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- Direct current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport
- Peihui Zou , Peng Li , Jia Liu , Pei Cao , Qingxian Luan
- J. Microbiol. 2022;60(1):70-78. Published online November 26, 2021
- DOI: https://doi.org/10.1007/s12275-022-1238-5
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- 7 Web of Science
- 7 Crossref
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Abstract
- Low electric current can inhibit certain microbial biofilms and enhance the efficacy of antimicrobials against them. This study investigated the electricidal and bioelectric effects of direct current (DC) against Porphyromonas gingivalis biofilms as well as the underlying mechanisms. Here, we firstly showed that DC significantly suppressed biofilm formation of P. gingivalis in time- and intensity-dependent manners, and markedly inhibited preformed P. gingivalis biofilms. Moreover, DC enhanced the killing efficacy of metronidazole (MTZ) and amoxicillin with clavulanate potassium (AMC) against the biofilms. Notably, DC-treated biofilms displayed upregulated intracellular ROS and expression of ROS related genes (sod, feoB, and oxyR) as well as porin gene. Interestingly, DC-induced killing of biofilms was partially reversed by ROS scavenger N-dimethylthiourea (DMTU), and the synergistic effect of DC with MTZ/AMC was weakened by small interfering RNA of porin gene (si-Porin). In conclusion, DC can exert electricidal and bioelectric effects against P. gingivalis biofilms partially via promotion of oxidative stress and antibiotic transport, which offers a promising approach for effective management of periodontitis.
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Citations
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Bioactive Materials.2023; 24: 1. CrossRef - Molecular Study of Porphyromonas Gingivalis Strains With fimA Genotypes in Periodontitis Patients
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Journal of Controlled Release.2023; 353: 350. CrossRef - Weak direct current exerts synergistic effect with antibiotics and reduces the antibiotic resistance: An in vitro subgingival plaque biofilm model
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Journal of Periodontal Research.2023; 58(1): 143. CrossRef - Bioelectric device for effective biofilm inflammation management of dental implants
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Scientific Reports.2023;[Epub] CrossRef - A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections
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Advanced Materials.2023;[Epub] CrossRef
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