- Environmental Adaptation of Psychrophilic Bacteria Subtercola spp. Isolated from Various Cryospheric Habitats
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Hanbyul Lee , Yong-Joon Cho , Ahnna Cho , Ok-Sun Kim
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J. Microbiol. 2023;61(7):663-672. Published online August 24, 2023
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DOI: https://doi.org/10.1007/s12275-023-00068-y
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Subtercola boreus K300T
is a novel psychrophilic strain that was isolated from permanently cold groundwater in Finland
and has also been found in several places in Antarctica including lake, soil, and rocks. We performed genomic and transcriptomic
analyses of 5 strains from Antarctica and a type strain to understand their adaptation to different environments.
Interestingly, the isolates from rocks showed a low growth rate and smaller genome size than strains from the other isolation
sources (lake, soil, and groundwater). Based on these habitat-dependent characteristics, the strains could be classified
into two ecotypes, which showed differences in energy production, signal transduction, and transcription in the clusters of
orthologous groups of proteins (COGs) functional category. In addition, expression pattern changes revealed differences
in metabolic processes, including uric acid metabolism, DNA repair, major facilitator superfamily (MFS) transporters, and
xylose degradation, depending on the nutritional status of their habitats. These findings provide crucial insights into the
environmental adaptation of bacteria, highlighting genetic diversity and regulatory mechanisms that enable them to thrive
in the cryosphere.
- A mucin-responsive hybrid two-component system controls Bacteroides thetaiotaomicron colonization and gut homeostasis
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Ju-Hyung Lee , Soo-Jeong Kwon , Ji-Yoon Han , Sang-Hyun Cho , Yong-Joon Cho , Joo-Hong Park
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J. Microbiol. 2022;60(2):215-223. Published online February 1, 2022
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DOI: https://doi.org/10.1007/s12275-022-1649-3
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377
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The mammalian intestinal tract contains trillions of bacteria.
However, the genetic factors that allow gut symbiotic bacteria
to occupy intestinal niches remain poorly understood. Here,
we identified genetic determinants required for Bacteroides
thetaiotaomicron colonization in the gut using transposon
sequencing analysis. Transposon insertion in BT2391, which
encodes a hybrid two-component system, increased the competitive
fitness of B. thetaiotaomicron. The BT2391 mutant
showed a growth advantage in a mucin-dependent manner
and had an increased ability to adhere to mucus-producing
cell lines. The increased competitive advantage of the BT2391
mutant was dependent on the BT2392–2395 locus containing
susCD homologs. Deletion of BT2391 led to changes in
the expression levels of B. thetaiotaomicron genes during gut
colonization. However, colonization of the BT2391 mutant
promoted DSS colitis in low-fiber diet-fed mice. These results
indicate that BT2391 contributes to a sustainable symbiotic
relationship by maintaining a balance between mucosal
colonization and gut homeostasis.
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Citations
Citations to this article as recorded by  - Saliva-driven surface-engineered Bacteroides thetaiotaomicron alleviates hypertension
Shuo Xu, Huilong Luo, Lin-Juan Du, Ting Dong, Lu-Jun Zhou, Bo-Yan Chen, Yu-Lin Li, Guo-Cai Tian, Xiao-Qian Meng, Xue-Bing Bai, Hui-Lin Ye, Jun Zhang, Wen-Zhen Lin, Wu-Chang Zhang, Jinyao Liu, Sheng-Zhong Duan
Bioactive Materials.2026; 57: 137. CrossRef - The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron
Ann-Sophie Rüttiger, Daniel Ryan, Luisella Spiga, Vanessa Lamm-Schmidt, Gianluca Prezza, Sarah Reichardt, Madison Langford, Lars Barquist, Franziska Faber, Wenhan Zhu, Alexander J. Westermann
Nature Communications.2025;[Epub] CrossRef - Effect of Lactobacillus plantarum BFS1243 on a female frailty model induced by fecal microbiota transplantation in germ-free mice
Sashuang Dong, Qi Zeng, Weimin He, Wei Cheng, Ling Zhang, Ruimin Zhong, Wen He, Xiang Fang, Hong Wei
Food & Function.2024; 15(8): 3993. CrossRef -
A conserved inhibitory interdomain interaction regulates DNA-binding activities of hybrid two-component systems in
Bacteroides
Rong Gao, Ti Wu, Ann M. Stock, Michael T. Laub
mBio.2024;[Epub] CrossRef - Polysaccharides from Polygonatum cyrtonema Hua prevent depression-like behaviors in mice with chronic unpredictable mild stress through refining gut microbiota-lipopolysaccharide-paraventricular nucleus signal axis
Xinya Wang, Xueqing Wang, Feng Gao, Shaojie Yang, Yilan Zhen, Xuncui Wang, Guoqi Zhu
Heliyon.2024; 10(19): e38554. CrossRef - Metal Messengers: Communication in the Bacterial World through Transition-Metal-Sensing Two-Component Systems
Alexander Paredes, Chioma Iheacho, Aaron T. Smith
Biochemistry.2023; 62(16): 2339. CrossRef - Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model
Wen Yin, Si-Qi Zhang, Wen-Lin Pang, Xiao-Jiao Chen, Jing Wen, Jiong Hou, Cui Wang, Li-Yun Song, Zhen-Ming Qiu, Peng-Tao Liang, Jia-Li Yuan, Zhong-Shan Yang, Yao Bian
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 2563. CrossRef
- The human symbiont Bacteroides thetaiotaomicron promotes diet-induced obesity by regulating host lipid metabolism
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Sang-Hyun Cho , Yong-Joon Cho , Joo-Hong Park
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J. Microbiol. 2022;60(1):118-127. Published online December 29, 2021
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DOI: https://doi.org/10.1007/s12275-022-1614-1
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469
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The gut microbiome plays an important role in lipid metabolism.
Consumption of a high-fat diet (HFD) alters the bacterial
communities in the gut, leading to metabolic disorders.
Several bacterial species have been associated with diet-induced
obesity, nonalcoholic fatty liver disease, and metabolic
syndrome. However, the mechanisms underlying the control
of lipid metabolism by symbiotic bacteria remain elusive.
Here, we show that the human symbiont Bacteroides thetaiotaomicron
aggravates metabolic disorders by promoting lipid
digestion and absorption. Administration of B. thetaiotaomicron
to HFD-fed mice promoted weight gain, elevated fasting
glucose levels, and impaired glucose tolerance. Furthermore,
B. thetaiotaomicron treatment upregulated the gene
expression of the fatty acid transporter and increased fatty
acid accumulation in the liver. B. thetaiotaomicron inhibits
expression of the gene encoding a lipoprotein lipase inhibitor,
angiopoietin-like protein 4 (ANGPTL4), thereby increasing
lipase activity in the small intestine. In particular, we found
that B. thetaiotaomicron induced the expression of hepcidin,
the master regulator of iron metabolism and an antimicrobial
peptide, in the liver. Hepcidin treatment resulted in a decrease
in ANGPTL4 expression in Caco-2 cells, whereas treatment
with an iron chelator restored ANGPTL4 expression in hepcidin-
treated cells. These results indicate that B. thetaiotaomicron-
mediated regulation of iron storage in intestinal epithelial
cells may contribute to increased fat deposition and
impaired glucose tolerance in HFD-fed mice.
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Citations
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Food Research International.2025; 206: 116101. CrossRef - Investigating Polyreactivity of CD4+ T Cells to the Intestinal Microbiota
Ahmed Saadawi, Florian Mair, Esther Rosenwald, Daniel Hoces, Emma Slack, Manfred Kopf
European Journal of Immunology.2025;[Epub] CrossRef - Three Kampo medicines—bofutsushosan, boiogito, and daisaikoto—have different effects on host fat accumulation and the intestinal microbiota in a high-fat-diet–induced mouse model of obesity
Kosuke Nakamichi, Tetsuhiro Yoshino, Masahiro Akiyama, Aya Jibiki, Yuta Yokoyama, Hitoshi Kawazoe, Sayo Suzuki, Kenji Watanabe, Yun-Gi Kim, Tomonori Nakamura
Journal of Natural Medicines.2025; 79(5): 1044. CrossRef - Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up
Brooke C. Wilson, Michele Zuppi, José G. B. Derraik, Benjamin B. Albert, Ry Y. Tweedie-Cullen, Karen S. W. Leong, Kathryn L. Beck, Tommi Vatanen, Justin M. O’Sullivan, Wayne S. Cutfield, Benjamin Albert, Kathryn Beck, Valentina Chiavaroli, Cathryn Conlon,
Nature Communications.2025;[Epub] CrossRef - Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome
Babi Dutta, Aparna Tripathy, P. R. Archana, Shobha U. Kamath
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef - High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis
Xiaoshan Huang, Xiaopeng Tang, Qiuyue He, Dawit Adisu Tadese, Kaixun Cao, Jinai Gao, Qiuyue Xu, Ruomei Cheng, Qiumin Lu, Yifan Chen, Min Yang, Yan Du, James Mwangi, Heyu Ni, Ren Lai
Cell Reports Medicine.2025; 6(8): 102260. CrossRef - Effects of dietary lipid and protein levels on metamorphosis, growth, metabolism and gut microbiota of tadpole (Lithobates catesbeianus)
Bo Zhu, Lei Zhong, Chuang Shao, Wenjie Xu, Shuhui Xiang, Shuiquan Fu, Yi Hu
Aquaculture.2024; 587: 740900. CrossRef - Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice
Jennifer Lee, Kerry Wellenstein, Ali Rahnavard, Andrew T. Nelson, Marlena M. Holter, Bethany P. Cummings, Vladimir Yeliseyev, Angela Castoldi, Clary B. Clish, Lynn Bry, Dionicio Siegel, Barbara B. Kahn
Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef - Anti-obesity activity of human gut microbiota Bacteroides stercoris KGMB02265
Seoung Woo Ryu, Jeong Chan Moon, Byeong Seob Oh, Seung Yeob Yu, Jeong Eun Bak, Eun Seo Heo, Jae-Ho Jeong, Ju Huck Lee
Archives of Microbiology.2024;[Epub] CrossRef -
Bacteroides thetaiotaomicron
ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids metabolism
Hu Li, Xue-Kai Wang, Mei Tang, Lei Lei, Jian-Rui Li, Han Sun, Jing Jiang, Biao Dong, Hong-Ying Li, Jian-Dong Jiang, Zong-Gen Peng
Gut Microbes.2024;[Epub] CrossRef - Gut microbiota and metabolic modulation by supplementation of polysaccharide-producing Bacillus licheniformis from Tibetan Yaks: A comprehensive multi-omics analysis
Zhibo Zeng, Chuxian Quan, Shimeng Zhou, Saisai Gong, Mudassar Iqbal, Muhammad Fakhar-e-Alam Kulyar, Shah Nawaz, Kewei Li, Jiakui Li
International Journal of Biological Macromolecules.2024; 254: 127808. CrossRef - Insights from metagenomics into gut microbiome associated with acute coronary syndrome therapy
Yuee Guan, Shuru Zhao, Jing Li, Wenqian Zhang, Zhonghao Guo, Yi Luo, Xiaofei Jiang, Jun Li, Jianxiong Liu, Xi Chen, Zicheng Zhao, Zhe Zhang
Frontiers in Microbiology.2024;[Epub] CrossRef - Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes
Martin Šimon, Špela Mikec, Santosh S. Atanur, Janez Konc, Nicholas M. Morton, Simon Horvat, Tanja Kunej
Genes & Genomics.2024; 46(5): 557. CrossRef - Extract of Gardenia jasminoides Ellis Attenuates High-Fat Diet-Induced Glycolipid Metabolism Disorder in Rats by Targeting Gut Microbiota and TLR4/Myd88/NF-κB Pathway
Chenghao Lv, Xin Liu, Shiyun Chen, Yuhang Yi, Xinnian Wen, Tao Li, Si Qin
Antioxidants.2024; 13(3): 293. CrossRef - A microbial causal mediation analytic tool for health disparity and applications in body mass index
Chan Wang, Jiyoung Ahn, Thaddeus Tarpey, Stella S. Yi, Richard B. Hayes, Huilin Li
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Hwan-Hee Jang, Hwayoung Noh, Gichang Kim, Su-Yeon Cho, Hyeon-Jeong Kim, Jeong-Sook Choe, Jeongseon Kim, Augustin Scalbert, Marc J. Gunter, Oran Kwon, Hyesook Kim
Frontiers in Nutrition.2023;[Epub] CrossRef - Impact of diet and host genetics on the murine intestinal mycobiome
Yask Gupta, Anna Lara Ernst, Artem Vorobyev, Foteini Beltsiou, Detlef Zillikens, Katja Bieber, Simone Sanna-Cherchi, Angela M. Christiano, Christian D. Sadik, Ralf J. Ludwig, Tanya Sezin
Nature Communications.2023;[Epub] CrossRef - Effects of OsomeFood Clean Label plant-based meals on the gut microbiome
Dwiyanto Jacky, Chia Bibi, Look Melvin Chee Meng, Fong Jason, Tan Gwendoline, Lim Jeremy, Chong Chun Wie
BMC Microbiology.2023;[Epub] CrossRef - Consumption of Antioxidant-Rich “Cerrado” Cashew Pseudofruit Affects Hepatic Gene Expression in Obese C57BL/6J High Fat-Fed Mice
Mariana Buranelo Egea, Gavin Pierce, Si-Hong Park, Sang-In Lee, Fabienne Heger, Neil Shay
Foods.2022; 11(17): 2543. CrossRef - Host—microbial interactions in metabolic diseases: from diet to immunity
Ju-Hyung Lee, Joo-Hong Park
Journal of Microbiology.2022; 60(6): 561. CrossRef
- Regulation of iron homeostasis by peroxide-sensitive CatR, a Fur-family regulator in Streptomyces coelicolor
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Yeonbum Kim , Jung-Hye Roe , Joo-Hong Park , Yong-Joon Cho , Kang-Lok Lee
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J. Microbiol. 2021;59(12):1083-1091. Published online December 4, 2021
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DOI: https://doi.org/10.1007/s12275-021-1457-1
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379
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Abstract
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CatR, a peroxide-sensing transcriptional repressor of Fur
family, can de-repress the transcription of the catA gene encoding
catalase upon peroxide stress in Streptomyces coelicolor.
Since CatR-regulated genes other than catA and its own
gene catR have not been identified in detail, the understanding
of the role of CatR regulon is very limited. In this study,
we performed transcriptomic analysis to identify genes influenced
by both atR mutation and hydrogen peroxide treatment.
Through ChIP-qPCR and other analyses, a new consensus
sequence was found in CatR-responsive promoter region
of catR gene and catA operon for direct regulation. In
addition, vtlA (SCO2027) and SCO4983 were identified as new
members of the CatR regulon. Expression levels of iron uptake
genes were reduced by hydrogen peroxide and a DmdR1 binding
sequence was identified in promoters of these genes. The
increase in free iron by hydrogen peroxide was thought to
suppress the iron import system by DmdR1. A putative exporter
protein VtlA regulated by CatR appeared to reduce intracellular
iron to prevent oxidative stress. The name vtlA
(VIT1-like transporter) was proposed for iron homeostasis
related gene SCO2027.
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PLOS Biology.2025; 23(6): e3003183. CrossRef - Pirin, a redox-sensitive modulator of beta-oxidation, generates hydroxyl radicals and interacts with CatR, the transcriptional repressor of the major vegetative catalase gene in Streptomyces
Matteo Calcagnile, Fabrizio Damiano, Adelfia Talà, Pietro Alifano
Microbiological Research.2025; 301: 128310. CrossRef -
Functional versatility of Zur in metal homeostasis, motility, biofilm formation, and stress resistance in
Yersinia pseudotuberculosis
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Streptomyces
Si-Min Fan, Ze-Qi Li, Shi-Zhe Zhang, Liang-Yu Chen, Xi-Ying Wei, Jian Liang, Xin-Qing Zhao, Chun Su, Xiao-Hua Zhang
mSystems.2023;[Epub] CrossRef - The regulatory role of Fur-encoding SCLAV_3199 in iron homeostasis in Streptomyces clavuligerus
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