Journal of Microbiology

Research Article

Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus: Jueun Oh, Hayeon Kim, Jihye Lee, Suhyun Kim, Seyun Shin, Young-Eui Kim, Sehee Park, SangJoon Lee; J. Microbiol. 2025;63(1):e.2409007. Published online January 24, 2025; DOI: https://doi.org/10.71150/jm.2409007

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Abstract PDF Supplementary Material: Korean Red ginseng has emerged as a potent candidate in the fight against various viral infections, demonstrating significant efficacy both in vitro and in vivo, particularly against influenza A viruses. Despite substantial evidence of its antiviral properties, the detailed molecular mechanisms through which it reduces viral lethality remain insufficiently understood. Our investigations have highlighted the superior effectiveness of Korean Red ginseng against influenza viruses, outperforming its effects on numerous other viral strains. We aim to uncover the specific mechanisms by which Korean Red ginseng exerts its antiviral effects, focusing on influenza A viruses. Our prior studies have identified the role of Z-DNA-binding protein 1 (ZBP1), a signaling complex involved in inducing programmed cell death in response to influenza virus infection. Given the critical role of ZBP1 as a sensor for viral nucleic acid, we hypothesize that Korean Red ginseng may modulate the ZBP1-derived cell death pathway. This interaction is anticipated to enhance cell death while concurrently suppressing viral protein expression, offering novel insights into the antiviral mechanism of Korean Red ginseng against influenza A viruses.

Journal Articles

NEDD4 Regulated Pyroptosis Occurred from Co‑infection between Influenza A Virus and Streptococcus pneumoniae: Jiangzhou You , Linlin Zhou , Xudong San , Hailing Li , Mingyuan Li , Baoning Wang; J. Microbiol. 2023;61(8):777-789. Published online October 4, 2023; DOI: https://doi.org/10.1007/s12275-023-00076-y

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Co-infection of respiratory tract viruses and bacteria often result in excess mortality, especially pneumonia caused by influenza viruses and Streptococcus pneumoniae. However, the synergistic mechanisms remain poorly understood. Therefore, it is necessary to develop a clearer understanding of the molecular basis of the interaction between influenza virus and Streptococcus pneumonia. Here, we developed the BALB/c mouse model and the A549 cell model to investigate inflammation and pyroptotic cell death during co-infection. Co-infection significantly activated the NLRP3 inflammasome and induced pyroptotic cell death, correlated with excess mortality. The E3 ubiquitin ligase NEDD4 interacted with both NLRP3 and GSDMD, the executor of pyroptosis. NEDD4 negatively regulated NLRP3 while positively regulating GSDMD, thereby modulating inflammation and pyroptotic cell death. Our findings suggest that NEDD4 may play a crucial role in regulating the GSDMD-mediated pyroptosis signaling pathway. Targeting NEDD4 represents a promising approach to mitigate excess mortality during influenza pandemics by suppressing synergistic inflammation during co-infection of influenza A virus and Streptococcus pneumoniae.

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Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis
Zhe Song, Chengen Han, Guangzhi Luo, Guangyuan Jia, Xiao Wang, Baoqing Zhang
Frontiers in Pharmacology.2024;[Epub] CrossRef
Overexpression of DTX1 inhibits D-GalN/TNF-α-induced pyroptosis and inflammation in hepatocytes by regulating NLRP3 ubiquitination
Mingshui Liu, Jing Gu, Li Chen, Wei Sun, Xiaoping Huang, Jianhe Gan
Toxicology Research.2024;[Epub] CrossRef
NLRP3 Inflammasomes: Dual Function in Infectious Diseases
Yanbo Li, Rui Qiang, Zhengmin Cao, Qingjuan Wu, Jiuchong Wang, Wenliang Lyu
The Journal of Immunology.2024; 213(4): 407. CrossRef

NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells: Lin Yuan , Yurong Zhu , Shuang Huang , Lin Lin , Xugan Jiang , Shengxia Chen; J. Microbiol. 2021;59(8):771-781. Published online June 1, 2021; DOI: https://doi.org/10.1007/s12275-021-0692-9

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Abstract

Listeria monocytogenes is a food-borne pathogen responsible for neurolisteriosis, which is potentially lethal in immunocompromised individuals. Microglia are the main target cells for L. monocytogenes in central nervous system (CNS). However, the precise mechanisms by which they trigger neuroinflammatory processes remain unknown. The BV2 microglial cell line and a murine model of L. monocytogenes infection were used for experiments in this study. Listeria monocytogenes induced pyroptosis and nucleotide binding and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3) inflammasome activation in BV2. Pharmacological inhibition of the NLRP3 inflammasome attenuated L. monocytogenes- induced pyroptosis. Moreover, inhibition of nuclear factor kappa-B (NF-κB) and extracellular regulated protein kinases (ERK) pathways induced a decrease in caspase1 activation and mature IL-1β-17 secretion. Our collective findings support critical involvement of the NLRP3 inflammasome in L. monocytogenes-induced neuroinflammation and, to an extent, ROS production. In addition, ERK and NF-κB signaling play an important role in activation of the NLRP3 inflammasome, both in vitro and in vivo.

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Zixi Song, Mingxu Jiang, Mengya Wang, Jiahong Zou, Zhenwei Chen, Feifei Zheng, Qingchao Wang
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Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natália Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patrícia Paiva Corsetti, Leonardo Augusto de Almeida
Life Sciences.2023; 331: 122076. CrossRef
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International Journal of Molecular Sciences.2023; 24(21): 15957. CrossRef
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Acta Pharmaceutica.2023; 73(1): 121. CrossRef
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Xian Wu, Teng Wan, Xiaoyu Gao, Mingyuan Fu, Yunfeng Duan, Xiangru Shen, Weiming Guo
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Review

Recent advances in the development of β-lactamase inhibitors: Shivakumar S. Jalde , Hyun Kyung Choi; J. Microbiol. 2020;58(8):633-647. Published online July 27, 2020; DOI: https://doi.org/10.1007/s12275-020-0285-z

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Abstract

β-Lactam antibiotics are the most commonly prescribed antibiotics worldwide; however, antimicrobial resistance (AMR) is a global challenge. The β-lactam resistance in Gram-negative bacteria is due to the production of β-lactamases, including extended-spectrum β-lactamases, metallo-β-lactamases, and carbapenem-hydrolyzing class D β-lactamases. To restore the efficacy of BLAs, the most successful strategy is to use them in combination with β-lactamase inhibitors (BLI). Here we review the medically relevant β-lactamase families and penicillins, diazabicyclooctanes, boronic acids, and novel chemical scaffold-based BLIs, in particular approved and under clinical development.

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Molecules.2024; 29(16): 3944. CrossRef
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Shakir Ali Siddiqui, Kshatresh Dutta Dubey
Inorganic Chemistry.2024; 63(40): 18963. CrossRef
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ACS Infectious Diseases.2023; 9(5): 1123. CrossRef
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Tomefa E Asempa, Abigail K Kois, Christian M Gill, David P Nicolau
Journal of Antimicrobial Chemotherapy.2023; 78(3): 636. CrossRef
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Yushuang Wu, Shudi Huang, Donglai Zhang, Hua Ji, Yongqing Ni, Xueling Zhang, Juan Dong, Baokun Li
Foodborne Pathogens and Disease.2023; 20(7): 270. CrossRef
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Russian Journal of Bioorganic Chemistry.2022; 48(5): 1059. CrossRef
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Zafar Iqbal, Jian Sun, Haikang Yang, Jingwen Ji, Lili He, Lijuan Zhai, Jinbo Ji, Pengjuan Zhou, Dong Tang, Yangxiu Mu, Lin Wang, Zhixiang Yang
Molecules.2022; 27(12): 3832. CrossRef
Retracted and replaced: Phenotypes, genotypes and breakpoints: an assessment of β-lactam/ β-lactamase inhibitor combinations against OXA-48
Tomefa E Asempa, Abigail K Kois, Christian M Gill, David P Nicolau
Journal of Antimicrobial Chemotherapy.2022; 77(10): 2622. CrossRef
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Søren Brøgger Christensen
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ACS Infectious Diseases.2021; 7(6): 1765. CrossRef
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ACS Infectious Diseases.2021; 7(5): 1164. CrossRef

Research Support, Non-U.S. Gov'ts

Molecular characterization of mammalian-adapted Korean-type avian H9N2 virus and evaluation of its virulence in mice: Kuk Jin Park , Min-Suk Song , Eun-Ha Kim , Hyeok-il Kwon , Yun Hee Baek , Eun-hye Choi , Su-Jin Park , Se Mi Kim , Young-il Kim , Won-Suk Choi , Dae-Won Yoo , Chul-Joong Kim , Young Ki Choi; J. Microbiol. 2015;53(8):570-577. Published online July 31, 2015; DOI: https://doi.org/10.1007/s12275-015-5329-4

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Abstract

Avian influenza A virus (AIV) is commonly isolated from domestic poultry and wild migratory birds, and the H9N2 subtype is the most prevalent and the major cause of severe disease in poultry in Korea. In addition to the veterinary concerns regarding the H9N2 subtype, it is also considered to be the next potential human pandemic strain due to its rapid evolution and interspecies transmission. In this study, we utilize serial lung-to-lung passage of a low pathogenic avian influenza virus (LPAI) H9N2 (A/Ck/Korea/163/04, WT163) (Y439-lineage) in mice to increase pathogenicity and investigate the potential virulence marker. Mouse-adapted H9N2 virus obtained high virulence (100% mortality) in mice after 98 serial passages. Sequence results show that the mouse adaptation (ma163) possesses several mutations within seven gene segments (PB2, PA, HA, NP, NA, M, and NS) relative to the wild-type strain. The HA gene showed the most mutations (at least 11) with one resulting in the loss of an N-glycosylation site (at amino acid 166). Moreover, reverse genetic studies established that an E627K substitution in PB2 and the loss of the N-glycosylation site in the HA protein (aa166) are critical virulence markers in the mouse-adapted H9N2 virus. Thus, these results add to the increasing body of mutational analysis data defining the function of the viral polymerase and HA genes and their roles in mammalian host adaptation. To our knowledge, this is first report of the generation of a mammalian-adapted Korea H9N2 virus (Y493-lineages). Therefore, this study offers valuable insights into the molecular evolution of the LPAI Korean H9N2 in a new host and adds to the current knowledge of the molecular markers associated with increased virulence.

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An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization
Carol M. Sheppard, Daniel H. Goldhill, Olivia C. Swann, Ecco Staller, Rebecca Penn, Olivia K. Platt, Ksenia Sukhova, Laury Baillon, Rebecca Frise, Thomas P. Peacock, Ervin Fodor, Wendy S. Barclay
Nature Communications.2023;[Epub] CrossRef
Current situation and control strategies of H9N2 avian influenza in South Korea
Mingeun Sagong, Kwang-Nyeong Lee, Eun-Kyoung Lee, Hyunmi Kang, Young Ki Choi, Youn-Jeong Lee
Journal of Veterinary Science.2023;[Epub] CrossRef
Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994–2019 in China
Qingzheng Liu, Lingcai Zhao, Yanna Guo, Yongzhen Zhao, Yingfei Li, Na Chen, Yuanlu Lu, Mengqi Yu, Lulu Deng, Jihui Ping
Viruses.2022; 14(4): 726. CrossRef
Molecular epidemiology and pathogenicity of H5N1 and H9N2 avian influenza viruses in clinically affected chickens on farms in Bangladesh
Ripatun Nahar Ripa, Joshua E. Sealy, Jayna Raghwani, Tridip Das, Himel Barua, Md. Masuduzzaman, A. K. M. Saifuddin, Md. Reajul Huq, Mohammad Inkeyas Uddin, Munir Iqbal, Ian Brown, Nicola S. Lewis, Dirk Pfeiffer, Guillaume Fournie, Paritosh Kumar Biswas
Emerging Microbes & Infections.2021; 10(1): 2223. CrossRef
Mouse adaptation of the H9N2 avian influenza virus causes the downregulation of genes related to innate immune responses and ubiquitin-mediated proteolysis in mice
Jing Guo, Xinxin Gao, Baotao Liu, Yubao Li, Wenqiang Liu, Jianbiao Lu, Cheng Liu, Rui Xue, Xuyong Li
Medical Microbiology and Immunology.2020; 209(2): 151. CrossRef
H9 Influenza Viruses: An Emerging Challenge
Silvia Carnaccini, Daniel R. Perez
Cold Spring Harbor Perspectives in Medicine.2020; 10(6): a038588. CrossRef
Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs
Liu Lina, Chen Saijuan, Wang Chengyu, Lu Yuefeng, Dong Shishan, Chen Ligong, Guo Kangkang, Guo Zhendong, Li Jiakai, Zhang Jianhui, Luo Qingping, Zhang Wenting, Shang Yu, Wang Honglin, Zhang Tengfei, Wen Guoyuan, Zhu Jiping, Zhang Chunmao, Jin Meilin, Gao
Scientific Reports.2019;[Epub] CrossRef
A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice
Haruhiko Kamiki, Hiromichi Matsugo, Tomoya Kobayashi, Hiroho Ishida, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto
Viruses.2018; 10(11): 653. CrossRef
Genetics and biological property analysis of Korea lineage of influenza A H9N2 viruses
Min Kang, Hyung-Kwan Jang
Veterinary Microbiology.2017; 204: 96. CrossRef
The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents
Won-Suk Choi, Khristine Kaith S. Lloren, Yun Hee Baek, Min-Suk Song
Clinical and Experimental Vaccine Research.2017; 6(2): 83. CrossRef
Rapid acquisition of polymorphic virulence markers during adaptation of highly pathogenic avian influenza H5N8 virus in the mouse
Won-Suk Choi, Yun Hee Baek, Jin Jung Kwon, Ju Hwan Jeong, Su-Jin Park, Young-il Kim, Sun-Woo Yoon, Jungwon Hwang, Myung Hee Kim, Chul-Joong Kim, Richard J. Webby, Young Ki Choi, Min-Suk Song
Scientific Reports.2017;[Epub] CrossRef
Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy
Se Mi Kim, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Hyeok-il Kwon, Young-Jae Si, In-Won Lee, Min-Suk Song, Young Ki Choi, Jae U. Jung
Journal of Virology.2017;[Epub] CrossRef
Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014
Duong Mai Thuy, Thomas P. Peacock, Vu Thi Ngoc Bich, Thomas Fabrizio, Dang Nguyen Hoang, Nguyen Dang Tho, Nguyen Thi Diep, Minh Nguyen, Le Nguyen Minh Hoa, Hau Thi Thu Trang, Marc Choisy, Ken Inui, Scott Newman, Nguyen vu Trung, Rogier van Doorn, Thanh Lo
Infection, Genetics and Evolution.2016; 44: 530. CrossRef
PB2 subunit of avian influenza virus subtype H9N2: a pandemic risk factor
Hanna Sediri, Swantje Thiele, Folker Schwalm, Gülsah Gabriel, Hans-Dieter Klenk
Journal of General Virology.2016; 97(1): 39. CrossRef

Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model: Hwan Hee Lee , Heejin Park , Gi-Ho Sung , Kanghyo Lee , Taeho Lee , Ilseob Lee , Man-seong Park , Yong Woo Jung , Yu Su Shin , Hyojeung Kang , Hyosun Cho; J. Microbiol. 2014;52(8):696-701. Published online July 18, 2014; DOI: https://doi.org/10.1007/s12275-014-4300-0

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Abstract

The immune-modulatory as well as anti-influenza effects of Cordyceps extract were investigated using a DBA/2 mouse model. Three different concentrations of Cordyceps extract, red ginseng extract, or drinking water were orally administered to mice for seven days, and then the mice were intranasally infected with 2009 pandemic influenza H1N1 virus. Body weight changes and survival rate were measured daily post-infection. Plasma IL-12, TNF-α, and the frequency of natural killer (NK) cells were measured on day 4 post-infection. The DBA/2 strain was highly susceptible to H1N1 virus infection. We also found that Cordyceps extract had an antiinfluenza effect that was associated with stable body weight and reduced mortality. The anti-viral effect of Cordyceps extract on influenza infection was mediated presumably by increased IL-12 expression and greater number of NK cells. However, high TNF-α expression after infection of H1N1 virus in mice not receiving treatment with Cordyceps extract suggested a two-sided effect of the extract on host immune regulation.

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Journal of Ayurveda and Integrative Medicine.2024; 15(3): 100979. CrossRef
Chitin Synthases in Cordyceps militaris: Genome-Wide Gene Identification, Evolutionary Insights, and Life Cycle Transcript Profiling
Shoumian Li, Huihui Ren, Jie Zhang, Shangpai Gao, Zixuan Chen, Guojie Li, Jinghua Tian, Junling Wang, Ming Li, Xiao Li, Caihong Dong
Horticulturae.2024; 10(5): 494. CrossRef
Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation
Siddharth Dubhashi, Sagar Sinha, Sankalp Dwivedi, Jaishree Ghanekar, Sameer Kadam, Parineeta Samant, Vibha Datta, Sarman Singh, Irshad H Chaudry, Padma Gurmet, Harshawardhan Kelkar, Rakesh Mishra, Sagar Galwankar, Amit Agrawal
Cureus.2023;[Epub] CrossRef
Chitinase Is Involved in the Fruiting Body Development of Medicinal Fungus Cordyceps militaris
Zi-Juan Zhang, Yuan-Yuan Yin, Yao Cui, Yue-Xuan Zhang, Bi-Yang Liu, You-Chu Ma, Yong-Nan Liu, Gao-Qiang Liu
Life.2023; 13(3): 764. CrossRef
Boosting cordycepin production through plant-based oils for vegetarian consumption
Watcharin Yuttavanichakul, Nipaporn Kanthong, Nuntaporn Pungsungvorn
Journal of Applied Research on Science and Technology (JARST).2023;[Epub] CrossRef
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Abdul-Rehman Phull, Madiha Ahmed, Hye-Jin Park
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Yu Zhang, Guoying Zhang, Jianya Ling
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Antioxidants.2021; 10(12): 1899. CrossRef
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ACS Omega.2021; 6(2): 1505. CrossRef
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International Journal of Molecular Sciences.2021; 22(2): 643. CrossRef
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Akalesh Kumar Verma, Vikas Kumar, Sweta Singh, Bhabesh Ch. Goswami, Ihosvany Camps, Aishwarya Sekar, Sanghwa Yoon, Keun Woo Lee
Biomedicine & Pharmacotherapy.2021; 137: 111356. CrossRef
A new nucleoside and two new pyrrole alkaloid derivatives from Cordyceps militaris
Yafu Xue, Leilei Wu, Yulian Ding, Xinming Cui, Zhuzhen Han, Hong Xu
Natural Product Research.2020; 34(3): 341. CrossRef
CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue‐light receptors in edible fungus Cordyceps militaris
Jiaojiao Zhang, Fen Wang, Ying Yang, Ying Wang, Caihong Dong
Environmental Microbiology.2020; 22(1): 466. CrossRef
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Yong-Nan Liu, Bi-Yang Liu, You-Chu Ma, Hai-Long Yang, Gao-Qiang Liu, Shwet Kamal
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Journal of Microbiology.2015; 53(7): 468. CrossRef

Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus: Min-Kyu Kwak , Rui Liu , Jun-Oh Kwon , Min-Kyu Kim , Andrew HyoungJin Kim , Sa-Ouk Kang; J. Microbiol. 2013;51(6):836-843. Published online December 19, 2013; DOI: https://doi.org/10.1007/s12275-013-3521-y

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Abstract

We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria, including Lactobacillus spp., Leuconostoc spp., Weissella spp., and Lactococcus lactis.

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PLOS ONE.2022; 17(8): e0271269. CrossRef
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Biochemistry.2021; 60(1): 64. CrossRef
Korean traditional foods as antiviral and respiratory disease prevention and treatments: A detailed review
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Trends in Food Science & Technology.2021; 116: 415. CrossRef
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Carolina Díaz-Cárdenas, Laura Yinneth Rojas, Susana Fiorentino, Monica P. Cala, Jorge I Díaz, Freddy A. Ramos, Jean Armengaud, Silvia Restrepo, Sandra Baena
Molecules.2020; 25(11): 2546. CrossRef
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José Aníbal Mora-Villalobos, Jéssica Montero-Zamora, Natalia Barboza, Carolina Rojas-Garbanzo, Jessie Usaga, Mauricio Redondo-Solano, Linda Schroedter, Agata Olszewska-Widdrat, José Pablo López-Gómez
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Quantification of Proline-containing Cyclic Dipeptides by LC-MS/MS
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Analytical Sciences.2020; 36(8): 977. CrossRef
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Molecular Biology Reports.2020; 47(3): 1871. CrossRef
Inhibitory effect of lactic acid bacteria isolated from kimchi against murine norovirus
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Food Control.2020; 109: 106881. CrossRef
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Journal of Functional Foods.2020; 72: 104081. CrossRef
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Fataneh Hashempour-Baltork, Hedayat Hosseini, Saeedeh Shojaee-Aliabadi, Mohammadali Torbati, Adel Mirza Alizadeh, Matin Alizadeh
Advanced Pharmaceutical Bulletin.2019; 9(3): 335. CrossRef
Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining
Ahmed Ghamry Abdelhamid, Samar S. El-Masry, Noha K. El-Dougdoug
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Huan-Huan Zhang, Wen-Ying Yu, Lan Li, Fang Wu, Qin Chen, Yang Yang, Chen-Huan Yu
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The cyclization mechanism of cis DAA-DAA dipeptide: an ab initio study
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Nutrients.2018; 10(10): 1356. CrossRef
Cyclo-( l -Phe- l -Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To Confer Resistance against Oxidative
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Infection and Immunity.2018;[Epub] CrossRef
Antimicrobial activity of cyclic dipeptides produced by Lactobacillus plantarum LBP-K10 against multidrug-resistant bacteria, pathogenic fungi, and influenza A virus
Min-Kyu Kwak, Rui Liu, Sa-Ouk Kang
Food Control.2018; 85: 223. CrossRef
Induction of systemic disease resistance in Nicotiana benthamiana by the cyclodipeptides cyclo (l‐Pro‐l‐Pro) and cyclo (d‐Pro‐d‐Pro)
Liming Wu, Huijun Wu, Lina Chen, Hongyue Zhang, Xuewen Gao
Molecular Plant Pathology.2017; 18(1): 67. CrossRef
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Molecules.2017; 22(6): 1024. CrossRef
Proline-Based Cyclic Dipeptides from Korean Fermented Vegetable Kimchi and from Leuconostoc mesenteroides LBP-K06 Have Activities against Multidrug-Resistant Bacteria
Rui Liu, Andrew H. Kim, Min-Kyu Kwak, Sa-Ouk Kang
Frontiers in Microbiology.2017;[Epub] CrossRef
Bioactive compounds detected for the first time in corn oil: Cyclic dipeptides and other nitrogenated compounds
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Journal of Food Composition and Analysis.2017; 62: 197. CrossRef
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Awdhesh Mishra, Jaehyuk Choi, Seong-Jin Choi, Kwang-Hyun Baek
Molecules.2017; 22(10): 1796. CrossRef
DFT study on reaction mechanisms of cyclic dipeptide generation
Yue Li, Fangfang Li, Yanyan Zhu, Xue Li, Ziyuan Zhou, Chunmei Liu, Wenjing Zhang, Mingsheng Tang
Structural Chemistry.2016; 27(4): 1165. CrossRef
Cyclo(phenylalanine‐proline) induces DNA damage in mammalian cells via reactive oxygen species
Kwanghyun Lee, Jae Eun Jeong, In Hwang Kim, Kun‐Soo Kim, Bong‐Gun Ju
Journal of Cellular and Molecular Medicine.2015; 19(12): 2851. CrossRef
Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model
Joo Yeon Kang, Do Kyung Lee, Nam Joo Ha, Hea Soon Shin
Journal of Microbiology.2015; 53(11): 796. CrossRef
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BioMed Research International.2015; 2015: 1. CrossRef
Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus
Song-Yi Ha, Hana Youn, Chang-Seon Song, Se Chan Kang, Jong Jin Bae, Hee Tae Kim, Kwang Min Lee, Tae Hoon Eom, In Su Kim, Jong Hwan Kwak
Journal of Microbiology.2014; 52(4): 340. CrossRef
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Min-Kyu Kwak, Rui Liu, Min-Kyu Kim, Dohyun Moon, Andrew HyoungJin Kim, Sung-Hyun Song, Sa-Ouk Kang
Journal of Microbiology.2014; 52(1): 64. CrossRef

Adjuvant Efficacy of mOMV against Avian Influenza Virus Infection in Mice: Byeong-Jae Lee , Sang-Ho Lee , Min-Suk Song , Philippe Noriel Q. Pascua , Hyeok-il Kwon , Su-Jin Park , Eun-Ha Kim , Arun Decano , Se Mi Kim , Gyo Jin Lim , Doo-Jin Kim , Kyu-Tae Chang , Sang-Hyun Kim , Young Ki Choi; J. Microbiol. 2013;51(5):682-688. Published online October 31, 2013; DOI: https://doi.org/10.1007/s12275-013-3411-3

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Abstract: Highly pathogenic avian influenza H5N1 viruses are found chiefly in birds and have caused severe disease and death in infected humans. Development of influenza vaccines capable of inducing heterosubtypic immunity against a broad range of influenza viruses is the best option for the preparedness, since vaccination remains the principal method in controlling influenza viral infections. Here, a mOMV-adjuvanted recombinant H5N2 (rH5N2) whole virus antigen vaccine with A/Environment/Korea/W149/06(H5N1)-derived H5 HA and A/Chicken/Korea/ma116/04(H9N2)-derived N2 NA in the backbone of A/Puerto Rico/8/34(H1N1) was prepared and generated by reverse genetics. Groups of mice were vaccinated by a prime-boost regime with the rH5N2 vaccine (1.75 μg of HA with/without 10 μg mOMV or aluminum hydroxide adjuvant for comparison). At two weeks post-immunizations, vaccinated mice were challenged with lethal doses of 103.5 EID50/ml of H5N1 or H9N2 avian influenza viruses, and were monitored for 15 days. Both mOMV- and alum-adjuvant vaccine groups had high survival rates after H5N1 infection and low levels of body weight changes compared to control groups. Interestingly, the mOMV-adjuvanted group induced better cross-reactive antibody responses serologically and promoted cross-protectivity against H5N1 and H9N2 virus challenges. Our results suggest that mOMV could be used as a vaccine adjuvant in the development of effective vaccines used to control influenza A virus transmission.

Journal Article

The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection: Mei Ling Xu , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim; J. Microbiol. 2013;51(3):389-393. Published online April 26, 2013; DOI: https://doi.org/10.1007/s12275-013-2683-y

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Abstract: Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

Research Support, Non-U.S. Gov't

Molecular Characterization and Phylogenetic Analysis of H3N2 Human Influenza A Viruses in Cheongju, South Korea: Yun Hee Baek , Jeung Hyun Park , Young Jun Song , Min-Suk Song , Philippe Noriel Q. Pascua , Yoon-Soo Hahn , Heon-Seok Han , Ok-Jun Lee , Ki-Soon Kim , Chun Kang , Young-Ki Choi; J. Microbiol. 2009;47(1):91-100. Published online February 20, 2009; DOI: https://doi.org/10.1007/s12275-008-0207-y

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Abstract: To investigate the genetic characteristics of human influenza viruses circulating in Chungbuk province, we tested 510 clinical samples of nasopharyngeal suction from pediatric patients diagnosed with respiratory illness between June 2007 and June 2008. Genetic characterization of the HA genes of H3N2 isolates indicated the relative higher similarity to A/Virginia/04/07 (99.6%) rather than that of A/Wisconsin/67/2005 (98.4%), a Northern Hemisphere 2007~2008 vaccine strain, based on amino acid sequences. We found several altered amino acids at the H3 HA1 antigenic sites compared with the vaccine strain; K140I at site A, K158R at site B, and K173N (H471) or K173Q, and S262N at site E, but there was no antigenic shift among the H3N2 viruses. Interestingly, A/Cheongju/H383/08 and A/Cheongju/H407/08 isolates had single amino acid substitution at D151G on the catalytic site of the N2 NA while A/Cheongju/H412/08 and A/Cheongju/H398/07 isolates had one amino acid deletion at residue 146. Furthermore, we found that 25% (3 out of 12 isolates) of the H3N2 subtype viruses had the amino acid substitution at position 31 on the M2 protein (Aspartic acid to Asparagine) and confirmed their drug-resistance by biological assays. Taken together, the results of this study demonstrated continuous evolutions of human H3N2 viruses by antigenic drift and also highlighted the need to closely monitor antigenic drug resistance in influenza A viruses to aid in the early detection of potentially pandemic strains, as well as underscore the need for new therapeutics.

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