MSK
Search
- Page Path
- HOME > Search
Journal Article
- Caspase-3 inhibitor inhibits enterovirus D68 production
- Wenbo Huo , Jinghua Yu , Chunyu Liu , Ting Wu , Yue Wang , Xiangling Meng , Fengmei Song , Shuxia Zhang , Ying Su , Yumeng Liu , Jinming Liu , Xiaoyan Yu , Shucheng Hua
- J. Microbiol. 2020;58(9):812-820. Published online September 1, 2020
- DOI: https://doi.org/10.1007/s12275-020-0241-y
- 63 View
- 0 Download
- 8 Web of Science
- 8 Crossref
-
Abstract
- Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.
-
Citations
Citations to this article as recorded by
- Non-Polio Enterovirus Inhibitors: Scaffolds, Targets, and Potency─What’s New?
Hugo Fernando Georges Roux, Franck Touret, Pascal Rathelot, Pietro Sciò, Antonio Coluccia, Patrice Vanelle, Manon Roche
ACS Infectious Diseases.2024;[Epub] CrossRef - Mode of cell death in the penile cavernous tissue of type 1 diabetes mellitus rats
Jing Li, Qilan Jiang, Jun Jiang, Rui Jiang
The Journal of Sexual Medicine.2024; 21(8): 652. CrossRef - MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions
Yayun Chen, Qian Jiang, Furong Qing, Junxia Xue, Qiuxiang Xiao, Wenji He, Lina Sui, Zhiping Liu
Inflammation.2024; 47(1): 191. CrossRef - Caspase-8 activation regulates enterovirus D68 infection-induced inflammatory response and cell death
Yuanyuan Zhou, Chongtao Zhang, Yuhan Zhang, Fei Li, Jun Shen
Biosafety and Health.2024; 6(3): 171. CrossRef - Enterovirus D68 Infection Induces TDP-43 Cleavage, Aggregation, and Neurotoxicity
Lili Zhang, Jiaxin Yang, Huili Li, Zhe Zhang, Zhilin Ji, Lirong Zhao, Wei Wei, Rebecca Ellis Dutch
Journal of Virology.2023;[Epub] CrossRef - Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway
Ying Su, Ting Wu, Xiao-Yan Yu, Wen-Bo Huo, Shao-Hua Wang, Chen Huan, Yu-Meng Liu, Jin-Ming Liu, Min-Na Cui, Xin-Hua Li, Jing-Hua Yu
Phytomedicine.2022; 99: 153977. CrossRef - Urolithin A inhibits enterovirus 71 replication and promotes autophagy and apoptosis of infected cells in vitro
Shengyu Wang, Junhua Qiao, Yaping Chen, Langfei Tian, Xin Sun
Archives of Virology.2022; 167(10): 1989. CrossRef - Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection
Aijiao Gao, Huixin Tang, Qian Zhang, Ruiqing Liu, Lin Wang, Yashan Liu, Zhi Qi, Yanna Shen
Journal of Microbiology.2021; 59(7): 681. CrossRef
- Non-Polio Enterovirus Inhibitors: Scaffolds, Targets, and Potency─What’s New?
First
Prev
TOP
