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- Metabolic Interaction Between Host and the Gut Microbiota During High‑Fat Diet‑Induced Colorectal Cancer
- Chaeeun Lee, Seungrin Lee, Woongjae Yoo
- J. Microbiol. 2024;62(3):153-165. Published online April 16, 2024
- DOI: https://doi.org/10.1007/s12275-024-00123-2
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- 3 Download
- 6 Web of Science
- 6 Crossref
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Abstract
- Colorectal cancer (CRC) is the second-highest cause of cancer-associated mortality among both men and women worldwide. One of the risk factors for CRC is obesity, which is correlated with a high-fat diet prevalent in Western dietary habits. The association between an obesogenic high-fat diet and CRC has been established for several decades; however, the mechanisms by which a high-fat diet increases the risk of CRC remain unclear. Recent studies indicate that gut microbiota strongly infuence the pathogenesis of both high-fat diet-induced obesity and CRC. The gut microbiota is composed of hundreds of bacterial species, some of which are implicated in CRC. In particular, the expansion of facultative anaerobic Enterobacteriaceae, which is considered a microbial signature of intestinal microbiota functional imbalance (dysbiosis), is associated with both high-fat diet-induced obesity and CRC. Here, we review the interaction between the gut microbiome and its metabolic byproducts in the context of colorectal cancer (CRC) during high-fat diet-induced obesity. In addition, we will cover how a high-fat diet can drive the expansion of genotoxin-producing Escherichia coli by altering intestinal epithelial cell metabolism during gut infammation conditions.
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Citations
Citations to this article as recorded by
- Wheat β-glucan reduces obesity and hyperlipidemia in mice with high-fat and high-salt diet by regulating intestinal flora
Min Li, Qingshan Wang, Xiuwei Zhang, Kaikai Li, Meng Niu, Siming Zhao
International Journal of Biological Macromolecules.2025; 288: 138754. CrossRef - Microbial Metabolites-induced Epigenetic Modifications for Inhibition of Colorectal Cancer: Current Status and Future Perspectives
Vaibhav Singh, Ekta Shirbhate, Rakesh Kore, Subham Vishwakarma, Shadiya Parveen, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak
Mini-Reviews in Medicinal Chemistry.2025; 25(1): 76. CrossRef - Deciphering the impact of dietary habits and behavioral patterns on colorectal cancer
Qihang Yuan, Jiahua Liu, Xinyu Wang, Chunchun Du, Yao Zhang, Lin Lin, Chengfang Wang, Zhijun Hong
International Journal of Surgery.2025; 111(3): 2603. CrossRef - Molecular Mechanisms of Skatole-Induced Inflammatory Responses in Intestinal Epithelial Caco-2 Cells: Implications for Colorectal Cancer and Inflammatory Bowel Disease
Katsunori Ishii, Kazuma Naito, Dai Tanaka, Yoshihito Koto, Koichi Kurata, Hidehisa Shimizu
Cells.2024; 13(20): 1730. CrossRef - Research Progress on the Relationship between Intestinal Flora and Gastrointestinal Malignancy
军 陈
Advances in Clinical Medicine.2024; 14(11): 262. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- Wheat β-glucan reduces obesity and hyperlipidemia in mice with high-fat and high-salt diet by regulating intestinal flora
- Rediscovery of antimicrobial peptides as therapeutic agents
- Minkyung Ryu , Jaeyeong Park , Ji-Hyun Yeom , Minju Joo , Kangseok Lee
- J. Microbiol. 2021;59(2):113-123. Published online February 1, 2021
- DOI: https://doi.org/10.1007/s12275-021-0649-z
- 54 View
- 0 Download
- 26 Web of Science
- 28 Crossref
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Abstract
- In recent years, the occurrence of antibiotic-resistant pathogens is increasing rapidly. There is growing concern as the development of antibiotics is slower than the increase in the resistance of pathogenic bacteria. Antimicrobial peptides (AMPs) are promising alternatives to antibiotics. Despite their name, which implies their antimicrobial activity, AMPs have recently been rediscovered as compounds having antifungal, antiviral, anticancer, antioxidant, and insecticidal effects. Moreover, many AMPs are relatively safe from toxic side effects and the generation of resistant microorganisms due to their target specificity and complexity of the mechanisms underlying their action. In this review, we summarize the history, classification, and mechanisms of action of AMPs, and provide descriptions of AMPs undergoing clinical trials. We also discuss the obstacles associated with the development of AMPs as therapeutic agents and recent strategies formulated to circumvent these obstacles.
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Citations
Citations to this article as recorded by- A stitch in time: Sustainable and eco-friendly solutions for kiwifruit bacterial canker
Muhammad Asif, Shuang Liang, Hu RenJian, Xin Xie, Zhibo Zhao
Physiological and Molecular Plant Pathology.2025; 136: 102506. CrossRef - Mechanistic insights on the antibacterial action of the kyotorphin peptide derivatives revealed by in vitro studies and Galleria mellonella proteomic analysis
Vitor M. de Andrade, Vitor D.M. de Oliveira, Uilla Barcick, Vasanthakumar G. Ramu, Montserrat Heras, Eduard R. Bardají, Miguel A.R.B. Castanho, André Zelanis, Aline Capella, Juliana C. Junqueira, Katia Conceição
Microbial Pathogenesis.2024; 189: 106607. CrossRef - Antimicrobial Peptides Derived from Bacteria: Classification, Sources, and Mechanism of Action against Multidrug-Resistant Bacteria
Raynichka Mihaylova-Garnizova, Slavena Davidova, Yordan Hodzhev, Galina Satchanska
International Journal of Molecular Sciences.2024; 25(19): 10788. CrossRef - A Zeolitic Imidazolate Framework-Based Antimicrobial Peptide Delivery System with Enhanced Anticancer Activity and Low Systemic Toxicity
Jingwen Jiang, Kaderya Kaysar, Yanzhu Pan, Lijie Xia, Jinyao Li
Pharmaceutics.2024; 16(12): 1591. CrossRef - Enhancing Antimicrobial Peptide Activity through Modifications of Charge, Hydrophobicity, and Structure
Przemysław Gagat, Michał Ostrówka, Anna Duda-Madej, Paweł Mackiewicz
International Journal of Molecular Sciences.2024; 25(19): 10821. CrossRef - Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs)
Cédric Couturier, Quentin Ronzon, Giulia Lattanzi, Iain Lingard, Sebastien Coyne, Veronique Cazals, Nelly Dubarry, Stephane Yvon, Corinne Leroi-Geissler, Obdulia Rabal Gracia, Joanne Teague, Sylvie Sordello, David Corbett, Caroline Bauch, Chantal Monlong,
European Journal of Medicinal Chemistry.2024; 265: 116097. CrossRef - Antimicrobial Peptides: The Game-Changer in the Epic Battle Against Multidrug-Resistant Bacteria
Helal F. Hetta, Nizar Sirag, Shumukh M. Alsharif, Ahmad A. Alharbi, Tala T. Alkindy, Alanoud Alkhamali, Abdullah S. Albalawi, Yasmin N. Ramadan, Zainab I. Rashed, Fawaz E. Alanazi
Pharmaceuticals.2024; 17(11): 1555. CrossRef - Proteomic and antimicrobial peptide analyses of Buffalo colostrum and mature Milk whey: A comparative study
Runfeng Liu, Yuan Yang, Yue Zhang, Qinqiang Sun, Pingchuan Zhu, Huiyan Xu, Wei Zheng, Yangqing Lu, Qiang Fu
Food Chemistry.2024; 448: 139119. CrossRef - Contemporary Insights into Non-typhoidal Salmonella: Understanding the Pathogenicity, Infection Mechanisms, and Strategies for Prevention and Control
Minho Lee
Journal of Bacteriology and Virology.2024; 54(4): 247. CrossRef - Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins
Daniel Balleza
The Journal of Membrane Biology.2023; 256(4-6): 317. CrossRef - Evaluation of glycyl-arginine and lysyl-aspartic acid dipeptides for their antimicrobial, antibiofilm, and anticancer potentials
Handan Sevim Akan, Gülcan Şahal, Tuğçe Deniz Karaca, Özer Aylin Gürpınar, Meltem Maraş, Alev Doğan
Archives of Microbiology.2023;[Epub] CrossRef - The biological role of charge distribution in linear antimicrobial peptides
Harry Morales Duque, Gisele Rodrigues, Lucas Souza Santos, Octávio Luiz Franco
Expert Opinion on Drug Discovery.2023; 18(3): 287. CrossRef - Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant Pathogens
Walaa K. Mousa, Rose Ghemrawi, Tareq Abu-Izneid, Azza Ramadan, Farah Al-Marzooq
International Journal of Molecular Sciences.2023; 24(8): 6901. CrossRef - An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing
Tianqi Feng, Hongyan Wu, Wendi Ma, Zhaoguo Wang, Chunli Wang, Yilong Wang, Siyao Wang, Mei Zhang, Linlin Hao
Journal of Materials Chemistry B.2022; 10(32): 6143. CrossRef - Dissecting the relationship between antimicrobial peptides and mesenchymal stem cells
Amandda Évelin Silva-Carvalho, Marlon Henrique Cardoso, Thuany Alencar-Silva, Gabriela Muller Reche Bogéa, Juliana Lott Carvalho, Octávio Luiz Franco, Felipe Saldanha-Araujo
Pharmacology & Therapeutics.2022; 233: 108021. CrossRef - A Solid Support‐Based Synthetic Strategy for the Site‐Selective Functionalization of Peptides with Organometallic Half‐Sandwich Moieties
Dianna Truong, Nelson Y. S. Lam, Meder Kamalov, Mie Riisom, Stephen M. F. Jamieson, Paul W. R. Harris, Margaret A. Brimble, Nils Metzler‐Nolte, Christian G. Hartinger
Chemistry – A European Journal.2022;[Epub] CrossRef - Bacteria-derived chimeric toxins as potential anticancer agents
Saeed Khoshnood, Hadis Fathizadeh, Foroogh Neamati, Babak Negahdari, Piyush Baindara, Mohd Azmuddin Abdullah, Mohammad Hossein Haddadi
Frontiers in Oncology.2022;[Epub] CrossRef - Identification of antimicrobial peptides from the human gut microbiome using deep learning
Yue Ma, Zhengyan Guo, Binbin Xia, Yuwei Zhang, Xiaolin Liu, Ying Yu, Na Tang, Xiaomei Tong, Min Wang, Xin Ye, Jie Feng, Yihua Chen, Jun Wang
Nature Biotechnology.2022; 40(6): 921. CrossRef - Anticancer Peptide Prediction via Multi-Kernel CNN and Attention Model
Xiujin Wu, Wenhua Zeng, Fan Lin, Peng Xu, Xinzhu Li
Frontiers in Genetics.2022;[Epub] CrossRef - Multitalented Synthetic Antimicrobial Peptides and Their Antibacterial, Antifungal and Antiviral Mechanisms
Tania Vanzolini, Michela Bruschi, Andrea C. Rinaldi, Mauro Magnani, Alessandra Fraternale
International Journal of Molecular Sciences.2022; 23(1): 545. CrossRef - Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee
Journal of Microbiology.2022; 60(1): 128. CrossRef - Polymeric Coatings and Antimicrobial Peptides as Efficient Systems for Treating Implantable Medical Devices Associated-Infections
Irina Negut, Bogdan Bita, Andreea Groza
Polymers.2022; 14(8): 1611. CrossRef - Development of DNA aptamers specific for small therapeutic peptides using a modified SELEX method
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Journal of Microbiology.2022; 60(7): 659. CrossRef - In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid
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Frontiers in Chemistry.2021;[Epub] CrossRef - Preliminary Study on the Antibacterial and Cytotoxic Effects of the Synthetic New Peptide NJP9-A
Kai Ren, Xiumei Chi, Tiange Wu, Mujie Kan, Jiankai Liu, Jiayue Cui
International Journal of Peptide Research and Therapeutics.2021; 27(4): 2199. CrossRef - Lysozyme-like Protein Produced by Bifidobacterium longum Regulates Human Gut Microbiota Using In Vitro Models
Mingzhu Du, Xinqiang Xie, Shuanghong Yang, Ying Li, Tong Jiang, Juan Yang, Longyan Li, Yunxiao Huang, Qingping Wu, Wei Chen, Jumei Zhang
Molecules.2021; 26(21): 6480. CrossRef - Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome
Pasquale Marrazzo, Valeria Pizzuti, Silvia Zia, Azzurra Sargenti, Daniele Gazzola, Barbara Roda, Laura Bonsi, Francesco Alviano
Antibiotics.2021; 10(7): 750. CrossRef - Therapeutic Effect of an Antibody-Derived Peptide in a Galleria mellonella Model of Systemic Candidiasis
Emerenziana Ottaviano, Elisa Borghi, Laura Giovati, Monica Falleni, Delfina Tosi, Walter Magliani, Giulia Morace, Stefania Conti, Tecla Ciociola
International Journal of Molecular Sciences.2021; 22(20): 10904. CrossRef
- A stitch in time: Sustainable and eco-friendly solutions for kiwifruit bacterial canker
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