MSK
- About
- Browse Articles
-
Special Issues
- Pioneering strategies for overcoming bacterial drug resistance (2026)
- Advancing microbial engineering through synthetic biology (2025)
- Host-associated microbiome (2024)
- Bacterial regulatory mechanisms for the control of complex cellular mechanisms (2023)
- Two years into COVID-19 pandemic: Where are we? (2022)
- Collections
- For Contributors
- Policies
- E-Submission
- About
- Browse Articles
-
Special Issues
- Pioneering strategies for overcoming bacterial drug resistance (2026)
- Advancing microbial engineering through synthetic biology (2025)
- Host-associated microbiome (2024)
- Bacterial regulatory mechanisms for the control of complex cellular mechanisms (2023)
- Two years into COVID-19 pandemic: Where are we? (2022)
- Collections
- Policies
- For Contributors
Search
- Page Path
- HOME > Search
Article
- In Silico Intensive Analysis for the E4 Gene Evolution of Human Adenovirus Species D
- Chanhee Lee, Anyeseu Park, Jeong Yoon Lee
- J. Microbiol. 2024;62(5):409-418. Published online April 30, 2024
- DOI: https://doi.org/10.1007/s12275-024-00132-1
- 436 View
- 6 Download
- 3 Web of Science
- 3 Crossref
-
Abstract
PDF - Adenovirus (Ad) is a ubiquitous pathogen capable of infecting a wide range of animals and humans. Human Adenovirus (HAdV) can cause severe infection, particularly in individuals with compromised immune systems. To date, over 110 types of HAdV have been classified into seven species from A to G, with the majority belonging to the human adenovirus species D (HAdV-D). In the HAdV-D, the most significant factor for the creation of new adenovirus types is homologous recombination between viral genes involved in determining the virus tropism or evading immune system of host cells. The E4 gene, consisting of seven Open Reading Frames (ORFs), plays a role in both the regulation of host cell metabolism and the replication of viral genes. Despite long-term studies, the function of each ORF remains unclear. Based on our updated information, ORF2, ORF3, and ORF4 have been identified as regions with relatively high mutations compared to other ORFs in the E4 gene, through the use of in silico comparative analysis. Additionally, we managed to visualize high mutation sections, previously undetectable at the DNA level, through a powerful amino acid sequence analysis tool known as proteotyping. Our research has revealed the involvement of the E4 gene in the evolution of human adenovirus, and has established accurate sequence information of the E4 gene, laying the groundwork for further research.
-
Citations
Citations to this article as recorded by
- A novel chimpanzee-derived adenovirus, a recombinant of Mastadenovirus exoticum and Mastadenovirus blackbeardi members, reveals lineage-specific recombination hotspots in simian adenoviruses
Ereth A. Robles-Chávez, Raúl E. López, Ramón A. González, Angélica Valle-Constantino, León P. Martínez Castilla, Adan Barbosa-López, Selene Maldonado-López, Julio C. Medina Ávila, Ma Isabel Salazar, Arturo Reyes-Sandoval, Jesús M. Torres-Flores
Virology.2026; 618: 110855. CrossRef - Commentary: E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection
Masoud Nateqi, Vijay Hegde, Nikhil V. Dhurandhar
Frontiers in Virology.2026;[Epub] CrossRef - Exploration of genes and identification of evolutionary evidence in adeno-associated viruses
Chanhee Lee, Jihong Min, Somin Lim, Anyeseu Park, Seokjin Kwak, Soyeon Hwang, Sooyeon Park, Yong-Suk Jang, Se-Yeoun Cha, Sung-Gook Cho, Jeong Yoon Lee
Journal of Microbiology.2026; 64(2): e2511016. CrossRef
- A novel chimpanzee-derived adenovirus, a recombinant of Mastadenovirus exoticum and Mastadenovirus blackbeardi members, reveals lineage-specific recombination hotspots in simian adenoviruses
First
Prev
TOP
