Journal of Microbiology

Nancy P. Keller

3 Articles

Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model: Katherine D. Mueller , Hao Zhang , Christian R. Serrano , R. Blake Billmyre , Eun Young Huh , Philipp Wiemann , Nancy P. Keller , Yufeng Wang , Joseph Heitman , Soo Chan Lee; J. Microbiol. 2019;57(6):509-520. Published online May 27, 2019; DOI: https://doi.org/10.1007/s12275-019-8682-x

1,066 View
3 Download
23 Web of Science
22 Crossref

Mucor circinelloides is a pathogenic fungus and etiologic agent of mucormycosis. In 2013, cases of gastrointestinal illness after yogurt consumption were reported to the US FDA, and the producer found that its products were contaminated with Mucor. A previous study found that the Mucor strain isolated from an open contaminated yogurt exhibited virulence in a murine systemic infection model and showed that this strain is capable of surviving passage through the gastrointestinal tract of mice. In this study, we isolated another Mucor strain from an unopened yogurt that is closely related but distinct from the first Mucor strain and subsequently examined if Mucor alters the gut microbiota in a murine host model. DNA extracted from a ten-day course of stool samples was used to analyze the microbiota in the gastrointestinal tracts of mice exposed via ingestion of Mucor spores. The bacterial 16S rRNA gene and fungal ITS1 sequences obtained were used to identify taxa of each kingdom. Linear regressions revealed that there are changes in bacterial and fungal abundance in the gastrointestinal tracts of mice which ingested Mucor. Furthermore, we found an increased abundance of the bacterial genus Bacteroides and a decreased abundance of the bacteria Akkermansia muciniphila in the gastrointestinal tracts of exposed mice. Measurements of abundances show shifts in relative levels of multiple bacterial and fungal taxa between mouse groups. These findings suggest that exposure of the gastrointestinal tract to Mucor can alter the microbiota and, more importantly, illustrate an interaction between the intestinal mycobiota and bacteriota. In addition, Mucor was able to induce increased permeability in epithelial cell monolayers in vitro, which might be indicative of unstable intestinal barriers. Understanding how the gut microbiota is shaped is important to understand the basis of potential methods of treatment for gastrointestinal illness. How the gut microbiota changes in response to exposure, even by pathogens not considered to be causative agents of food-borne illness, may be important to how commercial food producers prevent and respond to contamination of products aimed at the public. This study provides evidence that the fungal microbiota, though understudied, may play an important role in diseases of the human gut.

Citations

Citations to this article as recorded by

Two decades of mucormycosis: molecular epidemiology and antifungal susceptibility trends in Türkiye
Ayşen İkkan, Osman Merdan, Seçil Ak-Aksoy, Zeinep Chavouz Ametoglou, İmran Sağlık, Hazel Öztürk-Belik, Büşra Çalışır, Özlem Saraydaroğlu, Samet Kızıl, Beyhan Bülbül, Esra Kazak, Beyza Ener
Frontiers in Cellular and Infection Microbiology.2026;[Epub] CrossRef
Microbe on the move: Akkermansia in infectious diseases and emerging roles in gynecological health
Stephanie M. Marroquin, Kelly S. Doran, Michael Y. Galperin
Journal of Bacteriology.2026;[Epub] CrossRef
Yeasts in the gastrointestinal tract
Katherine D Mueller, Soo Chan Lee, Jung Won Hee
FEMS Yeast Research.2026;[Epub] CrossRef
Cytokine Profile and Oxidative Patterns in Murine Models of Disseminated Infection by Mucorales Species
Hiram Villanueva-Lozano, Martín García-Juárez, Adrián G. Rosas-Taraco, Rogelio de J. Treviño-Rangel, Gloria M. González
Pathogens.2025; 14(10): 1036. CrossRef
Towards a green climate: Production of slag–red brick waste-based geopolymer mingled with WO3 nanoparticles with bio-mechanical achievements
Mostafa.A. Sayed, S.M.A. El-Gamal, Alaa Mohsen, M. Ramadan, Mona M. Wetwet, Noha M. Deghiedy, Ahmed E. Swilem, M.M. Hazem
Construction and Building Materials.2024; 413: 134909. CrossRef
Interactions among microorganisms open up a new world for anti‐infectious therapy
Yejia Zhang, Hanchi Zhang, Tian Xu, Lingbing Zeng, Fadi Liu, Xiaotian Huang, Qiong Liu
The FEBS Journal.2024; 291(8): 1615. CrossRef
Different fungal signatures in ALD and MAFLD
Daya Zhang, Qi Wang, Da Li, Chen Chen, Yanting Lv, Shimei Huang, Fan Zeng, Xianfeng Huang, Fengjiao Mao, Feihu Bai
Frontiers in Microbiology.2024;[Epub] CrossRef
Interaction between intestinal mycobiota and microbiota shapes lung inflammation
Youxia Wang, Fang He, Bingnan Liu, Xiaoyan Wu, Ziyi Han, Xuefei Wang, Yuexia Liao, Jielin Duan, Wenkai Ren
iMeta.2024;[Epub] CrossRef
Characterisation of the surface growth of Mucor circinelloides in cheese agar media using predictive mathematical models
Martina Koňuchová, Agáta Boháčiková, Ľubomír Valík
Heliyon.2024; 10(9): e30812. CrossRef
Landscape of the gut mycobiome dynamics during pregnancy and its relationship with host metabolism and pregnancy health
Yuanqing Fu, Wanglong Gou, Ping Wu, Yuwei Lai, Xinxiu Liang, Ke Zhang, Menglei Shuai, Jun Tang, Zelei Miao, Jieteng Chen, Jiaying Yuan, Bin Zhao, Yunhaonan Yang, Xiaojuan Liu, Yayi Hu, An Pan, Xiong-Fei Pan, Ju-Sheng Zheng
Gut.2024; 73(8): 1302. CrossRef
Mapping the human oral and gut fungal microbiota in patients with metabolic dysfunction-associated fatty liver disease
Chenguang Niu, Ye Tu, Qiaoqiao Jin, Zhanyi Chen, Keyong Yuan, Min Wang, Pengfei Zhang, Junyuan Luo, Hao Li, Yueyi Yang, Xiaoyu Liu, Mengying Mao, Ting Dong, Wenduo Tan, Xuchen Hu, Yihuai Pan, Lili Hou, Rui Ma, Zhengwei Huang
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Exploration of mechanical performance, porous structure, and self-cleaning behavior for hydrothermally cured sustainable cementitious composites containing de-aluminated metakaolin waste and TiO2 nanoparticles
M. Ramadan, Mohamed Kohail, Aref A. Abadel, Yousef R. Alharbi, Ahmed M. Soliman, Alaa Mohsen
Journal of Materials Research and Technology.2023; 25: 3998. CrossRef
Evaluation of Mechanical Performance, Porous Structure and Self-Cleaning Behavior for Hydrothermally Cured Cementitious Composites Containing De-Aluminated Metakaolin Waste and Tio2 Nanoparticles
Alaa Mohsen, Mohamed Kohail, Aref abadel, Yousef Alharbi, Moncef L. Nehdi, Mohammed Ramadan
SSRN Electronic Journal .2022;[Epub] CrossRef
The role of gut mycobiome in health and diseases
Lin Zhang, Hui Zhan, Wenye Xu, Shuai Yan, Siew C. Ng
Therapeutic Advances in Gastroenterology.2021;[Epub] CrossRef
Mycobiome and Cancer: What Is the Evidence?
Natalia Vallianou, Dimitris Kounatidis, Gerasimos Socrates Christodoulatos, Fotis Panagopoulos, Irene Karampela, Maria Dalamaga
Cancers.2021; 13(13): 3149. CrossRef
Caenorhabditis elegans as an Infection Model for Pathogenic Mold and Dimorphic Fungi: Applications and Challenges
Chukwuemeka Samson Ahamefule, Blessing C. Ezeuduji, James C. Ogbonna, Anene N. Moneke, Anthony C. Ike, Cheng Jin, Bin Wang, Wenxia Fang
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Crossing Kingdoms: How the Mycobiota and Fungal-Bacterial Interactions Impact Host Health and Disease
William Santus, Jason R. Devlin, Judith Behnsen, Karen M. Ottemann
Infection and Immunity.2021;[Epub] CrossRef
A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides
Sandeep Vellanki, R. Blake Billmyre, Alejandra Lorenzen, Micaela Campbell, Broderick Turner, Eun Young Huh, Joseph Heitman, Soo Chan Lee, Michael Lorenz
mBio.2020;[Epub] CrossRef
From Birth and Throughout Life: Fungal Microbiota in Nutrition and Metabolic Health
William D. Fiers, Irina Leonardi, Iliyan D. Iliev
Annual Review of Nutrition.2020; 40(1): 323. CrossRef
Understanding Mucormycoses in the Age of “omics”
Alexandra Y. Soare, Tonya N. Watkins, Vincent M. Bruno
Frontiers in Genetics.2020;[Epub] CrossRef
Eukaryotic and Prokaryotic Microbiota Interactions
Aly Kodio, Estelle Menu, Stéphane Ranque
Microorganisms.2020; 8(12): 2018. CrossRef
Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides
Zanetta Chang, Joseph Heitman, Antonio Di Pietro
mBio.2019;[Epub] CrossRef

Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity: Gregory J. Fischer , Nancy P. Keller; J. Microbiol. 2016;54(3):254-264. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5620-z

1,113 View
2 Download
71 Crossref

Abstract PDF

Oxylipins are a class of molecules derived from the incorporation of oxygen into polyunsaturated fatty acid substrates through the action of oxygenases. While extensively investigated in the context of mammalian immune responses, over the last decade it has become apparent that oxylipins are a common means of communication among and between plants, animals, and fungi to control development and alter hostmicrobe interactions. In fungi, some oxylipins are derived nonenzymatically while others are produced by lipoxygenases, cyclooxygenases, and monooxygenases with homology to plant and human enzymes. Recent investigations of numerous plant and human fungal pathogens have revealed oxylipins to be involved in the establishment and progression of disease. This review highlights oxylipin production by pathogenic fungi and their role in fungal development and pathogen/ host interactions.

Citations

Citations to this article as recorded by

Catalytic and structural comparisons of linoleate dioxygenases and their cytochrome P450 companions with enzymes of the cyclooxygenase cascade
Ernst H. Oliw
Journal of Biological Chemistry.2026; 302(4): 111263. CrossRef
Metabolic profile and biological characteristics of Beauveria bassiana under chlorantraniliprole exposure
Chen Zhang, Benjin Hu, Yinhao Wang, Liaoqin Zhang, Lei Wang, Bin Teng, Song Jin
Journal of Invertebrate Pathology.2026; 218: 108672. CrossRef
Phytohormones in fungi: inter-kingdom modulators or fungal self-controlling elements?
David A. García-Estrada, Melanie Ruvalcaba-Villagrán, Axel G. Sánchez-Fonseca, Jonathan Duran-Palmerin, Juan Ornelas-Paz, Francisco Vargas-Gasca, Vianey Olmedo-Monfil, Alfredo Herrera-Estrella, Joseph Heitman
Microbiology and Molecular Biology Reviews.2026;[Epub] CrossRef
Exploring Oxylipins in Host–Microbe Interactions and Their Impact on Infection and Immunity
Robert J. Neff, Christopher D. Radka
Current Issues in Molecular Biology.2025; 47(3): 190. CrossRef
Insights into PUFA and oxylipin production from incubation of Aspergillus novoparasiticus in sugarcane juice
Augusto Leonardo dos Santos, Marcelo José Pena Ferreira, Patricia Sartorelli, Josué José da Silva, Beatriz Thie Iamanaka, Jens Christian Frisvad, Marta Hiromi Taniwaki
Food Chemistry.2025; 473: 143051. CrossRef
Structural comparisons of bifunctional fatty acid dioxygenases with allene oxide, epoxy alcohol, or diol synthase activities
Ernst H. Oliw
Archives of Biochemistry and Biophysics.2025; 771: 110490. CrossRef
Fatty acids in filamentous pathogenic fungi: Multidimensional regulation and pathogenic mechanisms
Haiyan Lin, Yuejin Peng
Virulence.2025;[Epub] CrossRef
Catalytic and structural comparisons of fatty acid dioxygenases related to cyclooxygenases and peroxidases
Ernst H. Oliw
Archives of Biochemistry and Biophysics.2025; 773: 110574. CrossRef
Organ-specific genetic and metabolic mechanisms underlying grapevine resistance to Botrytis cinerea
Yanqiu Shen, Yaping Tian, Yichu Zhang, Min Bao, Shaoqiang Cui, Jinling Zheng, Bingcan Sun, Yingyao Liu, Zhi Li, Yijie Zhao, Xiping Wang
Horticultural Plant Journal.2025;[Epub] CrossRef
Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway
Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang
Cellular and Molecular Life Sciences.2024;[Epub] CrossRef
Physiological response of Metarhizium rileyi with linoleic acid supplementation
Leidy Esther Sánchez-Rey, Nubia Moreno-Sarmiento, Erika Paola Grijalba-Bernal, Ginna Quiroga-Cubides
Fungal Biology.2024; 128(4): 1827. CrossRef
The gut-lung axis: the impact of the gut mycobiome on pulmonary diseases and infections
Emily A Sey, Adilia Warris
Oxford Open Immunology.2024;[Epub] CrossRef
The volatile components from Bacillus cereus N4 can restrain brown rot of peach fruit by inhibiting sporulation of Monilinia fructicola and inducing disease resistance
Yingying Shi, Song Zhang, Jinghan Zhang, Xiaorui Wang, Yuan He, Xiongde Han, Zunyang Song, Jingying Shi
Postharvest Biology and Technology.2024; 210: 112755. CrossRef
Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology
Kar On Cheng, Dolly E Montaño, Teresa Zelante, Axel Dietschmann, Mark S Gresnigt
Oxford Open Immunology.2024;[Epub] CrossRef
Trichoderma longibrachiatum’s Secondary Metabolite-A Review on Potential Compounds for Plant Growth and Biological Control for Plant Pathogens
Priya Ramasamy, Balachandar Subbu, Prabhakaran Narayanasamy
Asian Journal of Biological Sciences.2023; 16(3): 202. CrossRef
Mutational Analysis of Aspergillus fumigatus Volatile Oxylipins in a Drosophila Eclosion Assay
Hadeel S. Almaliki, Mengyao Niu, Nancy P. Keller, Guohua Yin, Joan W. Bennett
Journal of Fungi.2023; 9(4): 402. CrossRef
Plant Host Traits Mediated by Foliar Fungal Symbionts and Secondary Metabolites
Moriah Sandy, Tina I. Bui, Kenia Segura Abá, Nestor Ruiz, John Paszalek, Elise W. Connor, Christine V. Hawkes
Microbial Ecology.2023; 86(1): 408. CrossRef
Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen
Yi Ding, Donald M. Gardiner, Kemal Kazan
Microbiological Research.2022; 256: 126951. CrossRef
Phenotypic plasticity of Monilinia spp. in response to light wavelengths: From in vitro development to virulence on nectarines
Lucía Verde-Yáñez, Núria Vall-llaura, Josep Usall, Neus Teixidó, Rosario Torres
International Journal of Food Microbiology.2022; 373: 109700. CrossRef
Light and mycelial injury influences the volatile and non-volatile metabolites and the biocontrol properties of Trichoderma atroviride
Hexon Angel Contreras-Cornejo, Omar Orozco-Granados, Arturo Ramírez-Ordorica, Perla García-Juárez, José López-Bucio, Lourdes Macías-Rodríguez
Rhizosphere.2022; 22: 100511. CrossRef
Editorial: Lipid metabolism and membrane structure in plant biotic interactions
Fiona L. Goggin, Jyoti Shah, Glenda Gillaspy
Frontiers in Plant Science.2022;[Epub] CrossRef
Biotic stress caused by in vitro co-inoculation enhances the expression of acetylcholinesterase inhibitors by fungi
Geane Pereira de Oliveira, Debora Luiza Costa Barreto, Mauro Ramalho Silva, Rodinei Augusti, Ivanildo Evódio Marriel, Ubiraci Gomes de Paula Lana, Jacqueline Aparecida Takahashi
Natural Product Research.2022; 36(16): 4266. CrossRef
Towards understanding of fungal biocontrol mechanisms of different yeasts antagonistic to Botrytis cinerea through exometabolomic analysis
Alicia Fernandez-San Millan, Jordi Gamir, Luis Larraya, Inmaculada Farran, Jon Veramendi
Biological Control.2022; 174: 105033. CrossRef
Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin
Giuseppe Ianiri, Salomé LeibundGut-Landmann, Thomas L. Dawson
Annual Review of Microbiology.2022; 76(1): 757. CrossRef
Bacterial lipoxygenases: Biochemical characteristics, molecular structure and potential applications
Ruth Chrisnasari, Marie Hennebelle, Jean-Paul Vincken, Willem J.H. van Berkel, Tom A. Ewing
Biotechnology Advances.2022; 61: 108046. CrossRef
Mechanisms of Plant Natural Immunity and the Role of Selected Oxylipins as Molecular Mediators in Plant Protection
Piotr Barbaś, Dominika Skiba, Piotr Pszczółkowski, Barbara Sawicka
Agronomy.2022; 12(11): 2619. CrossRef
Iron and manganese lipoxygenases of plant pathogenic fungi and their role in biosynthesis of jasmonates
Ernst H. Oliw
Archives of Biochemistry and Biophysics.2022; 722: 109169. CrossRef
Eight-carbon volatiles: prominent fungal and plant interaction compounds
Kayla K Pennerman, Guohua Yin, Joan W Bennett, Maaria Rosenkranz
Journal of Experimental Botany.2022; 73(2): 487. CrossRef
Unfolded Protein Response and Scaffold Independent Pheromone MAP Kinase Signaling Control Verticillium dahliae Growth, Development, and Plant Pathogenesis
Jessica Starke, Rebekka Harting, Isabel Maurus, Miriam Leonard, Rica Bremenkamp, Kai Heimel, James W. Kronstad, Gerhard H. Braus
Journal of Fungi.2021; 7(4): 305. CrossRef
WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
Ernst H. Oliw
Fungal Genetics and Biology.2021; : 103603. CrossRef
FgPKS7 is an essential player in mating‐type‐mediated regulatory pathway required for completing sexual cycle in Fusarium graminearum
Da‐Woon Kim, Yoo‐Kyoung Shin, Sang‐Won Lee, Kanphassorn Wimonmuang, Kyo Bin Kang, Young‐Sang Lee, Sung‐Hwan Yun
Environmental Microbiology.2021; 23(4): 1972. CrossRef
Dietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits
Bharat Kapoor, Dhriti Kapoor, Shristy Gautam, Rahul Singh, Savita Bhardwaj
Current Nutrition Reports.2021; 10(3): 232. CrossRef
Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators
Jung-Ung An, Seong-Eun Kim, Deok-Kun Oh
Progress in Lipid Research.2021; 83: 101110. CrossRef
Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic
Timothy C. Cairns, Xiaomei Zheng, Ping Zheng, Jibin Sun, Vera Meyer
Journal of Fungi.2021; 7(7): 535. CrossRef
Emission of novel volatile biomarkers for wheat powdery mildew
Kamirán Áron Hamow, Zsuzsanna Ambrózy, Katalin Puskás, Imre Majláth, Mónika Cséplő, Réka Mátyus, Katalin Posta, Péter Lukács, László Sági
Science of The Total Environment.2021; 781: 146767. CrossRef
Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens
Ernst H. Oliw
Fungal Genetics and Biology.2021; 157: 103623. CrossRef
Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review
Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin
Journal of Fungi.2021; 7(8): 606. CrossRef
Fungal G-Protein-Coupled Receptors: A Promising Mediator of the Impact of Extracellular Signals on Biosynthesis of Ochratoxin A
Jing Gao, Xinge Xu, Kunlun Huang, Zhihong Liang
Frontiers in Microbiology.2021;[Epub] CrossRef
Eicosapolyenoic fatty acids alter oxylipin gene expression and fatty acid hydroperoxide profiles in tomato and pepper roots
Sara M. Dye, Jun Yang, Richard M. Bostock
Physiological and Molecular Plant Pathology.2020; 109: 101444. CrossRef
Molecular crosstalk between the endophyte Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum – Modulation of lipoxygenase activity and beauvericin production during the interaction
Margot Bärenstrauch, Stéphane Mann, Chloé Jacquemin, Sarra Bibi, Oum-Kalthoum Sylla, Emmanuel Baudouin, Didier Buisson, Soizic Prado, Caroline Kunz
Fungal Genetics and Biology.2020; 139: 103383. CrossRef
Fungal evolution: cellular, genomic and metabolic complexity
Miguel A. Naranjo‐Ortiz, Toni Gabaldón
Biological Reviews.2020; 95(5): 1198. CrossRef
Plant Antifungal Lectins: Mechanism of Action and Targets on Human Pathogenic Fungi
Marianela Del Rio, Laura de la Canal, Mariana Regente
Current Protein & Peptide Science.2020; 21(3): 284. CrossRef
Critical thresholds of 1-Octen-3-ol shape inter-species Aspergillus interactions modulating the growth and secondary metabolism
Digar Singh, Su Young Son, Choong Hwan Lee
Scientific Reports.2020;[Epub] CrossRef
Comparisons of the Sexual Cycles for the Coccidian Parasites Eimeria and Toxoplasma
Bruno Martorelli Di Genova, Laura J. Knoll
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef
Laminariales Host Does Impact Lipid Temperature Trajectories of the Fungal Endophyte Paradendryphiella salina (Sutherland.)
Marine Vallet, Tarik Meziane, Najet Thiney, Soizic Prado, Cédric Hubas
Marine Drugs.2020; 18(8): 379. CrossRef
Understanding Host–Pathogen Interactions in Brassica napus in the Omics Era
Ting Xiang Neik, Junrey Amas, Martin Barbetti, David Edwards, Jacqueline Batley
Plants.2020; 9(10): 1336. CrossRef
The novel bZIP transcription factor Fpo1 negatively regulates perithecial development by modulating carbon metabolism in the ascomycete fungus Fusarium graminearum
Jiyoung Shin, Duc‐Cuong Bui, Sieun Kim, So Yun Jung, Hye Jin Nam, Jae Yun Lim, Gyung Ja Choi, Yin‐Won Lee, Jung‐Eun Kim, Hokyoung Son
Environmental Microbiology.2020; 22(7): 2596. CrossRef
Co‐opting oxylipin signals in microbial disease
Mengyao Niu, Nancy P. Keller
Cellular Microbiology.2019; 21(6): e13025. CrossRef
Fathoming Aspergillus oryzae metabolomes in formulated growth matrices
Digar Singh, Sunmin Lee, Choong Hwan Lee
Critical Reviews in Biotechnology.2019; 39(1): 35. CrossRef
Metabolomic variation in wild and cultured cordyceps and mycelia of Isaria cicadae
Yaqiong He, Wancun Zhang, Fan Peng, Ruili Lu, Hong Zhou, Guanhu Bao, Bin Wang, Bo Huang, Zengzhi Li, Fenglin Hu
Biomedical Chromatography.2019;[Epub] CrossRef
An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere
Svetlana Pakhomova, William E. Boeglin, David B. Neau, Sue G. Bartlett, Alan R. Brash, Marcia E. Newcomer
Protein Science.2019; 28(5): 920. CrossRef
Differential expression analysis of Trichoderma virens RNA reveals a dynamic transcriptome during colonization of Zea mays roots
Elizabeth A. Malinich, Ken Wang, Prasun K. Mukherjee, Michael Kolomiets, Charles M. Kenerley
BMC Genomics.2019;[Epub] CrossRef
Carbohydrate, glutathione, and polyamine metabolism are central to Aspergillus flavus oxidative stress responses over time
Jake C. Fountain, Liming Yang, Manish K. Pandey, Prasad Bajaj, Danny Alexander, Sixue Chen, Robert C. Kemerait, Rajeev K. Varshney, Baozhu Guo
BMC Microbiology.2019;[Epub] CrossRef
How Histone Deacetylase Inhibitors Alter the Secondary Metabolites of Botryosphaeria mamane, an Endophytic Fungus Isolated from Bixa orellana
Asih Triastuti, Marieke Vansteelandt, Fatima Barakat, Manon Trinel, Patricia Jargeat, Nicolas Fabre, Carlos A. Amasifuen Guerra, Kember Mejia, Alexis Valentin, Mohamed Haddad
Chemistry & Biodiversity.2019;[Epub] CrossRef
Disturbance in biosynthesis of arachidonic acid impairs the sexual development of the onion blight pathogen Stemphylium eturmiunum
Yanxia Zhao, Qun Wang, Shi Wang, Xiaoman Liu, Jae-HyuK Yu, Weifa Zheng, Xiuguo Zhang
Current Genetics.2019; 65(3): 759. CrossRef
Recombinant Lipoxygenases and Hydroperoxide Lyases for the Synthesis of Green Leaf Volatiles
Holly Stolterfoht, Claudia Rinnofner, Margit Winkler, Harald Pichler
Journal of Agricultural and Food Chemistry.2019; 67(49): 13367. CrossRef
Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus
Anna-Maria Dietl, Zohar Meir, Yona Shadkchan, Nir Osherov, Hubertus Haas
Virulence.2018; 9(1): 1036. CrossRef
Deciphering drought‐induced metabolic responses and regulation in developing maize kernels
Liming Yang, Jake C. Fountain, Pingsheng Ji, Xinzhi Ni, Sixue Chen, Robert D. Lee, Robert C. Kemerait, Baozhu Guo
Plant Biotechnology Journal.2018; 16(9): 1616. CrossRef
Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum
Jiyoung Shin, Jung-Eun Kim, Yin-Won Lee, Hokyoung Son
Toxins.2018; 10(3): 112. CrossRef
De novo assembly and comparative transcriptome analysis of Monilinia fructicola, Monilinia laxa and Monilinia fructigena, the causal agents of brown rot on stone fruits
Rita M. De Miccolis Angelini, Domenico Abate, Caterina Rotolo, Donato Gerin, Stefania Pollastro, Francesco Faretra
BMC Genomics.2018;[Epub] CrossRef
Root Exudates of Stressed Plants Stimulate and AttractTrichodermaSoil Fungi
Nadia Lombardi, Stefania Vitale, David Turrà, Massimo Reverberi, Corrado Fanelli, Francesco Vinale, Roberta Marra, Michelina Ruocco, Alberto Pascale, Giada d’Errico, Sheridan L. Woo, Matteo Lorito
Molecular Plant-Microbe Interactions®.2018; 31(10): 982. CrossRef
Comprehensive Secondary Metabolite Profiling Toward Delineating the Solid and Submerged-State Fermentation of Aspergillus oryzae KCCM 12698
Su Y. Son, Sunmin Lee, Digar Singh, Na-Rae Lee, Dong-Yup Lee, Choong H. Lee
Frontiers in Microbiology.2018;[Epub] CrossRef
Cyclooxygenases and lipoxygenases are used by the fungus Podospora anserina to repel nematodes
Roselyne Ferrari, Isabelle Lacaze, Pauline Le Faouder, Justine Bertrand-Michel, Camille Oger, Jean-Marie Galano, Thierry Durand, Stéphane Moularat, Laetitia Chan Ho Tong, Charlie Boucher, Jaafar Kilani, Yohann Petit, Océane Vanparis, César Trannoy, Sylvai
Biochimica et Biophysica Acta (BBA) - General Subjects.2018; 1862(10): 2174. CrossRef
Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures
Meritxell Riquelme, Jesús Aguirre, Salomon Bartnicki-García, Gerhard H. Braus, Michael Feldbrügge, Ursula Fleig, Wilhelm Hansberg, Alfredo Herrera-Estrella, Jörg Kämper, Ulrich Kück, Rosa R. Mouriño-Pérez, Norio Takeshita, Reinhard Fischer
Microbiology and Molecular Biology Reviews.2018;[Epub] CrossRef
Eicosanoid biosynthesis influences the virulence of Candida parapsilosis
Tanmoy Chakraborty, Ernst Thuer, Marieke Heijink, Renáta Tóth, László Bodai, Csaba Vágvölgyi, Martin Giera, Toni Gabaldón, Attila Gácser
Virulence.2018; 9(1): 1019. CrossRef
Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus
Gregory J. Fischer, William Bacon, Jun Yang, Jonathan M. Palmer, Taylor Dagenais, Bruce D. Hammock, Nancy P. Keller
Frontiers in Microbiology.2017;[Epub] CrossRef
Oxylipins and oxylipin synthesis pathways in fungi
N. N. Gessler, S. Yu. Filippovich, G. P. Bachurina, E. A. Kharchenko, N. V. Groza, T. A. Belozerskaya
Applied Biochemistry and Microbiology.2017; 53(6): 628. CrossRef
Fungal manipulation of hormone-regulated plant defense
Rajesh N. Patkar, Naweed I. Naqvi, Cyril Zipfel
PLOS Pathogens.2017; 13(6): e1006334. CrossRef
Functional characterization of cytochrome P450 monooxygenases in the cereal head blight fungus Fusarium graminearum
Ji Young Shin, Duc‐Cuong Bui, Yoonji Lee, Hyejin Nam, Soyun Jung, Miao Fang, Jin‐Cheol Kim, Theresa Lee, Hun Kim, Gyung Ja Choi, Hokyoung Son, Yin‐Won Lee
Environmental Microbiology.2017; 19(5): 2053. CrossRef
Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Secondary metabolism in Trichoderma – Chemistry meets genomics
Susanne Zeilinger, Sabine Gruber, Ravindra Bansal, Prasun K. Mukherjee
Fungal Biology Reviews.2016; 30(2): 74. CrossRef

Transcriptional Regulatory Elements in Fungal Secondary Metabolism: Wenbing Yin , Nancy P. Keller; J. Microbiol. 2011;49(3):329-339. Published online June 30, 2011; DOI: https://doi.org/10.1007/s12275-011-1009-1

1,295 View
2 Download
124 Crossref

Abstract PDF

Filamentous fungi produce a variety of secondary metabolites of diverse beneficial and detrimental activities to humankind. The genes required for a given secondary metabolite are typically arranged in a gene cluster. There is considerable evidence that secondary metabolite gene regulation is, in part, by transcriptional control through hierarchical levels of transcriptional regulatory elements involved in secondary metabolite cluster regulation. Identification of elements regulating secondary metabolism could potentially provide a means of increasing production of beneficial metabolites, decreasing production of detrimental metabolites, aid in the identification of ‘silent’ natural products and also contribute to a broader understanding of molecular mechanisms by which secondary metabolites are produced. This review summarizes regulation of secondary metabolism associated with transcriptional regulatory elements from a broad view as well as the tremendous advances in discovery of cryptic or novel secondary metabolites by genomic mining.

Citations

Citations to this article as recorded by

Novel Zn2Cys6 transcription factor AfEcm22 positively regulates aflatoxin biosynthesis in Aspergillus flavus
Shan Wei, Shan Pei, Donghai Li, Fangjing Jia, Di Chen, Yang Lei, Fengguang Zhao, Yangyong Lv, Yuansen Hu, Liang Huang
Food Bioscience.2026; 75: 108079. CrossRef
Comparative Genomics Analysis Reveals the Genomic Basis of S8 Proteases, CAZymes, and Secondary Metabolism Associated with Nematode Biocontrol in Purpureocillium lilacinum
Xiaoxi Cheng, Li Liu, Zhimin Zhu, Minghao Chen, Wenbo Wang, Jialin Li, Ramon Santos Bermudez, Xiujun Zhang, Wenxing He
International Journal of Molecular Sciences.2026; 27(11): 4687. CrossRef
Targeted deletion of cc63tf and cc12grf Reveals Opposing Regulation of beauvericin Biosynthesis in Cordyceps cicadae
Xingying Wang, Xiqiang Zhu, Adam Junka, Lifan Yu, Gadallah Mohamed, Penghong Yin, Changsheng Sun, Yuqin Wang, Bowei He, Zhonghua Lu, Sheng Zhao, Xiangjun Tu, Yanfang Sun
Fungal Genetics and Biology.2026; 185: 104085. CrossRef
Activation of secondary metabolism in Aspergillus and related filamentous fungi through regulatory engineering
Jennifer Shyong, Clay C. C. Wang
RSC Chemical Biology.2026; 7(9): 1669. CrossRef
Phylogenomic and Comparative Genomic Analyses Reveal Deep Evolutionary Structure and Cryptic Diversity in the Genus Trichoderma
Felipe Cabarcas, Juliana Lopez-Jimenez, Maria Patricia Ricardo, Isabel Luna, Juan F. Alzate
International Journal of Molecular Sciences.2026; 27(18): 8204. CrossRef
Recent Advances in the Comprehension of Molecular and Genetic Mechanisms Underlying Yeast Biocontrol Efficacy Against Fungal Pathogens in Agriculture
Guillaume Legrand Ngolong Ngea, Samuele Doganiero, Carelle Jimdjo Kouasseu, Davide Palmieri, Raffaello Castoria, Giuseppe Ianiri
Phytopathology®.2026; 116(10): 1524. CrossRef
Spray-Induced Gene Silencing (SIGS) as a Tool for the Management of Pine Pitch Canker Forest Disease
Irene Teresa Bocos-Asenjo, Huma Amin, Sandra Mosquera, Sergio Díez-Hermano, Mireille Ginésy, Julio Javier Diez, Jonatan Niño-Sánchez
Plant Disease.2025; 109(1): 49. CrossRef
Developing filamentous fungal chassis for natural product production
Jie Fan, Peng-Lin Wei, Yuanyuan Li, Shengquan Zhang, Zedong Ren, Wei Li, Wen-Bing Yin
Bioresource Technology.2025; 415: 131703. CrossRef
Regulation and induction of fungal secondary metabolites: a comprehensive review
Shaurya Prakash, Hemlata Kumari, Minakshi Sinha, Antresh Kumar
Archives of Microbiology.2025;[Epub] CrossRef
Unconventional semi-solid cultivation enhances cytochalasins production by the Colombian fungus Xylaria sp. CM-UDEA-H199
Daniela Valencia-Revelo, Esteban Charria-Girón, Katharina Schmidt, Silke Reinecke, Aida M. Vasco-Palacios, Theresia Stradal, Yasmina Marin-Felix, Nelson H. Caicedo-Ortega, Sherif S. Ebada
BMC Biotechnology.2025;[Epub] CrossRef
Research on the pathogen causing root rot on Phyllanthus emblica from the perspectives of identification, bionomics, fungicide sensitivity assay, and transcriptome analysis under different pH stress
Yiming Zhang, Minyan Song, Yonghong He, Yehua Si
Frontiers in Microbiology.2025;[Epub] CrossRef
From the bench to the reactor: engineered filamentous fungi for biochemical and biomaterial production
Venkataramanan Subramanian, Meaghan J. Adler, Marcus Benyamin, Randi M. Pullen, Matthew D. Servinsky, Mark T. Kozlowski, Stephen R. Decker
Biotechnology for Biofuels and Bioproducts.2025;[Epub] CrossRef
Systematic over-expression of secondary metabolism transcription factors to reveal the pharmaceutical potential of Aspergillus nidulans
Shuhui Guo, Lakhansing Pardeshi, Longguang Qin, Chris Y. Cheung, Xiaofeng Liu, Lu Fan, Chi Cheng Mok, Chirag Parsania, Zhiqiang Dong, Ben C. B. Ko, Kaeling Tan, Koon Ho Wong
Communications Biology.2025;[Epub] CrossRef
Functional characterization of grammicin biosynthesis genes in Xylaria grammica and strategies for enhanced metabolite production
Sunmin An, Miju Jo, Yerim Lee, Youngmin Kim, Min-Hye Jeong, Jongbum Jeon, Soonok Kim, Won-Jae Chi, Sook-Young Park
Scientific Reports.2025;[Epub] CrossRef
Epigenetic Regulation of Fungal Secondary Metabolism
Yufei Zhang, Wenbin Yu, Yi Lu, Yichuan Wu, Zhiwei Ouyang, Yayi Tu, Bin He
Journal of Fungi.2024; 10(9): 648. CrossRef
Genome and metabolome analysis of Bacillus sp. Hex-HIT36: A newly screened functional microorganism for the degradation of 1-hexadecene in industrial wastewater
Lei Yang, Chuan Chen, Xijun Xu, Xue-Ting Wang, Defeng Xing, Nanqi Ren, Duu-Jong Lee
Environmental Research.2024; 260: 119594. CrossRef
Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer's disease
Jennifer Shyong, Jinliang Wang, Quoc-Dung Tran Huynh, Marina Fayzullina, Bo Yuan, Ching-Kuo Lee, Thomas Minehan, Paul M. Seidler, Clay C. C. Wang
Chemical Science.2024; 15(48): 20467. CrossRef
Transcriptomic Screening of Alternaria oxytropis Isolated from Locoweed Plants for Genes Involved in Mycotoxin Swainsonine Production
Shuangjie Yuan, Qingmei Zhao, Kun Yu, Ying Gao, Zhengbing Ma, Huanyu Li, Yongtao Yu
Journal of Fungi.2024; 10(1): 88. CrossRef
Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster
Alexander J. Bradshaw, Virginia Ramírez-Cruz, Ali R. Awan, Giuliana Furci, Laura Guzmán-Dávalos, Bryn T. M. Dentinger
Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef
Effects of temperature on the production of ochratoxin A by Aspergillus niger
Yige Zhang, Zhihui Zhang, Qianru Xu, Yangyong Lv, Shuaibing Zhang, Huanchen Zhai, Yuansen Hu, Shan Wei
LWT.2024; 191: 115684. CrossRef
Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans
Heungyun Moon, Mi-Kyung Lee, Ilhan Bok, Jin Woo Bok, Nancy P. Keller, Jae-Hyuk Yu, Gustavo H. Goldman
Microbiology Spectrum.2023;[Epub] CrossRef
Discovery of pyranonaphthoquinones and an eighteen-membered ring macrolide from the rhizospheric soil-derived fungus Phialocephala sp. YUD18001 by OSMAC strategy
Fei Xie, Yue Sun, Zhi-Feng Zi, Wen-Jing Wang, Dai-Yu Wan, Hao Zhou, Zhong-Tao Ding
Fitoterapia.2023; 171: 105690. CrossRef
Editorial: Gene regulation of fungal secondary metabolism
Pinmei Wang, Hee-Soo Park, Wenjie Wang, Wen-Bing Yin
Frontiers in Microbiology.2023;[Epub] CrossRef
Construction of RNA silencing system of Penicillium brevicompactum and genetic manipulation of the regulator pbpcz in mycophenolic acid production
TingTing Hu, Jingjing Wang, Mianhui Chen, Lin Lin, Wei Wei, Dongzhi Wei
Fungal Genetics and Biology.2023; 169: 103843. CrossRef
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products
Peng-Lin Wei, Jie Fan, Jingwen Yu, Zihui Ma, Xian Guo, Nancy P. Keller, Erwei Li, Chunbo Lou, Wen-Bing Yin
Science China Life Sciences.2023; 66(4): 848. CrossRef
Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle
Alexander A. Zhgun
International Journal of Molecular Sciences.2023; 24(13): 11184. CrossRef
Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex
Zili Song, Shuang Zhou, Hongjiao Zhang, Nancy P. Keller, Berl R. Oakley, Xiao Liu, Wen-Bing Yin
Nature Communications.2023;[Epub] CrossRef
Eco-Friendly Biocontrol Strategies of Alternaria Phytopathogen Fungus: A Focus on Gene-Editing Techniques
Domingo Cesar Carrascal-Hernández, Edwin Flórez-López, Yeimmy Peralta-Ruiz, Clemencia Chaves-López, Carlos David Grande-Tovar
Agriculture.2022; 12(10): 1722. CrossRef
Nitrogen source as a modulator of the metabolic activity of Pedobacter lusitanus NL19: a transcriptomic approach
Covas C., Vaz A., Almeida B., Lourenço J., Figueiredo G., Franco O. L., Mendo S., Caetano T.
Applied Microbiology and Biotechnology.2022; 106(4): 1583. CrossRef
Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica
Eunice Ordóñez-Enireb, Roberto V. Cucalón, Diana Cárdenas, Nadia Ordóñez, Santiago Coello, Paola Elizalde, Washington B. Cárdenas
Scientific Reports.2022;[Epub] CrossRef
Whole-Genome Sequence Analysis of an Endophytic Fungus Alternaria sp. SPS-2 and Its Biosynthetic Potential of Bioactive Secondary Metabolites
Jianyun Tao, Xuelian Bai, Mingyuan Zeng, Mengshi Li, Zhe Hu, Yunfen Hua, Huawei Zhang
Microorganisms.2022; 10(9): 1789. CrossRef
Transcriptome Analysis Identifies a Gene Cluster for the Biosynthesis of Biruloquinone, a Rare Phenanthraquinone, in a Lichen-Forming Fungus Cladonia macilenta
Wonyong Kim, Min-Hye Jeong, Sung-Hwan Yun, Jae-Seoun Hur
Journal of Fungi.2021; 7(5): 398. CrossRef
Fungal Secondary Metabolism
Javier Avalos, M. Carmen Limón
Encyclopedia.2021; 2(1): 1. CrossRef
Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters
Wenjie Wang, Yuchao Yu, Nancy P. Keller, Pinmei Wang
International Journal of Molecular Sciences.2021; 22(16): 8709. CrossRef
Involvement of BbTpc1, an important Zn(II)2Cys6 transcriptional regulator, in chitin biosynthesis, fungal development and virulence of an insect mycopathogen
Lei Qiu, Jing Zhang, Ji-Zheng Song, Shun-Juan Hu, Tong-Sheng Zhang, Ze Li, Juan-Juan Wang, Wen Cheng
International Journal of Biological Macromolecules.2021; 166: 1162. CrossRef
Depside and Depsidone Synthesis in Lichenized Fungi Comes into Focus through a Genome-Wide Comparison of the Olivetoric Acid and Physodic Acid Chemotypes of Pseudevernia furfuracea
Garima Singh, Daniele Armaleo, Francesco Dal Grande, Imke Schmitt
Biomolecules.2021; 11(10): 1445. CrossRef
Comparative Transcriptome Analysis of Genes Involved in Sesquiterpene Alkaloid Biosynthesis in Trichoderma longibrachiatum MD33 and UN32
Xu Qian, Hui Jin, Zhuojun Chen, Qingqing Dai, Surendra Sarsaiya, Yitong Qin, Qi Jia, Leilei Jin, Jishuang Chen
Frontiers in Microbiology.2021;[Epub] CrossRef
Activation of biosynthetic gene clusters by the global transcriptional regulator TRI6 in Fusarium graminearum
Kristina Shostak, Christopher Bonner, Amanda Sproule, Indira Thapa, Samuel W. J. Shields, Barbara Blackwell, John Vierula, David Overy, Rajagopal Subramaniam
Molecular Microbiology.2020; 114(4): 664. CrossRef
Diverse bioactive metabolites from Penicillium sp. MMA derived from the red sea: structure identification and biological activity studies
Ann G. Boulis, Ahmed A. Hamed, Mohamed E. El-awady, Attia R. Mohamed, Essam M. Eliwa, Mohsen M. S. Asker, Mohamed Shaaban
Archives of Microbiology.2020; 202(7): 1985. CrossRef
Pullulan biosynthesis in yeast-like fungal cells is regulated by the transcriptional activator Msn2 and cAMP-PKA signaling pathway
Guang Yang, Guang-Lei Liu, Shu-Jun Wang, Zhen-Ming Chi, Zhe Chi
International Journal of Biological Macromolecules.2020; 157: 591. CrossRef
Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review
Valdet Uka, Jeffrey W. Cary, Matthew D. Lebar, Olivier Puel, Sarah De Saeger, José Diana Di Mavungu
Comprehensive Reviews in Food Science and Food Safety.2020; 19(6): 2797. CrossRef
Secondary Metabolites of the Rice Blast Fungus Pyricularia oryzae: Biosynthesis and Biological Function
Takayuki Motoyama
International Journal of Molecular Sciences.2020; 21(22): 8698. CrossRef
Fungal evolution: cellular, genomic and metabolic complexity
Miguel A. Naranjo‐Ortiz, Toni Gabaldón
Biological Reviews.2020; 95(5): 1198. CrossRef
Regulation of Secondary Metabolism in the Penicillium Genus
Christelle El Hajj Assaf, Chrystian Zetina-Serrano, Nadia Tahtah, André El Khoury, Ali Atoui, Isabelle P. Oswald, Olivier Puel, Sophie Lorber
International Journal of Molecular Sciences.2020; 21(24): 9462. CrossRef
Metabolomics Reveals the Response of the Phenylpropanoid Biosynthesis Pathway to Starvation Treatment in the Grape Endophyte Alternaria sp. MG1
Yao Lu, Jinxin Che, Xiaoguang Xu, Bing Pang, Xixi Zhao, Yanlin Liu, Junling Shi
Journal of Agricultural and Food Chemistry.2020; 68(4): 1126. CrossRef
An overview on the biosynthesis and metabolic regulation of monacolin K/lovastatin
Yaru Zhang, Zhiting Chen, Qinyou Wen, Zixiao Xiong, Xiaohua Cao, Zhenghuai Zheng, Yangxin Zhang, Zhiwei Huang
Food & Function.2020; 11(7): 5738. CrossRef
Strategies for Discovering New Antibiotics from Bacteria in the Post-Genomic Era
Jia-Wei Zhu, Si-Jia Zhang, Wen-Guang Wang, Hui Jiang
Current Microbiology.2020; 77(11): 3213. CrossRef
Functional characterization of the sterigmatocystin secondary metabolite gene cluster in the filamentous fungus Podospora anserina: involvement in oxidative stress response, sexual development, pigmentation and interspecific competitions
Ling Shen, François‐Hugues Porée, Thomas Gaslonde, Hervé Lalucque, Florence Chapeland‐Leclerc, Gwenaël Ruprich‐Robert
Environmental Microbiology.2019; 21(8): 3011. CrossRef
Functional characterization of host toxic EcdB transcription factor protein of echinocandin B biosynthetic gene cluster
Arvind Kumar, Vinay Kumar, Antresh Kumar
Biotechnology and Applied Biochemistry.2019; 66(4): 626. CrossRef
Sterol inhibitor “Fluconazole” enhance the Taxol yield and molecular expression of its encoding genes cluster from Aspergillus flavipes
Ashraf S.A. El-Sayed, Dalia M.I. Ali, Marwa A. Yassin, Rawia A. Zayed, Gul Shad Ali
Process Biochemistry.2019; 76: 55. CrossRef
Progress and Challenges: Development and Implementation of CRISPR/Cas9 Technology in Filamentous Fungi
Qiang Wang, Jeffrey J. Coleman
Computational and Structural Biotechnology Journal.2019; 17: 761. CrossRef
Aspergillus flavus NRRL 3251 Growth, Oxidative Status, and Aflatoxins Production Ability In Vitro under Different Illumination Regimes
Tihomir Kovač, Bojan Šarkanj, Biljana Crevar, Marija Kovač, Ante Lončarić, Ivica Strelec, Chibundu N. Ezekiel, Michael Sulyok, Rudolf Krska
Toxins.2018; 10(12): 528. CrossRef
Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius
Gemma Castellá, M. Rosa Bragulat, Laura Puig, Walter Sanseverino, F. Javier Cabañes
Scientific Reports.2018;[Epub] CrossRef
From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites
T. Hautbergue, E. L. Jamin, L. Debrauwer, O. Puel, I. P. Oswald
Natural Product Reports.2018; 35(2): 147. CrossRef
Chromatin‐level regulation of the fragmented dothistromin gene cluster in the forest pathogen Dothistroma septosporum
Pranav Chettri, Pierre‐Yves Dupont, Rosie E. Bradshaw
Molecular Microbiology.2018; 107(4): 508. CrossRef
Cys 2 His 2 Zinc Finger Transcription Factor BcabaR1 Positively Regulates Abscisic Acid Production in Botrytis cinerea
Yingming Wang, Jinyan Zhou, Juan Zhong, Di Luo, Zhemin Li, Jie Yang, Dan Shu, Hong Tan, Harold L. Drake
Applied and Environmental Microbiology.2018;[Epub] CrossRef
Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin
Sietske Grijseels, Carsten Pohl, Jens Christian Nielsen, Zahida Wasil, Yvonne Nygård, Jens Nielsen, Jens C. Frisvad, Kristian Fog Nielsen, Mhairi Workman, Thomas Ostenfeld Larsen, Arnold J. M. Driessen, Rasmus John Normand Frandsen
Fungal Biology and Biotechnology.2018;[Epub] CrossRef
Dissimilar pigment regulation in Serpula lacrymans and Paxillus involutus during inter-kingdom interactions
James P. Tauber, Ramses Gallegos-Monterrosa, Ákos T. Kovács, Ekaterina Shelest, Dirk Hoffmeister
Microbiology.2018; 164(1): 65. CrossRef
Enhanced hypocrellin production via coexpression of alpha-amylase and hemoglobin genes in Shiraia bambusicola
Ruijie Gao, Huaxiang Deng, Zhengbing Guan, Xiangru Liao, Yujie Cai
AMB Express.2018;[Epub] CrossRef
Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products
Fernando Guzmán-Chávez, Reto D. Zwahlen, Roel A. L. Bovenberg, Arnold J. M. Driessen
Frontiers in Microbiology.2018;[Epub] CrossRef
Condition‐dependent co‐regulation of genomic clusters of virulence factors in the grapevine trunk pathogen Neofusicoccum parvum
Mélanie Massonnet, Abraham Morales‐Cruz, Rosa Figueroa‐Balderas, Daniel P. Lawrence, Kendra Baumgartner, Dario Cantu
Molecular Plant Pathology.2018; 19(1): 21. CrossRef
Enhanced hypocrellin production of Shiraia sp. SUPER-H168 by overexpression of alpha-amylase gene
Ruijie Gao, Zhecun Xu, Huaxiang Deng, Zhengbing Guan, Xiangru Liao, Ye Zhao, Xiaohui Zheng, Yujie Cai, Marie-Joelle Virolle
PLOS ONE.2018; 13(5): e0196519. CrossRef
Activation of Aflatoxin Biosynthesis Alleviates Total ROS in Aspergillus parasiticus
Gabriel Kenne, Phani Gummadidala, Mayomi Omebeyinje, Ananda Mondal, Dominic Bett, Sandra McFadden, Sydney Bromfield, Nora Banaszek, Michelle Velez-Martinez, Chandrani Mitra, Isabelle Mikell, Saurabh Chatterjee, Josephine Wee, Anindya Chanda
Toxins.2018; 10(2): 57. CrossRef
Strategies to diversify natural products for drug discovery
Gang Li, Hong‐Xiang Lou
Medicinal Research Reviews.2018; 38(4): 1255. CrossRef
Regulatory cascade and biological activity of Beauveria bassiana oosporein that limits bacterial growth after host death
Yanhua Fan, Xi Liu, Nemat O. Keyhani, Guirong Tang, Yan Pei, Wenwen Zhang, Sheng Tong
Proceedings of the National Academy of Sciences.2017;[Epub] CrossRef
The GATA-Type Transcription Factor Csm1 Regulates Conidiation and Secondary Metabolism in Fusarium fujikuroi
Eva-Maria Niehaus, Julia Schumacher, Immo Burkhardt, Patrick Rabe, Martin Münsterkötter, Ulrich Güldener, Christian M. K. Sieber, Jeroen S. Dickschat, Bettina Tudzynski
Frontiers in Microbiology.2017;[Epub] CrossRef
A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum
Feifei Guan, Yuanyuan Pan, Jinyang Li, Gang Liu
Science China Life Sciences.2017; 60(9): 958. CrossRef
Discovery of McrA, a master regulator of Aspergillus secondary metabolism
C. Elizabeth Oakley, Manmeet Ahuja, Wei‐Wen Sun, Ruth Entwistle, Tomohiro Akashi, Junko Yaegashi, Chun‐Jun Guo, Gustavo C. Cerqueira, Jennifer Russo Wortman, Clay C. C. Wang, Yi‐Ming Chiang, Berl R. Oakley
Molecular Microbiology.2017; 103(2): 347. CrossRef
Tpc1 is an important Zn(II)2Cys6 transcriptional regulator required for polarized growth and virulence in the rice blast fungus
Rita Galhano, Adriana Illana, Lauren S. Ryder, Julio Rodríguez-Romero, Marie Demuez, Muhammad Badaruddin, Ana Lilia Martinez-Rocha, Darren M. Soanes, David J. Studholme, Nicholas J. Talbot, Ane Sesma, Paul Birch
PLOS Pathogens.2017; 13(7): e1006516. CrossRef
Mechanism and regulation of sorbicillin biosynthesis by Penicillium chrysogenum
Fernando Guzmán‐Chávez, Oleksandr Salo, Yvonne Nygård, Peter P. Lankhorst, Roel A. L. Bovenberg, Arnold J. M. Driessen
Microbial Biotechnology.2017; 10(4): 958. CrossRef
Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae
Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
ACS Chemical Biology.2017; 12(9): 2270. CrossRef
Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans
Paula C. Alves, Diego O. Hartmann, Oscar Núñez, Isabel Martins, Teresa L. Gomes, Helga Garcia, Maria Teresa Galceran, Richard Hampson, Jörg D. Becker, Cristina Silva Pereira
BMC Genomics.2016;[Epub] CrossRef
The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species
Monika Schmoll, Christoph Dattenböck, Nohemí Carreras-Villaseñor, Artemio Mendoza-Mendoza, Doris Tisch, Mario Ivan Alemán, Scott E. Baker, Christopher Brown, Mayte Guadalupe Cervantes-Badillo, José Cetz-Chel, Gema Rosa Cristobal-Mondragon, Luis Delaye, Ed
Microbiology and Molecular Biology Reviews.2016; 80(1): 205. CrossRef
Microbial interactions: ecology in a molecular perspective
Raíssa Mesquita Braga, Manuella Nóbrega Dourado, Welington Luiz Araújo
Brazilian Journal of Microbiology.2016; 47: 86. CrossRef
Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin
Yi‐Ming Chiang, Manmeet Ahuja, C. Elizabeth Oakley, Ruth Entwistle, Anabanadam Asokan, Christoph Zutz, Clay C. C. Wang, Berl R. Oakley
Angewandte Chemie.2016; 128(5): 1694. CrossRef
The botrydial biosynthetic gene cluster of Botrytis cinerea displays a bipartite genomic structure and is positively regulated by the putative Zn(II)2Cys6 transcription factor BcBot6
Antoine Porquier, Guillaume Morgant, Javier Moraga, Bérengère Dalmais, Isabelle Luyten, Adeline Simon, Jean-Marc Pradier, Joëlle Amselem, Isidro González Collado, Muriel Viaud
Fungal Genetics and Biology.2016; 96: 33. CrossRef
Secondary metabolite gene clusters in the entomopathogen fungus Metarhizium anisopliae: genome identification and patterns of expression in a cuticle infection model
Nicolau Sbaraini, Rafael Lucas Muniz Guedes, Fábio Carrer Andreis, Ângela Junges, Guilherme Loss de Morais, Marilene Henning Vainstein, Ana Tereza Ribeiro de Vasconcelos, Augusto Schrank
BMC Genomics.2016;[Epub] CrossRef
Identification of a Halogenase Involved in the Biosynthesis of Ochratoxin A in Aspergillus carbonarius
Massimo Ferrara, Giancarlo Perrone, Lucia Gambacorta, Filomena Epifani, Michele Solfrizzo, Antonia Gallo, A. A. Brakhage
Applied and Environmental Microbiology.2016; 82(18): 5631. CrossRef
Deciphering the Anti-Aflatoxinogenic Properties of Eugenol Using a Large-Scale q-PCR Approach
Isaura Caceres, Rhoda El Khoury, Ángel Medina, Yannick Lippi, Claire Naylies, Ali Atoui, André El Khoury, Isabelle Oswald, Jean-Denis Bailly, Olivier Puel
Toxins.2016; 8(5): 123. CrossRef
Modulation of genetic clusters for synthesis of bioactive molecules in fungal endophytes: A review
V.B. Deepika, T.S. Murali, K. Satyamoorthy
Microbiological Research.2016; 182: 125. CrossRef
The global regulator LaeA controls biosynthesis of host-specific toxins, pathogenicity and development of Alternaria alternata pathotypes
Kazumi Takao, Yasunori Akagi, Takashi Tsuge, Yoshiaki Harimoto, Mikihiro Yamamoto, Motoichiro Kodama
Journal of General Plant Pathology.2016; 82(3): 121. CrossRef
Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin
Yi‐Ming Chiang, Manmeet Ahuja, C. Elizabeth Oakley, Ruth Entwistle, Anabanadam Asokan, Christoph Zutz, Clay C. C. Wang, Berl R. Oakley
Angewandte Chemie International Edition.2016; 55(5): 1662. CrossRef
Regulation and Role of Fungal Secondary Metabolites
Juliane Macheleidt, Derek J. Mattern, Juliane Fischer, Tina Netzker, Jakob Weber, Volker Schroeckh, Vito Valiante, Axel A. Brakhage
Annual Review of Genetics.2016; 50(1): 371. CrossRef
Microbial metabolomics in open microscale platforms
Layla J. Barkal, Ashleigh B. Theberge, Chun-Jun Guo, Joe Spraker, Lucas Rappert, Jean Berthier, Kenneth A. Brakke, Clay C. C. Wang, David J. Beebe, Nancy P. Keller, Erwin Berthier
Nature Communications.2016;[Epub] CrossRef
The Fdb3 transcription factor of the Fusarium Detoxification of Benzoxazolinone gene cluster is required for MBOA but not BOA degradation in Fusarium pseudograminearum
Andrew J. Kettle, Jason Carere, Jacqueline Batley, John M. Manners, Kemal Kazan, Donald M. Gardiner
Fungal Genetics and Biology.2016; 88: 44. CrossRef
Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals
Markus Gressler, Florian Meyer, Daniel Heine, Peter Hortschansky, Christian Hertweck, Matthias Brock
eLife.2015;[Epub] CrossRef
Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense
Yingjie Zhu, Jiang Xu, Chao Sun, Shiguo Zhou, Haibin Xu, David R. Nelson, Jun Qian, Jingyuan Song, Hongmei Luo, Li Xiang, Ying Li, Zhichao Xu, Aijia Ji, Lizhi Wang, Shanfa Lu, Alice Hayward, Wei Sun, Xiwen Li, David C. Schwartz, Yitao Wang, Shilin Chen
Scientific Reports.2015;[Epub] CrossRef
The global regulator FfSge1 is required for expression of secondary metabolite gene clusters but not for pathogenicity in Fusarium fujikuroi
Caroline B. Michielse, Lena Studt, Slavica Janevska, Christian M. K. Sieber, Birgit Arndt, Jose Juan Espino, Hans‐Ulrich Humpf, Ulrich Güldener, Bettina Tudzynski
Environmental Microbiology.2015; 17(8): 2690. CrossRef
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
Peter J. Rutledge, Gregory L. Challis
Nature Reviews Microbiology.2015; 13(8): 509. CrossRef
Penicyclones A–E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2
Wenqiang Guo, Zhenzhen Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li
Journal of Natural Products.2015; 78(11): 2699. CrossRef
Synthetic biology of fungal natural products
Derek J. Mattern, Vito Valiante, Shiela E. Unkles, Axel A. Brakhage
Frontiers in Microbiology.2015;[Epub] CrossRef
The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici
Xiuna Wang, Fan Wu, Ling Liu, Xingzhong Liu, Yongsheng Che, Nancy P. Keller, Liyun Guo, Wen-Bing Yin
Fungal Genetics and Biology.2015; 81: 221. CrossRef
Leucine metabolism regulates TRI6 expression and affects deoxynivalenol production and virulence in Fusarium graminearum
Rajagopal Subramaniam, Swara Narayanan, Sean Walkowiak, Li Wang, Manisha Joshi, Hélène Rocheleau, Thérèse Ouellet, Linda J. Harris
Molecular Microbiology.2015; 98(4): 760. CrossRef
Genetic and metabolic engineering of microorganisms for the development of new flavor compounds from terpenic substrates
Murillo L. Bution, Gustavo Molina, Meissa R.E. Abrahão, Gláucia M. Pastore
Critical Reviews in Biotechnology.2015; 35(3): 313. CrossRef
Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans
Junko Yaegashi, Berl R Oakley, Clay C C Wang
Journal of Industrial Microbiology and Biotechnology.2014; 41(2): 433. CrossRef
Fungal extrolites as a new source for therapeutic compounds and as building blocks for applications in synthetic biology
Ana Lúcia Leitão, Francisco J. Enguita
Microbiological Research.2014; 169(9-10): 652. CrossRef
Spatial and temporal control of fungal natural product synthesis
Fang Yun Lim, Nancy P. Keller
Nat. Prod. Rep..2014; 31(10): 1277. CrossRef
Strategies for mining fungal natural products
Philipp Wiemann, Nancy P Keller
Journal of Industrial Microbiology and Biotechnology.2014; 41(2): 301. CrossRef
Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus Leptosphaeria maculans
Jessica L. Soyer, Mennat El Ghalid, Nicolas Glaser, Bénédicte Ollivier, Juliette Linglin, Jonathan Grandaubert, Marie-Hélène Balesdent, Lanelle R. Connolly, Michael Freitag, Thierry Rouxel, Isabelle Fudal, Nicholas J. Talbot
PLoS Genetics.2014; 10(3): e1004227. CrossRef
A fungal prenyltransferase catalyzes the regular di-prenylation at positions 20 and 21 of paxilline
Chengwei Liu, Motoyoshi Noike, Atsushi Minami, Hideaki Oikawa, Tohru Dairi
Bioscience, Biotechnology, and Biochemistry.2014; 78(3): 448. CrossRef
Screening of a Botrytis cinerea one-hybrid library reveals a Cys2His2 transcription factor involved in the regulation of secondary metabolism gene clusters
Adeline Simon, Bérengère Dalmais, Guillaume Morgant, Muriel Viaud
Fungal Genetics and Biology.2013; 52: 9. CrossRef
Impact of alg3 gene deletion on growth, development, pigment production, protein secretion, and functions of recombinant Trichoderma reesei cellobiohydrolases in Aspergillus niger
Ziyu Dai, Uma K. Aryal, Anil Shukla, Wei-Jun Qian, Richard D. Smith, Jon K. Magnuson, William S. Adney, Gregg T. Beckham, Roman Brunecky, Michael E. Himmel, Stephen R. Decker, Xiaohui Ju, Xiao Zhang, Scott E. Baker
Fungal Genetics and Biology.2013; 61: 120. CrossRef
Aflatoxins, fumonisins, and trichothecenes: a convergence of knowledge
Charles P. Woloshuk, Won-Bo Shim
FEMS Microbiology Reviews.2013; 37(1): 94. CrossRef
Fine De Novo Sequencing of a Fungal Genome Using only SOLiD Short Read Data: Verification on Aspergillus oryzae RIB40
Myco Umemura, Yoshinori Koyama, Itaru Takeda, Hiroko Hagiwara, Tsutomu Ikegami, Hideaki Koike, Masayuki Machida, Mikael Rørdam Andersen
PLoS ONE.2013; 8(5): e63673. CrossRef
Engineering fungal secondary metabolism: A roadmap to novel compounds
Daniel H. Scharf, Axel A. Brakhage
Journal of Biotechnology.2013; 163(2): 179. CrossRef
Disruption of the nitrogen regulatory gene AcareA in Acremonium chrysogenum leads to reduction of cephalosporin production and repression of nitrogen metabolism
Jinyang Li, Yuanyuan Pan, Gang Liu
Fungal Genetics and Biology.2013; 61: 69. CrossRef
The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum
Marta Fernández-Aguado, Ricardo V. Ullán, Fernando Teijeira, Raquel Rodríguez-Castro, Juan F. Martín
Applied Microbiology and Biotechnology.2013; 97(7): 3073. CrossRef
Isolation and Characterization of Double Deletion Mutants of nsdD and veA or nsdC, the Genes Positive Regulating Sexual Development of Aspergillus nidulans
Lee-Han Kim, Ha-Eun Kim, Dong-Min Han
The Korean Journal of Microbiology.2013; 49(4): 419. CrossRef
Regulation of fungal secondary metabolism
Axel A. Brakhage
Nature Reviews Microbiology.2013; 11(1): 21. CrossRef
VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation
Jin Woo Bok, Alexandra A. Soukup, Elizabeth Chadwick, Yi‐Ming Chiang, Clay C. C. Wang, Nancy P. Keller
Molecular Microbiology.2013; 89(5): 963. CrossRef
Distinct Amino Acids of Histone H3 Control Secondary Metabolism in Aspergillus nidulans
Hans-Wilhelm Nützmann, Juliane Fischer, Kirstin Scherlach, Christian Hertweck, Axel A. Brakhage
Applied and Environmental Microbiology.2013; 79(19): 6102. CrossRef
Strategies for strain improvement in Fusarium fujikuroi: overexpression and localization of key enzymes of the isoprenoid pathway and their impact on gibberellin biosynthesis
Sabine Albermann, Pia Linnemannstöns, Bettina Tudzynski
Applied Microbiology and Biotechnology.2013; 97(7): 2979. CrossRef
MIDDAS-M: Motif-Independent De Novo Detection of Secondary Metabolite Gene Clusters through the Integration of Genome Sequencing and Transcriptome Data
Myco Umemura, Hideaki Koike, Nozomi Nagano, Tomoko Ishii, Jin Kawano, Noriko Yamane, Ikuko Kozone, Katsuhisa Horimoto, Kazuo Shin-ya, Kiyoshi Asai, Jiujiang Yu, Joan W. Bennett, Masayuki Machida, Kap-Hoon Han
PLoS ONE.2013; 8(12): e84028. CrossRef
FcStuA from Fusarium culmorum Controls Wheat Foot and Root Rot in a Toxin Dispensable Manner
Matias Pasquali, Francesca Spanu, Barbara Scherm, Virgilio Balmas, Lucien Hoffmann, Kim E. Hammond-Kosack, Marco Beyer, Quirico Migheli, Yin-Won Lee
PLoS ONE.2013; 8(2): e57429. CrossRef
The AreA transcription factor in Fusarium graminearum regulates the use of some nonpreferred nitrogen sources and secondary metabolite production
Henriette Giese, Teis Esben Sondergaard, Jens Laurids Sørensen
Fungal Biology.2013; 117(11-12): 814. CrossRef
Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
Gulay Ozcengiz, Arnold L. Demain
Biotechnology Advances.2013; 31(2): 287. CrossRef
Segregation of secondary metabolite biosynthesis in hybrids of Fusarium fujikuroi and Fusarium proliferatum
L. Studt, C. Troncoso, F. Gong, P. Hedden, C. Toomajian, J.F. Leslie, H.-U. Humpf, M.C. Rojas, B. Tudzynski
Fungal Genetics and Biology.2012; 49(7): 567. CrossRef
Order in the playground
Ben Field, Anne Osbourn
Mobile Genetic Elements.2012; 2(1): 46. CrossRef
Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production
Alexandra A. Soukup, Yi‐Ming Chiang, Jin Woo Bok, Yazmid Reyes‐Dominguez, Berl R. Oakley, Clay C. C. Wang, Joseph Strauss, Nancy P. Keller
Molecular Microbiology.2012; 86(2): 314. CrossRef
Advances in Aspergillus secondary metabolite research in the post-genomic era
James F. Sanchez, Amber D. Somoza, Nancy P. Keller, Clay C. C. Wang
Natural Product Reports.2012; 29(3): 351. CrossRef
Identification and Characterization of a Novel Diterpene Gene Cluster in Aspergillus nidulans
Kirsi Bromann, Mervi Toivari, Kaarina Viljanen, Anu Vuoristo, Laura Ruohonen, Tiina Nakari-Setälä, Gustavo Henrique Goldman
PLoS ONE.2012; 7(4): e35450. CrossRef
Fungal endophytes of grasses
Aiko Tanaka, Daigo Takemoto, Tetsuya Chujo, Barry Scott
Current Opinion in Plant Biology.2012; 15(4): 462. CrossRef
NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion
Alexandra A. Soukup, Mitra Farnoodian, Erwin Berthier, Nancy P. Keller
Fungal Genetics and Biology.2012; 49(11): 857. CrossRef
An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR
Wen‐Bing Yin, Saori Amaike, Dana J. Wohlbach, Audrey P. Gasch, Yi‐Ming Chiang, Clay C. C. Wang, Jin Woo Bok, Marko Rohlfs, Nancy P. Keller
Molecular Microbiology.2012; 83(5): 1024. CrossRef

Author index