anti-infective Therapy.2023; 21(12): 1355. CrossRef
Host microbiome in tuberculosis: disease, treatment, and immunity perspectives
Archana Pant, Bhabatosh Das, Gopalakrishnan Aneeshkumar Arimbasseri
Frontiers in Microbiology.2023;[Epub] CrossRef
Antibiotic Resistance to Mycobacterium tuberculosis and Potential Use of Natural and Biological Products as Alternative Anti-Mycobacterial Agents
Roberto Arrigoni, Andrea Ballini, Skender Topi, Lucrezia Bottalico, Emilio Jirillo, Luigi Santacroce
Antibiotics.2022; 11(10): 1431. CrossRef
In Vivo Efficacy of Bacillus velezensis Isolated from Korean Gochang Bokbunja Vinegar against Carbapenem-Resistant Klebsiella pneumoniae Infections
Fatemeh Ghorbanian, Hoonhee Seo, Hanieh Tajdozian, Youngkyoung Lee, MD Abdur Rahim, Sukyung Kim, Il-Yun Jung, Saebim Lee, Ho-Yeon Song
Polish Journal of Microbiology.2022; 71(4): 553. CrossRef

Crystal structure of human LC8 bound to a peptide from Ebola virus VP35: Dahwan Lim , Ho-Chul Shin , Joon Sig Choi , Seung Jun Kim , Bonsu Ku; J. Microbiol. 2021;59(4):410-416. Published online February 25, 2021; DOI: https://doi.org/10.1007/s12275-021-0641-7

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Abstract PDF

Zaire ebolavirus, commonly called Ebola virus (EBOV), is an RNA virus that causes severe hemorrhagic fever with high mortality. Viral protein 35 (VP35) is a virulence factor encoded in the EBOV genome. VP35 inhibits host innate immune responses and functions as a critical cofactor for viral RNA replication. EBOV VP35 contains a short conserved motif that interacts with dynein light chain 8 (LC8), which serves as a regulatory hub protein by associating with various LC8-binding proteins. Herein, we present the crystal structure of human LC8 bound to the peptide comprising residues 67−76 of EBOV VP35. Two VP35 peptides were found to interact with homodimeric LC8 by extending the central β- sheets, constituting a 2:2 complex. Structural analysis demonstrated that the intermolecular binding between LC8 and VP35 is mainly sustained by a network of hydrogen bonds and supported by hydrophobic interactions in which Thr73 and Thr75 of VP35 are involved. These findings were verified by binding measurements using isothermal titration calorimetry. Biochemical analyses also verified that residues 67−76 of EBOV VP35 constitute a core region for interaction with LC8. In addition, corresponding motifs from other members of the genus Ebolavirus commonly bound to LC8 but with different binding affinities. Particularly, VP35 peptides originating from pathogenic species interacted with LC8 with higher affinity than those from noninfectious species, suggesting that the binding of VP35 to LC8 is associated with the pathogenicity of the Ebolavirus species.

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Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide
Sujin Jung, Hye Seon Lee, Ho-Chul Shin, Joon Sig Choi, Seung Jun Kim, Bonsu Ku
Journal of Microbiology.2023; 61(8): 755. CrossRef
Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing
Nicolas Tarbouriech, Florian Chenavier, Junna Kawasaki, Kamel Bachiri, Jean-Marie Bourhis, Pierre Legrand, Lily L. Freslon, Estelle M. N. Laurent, Elsa Suberbielle, Rob W. H. Ruigrok, Keizo Tomonaga, Daniel Gonzalez-Dunia, Masayuki Horie, Etienne Coyaud,
Viruses.2022; 14(11): 2358. CrossRef
Structural and biochemical analysis of the PTPN4 PDZ domain bound to the C-terminal tail of the human papillomavirus E6 oncoprotein
Hye Seon Lee, Hye-Yeoung Yun, Eun-Woo Lee, Ho-Chul Shin, Seung Jun Kim, Bonsu Ku
Journal of Microbiology.2022; 60(4): 395. CrossRef

Review

[MINIREVIEW]Phosphate sugar isomerases and their potential for rare sugar bioconversion: Soo-Jung Kim , Yeong-Su Kim , Soo-Jin Yeom; J. Microbiol. 2020;58(9):725-733. Published online June 25, 2020; DOI: https://doi.org/10.1007/s12275-020-0226-x

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Abstract PDF

Phosphate sugar isomerases, catalyzing the isomerization between ketopentose/ketohexose phosphate and aldopentose/ aldohexose phosphate, play an important role in microbial sugar metabolism. They are present in a wide range of microorganisms. They have attracted increasing research interest because of their broad substrate specificity and great potential in the enzymatic production of various rare sugars. Here, the enzymatic properties of various phosphate sugar isomerases are reviewed in terms of their substrate specificities and their applications in the production of valuable rare sugars because of their functions such as low-calorie sweeteners, bulking agents, and pharmaceutical precursor. Specifically, we focused on the industrial applications of D-ribose-5-phosphate isomerase and D-mannose-6-phosphate isomerase to produce D-allose and L-ribose, respectively.

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Transforming monosaccharides: Recent advances in rare sugar production and future exploration
Shin-ichi Nakakita, Jun Hirabayashi
BBA Advances.2025; 7: 100143. CrossRef
Production of Value-Added Arabinofuranosyl Nucleotide Analogues from Nucleoside by an In Vitro Enzymatic Synthetic Biosystem
Yuxue Liu, Xiaojing Zhang, Erchu Yang, Xiaobei Liu, Weiwei Su, Zhenyu Wang, Hailei Wang
Biomolecules.2024; 14(11): 1440. CrossRef
Taxonomic Identification of the Arctic Strain Nocardioides Arcticus Sp. Nov. and Global Transcriptomic Analysis in Response to Hydrogen Peroxide Stress
Bailin Cong, Hui Zhang, Shuang Li, Shenghao Liu, Jing Lin, Aifang Deng, Wenqi Liu, Yan Yang
International Journal of Molecular Sciences.2023; 24(18): 13943. CrossRef
A putative glucose 6-phosphate isomerase has pleiotropic functions on virulence and other mechanisms in Acidovorax citrulli
Lynn Heo, Yoobin Han, Yongmin Cho, Junhyeok Choi, Jeongwook Lee, Sang-Wook Han
Frontiers in Plant Science.2023;[Epub] CrossRef
Assessing the genomic composition, putative ecological relevance and biotechnological potential of plasmids from sponge bacterial symbionts
Vanessa Oliveira, Ana R.M. Polónia, Daniel F.R. Cleary, Yusheng M. Huang, Nicole J. de Voogd, Tina Keller-Costa, Rodrigo Costa, Newton C.M. Gomes
Microbiological Research.2022; 265: 127183. CrossRef
Enhanced isomerization of rare sugars by ribose-5-phosphate isomerase A from Ochrobactrum sp. CSL1
Rong Wang, Xinqi Xu, Xuemei Yao, Hengtao Tang, Xin Ju, Liangzhi Li
Enzyme and Microbial Technology.2021; 148: 109789. CrossRef
Simultaneous Production of D-Tagatose, D-Arabitol and Galactitol from Cheese Whey Powder Using Combined Biotransformation and Fermentation Strategies
Guoyan Zhang, Hossain M. Zabed, Yingfeng An, Junhua Yun, Jiaqi Huang, Yufei Zhang, Xiaolan Li, Jiangfei Wang, Xianghui Qi
SSRN Electronic Journal .2021;[Epub] CrossRef
Engineering ribose-5-phosphate isomerase B from a central carbon metabolic enzyme to a promising sugar biocatalyst
Hengtao Tang, Xin Ju, Jing Zhao, Liangzhi Li
Applied Microbiology and Biotechnology.2021; 105(2): 509. CrossRef
Construction of recombinant Escherichia coli expressing xylitol-4-dehydrogenase and optimization for enhanced L-xylulose biotransformation from xylitol
Mesfin Angaw Tesfay, Xin Wen, Yujie Liu, Huibin Lin, Linxu Chen, Jianqiang Lin, Jianqun Lin
Bioprocess and Biosystems Engineering.2021; 44(6): 1021. CrossRef

Journal Articles

Autophagy of bovine mammary epithelial cell induced by intracellular Staphylococcus aureus: Na Geng , Kangping Liu , Jianwei Lu , Yuliang Xu , Xiaozhou Wang , Run Wang , Jianzhu Liu , Yongxia Liu , Bo Han; J. Microbiol. 2020;58(4):320-329. Published online February 26, 2020; DOI: https://doi.org/10.1007/s12275-020-9182-8

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Abstract PDF

Bovine mastitis is a common disease in the dairy industry that causes great economic losses. As the primary pathogen of contagious mastitis, Staphylococcus aureus (S. aureus) can invade bovine mammary epithelial cells, thus evading immune defenses and resulting in persistent infection. Recently, autophagy has been considered an important mechanism for host cells to clear intracellular pathogens. In the current study, autophagy caused by S. aureus was detected, and the correlation between autophagy and intracellular S. aureus survival was assessed. First, a model of intracellular S. aureus infection was established. Then, the autophagy of MAC-T cells was evaluated by confocal microscopy and western blot. Moreover, the activation of the PI3K-Akt-mTOR and ERK1/2 signaling pathways was determined by western blot. Finally, the relationship between intracellular bacteria and autophagy was analyzed by using autophagy regulators (3-methyladenine [3-MA], rapamycin [Rapa] and chloroquine [CQ]). The
results
showed that S. aureus caused obvious induction of autophagosome formation, transformation of LC3I/II, and degradation of p62/SQSTM1 in MAC-T cells; furthermore, the PI3K-Akt-mTOR and ERK1/2 signaling pathways were activated. The number of intracellular S. aureus increased significantly with autophagy activation by rapamycin, whereas the number decreased when the autophagy flux was inhibited by chloroquine. Therefore, this study indicated that intracellular S. aureus can induce autophagy and utilize it to survive in bovine mammary epithelial cells.

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Staphylococcus aureus regulates Th17 cells and autophagy via STING in chronic eosinophilic rhinosinusitis with nasal polyps
Weigang Gan, Xingchen Liu, Feng Liu, Junying Hu
European Archives of Oto-Rhino-Laryngology.2025; 282(2): 881. CrossRef
International Symposium on Ruminant Physiology: The immunometabolism of transition dairy cows from dry-off to early lactation—Lights and shadows
Erminio Trevisi, Luca Cattaneo, Fiorenzo Piccioli-Cappelli, Matteo Mezzetti, Andrea Minuti
Journal of Dairy Science.2025; 108(7): 7662. CrossRef
Network Pharmacology and Molecular Docking: Exploring the Mechanism of Peppermint in Mastitis Prevention and Treatment in Dairy Cows
Xinyu Wang, Jiaxin Lai, Fei Xu, Mingchun Liu
Veterinary Sciences.2025; 12(2): 129. CrossRef
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Construction of a genetically modified T7Select phage system to express the antimicrobial peptide 1018: David J. Lemon , Matthew K. Kay , James K. Titus , April A. Ford , Wen Chen , LCDR Nicholas J. Hamlin , Yoon Y. Hwang; J. Microbiol. 2019;57(6):532-538. Published online May 27, 2019; DOI: https://doi.org/10.1007/s12275-019-8686-6

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Abstract PDF

Bacteriophage therapy was an ascendant technology for combating bacterial infections before the golden age of antibiotics, but the therapeutic potential of phages was largely ignored after the discovery of penicillin. Recently, with antibioticresistant infections on the rise, these phages are receiving renewed attention to combat problematic bacterial infections. Our approach is to enhance bacteriophages with antimicrobial peptides, short peptides with broad-spectrum antibiotic or antibiofilm effects. We inserted coding sequences for 1018, an antimicrobial peptide previously shown to be an effective broad-spectrum antimicrobial and antibiofilm agent, or the fluorescent marker mCherry, into the T7Select phage genome. Transcription and production of 1018 or mCherry began rapidly after E. coli cultures were infected with genetically modified phages. mCherry fluorescence, which requires a 90 min initial maturation period, was observed in infected cultures after 2 h of infection. Finally, we tested phages expressing 1018 (1018 T7) against bacterial planktonic cultures and biofilms, and found the 1018 T7 phage was more effective than the unmodified T7Select phage at both killing planktonic cells and eradicating established biofilms, validating our phage-driven antimicrobial peptide expression system. The combination of narrow-spectrum phages delivering relatively high local doses of broad-spectrum antimicrobials could be a powerful
method
to combat resistant infections. The experiments we describe prove this combination is feasible in vitro, but further testing and optimization are required before genetically modified phages are ready for use in vivo.

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Water-based extracts of Zizania latifolia inhibit Staphylococcus aureus infection through the induction of human beta-defensin 2 expression in HaCaT cells: Bo Yeon Kang , Seung-Su Lee , Myun-Ho Bang , Hyoik Jeon , Hangeun Kim , Dae Kyun Chung; J. Microbiol. 2018;56(12):910-916. Published online November 27, 2018; DOI: https://doi.org/10.1007/s12275-018-8307-9

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Zizania latifolia is a perennial herb belonging to the family Gramineae that has been used as a health food in Asian countries. In this study, we investigated the antimicrobial effect of Z. latifolia, which increased human beta-defensin 2 (hBD2) expression in HaCaT cells. hBD2 expression was further increased in cells treated with Z. latifolia extracts and subsequently infected with Staphylococcus aureus. Inversely, S. aureus infection decreased after treatment. The induction of hBD2 in HaCaT cells was mediated by the Toll-like receptor 2 (TLR2) signaling pathway, including the activation of extracellular signal-regulated kinase (ERK) and activator protein 1 (AP-1). Further study using siRNA revealed that hBD2 played an important role in the inhibition of S. aureus infection in HaCaT cells. Our data suggest that Z. latifolia extracts can be used as an antimicrobial ingredient for skin treatment formulas.

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Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus: Hüseyin Ta&# , Ay&# , Nermin Topalo&# , Vildan Alptüzün; J. Microbiol. 2018;56(11):828-837. Published online October 24, 2018; DOI: https://doi.org/10.1007/s12275-018-8244-7

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Methicillin resistant Staphylococcus aureus (MRSA) with multiple drug resistance patterns is frequently isolated from skin and soft tissue infections that are involved in chronic wounds. Today, difficulties in the treatment of MRSA associated infections have led to the development of alternative approaches such as antimicrobial photodynamic therapy. This study aimed to investigate photoinactivation with cationic porphyrin derivative compounds against MRSA in in-vitro conditions. In the study, MRSA clinical isolates with different antibiotic resistance profiles were used. The newly synthesized cationic porphyrin derivatives (PM, PE, PPN, and PPL) were used as photosensitizer, and 655 nm diode laser was used as light source. Photoinactivation experiments were performed by optimizing energy doses and photosensitizer concentrations. In photoinactivation experiments with different energy densities and photosensitizer concentrations, more than 99% reduction was achieved in bacterial cell viability. No decrease in bacterial survival was observed in control groups. It was determined that there was an increase in photoinactivation efficiency by increasing the energy dose. At the energy dose of 150 J/cm2 a survival reduction of over 6.33 log10 was observed in each photosensitizer type. While 200 μM PM concentration was required for this photoinactivation, 12.50 μM was sufficient for PE, PPN, and PPL. In our study, antimicrobial photodynamic therapy performed with cationic porphyrin derivatives was found to have potent antimicrobial efficacy against multidrug resistant S. aureus which is frequently isolated from wound infections.

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Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient: Haejeong Lee , Jin Yang Baek , So Yeon Kim , HyunJi Jo , KyeongJin Kang , Jae-Hoon Ko , Sun Young Cho , Doo Ryeon Chung , Kyong Ran Peck , Jae-Hoon Song , Kwan Soo Ko; J. Microbiol. 2018;56(9):665-672. Published online August 23, 2018; DOI: https://doi.org/10.1007/s12275-018-8130-3

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Nine Klebsiella pneumoniae isolates coproducing NDM-1 and OXA-232 carbapenemases were successively isolated from a single patient. Although they were isolated simultaneously and were isogenic, they presented different colony phenotypes (matt and mucoid). All nine isolates were resistant to most antibiotics except colistin and fosfomycin. In addition, matt-type isolates were resistant to tigecycline. No differences were detected in the cps cluster sequences, except for the insertion of IS5 in the wzb gene of two matt-type isolates. In vitro virulence assays based on production of capsular polysaccharide, biofilm formation, and resistance to human serum indicated that the mucoid-type isolates were significantly more virulent than the matt-type. In addition, mucoid-type isolates showed higher survival rates than the matt-type ones in infection experiments in the fruit fly, suggesting a higher virulence of K. pneumoniae isolates with a mucoid phenotype. To our knowledge, this is the first report of K. pneumoniae colonies with different phenotypes being isolated from the same sample. In addition, we show that virulence varies with colony phenotype. Dissemination of K. pneumoniae isolates expressing both antibiotic resistance and high virulence would constitute a great threat.

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[PROTOCOL] Drosophila melanogaster as a polymicrobial infection model for Pseudomonas aeruginosa and Staphylococcus aureus: Young-Joon Lee , Hye-Jeong Jang , In-Young Chung , You-Hee Cho; J. Microbiol. 2018;56(8):534-541. Published online July 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8331-9

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Non-mammalian infection models have been developed over the last two decades, which is a historic milestone to understand the molecular basis of bacterial pathogenesis. They also provide small-scale research platforms for identification of virulence factors, screening for antibacterial hits, and evaluation of antibacterial efficacy. The fruit fly, Drosophila melanogaster is one of the model hosts for a variety of bacterial pathogens, in that the innate immunity pathways and tissue physiology are highly similar to those in mammals. We here present a relatively simple protocol to assess the key aspects of the polymicrobial interaction in vivo between the human opportunistic pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, which is based on the systemic infection by needle pricking at the dorsal thorax of the flies. After infection, fly survival and bacteremia over time for both P. aeruginosa and S. aureus within the infected flies can be monitored as a measure of polymicrobial virulence potential. The infection takes ~24 h including bacterial cultivation. Fly survival and bacteremia are assessed using the infected flies that are monitored up to ~60 h post-infection. These methods can be used to identify presumable as well as unexpected phenotypes during polymicrobial interaction between P. aeruginosa and S. aureus mutants, regarding bacterial pathogenesis and host immunity.

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Review

[Minireview] Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas: Sangmin Kang , Jinjong Myoung; J. Microbiol. 2017;55(5):319-329. Published online April 29, 2017; DOI: https://doi.org/10.1007/s12275-017-7075-2

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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the latest addition to the human herpesvirus family. Unlike alpha- and beta-herpesvirus subfamily members, gamma-herpesviruses, including Epstein-Barr virus (EBV) and KSHV, cause vari-ous tumors in humans. KSHV primarily infects endothelial and B cells in vivo, and is associated with at least three malig-nancies: Kaposi’s sarcoma and two B cell lymphomas, res-pectively. Although KSHV readily infects endothelial cells in vitro and thus its pathogenic mechanisms have been exten-sively studied, B cells had been refractory to KSHV infection. As such, functions of KSHV genes have mostly been eluci-dated in endothelial cells in the context of viral infection but not in B cells. Whether KSHV oncogenes, defined in endo-thelial cells, play the same roles in the tumorigenesis of B cells remains an open question. Only recently, through a few ground-breaking studies, B cell infection models have been established. In this review, those models will be compared and contrasted and putative mechanisms of KSHV-induced B cell transformation will be discussed.

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Analysis of KSHV B lymphocyte lineage tropism in human tonsil reveals efficient infection of CD138+ plasma cells
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Journal Articles

Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus: Mohammed Abd Alrahman , Sang Sun Yoon; J. Microbiol. 2017;55(1):68-74. Published online December 30, 2016; DOI: https://doi.org/10.1007/s12275-017-6515-3

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Pseudomonas aeruginosa has been identified as an important causative agent of airway infection, mainly in cystic fibrosis. This disease is characterized by defective mucociliary clearance induced in part by mucus hyper-production. Mucin is a major component of airway mucus and is heavily O-glycosylated, with a protein backbone. Airway infection is known to be established with bacterial adhesion to mucin. However, the genes involved in mucin degradation or utilization remain elusive. In this study, we sought to provide a genetic basis of P. aeruginosa airway growth by identifying those genes. First, using RNASeq analyses, we compared genome-wide expression profiles of PAO1, a prototype P. aeruginosa laboratory strain, grown in M9-mucin (M9M) and M9-glucose (M9G) media. Additionally, a PAO1 transposon (Tn) insertion mutants library was screened for mutants defective in growth in M9M medium. One mutant with a Tn insertion in the xcpU gene (PA3100) was determined to exhibit faulty growth in M9M medium. This gene contributes to the type II secretion system, suggesting that P. aeruginosa uses this secretion system to produce a number of proteins to break down and assimilate the mucin molecule. Furthermore, we screened the PAO1 genome for genes with protease activity. Of 13 mutants, one with mutation in PA3247 gene exhibited defective growth in M9M, suggesting that the PA3247-encoded protease plays a role in mucin utilization. Further mechanistic dissection of this particular process will reveal new drug targets, the inhibition of which could control recalcitrant P. aeruginosa infections.

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Epidemiology and resistance features of Acinetobacter baumannii isolates from the ward environment and patients in the burn ICU of a Chinese hospital: Yali Gong , Xiaodong Shen , Guangtao Huang , Cheng Zhang , Xiaoqiang Luo , Supeng Yin , Jing Wang , Fuquan Hu , Yizhi Peng , Ming Li; J. Microbiol. 2016;54(8):551-558. Published online August 2, 2016; DOI: https://doi.org/10.1007/s12275-016-6146-0

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Acinetobacter baumannii is an important opportunistic pathogen that causes severe nosocomial infections, especially in intensive care units (ICUs). Over the past decades, an everincreasing number of hospital outbreaks caused by A. baumannii have been reported worldwide. However, little attention has been directed toward the relationship between A. baumannii isolates from the ward environment and patients in the burn ICU. In this study, 88 A. baumannii isolates (26 from the ward environment and 62 from patients) were collected from the burn ICU of the Southwest Hospital in Chongqing, China, from July through December 2013. Antimicrobial susceptibility testing results showed that drug resistance was more severe in isolates from patients than from the ward environment, with all of the patient isolates being fully resistant to 10 out of 19 antimicrobials tested. Isolations from both the ward environment and patients possessed the β-lactamase genes blaOXA-51, blaOXA-23, blaAmpC, blaVIM, and blaPER. Using pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST), these isolates could be clustered into 4 major PFGE types and 4 main sequence types (ST368, ST369, ST195, and ST191) among which, ST368 was the dominant genotype. Epidemiologic and molecular typing data also revealed that a small-scale outbreak of A. baumannii infection was underway in the burn ICU of our hospital during the sampling period. These results suggest that dissemination of β-lactamase genes in the burn ICU might be closely associated with the high-level resistance of A. baumannii, and the ICU environment places these patients at a high risk for nosocomial infection. Cross-contamination should be an important concern in clinical activities to reduce hospital acquired infections caused by A. baumannii.

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Characteristics of the community-genotype sequence type 72 methicillin-resistant Staphylococcus aureus isolates that underlie their persistence in hospitals: Eun-Jeong Joo , Ji-Young Choi , Doo Ryeon Chung , Jae-Hoon Song , Kwan Soo Ko; J. Microbiol. 2016;54(6):445-450. Published online May 27, 2016; DOI: https://doi.org/10.1007/s12275-016-6157-x

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Panton-Valentine leukocidin-negative methicillin-resistant Staphylococcus aureus (MRSA) clone ST72, known as a major community-associated MRSA in Korea, has emerged as an important pathogen in hospitals. To understand bacterial properties that underlie transformation of this clone into a nosocomial pathogen, we compared characteristics of the community-genotype ST72 MRSA isolates with those of ST5 and ST239 MRSA, which have been predominant nosocomial MRSA clones in Korea. Several genes associated with adhesion and virulence were absent or rarely found in ST72 isolates. Many ST72 isolates (70.1%) belonged to agr group I, but the agr group of other ST72 isolates could not be determined. As indicated by δ-hemolysin production, ST72 isolates expressed fully functional agr, whereas agr dysfunction was observed in ST5 and ST239 isolates. In the biofilm formation assay, no upregulation of biofilm-forming activity of ST72 MRSA was detected. However, ST72 isolates demonstrated persistence under hypotonic and desiccating conditions (survival rates 72.3% and 33.9%, respectively), which was similar to characteristics of ST5 or ST239 isolates. ST72- MRSA isolates showed low virulence, but properties of their functional agr system could facilitate their spread in hospitals. In conclusion, tolerance to stressful environments, e.g., hypotonic and dry conditions, may also contribute to survival of the community-associated MRSA clones in healthcare facilities.

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Review

REVIEW] Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota: Sarah Höfs , Selene Mogavero , Bernhard Hube; J. Microbiol. 2016;54(3):149-169. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5514-0

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Abstract PDF

The interaction between Candida albicans and its host cells is characterized by a complex interplay between the expression of fungal virulence factors, which results in adherence, invasion and cell damage, and the host immune system, which responds by secreting proinflammatory cytokines, activating antimicrobial activities and killing the fungal pathogen. In this review we describe this interplay by taking a closer look at how C. albicans pathogenicity is induced and executed, how the host responds in order to prevent and clear an infection, and which mechanisms C. albicans has evolved to bypass these immune responses to avoid clearance. Furthermore, we review studies that show how the presence of other microorganisms affects this interplay.

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Critical Reviews in Microbiology.2025; 51(5): 755. CrossRef
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Gizem Babuccu, Özgür Albayrak, Füsun Can, Özlem Doğan
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Antibiotics.2025; 14(9): 876. CrossRef
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Rabeay Y.A. Hassan, Mohamed Medhat Ali, Shuna Cui, Ursula Bilitewski
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Journal of Fungi.2025; 11(10): 751. CrossRef
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Molecules.2021; 26(2): 505. CrossRef
Analysis of biofilm formation bySporothrix schenckii
Rocío Sánchez-Herrera, Lérida Liss Flores-Villavicencio, Juan Luis Pichardo-Molina, José Pedro Castruita-Domínguez, Xochilt Aparicio-Fernández, Myrna Sabanero López, Julio Cesar Villagómez-Castro
Medical Mycology.2021; 59(1): 31. CrossRef
Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis
Dongjia Lin, Lisa Yang, Liling Wen, Huanzi Lu, Qianming Chen, Zhi Wang
Mucosal Immunology.2021; 14(6): 1247. CrossRef
Modulation of Immune Responses by Particle Size and Shape
Maksim V. Baranov, Manoj Kumar, Stefano Sacanna, Shashi Thutupalli, Geert van den Bogaart
Frontiers in Immunology.2021;[Epub] CrossRef
Transcriptional Profiling of the Candida auris Response to Exogenous Farnesol Exposure
Ágnes Jakab, Noémi Balla, Ágota Ragyák, Fruzsina Nagy, Fruzsina Kovács, Zsófi Sajtos, Zoltán Tóth, Andrew M. Borman, István Pócsi, Edina Baranyai, László Majoros, Renátó Kovács, Aaron P. Mitchell
mSphere.2021;[Epub] CrossRef
Virulence related traits in yeast species associated with food; Debaryomyces hansenii, Kluyveromyces marxianus, and Wickerhamomyces anomalus
Laura Peréz-Través, Rosa de Llanos, Allen Flockhart, Lydia García-Domingo, Marizeth Groenewald, Roberto Pérez-Torrado, Amparo Querol
Food Control.2021; 124: 107901. CrossRef
Yeast-Host Interactions: Anadenanthera colubrina Modulates Virulence Factors of C. albicans and Inflammatory Response In Vitro
Carolina Medeiros de Almeida Maia, Silvana Pasetto, Cassiano Francisco Weege Nonaka, Edja Maria Melo de Brito Costa, Ramiro Mendonça Murata
Frontiers in Pharmacology.2021;[Epub] CrossRef
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Jasminka Talapko, Martina Juzbašić, Tatjana Matijević, Emina Pustijanac, Sanja Bekić, Ivan Kotris, Ivana Škrlec
Journal of Fungi.2021; 7(2): 79. CrossRef
Histatin 5 Metallopeptides and Their Potential against Candida albicans Pathogenicity and Drug Resistance
Gabriela Vieira Silva Zolin, Fauller Henrique da Fonseca, Carolina Reis Zambom, Saulo Santesso Garrido
Biomolecules.2021; 11(8): 1209. CrossRef
Interaction between Borrelia miyamotoi variable major proteins Vlp15/16 and Vlp18 with plasminogen and complement
Frederik L. Schmidt, Valerie Sürth, Tim K. Berg, Yi-Pin Lin, Joppe W. Hovius, Peter Kraiczy
Scientific Reports.2021;[Epub] CrossRef
Antibacterial and antifungal activities of encapsulated Au and Ag nanoparticles synthesized using Argemone mexicana L extract, against antibiotic-resistant bacteria and Candida albicans
Diana Guadalupe Téllez-de-Jesús, N.S. Flores-Lopez, J.A. Cervantes-Chávez, A.R. Hernández-Martínez
Surfaces and Interfaces.2021; 27: 101456. CrossRef
Изучение распространенности и резистентности к антимикотикам грибов рода Candida при инфекционных заболеваниях верхних и нижних дыхательных путей
N.I. Kovalenko, T.M. Zamazii, I.V. Novikova
ACTUAL INFECTOLOGY.2021; 8(5-6): 25. CrossRef
The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans
Chido Bvumbi, Godloves Fru Chi, Marc Y. Stevens, Molly Mombeshora, Stanley Mukanganyama, Ahmad Mansour
The Scientific World Journal.2021; 2021: 1. CrossRef
Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans
Shuangyan Yao, Yuting Feng, Amjad Islam, Manjari Shrivastava, Hongcheng Gu, Yumeng Lu, Jiaqi Sheng, Malcolm Whiteway, Jinrong Feng
Computational and Structural Biotechnology Journal.2020; 18: 4002. CrossRef
Action mechanisms of probiotics onCandidaspp. and candidiasis prevention: an update
F.C. Ribeiro, R.D. Rossoni, P.P. Barros, J.D. Santos, L.R.O. Fugisaki, M.P.V. Leão, J.C. Junqueira
Journal of Applied Microbiology.2020; 129(2): 175. CrossRef
The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies
Jana Maršíková, Martina Pavlíčková, Derek Wilkinson, Libuše Váchová, Otakar Hlaváček, Ladislava Hatáková, Zdena Palková
Proceedings of the National Academy of Sciences.2020; 117(26): 15123. CrossRef
Bio- and Nanotechnology as the Key for Clinical Application of Salivary Peptide Histatin: A Necessary Advance
Carolina Reis Zambom, Fauller Henrique da Fonseca, Saulo Santesso Garrido
Microorganisms.2020; 8(7): 1024. CrossRef
High frequency of azole resistant Candida spp. colonization among presumptive multidrug resistant tuberculosis (MDR-TB) patients
Surya Darma, Angga Ambara, Abu Tholib Aman, Luthvia Annisa, Nurrokhman, Titik Nuryastuti, Tri Wibawa, Selvakumar Subbian
PLOS ONE.2020; 15(11): e0242542. CrossRef
Resensitization of Fluconazole-Resistant Urinary Candida spp. Isolates by Amikacin through Downregulation of Efflux Pump Genes
EVA A. EDWARD, NELLY M. MOHAMED, AZZA S. ZAKARIA
Polish Journal of Microbiology.2020; 69(1): 73. CrossRef
Association of IL-17 and IL-23 Gene Variants with Plasma Levels and Risk of Vulvovaginal Candidiasis in a Chinese Han Population

Wei Li, Wenyin Shi, Yujun Yin, Juan Chen, Lanlan Luo
Pharmacogenomics and Personalized Medicine.2020; Volume 13: 725. CrossRef
Recurrent Vulvovaginal Candidiasis: An Immunological Perspective
Diletta Rosati, Mariolina Bruno, Martin Jaeger, Jaap ten Oever, Mihai G. Netea
Microorganisms.2020; 8(2): 144. CrossRef
Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
Luke D. Halder, Emeraldo A. H. Jo, Mohammad Z. Hasan, Marta Ferreira-Gomes, Thomas Krüger, Martin Westermann, Diana I. Palme, Günter Rambach, Niklas Beyersdorf, Cornelia Speth, Ilse D. Jacobsen, Olaf Kniemeyer, Berit Jungnickel, Peter F. Zipfel, Christine
Nature Communications.2020;[Epub] CrossRef
An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains
Sara B. Salazar, Rita S. Simões, Nuno A. Pedro, Maria Joana Pinheiro, Maria Fernanda N. N. Carvalho, Nuno P. Mira
Journal of Fungi.2020; 6(1): 23. CrossRef
The role of Candida albicans in root caries biofilms: an RNA-seq analysis
Laís Daniela EV, Nailê DAMÉ-TEIXEIRA, Thuy DO, Marisa MALTZ, Clarissa Cavalcanti Fatturi PAROLO
Journal of Applied Oral Science.2020;[Epub] CrossRef
Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits
Cristina Nicoleta Ciurea, Irina-Bianca Kosovski, Anca Delia Mare, Felicia Toma, Ionela Anca Pintea-Simon, Adrian Man
Microorganisms.2020; 8(6): 857. CrossRef
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains
Francesco Orofino, Giuseppina I. Truglio, Diego Fiorucci, Ilaria D'Agostino, Matteo Borgini, Federica Poggialini, Claudio Zamperini, Elena Dreassi, Laura Maccari, Riccardo Torelli, Cecilia Martini, Micaela Bernabei, Jacques F. Meis, Nitesh Kumar Khandelwa
International Journal of Antimicrobial Agents.2020; 55(3): 105865. CrossRef
Surface, adhesiveness and virulence aspects of Candida haemulonii species complex
Lívia S Ramos, Simone S C Oliveira, Laura N Silva, Marcela Q Granato, Diego S Gonçalves, Susana Frases, Sergio H Seabra, Alexandre J Macedo, Lucimar F Kneipp, Marta H Branquinha, André L S Santos
Medical Mycology.2020; 58(7): 973. CrossRef
Gastric Perforation Associated with Candidiasis and NSAIDS
Febriana Aquaresta, Arthur Pohan Kawilarang, Pepy Dwi Endraswari
Indonesian Journal of Tropical and Infectious Disease.2020; 8(3): 168. CrossRef
Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges
Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Cheyenne Marçal de Souza, Liliana Scorzoni, Juliana De Camargo Fenley, Juliana Campos Junqueira
Mycopathologia.2020; 185(3): 415. CrossRef
Candida isolates causing candidemia show different degrees of virulence in Galleria mellonella
Laura Judith Marcos-Zambrano, María Ángeles Bordallo-Cardona, Elisa Borghi, Monica Falleni, Delfina Tosi, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Medical Mycology.2020; 58(1): 83. CrossRef
Increasing Susceptibility of Drug-Resistant Candida albicans to Fluconazole and Terbinafine by 2(5H)-Furanone Derivative
Irshad S. Sharafutdinov, Georgii D. Ozhegov, Alina E. Sabirova, Valentina V. Novikova, Svetlana A. Lisovskaya, Alsu M. Khabibrakhmanova, Almira R. Kurbangalieva, Mikhail I. Bogachev, Airat R. Kayumov
Molecules.2020; 25(3): 642. CrossRef
Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis
Svetlana P. Ikonomova, Parisa Moghaddam‐Taaheri, Yan Wang, Mary T. Doolin, Kimberly M. Stroka, Bernhard Hube, Amy J. Karlsson
Protein Science.2020; 29(2): 480. CrossRef
Moonlighting Proteins at the Candidal Cell Surface
Dorota Satala, Justyna Karkowska-Kuleta, Aleksandra Zelazna, Maria Rapala-Kozik, Andrzej Kozik
Microorganisms.2020; 8(7): 1046. CrossRef
Recognition of Candida albicans and Role of Innate Type 17 Immunity in Oral Candidiasis
Anna Pavlova, Irshad Sharafutdinov
Microorganisms.2020; 8(9): 1340. CrossRef
Sugar Phosphorylation Controls Carbon Source Utilization and Virulence of Candida albicans
Stefanie Wijnants, Michael Riedelberger, Philipp Penninger, Karl Kuchler, Patrick Van Dijck
Frontiers in Microbiology.2020;[Epub] CrossRef
Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells
Jhones do Nascimento Dias, Calliandra de Souza Silva, Alyne Rodrigues de Araújo, Jessica Maria Teles Souza, Paulo Henrique de Holanda Veloso Júnior, Wanessa Felix Cabral, Maria da Glória da Silva, Peter Eaton, José Roberto de Souza de Almeida Leite, André
Scientific Reports.2020;[Epub] CrossRef
Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile
Marsel R. Garipov, Alina E. Sabirova, Roman S. Pavelyev, Nikita V. Shtyrlin, Svetlana A. Lisovskaya, Oksana V. Bondar, Aleksandr V. Laikov, Julia G. Romanova, Mikhail I. Bogachev, Airat R. Kayumov, Yurii G. Shtyrlin
Bioorganic Chemistry.2020; 104: 104306. CrossRef
Virulence Factors in Sporothrix schenckii, One of the Causative Agents of Sporotrichosis
Alma K. Tamez-Castrellón, Orazio Romeo, Laura C. García-Carnero, Nancy E. Lozoya-Pérez, Héctor M. Mora-Montes
Current Protein & Peptide Science.2020; 21(3): 295. CrossRef
The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes
Chahrazed Benzaid, Amine Belmadani, Ryad Djeribi, Mahmoud Rouabhia
Antibiotics.2019; 8(1): 10. CrossRef
Oxidative and nitrosative stress responses during macrophage–Candida albicansbiofilm interaction
Julio E Arce Miranda, José L Baronetti, Claudia E Sotomayor, M Gabriela Paraje
Medical Mycology.2019; 57(1): 101. CrossRef
Promising antifungal activity of Croton tricolor stem essential oil against Candida yeasts
Fabrício Mendes Miranda, Baraquizio Braga do Nascimento Junior, Rosane Moura Aguiar, Rafael Santos Pereira, Adonias De Oliveira Teixeira, Djalma Menezes De Oliveira, Edeltrudes de Oliveira Lima, Silvia Siag Oigman, Cláudia Moraes de Rezende, Guglielmina F
Journal of Essential Oil Research.2019; 31(3): 223. CrossRef
Interfacial Behavior of Fumonisin B1 Toxin and Its Degradation on the Membrane
Shiv K. Sharma, Sijan Poudel Sharma, Darlene Miller, Jean-Marie A. Parel, Roger M. Leblanc
Langmuir.2019; 35(7): 2814. CrossRef
Epidemiology and antifungal susceptibility patterns of Candida isolates from Greek women with vulvovaginal candidiasis
Sofia Maraki, Viktoria Eirini Mavromanolaki, Dimitra Stafylaki, Eleni Nioti, George Hamilos, Anna Kasimati
Mycoses.2019; 62(8): 692. CrossRef
Perspectives on Anti-Candida Drug Development
Ashok K. Dubey, Rajeev K. Singla
Current Topics in Medicinal Chemistry.2019; 19(26): 2375. CrossRef
Farnesol, a Quorum-Sensing Molecule of Candida albicans Triggers the Release of Neutrophil Extracellular Traps
Marcin Zawrotniak, Karolina Wojtalik, Maria Rapala-Kozik
Cells.2019; 8(12): 1611. CrossRef
Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin
Mónica Galocha, Pedro Pais, Mafalda Cavalheiro, Diana Pereira, Romeu Viana, Miguel C. Teixeira
International Journal of Molecular Sciences.2019; 20(9): 2345. CrossRef
Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model
Katja Graf, Antonia Last, Rena Gratz, Stefanie Allert, Susanne Linde, Martin Westermann, Marko Gröger, Alexander S. Mosig, Mark S. Gresnigt, Bernhard Hube
Disease Models & Mechanisms.2019;[Epub] CrossRef
Determination of the effects of cinnamon bark fractions on Candida albicans and oral epithelial cells
Marie-Pier Veilleux, Daniel Grenier
BMC Complementary and Alternative Medicine.2019;[Epub] CrossRef
Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity
Yao-Peng Xue, Mou-Chieh Kao, Chung-Yu Lan
Scientific Reports.2019;[Epub] CrossRef
“Candida AlbicansInteractions With The Host: Crossing The Intestinal Epithelial Barrier”
Louise Basmaciyan, Fabienne Bon, Tracy Paradis, Pierre Lapaquette, Frédéric Dalle
Tissue Barriers.2019; 7(2): 1612661. CrossRef
On‐site secretory vesicle delivery drives filamentous growth in the fungal pathogenCandida albicans
Allon Weiner, François Orange, Sandra Lacas‐Gervais, Katya Rechav, Vikram Ghugtyal, Martine Bassilana, Robert A. Arkowitz
Cellular Microbiology.2019; 21(1): e12963. CrossRef
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection
Wenjuan Wang, Zihou Deng, Hongyu Wu, Qun Zhao, Tiantian Li, Wencheng Zhu, Xiongjun Wang, Longhai Tang, Chengshu Wang, Shu-Zhong Cui, Hui Xiao, Jiangye Chen
Nature Communications.2019;[Epub] CrossRef
Neutrophil extracellular traps in fungal infection
Constantin F. Urban, Jeniel E. Nett
Seminars in Cell & Developmental Biology.2019; 89: 47. CrossRef
Yeasts isolated from tropical fruit ice creams: diversity, antifungal susceptibility and adherence to buccal epithelial cells
Gabriella Breder Lara Lima, Carlos Augusto Rosa, Susana Johann, Mariana de Lourdes Almeida Vieira, Fátima de Cássia Oliveira Gomes
Brazilian Journal of Food Technology.2019;[Epub] CrossRef
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype
Anja Forche, Norma V. Solis, Marc Swidergall, Robert Thomas, Alison Guyer, Annette Beach, Gareth A. Cromie, Giang T. Le, Emily Lowell, Norman Pavelka, Judith Berman, Aimeé M. Dudley, Anna Selmecki, Scott G. Filler, Gavin Sherlock
PLOS Genetics.2019; 15(5): e1008137. CrossRef
Candida albicans cell wall mannoprotein synergizes with lipopolysaccharide to affect RAW264.7 proliferation, phagocytosis and apoptosis
Xingxing Bie, Shuguang Zhang, Xue Luo, Rui-Qun Qi
Microbial Pathogenesis.2019; 131: 98. CrossRef
Characterization of aCandida albicansisolate from a recurrent cervical lymphadenitis patient
Chengzhen Zhang, Wenjuan Wang, Qingtao Kong, Fang Liu, Jiangye Chen, Hong Sang
Mycologia.2019; 111(6): 942. CrossRef
Disinfection of Pacifier Focusing on Candida albicans
Danielle Fernandes Lopes, Rafhaela Tostes Fernandes, Yuri de Lima Medeiros, Ana Carolina Morais Apolonio
Clinical Pediatrics.2019; 58(14): 1540. CrossRef
The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways
Raju Shivarathri, Michael Tscherner, Florian Zwolanek, Nitesh Kumar Singh, Neeraj Chauhan, Karl Kuchler
Scientific Reports.2019;[Epub] CrossRef
Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG
Camille Nina Allonsius, Dieter Vandenheuvel, Eline F. M. Oerlemans, Mariya I. Petrova, Gilbert G. G. Donders, Paul Cos, Peter Delputte, Sarah Lebeer
Scientific Reports.2019;[Epub] CrossRef
Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans
Olena P. Ishchuk, Olov Sterner, Ulf Ellervik, Sophie Manner
Antibiotics.2019; 9(1): 10. CrossRef
Les levures du clade CTG (clade Candida) : biologie, incidence en santé humaine et applications en biotechnologie
T.A. Defosse, Y. Le Govic, V. Courdavault, M. Clastre, P. Vandeputte, D. Chabasse, J.-P. Bouchara, N. Giglioli-Guivarc’h, N. Papon
Journal de Mycologie Médicale.2018; 28(2): 257. CrossRef
Efficacy of a nitric oxide dressing in decreasing bacterial counts on human skin
Rachel Nye, Kristi Robinia, Paul Peterson, Zachary Jodoin, Margaret Bohm, Meghan Anderman, Tess Peacock, Madison Moody, Alyssa Naimi, Josh Sharp
Journal of Wound Care.2018; 27(Sup7): S19. CrossRef
The Zebrafish as a Model Host for Invasive Fungal Infections
Emily E. Rosowski, Benjamin P. Knox, Linda S. Archambault, Anna Huttenlocher, Nancy P. Keller, Robert T. Wheeler, J. Muse Davis
Journal of Fungi.2018; 4(4): 136. CrossRef
A Phenylthiazole Derivative Demonstrates Efficacy On Treatment of the Cryptococcosis & Candidiasis in Animal Models
Nívea P Sá, Caroline M Lima, Julliana R A dos Santos, Marliete C Costa, Patrícia P de Barros, Juliana C Junqueira, Jéssica A Vaz, Renata B Oliveira, Beth B Fuchs, Eleftherios Mylonakis, Carlos A Rosa, Daniel A Santos, Susana Johann
Future Science OA.2018;[Epub] CrossRef
Role of the Inducible Adhesin CpAls7 in Binding of Candida parapsilosis to the Extracellular Matrix under Fluid Shear
Matthew N. Neale, Kyle A. Glass, Sarah J. Longley, Denny J. Kim, Sonia S. Laforce-Nesbitt, Jeremy D. Wortzel, Sunil K. Shaw, Joseph M. Bliss, George S. Deepe
Infection and Immunity.2018;[Epub] CrossRef
Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis
Rodnei Dennis Rossoni, Marisol dos Santos Velloso, Lívia Mara Alves Figueiredo, Carolina Pistille Martins, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
Folia Microbiologica.2018; 63(3): 307. CrossRef
Innate Immune and Fungal Model of Alzheimer’s Disease
Bodo Parady
Journal of Alzheimer's Disease Reports.2018; 2(1): 139. CrossRef
Amplitude-modulated cold atmospheric pressure plasma jet for treatment of oral candidiasis: In vivo study
Aline Chiodi Borges, Gabriela de Morais Gouvêa Lima, Thalita Mayumi Castaldelli Nishime, Aline Vidal Lacerda Gontijo, Konstantin Georgiev Kostov, Cristiane Yumi Koga-Ito, M. Hong Nguyen
PLOS ONE.2018; 13(6): e0199832. CrossRef
Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis
E. Gabrielli, E. Pericolini, N. Ballet, E. Roselletti, S. Sabbatini, P. Mosci, A. Cayzeele Decherf, F. Pélerin, S. Perito, P. Jüsten, A. Vecchiarelli
Beneficial Microbes.2018; 9(2): 219. CrossRef
The Candida albicans ENO1 gene encodes a transglutaminase involved in growth, cell division, morphogenesis, and osmotic protection
Elizabeth Reyna-Beltrán, María Iranzo, Karla Grisel Calderón-González, Ricardo Mondragón-Flores, María Luisa Labra-Barrios, Salvador Mormeneo, Juan Pedro Luna-Arias
Journal of Biological Chemistry.2018; 293(12): 4304. CrossRef
Large-scale patterning of living colloids for dynamic studies of neutrophil–microbe interactions
Jae Jung Kim, Eduardo Reátegui, Alex Hopke, Fatemeh Jalali, Maedeh Roushan, Patrick S. Doyle, Daniel Irimia
Lab on a Chip.2018; 18(11): 1514. CrossRef
Candida vaginitis: virulence, host response and vaccine prospects
Flavia De Bernardis, Sofia Graziani, Flavio Tirelli, Stavroula Antonopoulou
Medical Mycology.2018; 56(suppl_1): S26. CrossRef
A survey on cellular RNA editing activity in response to Candida albicans infections
Yaowei Huang, Yingying Cao, Jiarui Li, Yuanhua Liu, Wu Zhong, Xuan Li, Chen Chen, Pei Hao
BMC Genomics.2018;[Epub] CrossRef
Anti-biofilm activity of antibody directed against surface antigen complement receptor 3-related protein—comparison of Candida albicans and Candida dubliniensis
Jaroslava Chupáčová, Elisa Borghi, Giulia Morace, Agata Los, Helena Bujdáková
Pathogens and Disease.2018;[Epub] CrossRef
Micafungin Enhances the Human Macrophage Response to Candida albicans through β-Glucan Exposure
José Pedro Guirao-Abad, Ruth Sánchez-Fresneda, Francisco Machado, Juan Carlos Argüelles, María Martínez-Esparza
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef
Non-canonical Activities of Hog1 Control Sensitivity of Candida albicans to Killer Toxins From Debaryomyces hansenii
Ana Morales-Menchén, Federico Navarro-García, José P. Guirao-Abad, Elvira Román, Daniel Prieto, Ioana V. Coman, Jesús Pla, Rebeca Alonso-Monge
Frontiers in Cellular and Infection Microbiology.2018;[Epub] CrossRef
5-hydroxymethyl-2-furaldehyde from marine bacterium Bacillus subtilis inhibits biofilm and virulence of Candida albicans
Ganapathy Ashwinkumar Subramenium, Thirukannamangai Krishnan Swetha, Prasanth Mani Iyer, Krishnaswamy Balamurugan, Shunmugiah Karutha Pandian
Microbiological Research.2018; 207: 19. CrossRef
The significance ofCandidain the human respiratory tract: our evolving understanding
Kathryn M Pendleton, Gary B Huffnagle, Robert P Dickson
Pathogens and Disease.2017;[Epub] CrossRef
Clinical and Mycological Study of Vulvovaginal Candidiasis (VVC); Identification of Clinical Isolates by Polymerase Chain Reaction-Fragment Size Polymorphyim (PCR-FSP) Technique
Shekufeh Pouladian, Minoo Movahedi, Rasoul Mohammadi
Archives of Clinical Infectious Diseases.2017;[Epub] CrossRef
Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo
Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J. Krysan, Hyun Koo, Timothy J. Mitchell
PLOS Pathogens.2017; 13(6): e1006407. CrossRef
CO2 sensing in fungi: at the heart of metabolic signaling
Ronny Martin, Susann Pohlers, Fritz A. Mühlschlegel, Oliver Kurzai
Current Genetics.2017; 63(6): 965. CrossRef
Interaction of Candida Species with the Skin
Andreas Kühbacher, Anke Burger-Kentischer, Steffen Rupp
Microorganisms.2017; 5(2): 32. CrossRef
Fungal interactions with the human host: exploring the spectrum of symbiosis
Rebecca A Hall, Mairi C Noverr
Current Opinion in Microbiology.2017; 40: 58. CrossRef
Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides
Camille N. Allonsius, Marianne F. L. van den Broek, Ilke De Boeck, Shari Kiekens, Eline F. M. Oerlemans, Filip Kiekens, Kenn Foubert, Dieter Vandenheuvel, Paul Cos, Peter Delputte, Sarah Lebeer
Microbial Biotechnology.2017; 10(6): 1753. CrossRef
NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans
Elena Roselletti, Stefano Perito, Elena Gabrielli, Antonella Mencacci, Eva Pericolini, Samuele Sabbatini, Antonio Cassone, Anna Vecchiarelli
Scientific Reports.2017;[Epub] CrossRef
Candida parapsilosis Protects Premature Intestinal Epithelial Cells from Invasion and Damage by Candida albicans
Sara Gonia, Linda Archambault, Margaret Shevik, Marie Altendahl, Emily Fellows, Joseph M. Bliss, Robert T. Wheeler, Cheryl A. Gale
Frontiers in Pediatrics.2017;[Epub] CrossRef
Candida albicans isolates from a single hospital show low phenotypical specialization
Enikő Boros, Walter P. Pfliegler, Renátó Kovács, Ágnes Jakab, László Majoros, Zoltán Barta, István Pócsi
Journal of Basic Microbiology.2017; 57(11): 910. CrossRef
Cold atmospheric pressure plasma jet modulates Candida albicans virulence traits
Aline Chiodi Borges, Thalita Mayumi Castaldelli Nishime, Konstantin Georgiev Kostov, Gabriela de Morais Gouvêa Lima, Aline Vidal Lacerda Gontijo, Juliana Nóbrega Martins Marchesotti de Carvalho, Roberto Yzumi Honda, Cristiane Yumi Koga-Ito
Clinical Plasma Medicine.2017; 7-8: 9. CrossRef
The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation
Emily Larkin, Christopher Hager, Jyotsna Chandra, Pranab K. Mukherjee, Mauricio Retuerto, Iman Salem, Lisa Long, Nancy Isham, Laura Kovanda, Katyna Borroto-Esoda, Steve Wring, David Angulo, Mahmoud Ghannoum
Antimicrobial Agents and Chemotherapy.2017;[Epub] CrossRef
Lactobacillus paracasei modulates the immune system of Galleria mellonella and protects against Candida albicans infection
Rodnei Dennis Rossoni, Beth Burgwyn Fuchs, Patrícia Pimentel de Barros, Marisol dos Santos Velloso, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira, Eleftherios Mylonakis, George-John Nychas
PLOS ONE.2017; 12(3): e0173332. CrossRef
Phenotypic and genotypic characteristics of Candida albicans isolates from bloodstream and mucosal infections
Marina Mandelblat, Michael Frenkel, Darren Abbey, Ronen Ben Ami, Judith Berman, Esther Segal
Mycoses.2017; 60(8): 534. CrossRef
Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating
Antonio Cassone, Anna Vecchiarelli, Bernhard Hube, Donald C Sheppard
PLOS Pathogens.2016; 12(12): e1005992. CrossRef
Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells
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Journal Articles

The role of programmed death ligand 1 pathway in persistent biomaterial-associated infections: Agnieszka Magrys , Jolanta Paluch-Oles , Agnieszka Bogut , Michal Kielbus , Dorota Plewik , Maria Koziol-Montewka; J. Microbiol. 2015;53(8):544-552. Published online July 31, 2015; DOI: https://doi.org/10.1007/s12275-015-5022-7

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Abstract

Staphylococcus epidermidis is commonly involved in biomaterial- associated infections. Bacterial small colony variants (SCV) seem to be well adapted to persist intracellularly in professional phagocytes evading the host immune response. We studied the expression of PD-L1/L2 on macrophages infected with clinical isolates of S. epidermidis SCV and their parent wild type (WT) strains. The cytokine pattern which is triggered by the examined strains was also analysed. In the study, we infected macrophages with S. epidermidis WT and SCV strains. Persistence and release from macrophages were monitored via lysostaphin protection assays. Moreover, the effect of IFN-γ pre-treatment on bacterial internalisation was investigated. Expression of PD-L1/L2 molecules was analysed with the use of FACS. Inflammatory reaction was measured by IL-10, TNF-α ELISAs, and transcriptional induction of TNF-α. Our study revealed that clinical SCV isolates were able to persist and survive in macrophages for at least 3 days with a low cytotoxic effect and a reduced proinflammatory response as compared to WT strains. Bacteria upregulated PD-L1/L2 expression on macrophages as compared to non-stimulated cells. The results demonstrated that the ability of S. epidermidis SCVs to induce elevated levels of anti-inflammatory cytokine, IL-10, and reduced transcriptional induction of TNF-α, together with expression of PD-L1 on macrophages and the ability to persist intracellularly without damaging the host cell could be the key factor contributing to chronicity of SCV infections.

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Robert Manasherob, Shay I. Warren, Prerna Arora, Lyong Heo, Naomi L. Haddock, Ievgen Koliesnik, Diasuke Furukawa, Z. Ngalo Otieno-Ayayo, William J. Maloney, David W. Lowenberg, Stuart B. Goodman, Derek F. Amanatullah
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The first genomic characterization of a stable, hemin-dependent small colony variant strain of Staphylococcus epidermidis isolated from a prosthetic-joint infection
Agnieszka Bogut, Piotr Koper, Małgorzata Marczak, Paulina Całka
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Immune checkpoint upregulation in periprosthetic joint infection
Shay I. Warren, Gregory W. Charville, Robert Manasherob, Derek F. Amanatullah
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Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?
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Frontiers in Immunology.2019;[Epub] CrossRef
Expression of programmed death ligand‐1 on bladder tissues is detected in a clinically and histologically well‐defined interstitial cystitis cohort
Yuke Chen, Wei Yu, Yang Yang, Yunxiang Xiao, Yun Cui, Jihong Duan, Qun He, Jie Jin, Shiliang Wu
Neurourology and Urodynamics.2018; 37(4): 1396. CrossRef
The role of the PI3K/mTOR signaling pathway in Staphylococcus epidermidis small colony variants intracellular survival
Agnieszka Magryś, Agnieszka Bogut, Michał Kiełbus, Alina Olender
Immunological Investigations.2018; 47(3): 251. CrossRef
Intraphagolysosomal conditions predispose to Staphylococcus epidermidis small colony variants persistence in macrophages
Agnieszka Magryś, Kamil Deryło, Agnieszka Bogut, Alina Olender, Marek Tchórzewski, Holger Rohde
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Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection
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Extended stability of cyclin D1 contributes to limited cell cycle arrest at G1-phase in BHK-21 cells with Japanese encephalitis virus persistent infection: Ji Young Kim , Soo Young Park , Hey Rhyoung Lyoo , Eung Seo Koo , Man Su Kim , Yong Seok Jeong; J. Microbiol. 2015;53(1):77-83. Published online January 4, 2015; DOI: https://doi.org/10.1007/s12275-015-4661-z

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There is increasing evidence that many RNA viruses manipulate cell cycle control to achieve favorable cellular environments for their efficient replication during infection. Although virus-induced G0/G1 arrest often delays early apoptosis temporarily, a prolonged replication of the infected virus leads host cells to eventual death. In contrast, most mammalian cells with RNA virus persistent infection often escape cytolysis in the presence of productive viral replication. In this study, we demonstrated that the extended endurance of cyclin D1 was clearly associated with the suppression of glycogen synthase kinase-3β (GSK-3β) expression in BHK-21 cells that are persistently infected with Japanese encephalitis virus (JEV). The G0/G1 arrest of these cells turned much loose compared to the normal BHK-21 cells with JEV acute infection. After cycloheximide treatment, cyclin D1 in the persistently infected cells lasted several hours longer than those in acutely infected cells. Furthermore, both p21Cip1 and p27Kip1, positive regulators for cyclin D1 accumulation in the nucleus, were suppressed in their expression, which contrasts with those in JEV acute infection. Inhibition of the GSK-3β by lithium chloride treatment rescued a significant number of cells from cytolysis in JEV acute infection, which coincided with the levels of cyclin D1 that escaped from proteolysis. Therefore, the limitation of G1/S arrest in the BHK-21 cells with JEV persistent infection is associated with the suppression of GSK-3β expression, resulting in the extended duration of cyclin D1.

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Review

Minireivew] Protective Role of Gut Commensal Microbes against Intestinal Infections: My Young Yoon , Keehoon Lee , Sang Sun Yoon; J. Microbiol. 2014;52(12):983-989. Published online November 29, 2014; DOI: https://doi.org/10.1007/s12275-014-4655-2

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Abstract PDF

The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.

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Research Support, Non-U.S. Gov't

Superinfection Exclusion Reveals Heteroimmunity between Pseudomonas aeruginosa Temperate Phages: In-Young Chung , Hee-Won Bae , Hye-Jung Jang , Bi-o Kim , You-Hee Cho; J. Microbiol. 2014;52(6):515-520. Published online May 29, 2014; DOI: https://doi.org/10.1007/s12275-014-4012-5

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Temperate siphophages (MP29, MP42, and MP48) were isolated from the culture supernatant of clinical Pseudomonas aeruginosa isolates. The complete nucleotide sequences and annotation of the phage genomes revealed the overall synteny to the known temperate P. aeruginosa phages such as MP22, D3112, and DMS3. Genome-level sequence analysis showed the conservation of both ends of the linear genome and the divergence at the previously identified dissimilarity regions (R1 to R9). Protein sequence alignment of the c repressor (ORF1) of each phage enabled us to divide the six phages into two groups: D3112 group (D3112, MP29, MP42, and MP48) and MP22 group (MP22 and DMS3). Superinfection exclusion was observed between the phages belonging to the same group, which was mediated by the specific interaction between the c repressor and the cognate operator. Based on these, we suggest that the temperate siphophages prevalent in the clinical strains of P. aeruginosa represent at least two distinct heteroimmunity groups.

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Phage against the Machine: The SIE-ence of Superinfection Exclusion
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Reviews

REVIEW] When a Virus is not a Parasite: The Beneficial Effects of Prophages: Joseph Bondy-Denomy , Alan R. Davidson; J. Microbiol. 2014;52(3):235-242. Published online March 1, 2014; DOI: https://doi.org/10.1007/s12275-014-4083-3

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Abstract PDF

Most organisms on the planet have viruses that infect them. Viral infection may lead to cell death, or to a symbiotic relationship where the genomes of both virus and host replicate together. In the symbiotic state, both virus and cell potentially experience increased fitness as a result of the other. The viruses that infect bacteria, called bacteriophages (or phages), well exemplify the symbiotic relationships that can develop between viruses and their host. In this review, we will discuss the many ways that prophages, which are phage genomes integrated into the genomes of their hosts, influence bacterial behavior and virulence.

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Joan Roughgarden
Virus Evolution.2024;[Epub] CrossRef
Presence of phage-plasmids in multiple serovars of Salmonella enterica
Satheesh Nair, Clare R. Barker, Matthew Bird, David R. Greig, Caitlin Collins, Anaïs Painset, Marie Chattaway, Derek Pickard, Lesley Larkin, Saheer Gharbia, Xavier Didelot, Paolo Ribeca
Microbial Genomics .2024;[Epub] CrossRef
Snow viruses and their implications on red snow algal blooms
Adam R. Barno, Kevin Green, Forest Rohwer, Cynthia B. Silveira, Katrine Whiteson
mSystems.2024;[Epub] CrossRef
Prophages carrying Zot toxins on different Vibrio genomes: A comprehensive assessment using multilayer networks
Esteban F. Soto, Melissa Alegría, Felipe Sepúlveda, Katherine García, Gastón Higuera, Daniel Castillo, Francisco E. Fontúrbel, Roberto Bastías
Environmental Microbiology.2024;[Epub] CrossRef
Investigating the viral ecology and contribution to the microbial ecology in full-scale mesophilic anaerobic digesters
Bishav Bhattarai, Ananda Shankar Bhattacharjee, Felipe H. Coutinho, Ramesh Goel
Chemosphere.2024; 349: 140743. CrossRef
Soybean Bradyrhizobium spp. Spontaneously Produce Abundant and Diverse Temperate Phages in Culture
Vanessa A. Richards, Barbra D. Ferrell, Shawn W. Polson, K. Eric Wommack, Jeffry J. Fuhrmann
Viruses.2024; 16(11): 1750. CrossRef
Diverse Prophage Elements of Salmonella enterica Serovars Show Potential Roles in Bacterial Pathogenicity
Kirstie Andrews, Toby Landeryou, Thomas Sicheritz-Pontén, Janet Yakubu Nale
Cells.2024; 13(6): 514. CrossRef
The prophage-encoded transcriptional regulator AppY has pleiotropic effects on E. coli physiology
Naoual Derdouri, Nicolas Ginet, Yann Denis, Mireille Ansaldi, Aurélia Battesti, Melanie Blokesch
PLOS Genetics.2023; 19(3): e1010672. CrossRef
Improving phage therapy by evasion of phage resistance mechanisms
Inés Bleriot, Olga Pacios, Lucia Blasco, Laura Fernández-García, María López, Concha Ortiz-Cartagena, Antonio Barrio-Pujante, Rodolfo García-Contreras, Jean-Paul Pirnay, Thomas K Wood, María Tomás
JAC-Antimicrobial Resistance.2023;[Epub] CrossRef
A systematic analysis of marine lysogens and proviruses
Yi Yi, Shunzhang Liu, Yali Hao, Qingyang Sun, Xinjuan Lei, Yecheng Wang, Jiahua Wang, Mujie Zhang, Shan Tang, Qingxue Tang, Yue Zhang, Xipeng Liu, Yinzhao Wang, Xiang Xiao, Huahua Jian
Nature Communications.2023;[Epub] CrossRef
Investigation of Potassium Tetraborate Resistance in Dickeya spp.
Alice Lou
Cornell Undergraduate Research Journal.2023; 2(1): 28. CrossRef
Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies
Olaya Rendueles, Jorge AM de Sousa, Eduardo PC Rocha
eLife.2023;[Epub] CrossRef
Two novel Bartonella (sub)species isolated from edible dormice (Glis glis): hints of cultivation stress-induced genomic changes
Oldřich Bartoš, Běla Klimešová, Karolina Volfová, Martin Chmel, Jiří Dresler, Petr Pajer, Hana Kabíčková, Peter Adamík, David Modrý, Alena Myslivcová Fučíková, Jan Votýpka
Frontiers in Microbiology.2023;[Epub] CrossRef
Systematic analysis of prophage elements in actinobacterial genomes reveals a remarkable phylogenetic diversity
Vikas Sharma, Max Hünnefeld, Tom Luthe, Julia Frunzke
Scientific Reports.2023;[Epub] CrossRef
Occurrence and genetic diversity of prophage sequences identified in the genomes of L. casei group bacteria
Piotr Jarocki, Elwira Komoń-Janczara, Agata Młodzińska, Jan Sadurski, Kinga Kołodzińska, Łukasz Łaczmański, Jacek Panek, Magdalena Frąc
Scientific Reports.2023;[Epub] CrossRef
Novel virulent and temperate cyanophages predicted to infect Microcoleus associated with anatoxin‐producing benthic mats
Cecilio Valadez‐Cano, Adrian Reyes‐Prieto, Janice Lawrence
Environmental Microbiology.2023; 25(12): 3319. CrossRef
Bio-informatic analysis of CRISPR protospacer adjacent motifs (PAMs) in T4 genome
Omar Rawashdeh, Rabeah Y. Rawashdeh, Temesgen Kebede, David Kapp, Anca Ralescu
BMC Genomic Data.2022;[Epub] CrossRef
Insights into Gene Transcriptional Regulation of Kayvirus Bacteriophages Obtained from Therapeutic Mixtures
Sara Arroyo-Moreno, Colin Buttimer, Francesca Bottacini, Nina Chanishvili, Paul Ross, Colin Hill, Aidan Coffey
Viruses.2022; 14(3): 626. CrossRef
Prevalence, Diversity and UV-Light Inducibility Potential of Prophages in Bacillus subtilis and Their Possible Roles in Host Properties
Haftom Baraki Abraha, Youbin Choi, Woobin Hyun, Jae-Won Lee, Hai Seong Kang, Min Seo So, Donghyun Shin, Jong-Hyun Jung, Desta Berhe Sbhatu, Kwang-Pyo Kim
Viruses.2022; 14(3): 483. CrossRef
The Life Cycle Transitions of Temperate Phages: Regulating Factors and Potential Ecological Implications
Menghui Zhang, Tianyou Zhang, Meishun Yu, Yu-Lei Chen, Min Jin
Viruses.2022; 14(9): 1904. CrossRef
Accelerated Evolution by Diversity-Generating Retroelements
Benjamin R. Macadangdang, Sara K. Makanani, Jeff F. Miller
Annual Review of Microbiology.2022; 76(1): 389. CrossRef
Prophage: a crucial catalyst in infectious disease modulation
Roshan Nepal, Ghais Houtak, Peter-John Wormald, Alkis James Psaltis, Sarah Vreugde
The Lancet Microbe.2022; 3(3): e162. CrossRef
Isolation of a virus causing a chronic infection in the archaeal model organism Haloferax volcanii reveals antiviral activities of a provirus
Tomas Alarcón-Schumacher, Adit Naor, Uri Gophna, Susanne Erdmann
Proceedings of the National Academy of Sciences.2022;[Epub] CrossRef
Anti-CRISPR proteins as a therapeutic agent against drug-resistant bacteria
Pallavi Vyas, Harish
Microbiological Research.2022; 257: 126963. CrossRef
Detection of an IMI-2 carbapenemase-producing Enterobacter asburiae at a Swedish feed mill
Stefan Börjesson, Michael S. M. Brouwer, Emma Östlund, Jenny Eriksson, Josefine Elving, Oskar Karlsson Lindsjö, Linda I. Engblom
Frontiers in Microbiology.2022;[Epub] CrossRef
Host life-history traits influence the distribution of prophages and the genes they carry
Tyler Pattenden, Christine Eagles, Lindi M. Wahl
Philosophical Transactions of the Royal Society B: Biological Sciences.2022;[Epub] CrossRef
Killing the competition: a theoretical framework for liver-stage malaria
Clemente F. Arias, Francisco J. Acosta, Cristina Fernandez-Arias
Open Biology.2022;[Epub] CrossRef
Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
Henrique G. Ribeiro, Anna Nilsson, Luís D. R. Melo, Ana Oliveira
Frontiers in Microbiology.2022;[Epub] CrossRef
Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes
Supriya Khedkar, Georgy Smyshlyaev, Ivica Letunic, Oleksandr M Maistrenko, Luis Pedro Coelho, Askarbek Orakov, Sofia K Forslund, Falk Hildebrand, Mechthild Luetge, Thomas S B Schmidt, Orsolya Barabas, Peer Bork
Nucleic Acids Research.2022; 50(6): 3155. CrossRef
Comparative genome analysis of Vagococcus fluvialis reveals abundance of mobile genetic elements in sponge-isolated strains
Ana Rodriguez Jimenez, Nadège Guiglielmoni, Lise Goetghebuer, Etienne Dechamps, Isabelle F. George, Jean-François Flot
BMC Genomics.2022;[Epub] CrossRef
Higher phage virulence accelerates the evolution of host resistance
Carolin C. Wendling, Janina Lange, Heiko Liesegang, Michael Sieber, Anja Poehlein, Boyke Bunk, Jelena Rajkov, Henry Goehlich, Olivia Roth, Michael A. Brockhurst
Proceedings of the Royal Society B: Biological Sciences.2022;[Epub] CrossRef
An overview on Vibrio temperate phages: Integration mechanisms, pathogenicity, and lysogeny regulation
Zaatout Nawel, Ouchene Rima, Bouaziz Amira
Microbial Pathogenesis.2022; 165: 105490. CrossRef
Selective Isolation of Eggerthella lenta from Human Faeces and Characterisation of the Species Prophage Diversity
Colin Buttimer, Francesca Bottacini, Andrey N. Shkoporov, Lorraine A. Draper, Paul Ross, Colin Hill
Microorganisms.2022; 10(1): 195. CrossRef
Mutualistic interplay between bacteriophages and bacteria in the human gut
Andrey N. Shkoporov, Christopher J. Turkington, Colin Hill
Nature Reviews Microbiology.2022; 20(12): 737. CrossRef
Competition Between Phage-Resistance Mechanisms Determines the Outcome of Bacterial Co-Existence
Olaya Rendueles, Jorge A.M. de Sousa, Eduardo P.C. Rocha
SSRN Electronic Journal .2022;[Epub] CrossRef
Viruses in Subsurface Environments
Jennifer Wirth, Mark Young
Annual Review of Virology.2022; 9(1): 99. CrossRef
Genomic Analysis Unveils the Pervasiveness and Diversity of Prophages Infecting Erwinia Species
Tulio Morgan, Rafael Reis de Rezende, Thamylles Thuany Mayrink Lima, Flávia de Oliveira Souza, Poliane Alfenas-Zerbini
Pathogens.2022; 12(1): 44. CrossRef
Engineered Bacteriophage Therapeutics: Rationale, Challenges and Future
Małgorzata Łobocka, Krystyna Dąbrowska, Andrzej Górski
BioDrugs.2021; 35(3): 255. CrossRef
Fitness benefits to bacteria of carrying prophages and prophage‐encoded antibiotic‐resistance genes peak in different environments
Carolin C. Wendling, Dominik Refardt, Alex R. Hall
Evolution.2021; 75(2): 515. CrossRef
Towards the Characterization and Engineering of Bacteriophages in the Gut Microbiome
Bryan B. Hsu
mSystems.2021;[Epub] CrossRef
Bacteriophages as drivers of bacterial virulence and their potential for biotechnological exploitation
Kaat Schroven, Abram Aertsen, Rob Lavigne
FEMS Microbiology Reviews.2021;[Epub] CrossRef
Temperate Bacteriophages—The Powerful Indirect Modulators of Eukaryotic Cells and Immune Functions
Martyna Cieślik, Natalia Bagińska, Ewa Jończyk-Matysiak, Alicja Węgrzyn, Grzegorz Węgrzyn, Andrzej Górski
Viruses.2021; 13(6): 1013. CrossRef
Extending the natural adaptive capacity of coral holobionts
Christian R. Voolstra, David J. Suggett, Raquel S. Peixoto, John E. Parkinson, Kate M. Quigley, Cynthia B. Silveira, Michael Sweet, Erinn M. Muller, Daniel J. Barshis, David G. Bourne, Manuel Aranda
Nature Reviews Earth & Environment.2021; 2(11): 747. CrossRef
Revisiting the rules of life for viruses of microorganisms
Adrienne M. S. Correa, Cristina Howard-Varona, Samantha R. Coy, Alison Buchan, Matthew B. Sullivan, Joshua S. Weitz
Nature Reviews Microbiology.2021; 19(8): 501. CrossRef
The landscape of lysogeny across microbial community density, diversity and energetics
Cynthia B. Silveira, Antoni Luque, Forest Rohwer
Environmental Microbiology.2021; 23(8): 4098. CrossRef
Exploring Codon Adjustment Strategies towards Escherichia coli-Based Production of Viral Proteins Encoded by HTH1, a Novel Prophage of the Marine Bacterium Hypnocyclicus thermotrophus
Hasan Arsın, Andrius Jasilionis, Håkon Dahle, Ruth-Anne Sandaa, Runar Stokke, Eva Nordberg Karlsson, Ida Helene Steen
Viruses.2021; 13(7): 1215. CrossRef
Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut
Bryan B. Hsu, Jeffrey C. Way, Pamela A. Silver, Jack A. Gilbert
mSystems.2020;[Epub] CrossRef
RETRACTED ARTICLE: Cryptic prophages in a blaNDM-1-bearing plasmid increase bacterial survival against high NaCl concentration, high and low temperatures, and oxidative and immunological stressors
So Yeon Kim, Kwan Soo Ko
Journal of Microbiology.2020; 58(6): 483. CrossRef
The Russian Doll Model: How Bacteria Shape Successful and Sustainable Inter-Kingdom Relationships
Enrica Pessione
Frontiers in Microbiology.2020;[Epub] CrossRef
In situ reprogramming of gut bacteria by oral delivery
Bryan B. Hsu, Isaac N. Plant, Lorena Lyon, Frances M. Anastassacos, Jeffrey C. Way, Pamela A. Silver
Nature Communications.2020;[Epub] CrossRef
Genetically similar temperate phages form coalitions with their shared host that lead to niche-specific fitness effects
Jonelle T R Basso, Nana Y D Ankrah, Matthew J Tuttle, Alex S Grossman, Ruth-Anne Sandaa, Alison Buchan
The ISME Journal.2020; 14(7): 1688. CrossRef
The enemy from within: a prophage of Roseburia intestinalis systematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition
Jeffrey K Cornuault, Elisabeth Moncaut, Valentin Loux, Aurélie Mathieu, Harry Sokol, Marie-Agnès Petit, Marianne De Paepe
The ISME Journal.2020; 14(3): 771. CrossRef
A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length, and Genomic Positions
Belinda Loh, Jiayuan Chen, Prasanth Manohar, Yunsong Yu, Xiaoting Hua, Sebastian Leptihn
Frontiers in Microbiology.2020;[Epub] CrossRef
Quantifying the forces that maintain prophages in bacterial genomes
Amjad Khan, Lindi M. Wahl
Theoretical Population Biology.2020; 133: 168. CrossRef
Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems
Alan R. Davidson, Wang-Ting Lu, Sabrina Y. Stanley, Jingrui Wang, Marios Mejdani, Chantel N. Trost, Brian T. Hicks, Jooyoung Lee, Erik J. Sontheimer
Annual Review of Biochemistry.2020; 89(1): 309. CrossRef
Lysogeny in the oceans: Lessons from cultivated model systems and a reanalysis of its prevalence
Matthew J. Tuttle, Alison Buchan
Environmental Microbiology.2020; 22(12): 4919. CrossRef
The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection
Jasminka Talapko, Ivana Škrlec
Pharmaceuticals.2020; 13(10): 299. CrossRef
Looking for the hidden: Characterization of lysogenic phages in potential pathogenic Vibrio species from the North Sea
Ale Garin-Fernandez, Antje Wichels
Marine Genomics.2020; 51: 100725. CrossRef
Phage integration alters the respiratory strategy of its host
Jeffrey N Carey, Erin L Mettert, Daniel R Fishman-Engel, Manuela Roggiani, Patricia J Kiley, Mark Goulian
eLife.2019;[Epub] CrossRef
Mining, analyzing, and integrating viral signals from metagenomic data
Tingting Zheng, Jun Li, Yueqiong Ni, Kang Kang, Maria-Anna Misiakou, Lejla Imamovic, Billy K. C. Chow, Anne A. Rode, Peter Bytzer, Morten Sommer, Gianni Panagiotou
Microbiome.2019;[Epub] CrossRef
Mobilome and Resistome Reconstruction from Genomes Belonging to Members of the Bifidobacterium Genus
Walter Mancino, Gabriele Andrea Lugli, Douwe van Sinderen, Marco Ventura, Francesca Turroni
Microorganisms.2019; 7(12): 638. CrossRef
Viral Regulation on Bacterial Community Impacted by Lysis-Lysogeny Switch: A Microcosm Experiment in Eutrophic Coastal Waters
Xiaowei Chen, Ruijie Ma, Yunlan Yang, Nianzhi Jiao, Rui Zhang
Frontiers in Microbiology.2019;[Epub] CrossRef
Prophages enhance resistance to antibiotic stress in a blaNDM-1-carrying bacterial host: authors’ reply
So Yeon Kim, Kwan Soo Ko
International Journal of Antimicrobial Agents.2019; 54(2): 267. CrossRef
The prevalence and impact of lysogeny among oral isolates ofEnterococcus faecalis
Roy H. Stevens, Hongming Zhang, Christine Sedgley, Adam Bergman, Anil Reddy Manda
Journal of Oral Microbiology.2019; 11(1): 1643207. CrossRef
Genomic and Proteomic Characterization of Bacteriophage BH1 Spontaneously Released from Probiotic Lactobacillus rhamnosus Pen
Piotr Jarocki, Elwira Komoń-Janczara, Marcin Podleśny, Oleksandr Kholiavskyi, Monika Pytka, Monika Kordowska-Wiater
Viruses.2019; 11(12): 1163. CrossRef
Impact of Xenogeneic Silencing on Phage–Host Interactions
Eugen Pfeifer, Max Hünnefeld, Ovidiu Popa, Julia Frunzke
Journal of Molecular Biology.2019; 431(23): 4670. CrossRef
Biotransformation of 2,4-dinitrotoluene by the beneficial association of engineered Pseudomonas putida with Arabidopsis thaliana
Özlem Akkaya, Ebru Arslan
3 Biotech.2019;[Epub] CrossRef
Prophages in Lactobacillus reuteri Are Associated with Fitness Trade-Offs but Can Increase Competitiveness in the Gut Ecosystem
Jee-Hwan Oh, Xiaoxi B. Lin, Shenwei Zhang, Stephanie L. Tollenaar, Mustafa Özçam, Case Dunphy, Jens Walter, Jan-Peter van Pijkeren, Maia Kivisaar
Applied and Environmental Microbiology.2019;[Epub] CrossRef
Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms
Mads Frederik Hansen, Sine Lo Svenningsen, Henriette Lyng Røder, Mathias Middelboe, Mette Burmølle
Trends in Microbiology.2019; 27(9): 739. CrossRef
Cryptic-Prophage-Encoded Small Protein DicB Protects Escherichia coli from Phage Infection by Inhibiting Inner Membrane Receptor Proteins
Preethi T. Ragunathan, Carin K. Vanderpool, George O'Toole
Journal of Bacteriology.2019;[Epub] CrossRef
Bacteriophages benefit from generalized transduction
Alfred Fillol-Salom, Ahlam Alsaadi, Jorge A. Moura de Sousa, Li Zhong, Kevin R. Foster, Eduardo P. C. Rocha, José R. Penadés, Hanne Ingmer, Jakob Haaber, Michael Otto
PLOS Pathogens.2019; 15(7): e1007888. CrossRef
Optimality of the spontaneous prophage induction rate
Michael G. Cortes, Jonathan Krog, Gábor Balázsi
Journal of Theoretical Biology.2019; 483: 110005. CrossRef
Characterization of a Highly Virulent Edwardsiella anguillarum Strain Isolated From Greek Aquaculture, and a Spontaneously Induced Prophage Therein
Pantelis Katharios, Panos G. Kalatzis, Constantina Kokkari, Michail Pavlidis, Qiyao Wang
Frontiers in Microbiology.2019;[Epub] CrossRef
The dual lifestyle of genome‐integrating virophages in protists
Mónica Berjón‐Otero, Anna Koslová, Matthias G. Fischer
Annals of the New York Academy of Sciences.2019; 1447(1): 97. CrossRef
A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”
Simon Roux
mSystems.2019;[Epub] CrossRef
RETRACTED: Effects of prophage regions in a plasmid carrying a carbapenemase gene on survival against antibiotic stress
So Yeon KIM, Kwan Soo KO
International Journal of Antimicrobial Agents.2019; 53(1): 89. CrossRef
May the Phage be With You? Prophage-Like Elements in the Genomes of Soft Rot Pectobacteriaceae: Pectobacterium spp. and Dickeya spp.
Robert Czajkowski
Frontiers in Microbiology.2019;[Epub] CrossRef
Evolution of Immune Systems From Viruses and Transposable Elements
Felix Broecker, Karin Moelling
Frontiers in Microbiology.2019;[Epub] CrossRef
Can a Symbiont (Also) Be Food?
Kim L. Hoang, Levi T. Morran, Nicole M. Gerardo
Frontiers in Microbiology.2019;[Epub] CrossRef
Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy
Panos Kalatzis, Daniel Castillo, Pantelis Katharios, Mathias Middelboe
Antibiotics.2018; 7(1): 15. CrossRef
Cupriavidus metallidurans Strains with Different Mobilomes and from Distinct Environments Have Comparable Phenomes
Rob Van Houdt, Ann Provoost, Ado Van Assche, Natalie Leys, Bart Lievens, Kristel Mijnendonckx, Pieter Monsieurs
Genes.2018; 9(10): 507. CrossRef
Food Spoilage-Associated Leuconostoc, Lactococcus, and Lactobacillus Species Display Different Survival Strategies in Response to Competition
Margarita Andreevskaya, Elina Jääskeläinen, Per Johansson, Anne Ylinen, Lars Paulin, Johanna Björkroth, Petri Auvinen, Harold L. Drake
Applied and Environmental Microbiology.2018;[Epub] CrossRef
Close Encounters of Three Kinds: Bacteriophages, Commensal Bacteria, and Host Immunity
Eric C. Keen, Gautam Dantas
Trends in Microbiology.2018; 26(11): 943. CrossRef
Pathogenomics of Virulence Traits of Plesiomonas shigelloides That Were Deemed Inconclusive by Traditional Experimental Approaches
Temitope C. Ekundayo, Anthony I. Okoh
Frontiers in Microbiology.2018;[Epub] CrossRef
Metagenomic Analysis of Bacteria, Fungi, Bacteriophages, and Helminths in the Gut of Giant Pandas
Shengzhi Yang, Xin Gao, Jianghong Meng, Anyun Zhang, Yingmin Zhou, Mei Long, Bei Li, Wenwen Deng, Lei Jin, Siyue Zhao, Daifu Wu, Yongguo He, Caiwu Li, Shuliang Liu, Yan Huang, Hemin Zhang, Likou Zou
Frontiers in Microbiology.2018;[Epub] CrossRef
Spontaneously induced prophages are abundant in a naturally evolved bacterial starter culture and deliver competitive advantage to the host
Svetlana Alexeeva, Jesús Adrián Guerra Martínez, Maciej Spus, Eddy J. Smid
BMC Microbiology.2018;[Epub] CrossRef
Characterization of redundant tRNAIles with CAU and UAU anticodons in Lactobacillus plantarum
Chie Tomikawa, Sylvie Auxilien, Vincent Guérineau, Yuya Yoshioka, Kiyo Miyoshi, Hiroyuki Hori, Dominique Fourmy, Kazuyuki Takai, Satoko Yoshizawa
The Journal of Biochemistry.2018; 163(3): 233. CrossRef
Habitat Alterations by Viruses: Strategies by Tupanviruses and Others
Hiroyuki Ogata
Microbes and Environments.2018; 33(2): 117. CrossRef
Phages infecting Faecalibacterium prausnitzii belong to novel viral genera that help to decipher intestinal viromes
Jeffrey K. Cornuault, Marie-Agnès Petit, Mahendra Mariadassou, Leandro Benevides, Elisabeth Moncaut, Philippe Langella, Harry Sokol, Marianne De Paepe
Microbiome.2018;[Epub] CrossRef
Whole-Genome Sequence of the Novel Temperate Enterobacter Bacteriophage Tyrion, Isolated from the Gut of the Formosan Subterranean Termite
Chinmay Vijay Tikhe, Chris R. Gissendanner, Claudia Husseneder
Genome Announcements.2018;[Epub] CrossRef
Metavirome Sequencing of the Termite Gut Reveals the Presence of an Unexplored Bacteriophage Community
Chinmay V. Tikhe, Claudia Husseneder
Frontiers in Microbiology.2018;[Epub] CrossRef
The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs
Adair L. Borges, Alan R. Davidson, Joseph Bondy-Denomy
Annual Review of Virology.2017; 4(1): 37. CrossRef
Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis
Kinga Umenhoffer, Gábor Draskovits, Ákos Nyerges, Ildikó Karcagi, Balázs Bogos, Edit Tímár, Bálint Csörgő, Róbert Herczeg, István Nagy, Tamás Fehér, Csaba Pál, György Pósfai
ACS Synthetic Biology.2017; 6(8): 1471. CrossRef
Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer
Marie Touchon, Jorge A Moura de Sousa, Eduardo PC Rocha
Current Opinion in Microbiology.2017; 38: 66. CrossRef
Assessing Species Diversity Using Metavirome Data: Methods and Challenges
Damayanthi Herath, Duleepa Jayasundara, David Ackland, Isaam Saeed, Sen-Lin Tang, Saman Halgamuge
Computational and Structural Biotechnology Journal.2017; 15: 447. CrossRef
Microbial processes driving coral reef organic carbon flow
Cynthia B. Silveira, Giselle S. Cavalcanti, Juline M. Walter, Arthur W. Silva-Lima, Elizabeth A. Dinsdale, David G. Bourne, Cristiane C. Thompson, Fabiano L. Thompson
FEMS Microbiology Reviews.2017; 41(4): 575. CrossRef
Prophages of the genus Bifidobacterium as modulating agents of the infant gut microbiota
Gabriele Andrea Lugli, Christian Milani, Francesca Turroni, Denise Tremblay, Chiara Ferrario, Leonardo Mancabelli, Sabrina Duranti, Doyle V. Ward, Maria Cristina Ossiprandi, Sylvain Moineau, Douwe van Sinderen, Marco Ventura
Environmental Microbiology.2016; 18(7): 2196. CrossRef
Global repositioning of transcription start sites in a plant-fermenting bacterium
Magali Boutard, Laurence Ettwiller, Tristan Cerisy, Adriana Alberti, Karine Labadie, Marcel Salanoubat, Ira Schildkraut, Andrew C. Tolonen
Nature Communications.2016;[Epub] CrossRef
Uncovering Earth’s virome
David Paez-Espino, Emiley A. Eloe-Fadrosh, Georgios A. Pavlopoulos, Alex D. Thomas, Marcel Huntemann, Natalia Mikhailova, Edward Rubin, Natalia N. Ivanova, Nikos C. Kyrpides
Nature.2016; 536(7617): 425. CrossRef
Identification and Initial Characterization of Prophages in Vibrio campbellii
Nicola Lorenz, Matthias Reiger, Mauricio Toro-Nahuelpan, Andreas Brachmann, Lisa Poettinger, Laure Plener, Jürgen Lassak, Kirsten Jung, Baochuan Lin
PLOS ONE.2016; 11(5): e0156010. CrossRef
Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells
Jakob Haaber, Jørgen J. Leisner, Marianne T. Cohn, Arancha Catalan-Moreno, Jesper B. Nielsen, Henrik Westh, José R. Penadés, Hanne Ingmer
Nature Communications.2016;[Epub] CrossRef
Toxins go viral: phage‐encoded lysis releases group B colicins
Katrina van Raay, Benjamin Kerr
Environmental Microbiology.2016; 18(5): 1308. CrossRef
Temperate phages promote colicin‐dependent fitness of Salmonella enterica serovar Typhimurium
Lubov P. Nedialkova, Maja Sidstedt, Martin B. Koeppel, Stefanie Spriewald, Diana Ring, Roman G. Gerlach, Lionello Bossi, Bärbel Stecher
Environmental Microbiology.2016; 18(5): 1591. CrossRef
The Significance of Mutualistic Phages for Bacterial Ecology and Evolution
Nancy Obeng, Akbar Adjie Pratama, Jan Dirk van Elsas
Trends in Microbiology.2016; 24(6): 440. CrossRef
Experimental Evolution as an Underutilized Tool for Studying Beneficial Animal–Microbe Interactions
Kim L. Hoang, Levi T. Morran, Nicole M. Gerardo
Frontiers in Microbiology.2016;[Epub] CrossRef
Carriage of λ Latent Virus Is Costly for Its Bacterial Host due to Frequent Reactivation in Monoxenic Mouse Intestine
Marianne De Paepe, Laurent Tournier, Elisabeth Moncaut, Olivier Son, Philippe Langella, Marie-Agnès Petit, Diarmaid Hughes
PLOS Genetics.2016; 12(2): e1005861. CrossRef
Piggyback-the-Winner in host-associated microbial communities
Cynthia B Silveira, Forest L Rohwer
npj Biofilms and Microbiomes.2016;[Epub] CrossRef
The role of temperate bacteriophages in bacterial infection
Emily V. Davies, Craig Winstanley, Joanne L. Fothergill, Chloe E. James, Andrew Millard
FEMS Microbiology Letters.2016; 363(5): fnw015. CrossRef
Phages in the global fruit and vegetable industry
M. Żaczek, B. Weber-Dąbrowska, A. Górski
Journal of Applied Microbiology.2015; 118(3): 537. CrossRef
Absence of lysogeny in wild populations of Erwinia amylovora and Pantoea agglomerans
Dwayne R. Roach, David R. Sjaarda, Calvin P. Sjaarda, Carlos Juarez Ayala, Brittany Howcroft, Alan J. Castle, Antonet M. Svircev
Microbial Biotechnology.2015; 8(3): 510. CrossRef
Helicobacter pullorum Isolated from Fresh Chicken Meat: Antibiotic Resistance and Genomic Traits of an Emerging Foodborne Pathogen
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Applied and Environmental Microbiology.2015; 81(23): 8155. CrossRef
A standardized protocol for the UV induction of Sulfolobus spindle-shaped virus 1
Salvatore Fusco, Martina Aulitto, Simonetta Bartolucci, Patrizia Contursi
Extremophiles.2015; 19(2): 539. CrossRef
Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations
Stefan Helfrich, Eugen Pfeifer, Christina Krämer, Christian Carsten Sachs, Wolfgang Wiechert, Dietrich Kohlheyer, Katharina Nöh, Julia Frunzke
Molecular Microbiology.2015; 98(4): 636. CrossRef
When Competing Viruses Unify: Evolution, Conservation, and Plasticity of Genetic Identities
Luis P. Villarreal, Guenther Witzany
Journal of Molecular Evolution.2015; 80(5-6): 305. CrossRef
Impact of Spontaneous Prophage Induction on the Fitness of Bacterial Populations and Host-Microbe Interactions
Arun M. Nanda, Kai Thormann, Julia Frunzke, W. Margolin
Journal of Bacteriology.2015; 197(3): 410. CrossRef
Genome-Based Identification of Active Prophage Regions by Next Generation Sequencing in Bacillus licheniformis DSM13
Robert Hertel, David Pintor Rodríguez, Jacqueline Hollensteiner, Sascha Dietrich, Andreas Leimbach, Michael Hoppert, Heiko Liesegang, Sonja Volland, Raymond Schuch
PLOS ONE.2015; 10(3): e0120759. CrossRef
Molecular microbiology in antibacterial research
You-Hee Cho
Journal of Microbiology.2014; 52(3): 185. CrossRef
The chromosomal accommodation and domestication of mobile genetic elements
Marie Touchon, Louis-Marie Bobay, Eduardo PC Rocha
Current Opinion in Microbiology.2014; 22: 22. CrossRef

REVIEW] Chronic Obstructive Pulmonary Disease (COPD): Evaluation From Clinical, Immunological and Bacterial Pathogenesis Perspectives: Daniel J. Hassett , Michael T. Borchers , Ralph J. Panos; J. Microbiol. 2014;52(3):211-226. Published online March 1, 2014; DOI: https://doi.org/10.1007/s12275-014-4068-2

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Abstract PDF

Chronic obstructive pulmonary disease (COPD), a disease manifested by significantly impaired airflow, afflicts ~14.2 million cases in the United States alone with an estimated 63 million people world-wide. Although there are a number of causes, the predominant cause is excessive tobacco smoke. In fact, in China, there have been estimates of 315,000,000 people that smoke. Other less frequent causes are associated with indirect cigarette smoke, air pollutants, biomass fuels, and genetic mutations. COPD is often associated with heart disease, lung cancer, osteoporosis and conditions can worsen in patients with sudden falls. COPD also affects both innate and adaptive immune processes. Cigarette smoke increases the expression of matrix metalloproteases and proinflammatory chemokines and increases lung titers of natural killer cells and neutrophils. Yet, neutrophil reactive oxygen species (ROS) mediated by the phagocytic respiratory burst and phagocytosis is impaired by nicotine. In contrast to innate immunity in COPD, dendritic cells represent leukocytes recruited to the lung that link the innate immune responses to adaptive immune responses by activating naïve T cells through antigen presentation. The autoimmune process that is also a significant part of inflammation associated with COPD. Moreover, coupled with restricted FEV1 values, are the prevalence of patients with single or multiple infections by bacteria, viruses and fungi. Finally, we focus on one of the more problematic infectious agents, the Gram-negative opportunistic pathogenic bacterium, Pseudomonas aeruginosa. Specifically, we delve into the development of highly problematic biofilm infections that are highly refractory to conventional antibiotic therapies in COPD. We offer a nonconventional, biocidal treatment that may be effective for COPD airway infections as well as with combinations of current antibiotic regimens for more effective treatment outcomes and relief for patients with COPD.

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Citations to this article as recorded by

In vitro lung epithelial cell model reveals novel roles for Pseudomonas aeruginosa siderophores
Donghoon Kang, Qi Xu, Natalia V. Kirienko, Giordano Rampioni
Microbiology Spectrum.2024;[Epub] CrossRef
A metaplasia escamosa em dpoc: uma revisão sistemática
Daniela Sasso Pasquini, Isabella Vieira Laporte Ambrozewicz, Sofia Garcia Santana
Journal Archives of Health.2024; 5(1): 399. CrossRef
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
Rhea Nickerson, Christina S. Thornton, Brent Johnston, Amy H. Y. Lee, Zhenyu Cheng
Frontiers in Immunology.2024;[Epub] CrossRef
Unlocking the potential of lactic acid bacteria mature biofilm extracts as antibiofilm agents
Pamela Hindieh, Joseph Yaghi, Jean Claude Assaf, Ali Chokr, Ali Atoui, Nicolas Louka, André El Khoury
AMB Express.2024;[Epub] CrossRef
Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective
Pierachille Santus, Juan Camilo Signorello, Fiammetta Danzo, Giada Lazzaroni, Marina Saad, Dejan Radovanovic
Journal of Clinical Medicine.2024; 13(14): 4127. CrossRef
Biofilms as Battlefield Armor for Bacteria against Antibiotics: Challenges and Combating Strategies
Sara Bano, Noor Hassan, Muhammad Rafiq, Farwa Hassan, Maliha Rehman, Naveed Iqbal, Hazrat Ali, Fariha Hasan, Ying-Qian Kang
Microorganisms.2023; 11(10): 2595. CrossRef
Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli
David A. Kwasi, Chinedum P. Babalola, Olujide O. Olubiyi, Jennifer Hoffmann, Ikemefuna C. Uzochukwu, Iruka N. Okeke, Luther A. Bartelt
PLOS Neglected Tropical Diseases.2022; 16(10): e0010809. CrossRef
Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Pseudomonas aeruginosa Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance
Kayla A. Simanek, Jon E. Paczkowski
Microorganisms.2022; 10(6): 1247. CrossRef
Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features
Yingjian Yang, Wei Li, Yingwei Guo, Yang Liu, Qiang Li, Kai Yang, Shicong Wang, Nanrong Zeng, Wenxin Duan, Ziran Chen, Huai Chen, Xian Li, Wei Zhao, Rongchang Chen, Yan Kang
Frontiers in Medicine.2022;[Epub] CrossRef
The effect of N-acetylcysteine in patients with non-cystic fibrosis bronchiectasis (NINCFB): study protocol for a multicentre, double-blind, randomised, placebo-controlled trial
Yue Liao, Yanqiu Wu, Kai Zi, Yongchun Shen, Tao Wang, Jiangyue Qin, Lei Chen, Mei Chen, Lin Liu, Weiming Li, Hui Zhou, Shuguan Xiong, Fuqiang Wen, Jun Chen
BMC Pulmonary Medicine.2022;[Epub] CrossRef
Small-Angle Neutron Scattering Reveals the Nanostructure of Liposomes with Embedded OprF Porins of Pseudomonas aeruginosa
Francesco Spinozzi, Jean-Pierre Alcaraz, Maria Grazia Ortore, Landry Gayet, Aurel Radulescu, Donald K. Martin, Marco Maccarini
Langmuir.2022; 38(49): 15026. CrossRef
Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Ze-Guang Zheng, Wu-Zhuang Sun, Jie-Ying Hu, Zhi-Jun Jie, Jin-Fu Xu, Jie Cao, Yuan-Lin Song, Chang-Hui Wang, Jing Wang, Hui Zhao, Zhong-Liang Guo, Nan-Shan Zhong
Respiratory Research.2021;[Epub] CrossRef
Health economics matters in the nanomaterial world: Cost-effectiveness of utilizing an inhalable antibacterial nanomaterial for the treatment of multidrug-resistant pneumonia
Vuk Uskoković
Technology in Society.2021; 66: 101641. CrossRef
Microbial biofilm: A matter of grave concern for human health and food industry
Muzamil A. Rather, Kuldeep Gupta, Pritam Bardhan, Munmi Borah, Anupama Sarkar, Khalifa S. H. Eldiehy, Shuvam Bhuyan, Manabendra Mandal
Journal of Basic Microbiology.2021; 61(5): 380. CrossRef
Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms
Sajid Asghar, Ikram Ullah Khan, Saad Salman, Syed Haroon Khalid, Rabia Ashfaq, Thierry F. Vandamme
Advanced Drug Delivery Reviews.2021; 179: 114019. CrossRef
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies
R. Frèdi Langendonk, Daniel R. Neill, Joanne L. Fothergill
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Tissue-Specific Ultra-Short Telomeres in Chronic Obstructive Pulmonary Disease

Huseyin Cagsin, Ali Uzan, Ozgur Tosun, Finn Rasmussen, Nedime Serakinci
International Journal of Chronic Obstructive Pulmonary Disease.2020; Volume 15: 2751. CrossRef
Host responses to mucosal biofilms in the lung and gut
Jada C. Domingue, Julia L. Drewes, Christian A. Merlo, Franck Housseau, Cynthia L. Sears
Mucosal Immunology.2020; 13(3): 413. CrossRef
Overexpression of phzM contributes to much more production of pyocyanin converted from phenazine-1-carboxylic acid in the absence of RpoS in Pseudomonas aeruginosa
Kewen Wang, Le Kai, Kailu Zhang, Mengyue Hao, Yanjie Yu, Xinyu Xu, Zhifen Yu, Lijuan Chen, Xiaoyan Chi, Yihe Ge
Archives of Microbiology.2020; 202(6): 1507. CrossRef
Haemophilus influenzaepersists in biofilm communities in a smoke-exposed ferret model of COPD
Benjamin C. Hunt, Denise Stanford, Xin Xu, Jindong Li, Amit Gaggar, Steven M. Rowe, S. Vamsee Raju, W. Edward Swords
ERJ Open Research.2020; 6(3): 00200-2020. CrossRef
Airway Natural Killer Cells and Bacteria in Health and Disease
Maud Theresine, Neha D. Patil, Jacques Zimmer
Frontiers in Immunology.2020;[Epub] CrossRef
Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract
Momoyo Azuma, Keiji Murakami, Rina Murata, Keiko Kataoka, Hideki Fujii, Yoichiro Miyake, Yasuhiko Nishioka
Antibiotics.2020; 9(9): 626. CrossRef
Biofilm dispersion
Kendra P. Rumbaugh, Karin Sauer
Nature Reviews Microbiology.2020; 18(10): 571. CrossRef
Clinical significance of BPI‐ANCA detecting in COPD patients with Pseudomonas aeruginosa colonization
Yongjian Tian, Tingting Zeng, Liming Tan, Yang Wu, Jianlin Yu, Jiayi Huang, Zihuang Pei
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Signal Sensing and Transduction Are Conserved between the Periplasmic Sensory Domains of BifA and SagS
Jozef Dingemans, Rebecca E. Al-Feghali, Holger Sondermann, Karin Sauer, Bryan Krantz
mSphere.2019;[Epub] CrossRef
Wearable Cardiopulmonary Function Evaluation System for Six-Minute Walking Test
Bor-Shing Lin, Ruei-Jie Jhang, Bor-Shyh Lin
Sensors.2019; 19(21): 4656. CrossRef
Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection
Nicola Lorè, Noemi Veraldi, Camilla Riva, Barbara Sipione, Lorenza Spagnuolo, Ida De Fino, Medede Melessike, Elisa Calzi, Alessandra Bragonzi, Annamaria Naggi, Cristina Cigana
International Journal of Molecular Sciences.2018; 19(1): 207. CrossRef
Mechanisms and Targeted Therapies forPseudomonas aeruginosaLung Infection
Colleen S. Curran, Thomas Bolig, Parizad Torabi-Parizi
American Journal of Respiratory and Critical Care Medicine.2018; 197(6): 708. CrossRef
Establishment and Evaluation of a Rat Model of Sidestream Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Genfa Wang, Nabijan Mohammadtursun, Jing Sun, Yubao Lv, Hualiang Jin, Jinpei Lin, Lingwen Kong, Zhengxiao Zhao, Hongying Zhang, Jingcheng Dong
Frontiers in Physiology.2018;[Epub] CrossRef
Baicalin Exerts Anti‐Airway Inflammation and Anti‐Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease
Genfa Wang, Nabijan Mohammadtursun, Yubao Lv, Hongying Zhang, Jing Sun, Jingcheng Dong, Antonella Di Sotto
Evidence-Based Complementary and Alternative Medicine.2018;[Epub] CrossRef
Multifaceted activity ofN-acetyl-l-cysteine in chronic obstructive pulmonary disease
Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani, Mario Cazzola
Expert Review of Respiratory Medicine.2018; 12(8): 693. CrossRef
MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: An in vivo and in vitro study
Wen Shen, Jia Liu, Minjuan Fan, Shukun Wang, Yang Zhang, Linqiao Wen, Ruili Wang, Wei Wei, Na Li, You Zhang, Guohou Zhao
Experimental Cell Research.2018; 362(2): 370. CrossRef
Functional Characterization of Cell-Free Expressed OprF Porin from Pseudomonas aeruginosa Stably Incorporated in Tethered Lipid Bilayers
Marco Maccarini, Landry Gayet, Jean-Pierre Alcaraz, Lavinia Liguori, Barry Stidder, Erik B. Watkins, Jean-Luc Lenormand, Donald K. Martin
Langmuir.2017; 33(38): 9988. CrossRef
Respiratory Microbiome of Endangered Southern Resident Killer Whales and Microbiota of Surrounding Sea Surface Microlayer in the Eastern North Pacific
Stephen A. Raverty, Linda D. Rhodes, Erin Zabek, Azad Eshghi, Caroline E. Cameron, M. Bradley Hanson, J. Pete Schroeder
Scientific Reports.2017;[Epub] CrossRef
The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide
Warunya Panmanee, Nisanart Charoenlap, Sopapan Atichartpongkul, Aekkapol Mahavihakanont, Matthew D. Whiteside, Geoff Winsor, Fiona S. L. Brinkman, Skorn Mongkolsuk, Daniel J. Hassett, Michael R. Volkert
PLOS ONE.2017; 12(12): e0189066. CrossRef
Master Autophagy Regulator Transcription Factor EB Regulates Cigarette Smoke-Induced Autophagy Impairment and Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis
Manish Bodas, Neel Patel, David Silverberg, Kyla Walworth, Neeraj Vij
Antioxidants & Redox Signaling.2017; 27(3): 150. CrossRef
Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki, Péter Engelmann
Respiratory Research.2017;[Epub] CrossRef
Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae
Begoña Euba, Nahikari López-López, Irene Rodríguez-Arce, Ariadna Fernández-Calvet, Montserrat Barberán, Nuria Caturla, Sara Martí, Roberto Díez-Martínez, Junkal Garmendia
Scientific Reports.2017;[Epub] CrossRef
Human Lung Mononuclear Phagocytes in Health and Disease
Faezzah Baharom, Gregory Rankin, Anders Blomberg, Anna Smed-Sörensen
Frontiers in Immunology.2017;[Epub] CrossRef
IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa
Nicola Ivan Lorè, Cristina Cigana, Camilla Riva, Ida De Fino, Alessandro Nonis, Lorenza Spagnuolo, Barbara Sipione, Lisa Cariani, Daniela Girelli, Giacomo Rossi, Veronica Basso, Carla Colombo, Anna Mondino, Alessandra Bragonzi
Scientific Reports.2016;[Epub] CrossRef
A Putative ABC Transporter Permease Is Necessary for Resistance to Acidified Nitrite and EDTA in Pseudomonas aeruginosa under Aerobic and Anaerobic Planktonic and Biofilm Conditions
Cameron McDaniel, Shengchang Su, Warunya Panmanee, Gee W. Lau, Tristan Browne, Kevin Cox, Andrew T. Paul, Seung-Hyun B. Ko, Joel E. Mortensen, Joseph S. Lam, Daniel A. Muruve, Daniel J. Hassett
Frontiers in Microbiology.2016;[Epub] CrossRef
Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo
Laura A. Novotny, Joseph A. Jurcisek, Steven D. Goodman, Lauren O. Bakaletz
eBioMedicine.2016; 10: 33. CrossRef
‘”Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection
M. Alexandra Lake, Lyn R. Ambrose, Marc C. I. Lipman, David M. Lowe
BMC Medicine.2016;[Epub] CrossRef
Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases
Emily V.S. Ha, Duncan F. Rogers
Pharmacology.2016; 97(1-2): 84. CrossRef
Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short
Carla S. Andrews, Shingo Matsuyama, Byung-Cheol Lee, Jian-Dong Li
Scientific Reports.2016;[Epub] CrossRef
Population pharmacokinetics of fluticasone propionate/salmeterol using two different dry powder inhalers
K. Soulele, P. Macheras, L. Silvestro, S. Rizea Savu, V. Karalis
European Journal of Pharmaceutical Sciences.2015; 80: 33. CrossRef
Molecular microbiology in antibacterial research
You-Hee Cho
Journal of Microbiology.2014; 52(3): 185. CrossRef

REVIEW] Mechanisms of Synergy in Polymicrobial Infections: Justine L. Murray , Jodi L. Connell , Apollo Stacy , Keith H. Turner , Marvin Whiteley; J. Microbiol. 2014;52(3):188-199. Published online March 1, 2014; DOI: https://doi.org/10.1007/s12275-014-4067-3

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Abstract PDF

Communities of microbes can live almost anywhere and contain many different species. Interactions between members of these communities often determine the state of the habitat in which they live. When these habitats include sites on the human body, these interactions can affect health and disease. Polymicrobial synergy can occur during infection, in which the combined effect of two or more microbes on disease is worse than seen with any of the individuals alone. Powerful genomic methods are increasingly used to study microbial communities, including metagenomics to reveal the members and genetic content of a community and metatranscriptomics to describe the activities of community members. Recent efforts focused toward a mechanistic understanding of these interactions have led to a better appreciation of the precise bases of polymicrobial synergy in communities containing bacteria, eukaryotic microbes, and/or viruses. These studies have benefited from advances in the development of in vivo models of polymicrobial infection and modern techniques to profile the spatial and chemical bases of intermicrobial communication. This review describes the breadth of mechanisms microbes use to interact in ways that impact pathogenesis and techniques to study polymicrobial communities.

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Trends in Microbiology.2025; 33(5): 546. CrossRef
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Archives of Medical Research.2025; 56(1): 103101. CrossRef
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Chemical Engineering Journal.2025; 519: 165368. CrossRef
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Plant Pathology.2025; 74(7): 2121. CrossRef
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Expert Review of Anti-infective Therapy.2025; : 1. CrossRef
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Gina R. Lewin, Emma R. Evans, Marvin Whiteley, Varsha Singh
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Pathogens.2024; 13(10): 837. CrossRef
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Zoe Mumford, Yamni Nigam
Journal of Clinical Medicine.2024; 13(22): 6746. CrossRef
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Journal of Translational Medicine.2024;[Epub] CrossRef
Interplay of virulence factors shapes ecology and treatment outcomes in polymicrobial infections
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Mathematical Biosciences.2024; 377: 109293. CrossRef
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Sandra Timme, Sindy Wendler, Tilman E Klassert, Joao Pedro Saraiva, Ulisses Nunes da Rocha, Manuel Wittchen, Sareda Schramm, Ralf Ehricht, Stefan Monecke, Birgit Edel, Jürgen Rödel, Bettina Löffler, Maria Soledad Ramirez, Hortense Slevogt, Marc Thilo Figg
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Geraldine B. Dayrit, Mahmoud Mabrok, Sage Chaiyapechara, Channarong Rodkhum
Aquaculture International.2024; 32(6): 7509. CrossRef
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Alex Labossiere, Matthew Ramsey, Justin Merritt, Jens Kreth, Jacob Yount, Jessica A. Scoffield
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Microorganisms.2023; 11(2): 457. CrossRef
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Diagnostics.2023; 13(3): 429. CrossRef
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Journal of Environmental Management.2023; 348: 119408. CrossRef
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E3S Web of Conferences.2023; 449: 07016. CrossRef
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Nature Communications.2023;[Epub] CrossRef
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FEMS Microbiology Reviews.2023;[Epub] CrossRef
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Meng-Wei Chang, Cheng-Ta Wu, Shih-Hsiang Yen, Timothy L. Tan, Po-Chun Lin, Feng-Chih Kuo
Journal of Clinical Medicine.2023; 12(2): 600. CrossRef
Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms
Akito Sakanaka, Masae Kuboniwa, Shuichi Shimma, Samar A. Alghamdi, Shota Mayumi, Richard J. Lamont, Eiichiro Fukusaki, Atsuo Amano, Heather D. Bean
mSystems.2022;[Epub] CrossRef
Suppurative Thrombosis of the Portal Vein (Pylephlebits): A Systematic Review of Literature
Dorde Jevtic, Tatjana Gavrancic, Ivana Pantic, Terri Nordin, Charles W. Nordstrom, Marina Antic, Nikola Pantic, Marija Kaljevic, Bojan Joksimovic, Milan Jovanovic, Emilia Petcu, Mladen Jecmenica, Tamara Milovanovic, Lawrence Sprecher, Igor Dumic
Journal of Clinical Medicine.2022; 11(17): 4992. CrossRef
Effect of Polymicrobial Interactions on Antimicrobial Resistance: An in vitro Analysis in Human Ocular Infections
Sanchita Mitra, Aparajita Mallick, Shilpa Priyadarshini
Future Microbiology.2022; 17(7): 491. CrossRef
Precise spatial structure impacts antimicrobial susceptibility of S. aureus in polymicrobial wound infections
Carolyn B. Ibberson, Juan P. Barraza, Avery L. Holmes, Pengbo Cao, Marvin Whiteley
Proceedings of the National Academy of Sciences.2022;[Epub] CrossRef
PECULIARITIES OF DISTRIBUTION OF ANTIBIOTIC RESISTANT STRAINS OF E. COLI - E. FAECALIS ASSOCIATION IN THE UROGENITAL TRACT OF PREGNANT WOMEN
Olha S. Voronkova, Maksym V. Lusta, Yuliia S. Voronkova, Yelyzaveta S. Fawzy, Tetiana H. Ostanina
Wiadomości Lekarskie.2022; 75(2): 462. CrossRef
Corncob structures in dental plaque reveal microhabitat taxon specificity
Viviana Morillo-Lopez, Alexandra Sjaarda, Imon Islam, Gary G. Borisy, Jessica L. Mark Welch
Microbiome.2022;[Epub] CrossRef
Polymicrobial Infections and Biofilms: Clinical Significance and Eradication Strategies
V T Anju, Siddhardha Busi, Madangchanok Imchen, Ranjith Kumavath, Mahima S. Mohan, Simi Asma Salim, Pattnaik Subhaswaraj, Madhu Dyavaiah
Antibiotics.2022; 11(12): 1731. CrossRef
Potential Facilitation Between a Commensal and a Pathogenic Microbe in a Wildlife Disease
Franziska C. Sandmeier, Kendra L. Leonard, Chava L. Weitzman, C. Richard Tracy
EcoHealth.2022; 19(3): 427. CrossRef
Increasing the Efficacy of Treatment of Staphylococcus aureus–Candida albicans Mixed Infections with Myrtenol
Ruba Y. Mahmoud, Elena Y. Trizna, Rand K. Sulaiman, Roman S. Pavelyev, Ilmir R. Gilfanov, Svetlana A. Lisovskaya, Olga V. Ostolopovskaya, Larisa L. Frolova, Alexander V. Kutchin, Galina B. Guseva, Elena V. Antina, Mikhail B. Berezin, Liliya E. Nikitina, A
Antibiotics.2022; 11(12): 1743. CrossRef
Bacteriological Studies of Venomous Snakebite Wounds in Hangzhou, Southeast China
Sipin Hu, Zhengqing Lou, Yuchen Shen, Mengyun Tu
The American Journal of Tropical Medicine and Hygiene.2022; 107(4): 925. CrossRef
Environment Constrains Fitness Advantages of Division of Labor in Microbial Consortia Engineered for Metabolite Push or Pull Interactions
Ashley E. Beck, Kathryn Pintar, Diana Schepens, Ashley Schrammeck, Timothy Johnson, Alissa Bleem, Martina Du, William R. Harcombe, Hans C. Bernstein, Jeffrey J. Heys, Tomas Gedeon, Ross P. Carlson, Alejandra Rodríguez-Verdugo, Davide Ciccarese
mSystems.2022;[Epub] CrossRef
Porphyromonas gingivalis Tyrosine Kinase Is a Fitness Determinant in Polymicrobial Infections
John D. Perpich, Lan Yakoumatos, Kendall S. Stocke, Gina R. Lewin, Anayancy Ramos, Deborah R. Yoder-Himes, Marvin Whiteley, Richard J. Lamont, Andreas J. Bäumler
Infection and Immunity.2022;[Epub] CrossRef
Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms
J Z Alex Cheong, Chad J Johnson, Hanxiao Wan, Aiping Liu, John F Kernien, Angela L F Gibson, Jeniel E Nett, Lindsay R Kalan
The ISME Journal.2021; 15(7): 2012. CrossRef
A Pseudomonas aeruginosa Antimicrobial Affects the Biogeography but Not Fitness of Staphylococcus aureus during Coculture
Juan P. Barraza, Marvin Whiteley, Dominique H. Limoli, Michael S. Gilmore
mBio.2021;[Epub] CrossRef
Pseudomonas aeruginosa biofilms and their partners in crime
Maria del Mar Cendra, Eduard Torrents
Biotechnology Advances.2021; 49: 107734. CrossRef
Pseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategy
S. Lee McGill, Yeni Yung, Kristopher A. Hunt, Michael A. Henson, Luke Hanley, Ross P. Carlson
Scientific Reports.2021;[Epub] CrossRef
Effect of co-positivity for brucellosis and tuberculosis on milk yield and fertility of Holstein cows
M. Mellado, N. Treviño, F. G. Véliz, U. Macías-Cruz, L. Avendaño-Reyes, A. de Santiago, J. E. García
Tropical Animal Health and Production.2021;[Epub] CrossRef
Detection of bacterial fluorescence from in vivo wound biofilms using a point‐of‐care fluorescence imaging device
Andrea J. Lopez, Laura M. Jones, Landrye Reynolds, Rachel C. Diaz, Isaiah K. George, William Little, Derek Fleming, Anna D'souza, Monique Y. Rennie, Kendra P. Rumbaugh, Allie Clinton Smith
International Wound Journal.2021; 18(5): 626. CrossRef
Ditylenchus dipsaci and Fusarium oxysporum on garlic: one plus one does not equal two
Mary Ruth McDonald, Lilieth Ives, Kwasi Adusei-Fosu, Katerina S. Jordan
Canadian Journal of Plant Pathology.2021; 43(5): 749. CrossRef
Effects of inflammatory stimuli on responses of macrophages to Mycoplasma bovis infection
Monica Baquero, Ksenia Vulikh, Cassidy Wong, Meghan Domony, DeLenn Burrows, David Marom, Jose Perez-Casal, Hugh Y. Cai, Jeff L. Caswell
Veterinary Microbiology.2021; 262: 109235. CrossRef
Polymicrobial Interactions in the Urinary Tract: Is the Enemy of My Enemy My Friend?
Jordan R. Gaston, Alexandra O. Johnson, Kirsten L. Bair, Ashley N. White, Chelsie E. Armbruster, Karen M. Ottemann
Infection and Immunity.2021;[Epub] CrossRef
Clinical Implications of Polymicrobial Synergism Effects on Antimicrobial Susceptibility
William Little, Caroline Black, Allie Clinton Smith
Pathogens.2021; 10(2): 144. CrossRef
Bacterial Interactions with Aspergillus fumigatus in the Immunocompromised Lung
Anatte Margalit, James C. Carolan, Kevin Kavanagh
Microorganisms.2021; 9(2): 435. CrossRef
Characterization of Polybacterial versus Monobacterial Conjunctivitis Infections in Pediatric Subjects Across Multiple Studies and Microbiological Outcomes with Besifloxacin Ophthalmic Suspension 0.6%
Joseph M Blondeau, Howard M Proskin, Christine M Sanfilippo, Heleen H DeCory
Clinical Ophthalmology.2021; Volume 15: 4419. CrossRef
Prospective assessment of catheter-associated bacteriuria clinical presentation, epidemiology, and colonization dynamics in nursing home residents
Chelsie E. Armbruster, Aimee L. Brauer, Monica S. Humby, Jiahui Shao, Saptarshi Chakraborty
JCI Insight.2021;[Epub] CrossRef
Burns and biofilms: priority pathogens and in vivo models
Evgenia Maslova, Lara Eisaiankhongi, Folke Sjöberg, Ronan R. McCarthy
npj Biofilms and Microbiomes.2021;[Epub] CrossRef
Genetically Programmable Microbial Assembly
Mark T. Kozlowski, Bradley R. Silverman, Christopher P. Johnstone, David A. Tirrell
ACS Synthetic Biology.2021; 10(6): 1351. CrossRef
Hormones Can Influence Antibiotic Susceptibilities Even in Mono- and Co-Culture Conditions
Fatma Kalaycı-Yüksek, Defne Gümüş, Mine Anğ-Küçüker
Acta Biologica Marisiensis.2021; 4(2): 39. CrossRef
Synergistic Cues from Diverse Bacteria Enhance Multicellular Development in a Choanoflagellate
Ella V. Ireland, Arielle Woznica, Nicole King, Eric V. Stabb
Applied and Environmental Microbiology.2020;[Epub] CrossRef
Cooperation and Conflict Within the Microbiota and Their Effects On Animal Hosts
Alexandre R. T. Figueiredo, Jos Kramer
Frontiers in Ecology and Evolution.2020;[Epub] CrossRef
Weakest-Link Dynamics Predict Apparent Antibiotic Interactions in a Model Cross-Feeding Community
Elizabeth M. Adamowicz, William R. Harcombe
Antimicrobial Agents and Chemotherapy.2020;[Epub] CrossRef
Pseudomonad reverse carbon catabolite repression, interspecies metabolite exchange, and consortial division of labor
Heejoon Park, S. Lee McGill, Adrienne D. Arnold, Ross P. Carlson
Cellular and Molecular Life Sciences.2020; 77(3): 395. CrossRef
Strain Background, Species Frequency, and Environmental Conditions Are Important in Determining Pseudomonas aeruginosa and Staphylococcus aureus Population Dynamics and Species Coexistence
Selina Niggli, Rolf Kümmerli, Donald W. Schaffner
Applied and Environmental Microbiology.2020;[Epub] CrossRef
Molecular characteristics and risk factors associated with linezolid-resistant Enterococcus faecalis infection in Southwest China
Jiaqi Zou, Yun Xia
Journal of Global Antimicrobial Resistance.2020; 22: 504. CrossRef
From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis
Alexander B. Smith, Joshua Soto Ocana, Joseph P. Zackular, Anthony R. Richardson
Infection and Immunity.2020;[Epub] CrossRef
Successful treatment of a unique chronic multi-bacterial scalp infection with N-chlorotaurine, N-bromotaurine and bromamine T
Anthony M. Kyriakopoulos, Markus Nagl, Dorothea Orth-Höller, Janusz Marcinkiewicz, Stella Baliou, Vassilis Zoumbourlis
Access Microbiology .2020;[Epub] CrossRef
The social life of microbes in chronic infection
Carolyn B Ibberson, Marvin Whiteley
Current Opinion in Microbiology.2020; 53: 44. CrossRef
Polymicrobial Biofilm Interaction Between Histophilus somni and Pasteurella multocida
Briana Petruzzi, Allan Dickerman, Kevin Lahmers, William K. Scarratt, Thomas J. Inzana
Frontiers in Microbiology.2020;[Epub] CrossRef
Quantitative Framework for Model Evaluation in Microbiology Research Using Pseudomonas aeruginosa and Cystic Fibrosis Infection as a Test Case
Daniel M. Cornforth, Frances L. Diggle, Jeffrey A. Melvin, Jennifer M. Bomberger, Marvin Whiteley, Arturo Casadevall
mBio.2020;[Epub] CrossRef
Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogen Pseudomonas aeruginosa as a case example
Chiara Rezzoagli, Elisa T. Granato, Rolf Kümmerli
Journal of Medical Microbiology.2020; 69(2): 147. CrossRef
Comparison of sTREM‐1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors
Marie Dubar, Jean‐Pol Frippiat, Thomas Remen, Amir Boufenzer, Corentine Alauzet, Cedric Baumann, Sebastien Gibot, Catherine Bisson
Journal of Clinical Periodontology.2020; 47(9): 1064. CrossRef
Cooperative Interactions between Trichomonas vaginalis and Associated Bacteria Enhance Paracellular Permeability of the Cervicovaginal Epithelium by Dysregulating Tight Junctions
Annabel S. Hinderfeld, Niha Phukan, Ann-Katrein Bär, Anthony M. Roberton, Augusto Simoes-Barbosa, De'Broski R. Herbert
Infection and Immunity.2019;[Epub] CrossRef
The Structure of Dental Plaque Microbial Communities in the Transition from Health to Dental Caries and Periodontal Disease
Alex M. Valm
Journal of Molecular Biology.2019; 431(16): 2957. CrossRef
2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections
Kordo Saeed, Alex C. McLaren, Edward M. Schwarz, Valentin Antoci, William V. Arnold, Antonia F. Chen, Martin Clauss, Jaime Esteban, Vanya Gant, Edward Hendershot, Noreen Hickok, Carlos A. Higuera, Débora C. Coraça‐Huber, Hyonmin Choe, Jessica A. Jennings,
Journal of Orthopaedic Research.2019; 37(5): 1007. CrossRef
Antimicrobial resistance three ways: healthcare crisis, major concepts and the relevance of biofilms
Paula Jorge, Andreia Patrícia Magalhães, Tânia Grainha, Diana Alves, Ana Margarida Sousa, Susana Patrícia Lopes, Maria Olívia Pereira
FEMS Microbiology Ecology.2019;[Epub] CrossRef
Optimal environmental and culture conditions allow the in vitro coexistence of Pseudomonas aeruginosa and Staphylococcus aureus in stable biofilms
Maria del Mar Cendra, Núria Blanco-Cabra, Lucas Pedraz, Eduard Torrents
Scientific Reports.2019;[Epub] CrossRef
In vitro and ex vivo systems at the forefront of infection modeling and drug discovery
Di Shi, Gujie Mi, Mian Wang, Thomas J. Webster
Biomaterials.2019; 198: 228. CrossRef
Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa
Pushpa Pandiyan, Natarajan Bhaskaran, Mangge Zou, Elizabeth Schneider, Sangeetha Jayaraman, Jochen Huehn
Frontiers in Immunology.2019;[Epub] CrossRef
Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity
Young-Jung Jung, Daniel P. Miller, John D. Perpich, Zackary R. Fitzsimonds, Daonan Shen, Jun Ohshima, Richard J. Lamont, Indranil Biswas
mBio.2019;[Epub] CrossRef
Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A
Tiffany Y. Borbón, Breanna M. Scorza, Gwendolyn M. Clay, Fellipe Lima Nobre de Queiroz, Alan J. Sariol, Jayden L. Bowen, Yani Chen, Bayan Zhanbolat, Corey P. Parlet, Diogo G. Valadares, Suzanne L. Cassel, William M. Nauseef, Alexander R. Horswill, Fayyaz
PLOS Neglected Tropical Diseases.2019; 13(5): e0007247. CrossRef
A Rare Opportunist, Morganella morganii , Decreases Severity of Polymicrobial Catheter-Associated Urinary Tract Infection
Brian S. Learman, Aimee L. Brauer, Kathryn A. Eaton, Chelsie E. Armbruster, Marvin Whiteley
Infection and Immunity.2019;[Epub] CrossRef
Streptococcus gordonii programs epithelial cells to resist ZEB2 induction by Porphyromonas gingivalis
Jun Ohshima, Qian Wang, Zackary R. Fitzsimonds, Daniel P. Miller, Maryta N. Sztukowska, Young-Jung Jung, Mikako Hayashi, Marvin Whiteley, Richard J. Lamont
Proceedings of the National Academy of Sciences.2019; 116(17): 8544. CrossRef
The oral microbiota: dynamic communities and host interactions
Richard J. Lamont, Hyun Koo, George Hajishengallis
Nature Reviews Microbiology.2018; 16(12): 745. CrossRef
Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection
Natarajan Bhaskaran, Cheriese Quigley, Clarissa Paw, Shivani Butala, Elizabeth Schneider, Pushpa Pandiyan
Frontiers in Microbiology.2018;[Epub] CrossRef
Cross-feeding modulates antibiotic tolerance in bacterial communities
Elizabeth M Adamowicz, Jeffrey Flynn, Ryan C Hunter, William R Harcombe
The ISME Journal.2018; 12(11): 2723. CrossRef
Molecular Identification of Bacteria in Intra-abdominal Abscesses Using Deep Sequencing
Andrew Kozlov, Lorenzo Bean, Emilie V Hill, Lisa Zhao, Eric Li, Gary P Wang
Open Forum Infectious Diseases.2018;[Epub] CrossRef
Options and Limitations in Clinical Investigation of Bacterial Biofilms
Maria Magana, Christina Sereti, Anastasios Ioannidis, Courtney A. Mitchell, Anthony R. Ball, Emmanouil Magiorkinis, Stylianos Chatzipanagiotou, Michael R. Hamblin, Maria Hadjifrangiskou, George P. Tegos
Clinical Microbiology Reviews.2018;[Epub] CrossRef
Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media
Vinal Lakhani, Li Tan, Sayak Mukherjee, William C. L. Stewart, W. Edward Swords, Jayajit Das
Royal Society Open Science.2018; 5(11): 180810. CrossRef
Acclimation of Culturable Bacterial Communities under the Stresses of Different Organic Compounds
Hui Wang, Shuangfei Zhang, Amit Pratush, Xueying Ye, Jinli Xie, Huan Wei, Chongran Sun, Zhong Hu
Frontiers in Microbiology.2018;[Epub] CrossRef
Effects of Growth Surface Topography on Bacterial Signaling in Coculture Biofilms
Arunima Bhattacharjee, Mughees Khan, Maya Kleiman, Allon I. Hochbaum
ACS Applied Materials & Interfaces.2017; 9(22): 18531. CrossRef
In vitro microbicidal, anti‐biofilm and cytotoxic effects of different commercial antiseptics
Silvestre Ortega‐Peña, Christian Hidalgo‐González, Martin C Robson, Edgar Krötzsch
International Wound Journal.2017; 14(3): 470. CrossRef
Pseudomonas aeruginosa Contact-Dependent Growth Inhibition Plays Dual Role in Host-Pathogen Interactions
Jeffrey A. Melvin, Jordan R. Gaston, Shawn N. Phillips, Michael J. Springer, Christopher W. Marshall, Robert M. Q. Shanks, Jennifer M. Bomberger, Sarah E. F. D'Orazio
mSphere.2017;[Epub] CrossRef
Fungal Biofilms and Polymicrobial Diseases
Caroline Costa-Orlandi, Janaina Sardi, Nayla Pitangui, Haroldo De Oliveira, Liliana Scorzoni, Mariana Galeane, Kaila Medina-Alarcón, Wanessa Melo, Mônica Marcelino, Jaqueline Braz, Ana Fusco-Almeida, Maria Mendes-Giannini
Journal of Fungi.2017; 3(2): 22. CrossRef
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Lei Zhang, Varun Dewan, Hang Yin
Journal of Medicinal Chemistry.2017; 60(12): 5029. CrossRef
Potentiation and tolerance of toll-like receptor priming in human endothelial cells
Stephen R. Koch, Fred S. Lamb, Judith Hellman, Edward R. Sherwood, Ryan J. Stark
Translational Research.2017; 180: 53. CrossRef
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Allie Clinton Smith, Anne Rice, Bryan Sutton, Rebecca Gabrilska, Aimee K. Wessel, Marvin Whiteley, Kendra P. Rumbaugh, Beth McCormick
Infection and Immunity.2017;[Epub] CrossRef
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Berta Cortés‐Acha, Rui Figueiredo, Ramón Seminago, Francisco J. Roig, Carlos Llorens, Eduard Valmaseda‐Castellón
Journal of Periodontology.2017; 88(10): 1090. CrossRef
Identification by highly sensitive 16S metagenomic sequencing of an unusual case of polymicrobial bacteremia
Benjamin Lelouvier, Florence Servant, Pierre Delobel, Michael Courtney, Meyer Elbaz, Jacques Amar
Journal of Infection.2017; 75(3): 278. CrossRef
Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection
Masae Kuboniwa, John R. Houser, Erik L. Hendrickson, Qian Wang, Samar A. Alghamdi, Akito Sakanaka, Daniel P. Miller, Justin A. Hutcherson, Tiansong Wang, David A. C. Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M. Marcotte, Murray Hackett, Rich
Nature Microbiology.2017; 2(11): 1493. CrossRef
Rapid susceptibility profiling of carbapenem-resistant Klebsiella pneumoniae
K. T. Mulroney, J. M. Hall, X. Huang, E. Turnbull, N. M. Bzdyl, A. Chakera, U. Naseer, E. M. Corea, M. J. Ellington, K. L. Hopkins, A. L. Wester, O. Ekelund, N. Woodford, T. J. J. Inglis
Scientific Reports.2017;[Epub] CrossRef
Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts
George Hajishengallis, Richard J. Lamont
Trends in Microbiology.2016; 24(6): 477. CrossRef
Resource limitation drives spatial organization in microbial groups
Sara Mitri, Ellen Clarke, Kevin R Foster
The ISME Journal.2016; 10(6): 1471. CrossRef
Hydrogen peroxide is a central determinant of oral polymicrobial synergy
Richard J. Lamont
Environmental Microbiology.2016; 18(11): 3609. CrossRef
Interactions between Pseudomonas aeruginosa and Staphylococcus aureus during co-cultivations and polymicrobial infections
Angela T. Nguyen, Amanda G. Oglesby-Sherrouse
Applied Microbiology and Biotechnology.2016; 100(14): 6141. CrossRef
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Steve P. Bernier, Matthew L. Workentine, Xiang Li, Nathan A. Magarvey, George A. O'Toole, Michael G. Surette
Frontiers in Microbiology.2016;[Epub] CrossRef
16S rRNA analysis provides evidence of biofilms on all components of three infected periprosthetic knees including permanent braided suture
Matthew C. Swearingen, Alex C. DiBartola, Devendra Dusane, Jeffrey Granger, Paul Stoodley, Thomas Bjarnsholt
Pathogens and Disease.2016; 74(7): ftw083. CrossRef
A Commensal Bacterium Promotes Virulence of an Opportunistic Pathogen via Cross-Respiration
Apollo Stacy, Derek Fleming, Richard J. Lamont, Kendra P. Rumbaugh, Marvin Whiteley, Michael S. Gilmore, Vanessa Sperandio, Donald Demuth
mBio.2016;[Epub] CrossRef
Fusobacterium nucleatum infections: clinical spectrum and bacteriological features of 78 cases
E. Denes, O. Barraud
Infection.2016; 44(4): 475. CrossRef
The biogeography of polymicrobial infection
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Nature Reviews Microbiology.2016; 14(2): 93. CrossRef
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Surgical Infections.2016; 17(1): 27. CrossRef
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Ryan H. Hansen, Andrea C. Timm, Collin M. Timm, Amber N. Bible, Jennifer L. Morrell-Falvey, Dale A. Pelletier, Michael L. Simpson, Mitchel J. Doktycz, Scott T. Retterer, Xiangzhen Li
PLOS ONE.2016; 11(5): e0155080. CrossRef
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C. Vazquez, N. Lago, M. M. Mato, L. Esarte, J. L. Legido
Journal of Thermal Analysis and Calorimetry.2016; 125(2): 739. CrossRef
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Justin Merritt, Hidenobu Senpuku, Jens Kreth
Environmental Microbiology.2016; 18(1): 174. CrossRef
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Andreia P. Magalhães, Nuno F. Azevedo, Maria O. Pereira, Susana P. Lopes
Applied Microbiology and Biotechnology.2016; 100(3): 1163. CrossRef
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F1000Research.2015; 4: 179. CrossRef
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Patricia M. Barnabie, Marvin Whiteley, V. J. DiRita
Journal of Bacteriology.2015; 197(14): 2250. CrossRef
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Medicine.2015; 94(49): e2000. CrossRef
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Tal Luzzatto-Knaan, Alexey V. Melnik, Pieter C. Dorrestein
The Analyst.2015; 140(15): 4949. CrossRef
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Trends in Microbiology.2015; 23(2): 76. CrossRef
Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology
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F1000Research.2015; 4: 179. CrossRef
Pseudomonas aeruginosa adaptation to human hosts
Evan S Snitkin, Julia A Segre
Nature Genetics.2015; 47(1): 2. CrossRef
Biofilm Models of Polymicrobial Infection
Rebecca A Gabrilska, Kendra P Rumbaugh
Future Microbiology.2015; 10(12): 1997. CrossRef
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Journal of Molecular Biology.2015; 427(23): 3646. CrossRef
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BioMetals.2015; 28(3): 433. CrossRef
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Environmental Microbiology.2015; 17(11): 4352. CrossRef
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American Journal of Respiratory and Critical Care Medicine.2014; 189(11): 1309. CrossRef
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Journal of Microbiology.2014; 52(8): 702. CrossRef

Research Support, Non-U.S. Gov'ts

Phenotypic Characteristics of Natural Killer Cells in Acute Hepatitis: Hyosun Cho; J. Microbiol. 2013;51(2):247-251. Published online April 27, 2013; DOI: https://doi.org/10.1007/s12275-013-2522-1

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Abstract PDF

Natural killer (NK) cells are the principal effector cell population in innate immune defense against many types of infections. These cells are enriched in the liver, where they comprise approximately 40% to 60% of the intrahepatic lymphocyte pool compared to the peripheral blood compartment. In chronic HBV and HCV infection, NK cells were reported to be partially dysfunctional due to impaired IFN-γ secretion. Few studies have examined phenotypic features of NK cells in acute hepatitis. We identified NK (CD56+CD3-) cell populations in patients with acute hepatitis by examining the expressions of phenotypic NK cell markers (CD16, NKG2A, and NKG2D). Peripheral blood mononuclear cells were isolated from patients with acute hepatitis A (7) and patients with non-viral acute toxic hepatitis (6) during the symptomatic and convalescent phases. Expressions of NK (CD56+CD3-) cell markers, CD16, NKG2A, and NKG2D, were measured by flow cytometry. Symptomatic acute hepatitis including non-viral hepatitis and HAV infection showed significant increases of NKG2A expression compared to healthy controls. Interestingly, there was a direct correlation between the proportion of NK cell populations and liver function parameters (AST, ALT) in HAV infection. The strong correlation was also observed between the expression of NKG2A+NK cells and ALT, which suggests that most of NK cells in severe phase of disease express high level of NKG2A on their surface. In addition, decreased number of NK cells (CD56+CD3-) in symptomatic phase began to increase in the convalescent phase of acute hepatitis A. However, the expression of NKG2A tended to be reduced, which indicates that NKG2A, the inhibitory receptor on NK cells, can be a severity parameter in acute hepatitis.

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Establishment and Characterization of the Epithelioma Papulosum Cyprini (EPC) Cell Line Persistently Infected with Infectious Pancreatic Necrosis Virus (IPNV), an Aquabirnavirus: Hyoung Jun Kim , Jae-Kwon Cho , Hyung-Kyu Hwang , Myung-Joo Oh , Toyohiko Nishizawa; J. Microbiol. 2012;50(5):821-826. Published online November 4, 2012; DOI: https://doi.org/10.1007/s12275-012-2364-2

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Abstract

Infectious pancreatic necrosis virus (IPNV), a type species of aquabirnaviruses in the family Birnaviridae, is an etiological agent of infectious pancreatic necrosis and has been isolated from epizootics of cultured salmonids. In the present study, an epithelioma papulosum cyprini (EPC) cell line persistently infected with IPNV (PI-EPC) was experimentally established by subculturing EPC cells surviving IPNV infection, and was characterized. PI-EPC cells were morphologically indistinguishable from EPC, but continued to grow and yield IPNV. PI-EPC cells showed no cytopathic effect due to IPNV inoculation, and susceptibility of PI-EPC cells against heterologous viruses was not different from that of EPC cells. Only one cell of 103.5 PI-EPC cells produced IPNV at approximately 100.5 50% tissue culture infectious dose (TCID50)/cell/day, which was approximately 1,000 times lower than that of normal EPC cells. PI-EPC cells that did not yield IPNV (N-PI-EPC) were screened. The IPNV genome was detected from both PI-EPC and N-PI-EPC cells, and the IPNV VP2 structural protein was detected from both cell lines, but no other IPNV proteins were observed by Western blot analysis with anti-IPNV serum. Thus, multiplication of IPNV in PI-EPC cells was regulated by some host cell factors, except interferon.

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Effects of Phosphate Addition on Biofilm Bacterial Communities and Water Quality in Annular Reactors Equipped with Stainless Steel and Ductile Cast Iron Pipes: Hyun-Jung Jang , Young-June Choi , Hee-Myong Ro , Jong-Ok Ka; J. Microbiol. 2012;50(1):17-28. Published online February 27, 2012; DOI: https://doi.org/10.1007/s12275-012-1040-x

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Abstract PDF: The impact of orthophosphate addition on biofilm formation and water quality was studied in corrosion-resistant stainless steel (STS) pipe and corrosion-susceptible ductile cast iron (DCI) pipe using cultivation and culture-independent approaches. Sample coupons of DCI pipe and STS pipe were installed in annular reactors, which were operated for 9 months under hydraulic conditions similar to a domestic plumbing system. Addition of 5 mg/L of phosphate to the plumbing systems, under low residual chlorine conditions, promoted a more significant growth of biofilm and led to a greater rate reduction of disinfection by-products in DCI pipe than in STS pipe. While the level of THMs (trihalomethanes) increased under conditions of low biofilm concentration, the levels of HAAs (halo acetic acids) and CH (chloral hydrate) decreased in all cases in proportion to the amount of biofilm. It was also observed that chloroform, the main species of THM, was not readily decomposed biologically and decomposition was not proportional to the biofilm concentration; however, it was easily biodegraded after the addition of phosphate. Analysis of the 16S rDNA sequences of 102 biofilm isolates revealed that Proteobacteria (50%) was the most frequently detected phylum, followed by Firmicutes (10%) and Actinobacteria (2%), with 37% of the bacteria unclassified. Bradyrhizobium was the dominant genus on corroded DCI pipe, while Sphingomonas was predominant on non-corroded STS pipe. Methylobacterium and Afipia were detected only in the reactor without added phosphate. PCR-DGGE analysis showed that the diversity of species in biofilm tended to increase when phosphate was added regardless of the pipe material, indicating that phosphate addition upset the biological stability in the plumbing systems.

Research Support, N.I.H., Extramural

The Activity of a Small Lytic Peptide PTP-7 on Staphylococcus aureus Biofilms: Riddhi Kharidia , Jun F. Liang; J. Microbiol. 2011;49(4):663-668. Published online September 2, 2011; DOI: https://doi.org/10.1007/s12275-011-1013-5

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Abstract PDF: One of the most important features of bacterial biofilms is their resistance to antibiotics and to the host immune system. In this study, we have found that a small lytic peptide, PTP-7, is very potent to Gram-positive bacteria and is able to kill antibiotic sensitive and resistant Staphylococcus aureus indiscriminately. Further studies have revealed that despite being a cationic peptide, the antibacterial activity of PTP-7 was not affected by the negatively charged extracellular polymeric substance (EPS) of biofilms. PTP-7 could diffuse into the deep layer of S. aureus biofilms to kill bacteria inside biofilms efficiently and effectively. Neither the high concentrations of metal ions nor the acidic pH in biofilms affected the activity of peptide PTP-7. It seems that the unique sequence/structure together with the resistant bacteria killing ability of peptide PTP-7 confers its anti-biofilm activity. This study sheds new light on the treatment of bacterial biofilms, especially various biofilm related infections.

Research Support, Non-U.S. Gov'ts

Food-Borne Enterococci and Their Resistance to Oxidative Stress: Barbora Vlková , Tomá&# , Gabriel Minárik , Lubomíra Tóthová , Hana Drahovská , Ján Tur&# , Peter Celec; J. Microbiol. 2011;49(4):657-662. Published online September 2, 2011; DOI: https://doi.org/10.1007/s12275-011-0296-x

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Enterococci are important food-borne pathogens that cause serious infections. Several virulence factors have been described including aggregation substance, gelatinase, cytolysin, and enterococcal surface protein. The ability to cause infections is mainly dependent on the response to oxidative stress due to the production of reactive oxygen species by immune cells. The aim of our study was to analyze the resistance of enterococcal strains from food to clinically relevant antiseptic agents with regard to the presence of selected virulence factors, and to uncover potential mechanisms of the antioxidative resistance. Eighty-two enterococcal isolates from Bryndza cheese were tested using in vitro growth assays to study the ability of these isolates to survive exposure to antiseptic agents – hydrogen peroxide, hypochlorite, and chlorhexidine. Virulence genotypes of the isolates were determined by PCR, and RT real time PCR was used for gene expression under oxidative stress. Resistance against antiseptic agents depends on the concentration of applied chemicals, on the time of exposure, but also on virulence factors of the enterococcal strains. Oxidative stress induces the expression of antioxidative enzymes and down-regulates the expression of prooxidative enzymes. These effects are dependent on the virulence genotype of the enterococcal strains. These findings are important for future research, especially concerning the role of enterococci in oral diseases.

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Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents
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Species distribution, antibiotic resistance and virulence traits in enterococci from meat in Tunisia
Naouel Klibi, Leila Ben Said, Ahlem Jouini, Karim Ben Slama, Maria López, Rym Ben Sallem, Abdellatif Boudabous, Carmen Torres
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Antibacterial activity of CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine) generating reactive oxygen species
Hana Culakova, Vladimira Dzugasova, Yvetta Gbelska, Julius Subik
Microbiological Research.2013; 168(3): 147. CrossRef

Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007: Dieu Linh Tran , Kangmo Kim , Jae Yoo Choi , Hyun Dong Paik , Si-Woo Choi , Jin Yeul Ma , Sung-Soon Kim , Sung Joon Ahn , Young Bong Kim; J. Microbiol. 2011;49(2):274-279. Published online May 3, 2011; DOI: https://doi.org/10.1007/s12275-011-0311-2

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Highly pathogenic H5N1 avian influenza A virus (AIV) crossed the species barrier and caused a number of deaths in humans in Vietnam and 14 other countries. Since the last report of human H5N1 infection in November 2005, the first documented H5N1 human infection was reported in June 2007 in Vietnam and was followed by 7 more cases, including 5 fatalities. In this study, we isolated and analyzed the full length of the H5N1 genome from a sample from the first patient in 2007. Phylogenetic analysis of eight genomic segments of the H5N1 virus strain (A/Vietnam/HN/2007, VNH07) revealed that this strain appears to be of genotype V and contains the HA gene, which is classified into clade 2.3.4. The deduced amino acid sequence of the HA protein has a typical affinity sequence for α2,3 linkage (SAα2,3-Gal) receptors and typical multibasic cleavage sequences. Compared with other H5N1 isolates, VNH07 showed that the possible reassortments for the NA and NP segments occurred between A/goose/Guangxi/3017/2005-like isolates (2.3.2) and A/human/Zhejiang/16/2006-like isolates (2.3.4).

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Rethinking Approaches to Improve the Utilization of Nucleic Acid Amplification Tests for Detection and Characterization of Influenza A in Diagnostic and Reference Laboratories
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Comparative Analysis of Immune Responses to Mycobacterium abscessus Infection and Its Antigens in Two Murine Models: Bo-Young Jeon , Jeongyeon Kwak , Seung-Sub Lee , SangNae Cho , Chul Jae Won , Jin Man Kim , Sung Jae Shin; J. Microbiol. 2009;47(5):633-640. Published online October 24, 2009; DOI: https://doi.org/10.1007/s12275-009-0139-1

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Abstract PDF

Mycobacterium abscessus has been identified as an emerging pulmonary pathogen in humans. Because little is known regarding immune responses elicited by M. abscessus or its antigens, immunological responses were studied in two murine models subjected to intravenous (high-dose or systemic infection) or pulmonary (low-dose or local infection) inoculation with M. abscessus ATCC 19977. An overall comparison between the two models showed similar patterns of bacterial survival and host immune responses. The colonization of M. abscessus was the highest at 5 days post-infection (dpi) and its elimination was positively correlated with cell-mediated immunity in both challenges. However, an inverse relationship was observed between progressive inflammation and mycobacterial colonization levels in mice infected with a high dose at 14 dpi. Regarding antigens, culture filtrate (CF) of M. abscessus strongly induced IFN-γ secretion, whereas cellular extract (CE) antigen elicited strong antibody responses. The antibody response to M. abscessus antigens in mice subjected to low-dose infection increased when the cellular immune response decreased over 14 dpi. However, the antibody response for the high-dose infection increased promptly after the infection. In comparison of cytokine expression in lung homogenates after M. abscessus infection, Th1 and Th2 cytokines increased simultaneously in the high-dose infection, whereas only cell-mediated immunity developed in the low-dose pulmonary infection. These findings not only enhance our understanding of the immune response to M. abscessus infection according to systemic or pulmonary infection, but may also aid in immunological diagnosis and vaccine development.

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Camilla Riva, Enrico Tortoli, Federica Cugnata, Francesca Sanvito, Antonio Esposito, Marco Rossi, Anna Colarieti, Tamara Canu, Cristina Cigana, Alessandra Bragonzi, Nicola Ivan Loré, Paolo Miotto, Daniela Maria Cirillo
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Lindsay J. Caverly, Silvia M. Caceres, Cori Fratelli, Carrie Happoldt, Kelley M. Kidwell, Kenneth C. Malcolm, Jerry A. Nick, David P. Nichols, Nades Palaniyar
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Expression of c-Myc Is Related to Host Cell Death Following Salmonella typhimurium Infection in Macrophage: Jihyoun Seong , Hong Hua Piao , Phil Yeoul Ryu , Youn Uck Kim , Hyon E Choy , Yeongjin Hong; J. Microbiol. 2009;47(2):214-219. Published online May 2, 2009; DOI: https://doi.org/10.1007/s12275-008-0308-7

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It has been known that ornithine decarboxylase (ODC) induced by the binding of c-Myc to odc gene is closely linked to cell death. Here, we investigated the relationship between their expressions and cell death in macrophage cells following treatment with Salmonella typhimurium or lipopolysaccharide (LPS). ODC expression was increased by bacteria or LPS and repressed by inhibitors against mitogen-activated protein kinases (MAPKs) in Toll-like receptor 4 (TLR4) signaling pathway. In contrast, c-Myc protein level was increased after treatment with bacteria, but not by treatment with LPS or heat-killed bacteria although both bacteria and LPS increased the levels of c-myc mRNA to a similar extent. c-Myc protein level is dependent upon bacterial invasion because treatment with cytochalasin D (CCD), inhibitors of endocytosis, decreased c-Myc protein level. The cell death induced by bacteria was significantly decreased after treatment of CCD or c-Myc inhibitor, indicating that cell death by S. typhimurium infection is related to c-Myc, but not ODC. Consistent with this conclusion, treatment with bacteria mutated to host invasion did not increase c-Myc protein level and cell death rate. Taken together, it is suggested that induction of c-Myc by live bacterial infection is directly related to host cell death.

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Protective Effect of Polygoni Cuspidati Radix and Emodin on Vibrio vulnificus Cytotoxicity and Infection: Jong Ro Kim , Dool-Ri Oh , Mi Hye Cha , Byoung Sik Pyo , Joon Haeng Rhee , Hyon E. Choy , Won Keun Oh , Young Ran Kim; J. Microbiol. 2008;46(6):737-743. Published online December 24, 2008; DOI: https://doi.org/10.1007/s12275-008-0232-x

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Vibrio vulnificus, a good model organism of bacterial septicemia, causes fatal septicemia manifesting a fulminating course and a high mortality rate within days. In order to identify new natural substances preventing V. vulnificus infection, a plant library was screened for inhibiting cytotoxicity to host cells by using Trypan blue staining and LDH assay. We found that Polygoni Cuspidati Radix potently suppressed the acute death of HeLa and RAW264.7 cells in a dose dependent manner. Further studies revealed that Polygoni Cuspidati Radix inhibited V. vulnificus growth and survival in HI broth and seawater, respectively. We confirmed that Polygoni Cuspidati Radix contained high level of emodin by thin layer chromatography (TLC). Emodin showed direct antibacterial activity against V. vulnificus. In addition, emodin prevented the morphologic damages and acute death of HeLa cells caused from V. vulnificus. The safety of Polygoni Cuspidati Radix and emodin to host cells was confirmed by MTT assay. Polygoni Cuspidati Radix and emodin protected mice from V. vulnificus infection.

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Journal of Ethnopharmacology.2012; 139(2): 616. CrossRef
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Journal of Ethnopharmacology.2012; 139(2): 566. CrossRef
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PLoS Pathogens.2012; 8(3): e1002581. CrossRef

Enteric Bacteria Isolated from Acute Diarrheal Patients in the Republic of Korea between the Year 2004 and 2006: Seung-Hak Cho , Hyun-Ho Shin , Yeon-Hwa Choi , Mi-Sun Park , Bok-Kwon Lee; J. Microbiol. 2008;46(3):325-330. Published online July 5, 2008; DOI: https://doi.org/10.1007/s12275-008-0015-4

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Abstract PDF: In an epidemiological survey of human enterobacterial infections in the Republic of Korea during three years from 2004 to 2006, we isolated 1,784 (6.2%, isolation rate of enteropathogens from stool samples) in 2004, 2,547 (9.5%) in 2005 and 3,506 bacteria (12.3%) from people who visited clinics. Among the isolated bacteria, pathogenic Escherichia coli, especially, EAEC was the most frequently identified pathogen in both urban and rural regions followed by Staphylococcus aureus, Salmonella species, Bacillus cereus, Vibrio parahaemolyticus, Campylobacter jejuni, Clostridium perfringens, and Shigella species. Distinct seasonality was found in V. parahaemolyticus species, while this pathogen showed no age-specific patterns. However, other bacteria, i.e., pathogenic E. coli, S. aureus, Salmonella spp., and B. cereus showed similar seasonality throughout the year, showing a slight increase in the infection rate during the summer months and high prevalence among children under 10 years of age and elder-age people. The antibiotic susceptibility patterns of pathogenic E. coli, Salmonella spp., and S. aureus showed high resistance to penicillins. However, both pathogenic E. coli and Salmonella spp. were susceptible to several cephems, imipenem, and amikacin. Moreover, S. aureus strains resistant to vancomycin were not found. In conclusion, these surveillances can play an important role for the control and prevention to the diseases originated by enteritis bacteria.

Review

Reovirus and Tumor Oncolysis: Manbok Kim , Young-Hwa Chung , Randal N. Johnston; J. Microbiol. 2007;45(3):187-192.; DOI: https://doi.org/2544 [pii]

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Abstract PDF: REOviruses (Respiratory Enteric Orphan viruses) are ubiquitous, non-enveloped viruses containing 10 segments of double-stranded RNA (dsRNA) as their genome. They are common isolates of the respiratory and gastrointestinal tract of humans but are not associated with severe disease and are therefore considered relatively benign. An intriguing characteristic of reovirus is its innate oncolytic potential, which is linked to the transformed state of the cell. When immortalized cells are transfected in vitro with activated oncogenes such as Ras, Sos, v-erbB, or c-myc, they became susceptible to reovirus infection and subsequent cellular lysis, indicating that oncogene signaling pathways are exploited by reovirus. This observation has led to the use of the virus in clinical trials as an anti-cancer agent against oncogenic tumors. In addition to the exploitation of oncogene signaling, reovirus may further utilize host immune responses to enhance its antitumor activity in vivo due to its innate interferon induction ability. Reovirus is, however, not entirely benign to immunocompromised animal models. Reovirus causes so-called “black feet syndrome” in immunodeficient mice and can also harm neonatal animals. Because cancer patients often undergo immunosuppression due to heavy chemo/radiation-treatments or advanced tumor progression, this pathogenic response may be a hurdle in virus-based anticancer therapies. However, a genetically attenuated reovirus variant derived from persistent reovirus infection of cells in vitro is able to exert potent anti-tumor activity with significantly reduced viral pathogenesis in immunocompromised animals. Importantly, in this instance the attenuated reovirus maintains its oncolytic potential while significantly reducing viral pathogenesis in vivo.

Research Support, Non-U.S. Gov't

Identification of Genes Differentially Expressed in RAW264.7 Cells Infected by Salmonella typhimurium Using PCR Method: Kyung Ho Kang , Jung A Song , Dong-Jun Shin , Hyon E Choy , Yeongjin Hong; J. Microbiol. 2007;45(1):29-33.; DOI: https://doi.org/2495 [pii]

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Abstract PDF: Salmonella typhimurium, causing mouse typhoid, infects hosts such as macrophage cells, and proliferates in intracellular vacuoles causing infected cells to trigger numerous genes to respond against the infection. In this study, we tried to identify such genes in RAW264.7 cells by using the PCR screening method with degenerate primers. Fourteen genes were found to be differentially expressed after a 4 h infection in which the expression of 8 genes increased while expression of the others decreased. Most of the genes were involved in proinflammatory responses such as cytokines production and cell death. The mutation in msbB gene encoding the myristoyl transferase in lipid A of lipopolysaccharide (LPS) resulted in much lower toxicity to the inoculated animals. We compared the expression of the identified genes in wild-type and msbB-mutated S. typhimurium infections and found that Lyzs encoding lysozyme type M was differentially expressed. This gene is quite likely to be related to bacterial survival in the host cells.

Journal Article

Molecular Epidemiological Analysis of Bloodstream Isolates of Candida albicans from a University Hospital over a Five-Year Period: Jong Hee Shin , Yu Gyung Og , Duck Cho , Seung Jung Kee , Myung Geun Shin , Soon Pal Suh , Dong Wook Ryang; J. Microbiol. 2005;43(6):546-554.; DOI: https://doi.org/2291 [pii]

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Abstract PDF: We assessed the genetic relations and epidemiological links among bloodstream isolates of Candida albicans, which were obtained from a university hospital over a period of five years. The 54 bloodstream isolates from the 38 patients yielded 14 different karyotypes, 29 different patterns after digestion with SfiI (REAG-S), and 31 different patterns after digestion with BssHII (REAG-B) when analyzed using three different pulsed-field gel electrophoresis (PFGE) typing methods. In 11 patients with serial bloodstream isolates, all strains from each patient had the same PFGE pattern. The dendrograms for all of the strains revealed that the distribution of similarity values ranged from 0.70 to 1.0 in the REAG-S patterns, and from 0.35 to 1.0 in the REAG-B patterns. Overall, the combination of the three different PFGE methods identified 31 distinct types, reflecting the results obtained using the REAG-B alone different. different Five PFGE types were shared among 22 isolates from 12 patients. These types of strains were more frequently associated with central venous catheter-related fungemia than the other 26 type strains (92% versus 31%; P < 0.005). Of five PFGE types, four isolates were determined to be epidemiologically related: each of these types was primarily from two or three patients who had been hospitalized concurrently within the same intensive care unit. Our results suggest that the REAG-B constitutes perhaps the most useful PFGE method for investigating C. albicans candidemia and also shows that a relatively high proportion of C. albicans candidemia may be associated with exogenous acquisition of clonal strains.

Research Support, Non-U.S. Gov't

Molecular Survey of Latent Pseudorabies Virus Infection in Nervous Tissues of Slaughtered Pigs by Nested and Real-time PCR: Hyun A Yoon , Seong Kug Eo , Abi George Aleyas , Seong Ok Park , John Hwa Lee , Joon Seok Chae , Jeong Gon Cho , Hee Jong Song; J. Microbiol. 2005;43(5):430-436.; DOI: https://doi.org/2279 [pii]

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Abstract PDF: In this study, the prevalence and quantity of a latent pseudorabies virus (PrV) infection in the nervous tissues of randomly selected pigs was determined via nested and real-time PCR. The nervous tissues, including the trigeminal ganglion (TG), olfactory bulb (OB), and brain stem (BS), were collected from the heads of 40 randomly selected pigs. The majority of the nervous tissues from the selected pigs evidenced a positively amplified band on nested PCR. In particular, nested PCR targeted to the PrV glycoprotein B (gB) gene yielded positive results in all of the BS samples. Nested PCR for either the gE or gG gene produced positive bands in a less number of nervous tissues (57.5% and 42.5%, respectively). Real-time PCR revealed that the examined tissues harbored large copy numbers of latent PrV DNA, ranging between 100.1 and 107.2 (1-1.58x107) copies per 1 g of genomic DNA. Real-time PCR targeted to the PrV gE gene exhibited an accumulated fluorescence of reporter dye at levels above threshold, thereby indicating a higher prevalence than was observed on the nested PCR (100% for BS, 92% for OB, and 85% for TG). These results indicate that a large number of farm-grown pigs are latently infected with a field PrV strain with a variety of copy numbers. This result is similar to what was found in association with the human herpes virus.

Journal Article

Study on Persistent Infection of Japanese Encephalitis Virus Beijing-1 Strain in Serum-free Sf9 Cell Cultures: Hun Kim , Su Jeen Lee , Jin Yong Park , Yong Wook Park , Hyun Sung Kim , Heui-Yun Kang , Byung-Ki Hur , Yeon-Woo Ryu , Sang In Han , Jong Su Kim; J. Microbiol. 2004;42(1):25-31.; DOI: https://doi.org/2005 [pii]

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Abstract PDF: Sf9 cells have obvious advantages for the conventional production technology of vaccine. They are useful tools for high concentration and large-scale cultures. Sf9 cells were grown to maximal concentration, 8×10^6 cells/ml in a 500ml spinner flask, with a doubling time at the exponentially growing phase of 24.5 hours, using serum-free media. To explore the ability of Sf9 cells to be infected by the Japanese encephalitis (JE) virus Beijing-1 strain, Sf9 cells were infected with the virus. By 4-5 days post-infection, 10-15% of the Sf9 cells showed cytopathic effect (CPE), from granularity to the formation of syncytia and multinucleated giant cells continuously observed over a period of 35 days. Positive fluorescent reactions were detected in 30-40% of cells infected with the JE virus Beijing-1 strain, and the uninfected Sf9 cells were completely negative. Virus particles, propagated in Sf9 and Vero cells, were concentrated by sedimentation on 40% trehalose cushions by ultracentrifugation, and showed identical patterns of viral morphogenesis. Complete virus particles, 40 to 50 nm in diameter, were observed, and JE virus envelope (E) proteins, at 53 kDa, were found in the western blot analysis to the anti-JE virus E protein monoclonal antibody and reacted as a magenta band in the same position to the glycoprotein staining. To evaluate whether the infectious virus was produced in Sf9 cells inoculated with the JE virus Beijing-1 stain, Sf9 cells were inoculated with the virus, and sample harvested every 5 days. The titers of the JE virus Beijing-1 strain rose from 1.0×10^5 to 1.5×10^6 pfu/ml. The infected Sf9 cells could be subcultured in serum-free medium, with no change in the plaque sizes formed by the JE virus Beijing-1 strain in the plaque assay. It is suggested that the ability of the JE virus Beijing-1 strain to infect Sf9 cells in serum-free media will provide a useful insect cell system, where the JE virus replication, cytopathogenicity and vaccine immunogen can be studied.

Research Support, Non-U.S. Gov't

EDITORIAL] Human fungal pathogens: Why should we learn?: Jeong-Yoon Kim; J. Microbiol. 2016;54(3):145-148.; DOI: https://doi.org/10.1007/s12275-016-0647-8

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Abstract PDF

Human fungal pathogens that cause invasive infections are hidden killers, taking lives of one and a half million people every year. However, research progress in this field has not been rapid enough to effectively prevent or treat life-threatening fungal diseases. To update recent research progress and promote more active research in the field of human fungal pathogens, eleven review articles concerning the virulence mechanisms and host interactions of four major human fungal pathogens–Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and Histoplasma capsulatum–are presented in this special issue.

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Advanced Healthcare Materials.2022;[Epub] CrossRef
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International Journal of Molecular Sciences.2022; 23(18): 10645. CrossRef
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Redox Biology.2022; 56: 102461. CrossRef
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Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
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Sreyan Ghosh, Riya Mukherjee, Vinay S. Mahajan, Julie Boucau, Shiv Pillai, Jayanta Haldar
ACS Applied Materials & Interfaces.2022; 14(37): 42483. CrossRef
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International Journal of Molecular Sciences.2022; 23(11): 6345. CrossRef
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Proceedings of the National Academy of Sciences.2021;[Epub] CrossRef
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Journal of Biomaterials Science, Polymer Edition.2021; 32(8): 1009. CrossRef
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Journal of Microbiology.2021; 59(10): 911. CrossRef
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Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
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Reflection on Kinetic Models to the Chlorine Disinfection for Drinking Water Production: Yoon-jin Lee , Sang-ho Nam; J. Microbiol. 2002;40(2):119-124.

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Abstract PDF: Experiments for the characterization of inactivation were performed in a series of batch processes with the total coliform used as a general indicator organism based on the chlorine residuals as a disinfectant. The water samples were taken from the outlet of a settling basin in a conventional surface water treatment system that is provided with the raw water drawn from the mid-stream of the Han River. The inactivation of total coliform was experimentally analyzed for the dose of disinfectant, contact time, filtration and mixing intensity. The curves obtained from a series of batch processes were shaped with a general tailing-off and biphasic mode of inactivation, i.e. a sharp loss of bacterial viability within 15 min followed by an extended phase. In order to observe the effect of carry-over suspended solids on chlorine consumption and disinfection efficiency, the water samples were filtered, prior to inoculation with coliforms, with membranes of both 2.5 um and 11.0 um pore size, and with a sand filter of 1.0 mm in effective size and of 1.4 in uniformity coefficient. As far as the disinfection efficiency is concerned, there were no significant differences. The parameters estimated by the models of Chick-Watson, Hom and Selleck from our experimental data obtained within 120 min are: log(N/N_0 )=-0.16CT with n=1, log(N/N_0 )=-0.71C^0.87 T with n=/1 for the Chick-Watson model, log (N/N_0 )=-1.87C^0.47 T^ 0.36 for the Hom model, log (N/N_0 )=-2.13log (1+CT/0.11) for the Selleck model. It is notable that among the models reviewed with regard to the experimental data obtained, the Selleck model appeared to most closely resemble the total coliform survival curve.

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