- Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model
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Woon-ki Kim , You Jin Jang , SungJun Park , Sung-gyu Min , Heeun Kwon , Min Jung Jo , GwangPyo Ko
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J. Microbiol. 2024;62(2):91-99. Published online February 22, 2024
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DOI: https://doi.org/10.1007/s12275-024-00104-5
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 Abstract
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Atopic dermatitis (AD) is a chronic inflammatory skin disease with repeated exacerbations of eczema and pruritus. Probiotics
can prevent or treat AD appropriately via modulation of immune responses and gut microbiota. In this study, we evaluated
effects of Lactobacillus acidophilus (L. acidophilus) KBL409 using a house dust mite (Dermatophagoides farinae)-induced
in vivo AD model. Oral administration of L. acidophilus KBL409 significantly reduced dermatitis scores and decreased
infiltration of immune cells in skin tissues. L. acidophilus KBL409 reduced in serum immunoglobulin E and mRNA levels
of T helper (Th)1 (Interferon-γ), Th2 (Interleukin [IL]-4, IL-5, IL-13, and IL-31), and Th17 (IL-17A) cytokines in skin tissues.
The anti-inflammatory cytokine IL-10 was increased and Foxp3 expression was up-regulated in AD-induced mice with
L. acidophilus KBL409. Furthermore, L. acidophilus KBL409 significantly modulated gut microbiota and concentrations
of short-chain fatty acids and amino acids, which could explain its effects on AD. Our results suggest that L. acidophilus
KBL409 is the potential probiotic for AD treatment by modulating of immune responses and gut microbiota of host.
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Citations
Citations to this article as recorded by  - Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis
Sung Jae Jang, Eun Jung Jo, Cheonghoon Lee, Bo-Ram Cho, Yun Jeong Shin, Jun Soo Song, Woon-Ki Kim, Nanhee Lee, Hyungjin Lee, SungJun Park, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2025; 17(6): 4580. CrossRef - The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential
Maira Jimenez-Sanchez, Larissa S. Celiberto, Hyungjun Yang, Ho Pan Sham, Bruce A. Vallance
Gut Microbes.2025;[Epub] CrossRef - Probiotics ameliorate atopic dermatitis by modulating the dysbiosis of the gut microbiota in dogs
Hyokeun Song, Seung-Hyun Mun, Dae-Woong Han, Jung-Hun Kang, Jae-Uk An, Cheol-Yong Hwang, Seongbeom Cho
BMC Microbiology.2025;[Epub] CrossRef - The effect of daily oral probiotic and postbiotic supplementation on the canine skin microbiota: Insights from culture‐dependent and long‐read 16S rRNA gene sequencing methods
Letitia Grant, Manijeh Mohammadi Dehcheshmeh, Esmaeil Ebrahimie, Aliakbar Khabiri, Tania Veltman, Michael Shipstone, Darren J. Trott
Veterinary Dermatology.2025; 36(5): 581. CrossRef - The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair
Zhili He, Wenfang Song, Shichang Zhang, Minlei Zhao, Fan Wang, Shanshan He, Xiaochi Jie, Qi Gao, Jianguo Chen
Journal of Functional Foods.2025; 131: 106950. CrossRef -
Differential modulation of post-antibiotic colonization resistance to
Clostridioides difficile
by two probiotic
Lactobacillus
strains
Matthew H. Foley, Arthur S. McMillan, Sarah O'Flaherty, Rajani Thanissery, Molly E. Vanhoy, Mary Gracen Fuller, Rodolphe Barrangou, Casey M. Theriot, Jacques Ravel
mBio.2025;[Epub] CrossRef - Innovative microbial strategies in atopic dermatitis
Jingtai Ma, Yiting Fang, Jinxing Hu, Shiqi Li, Lilian Zeng, Siyi Chen, Zhifeng Li, Ruiling Meng, Xingfen Yang, Fenglin Zhang, Guiyuan Ji, Peihua Liao, Liang Chen, Wei Wu
Frontiers in Immunology.2025;[Epub] CrossRef - Nanoencapsulation of Biotics: Feasibility to Enhance Stability and Delivery for Improved Gut Health
Pedro Brivaldo Viana da Silva, Thiécla Katiane Osvaldt Rosales, João Paulo Fabi
Pharmaceutics.2025; 17(9): 1180. CrossRef - Microbiota Modulation as an Approach to Prevent the Use of Antimicrobials Associated with Canine Atopic Dermatitis
Tânia Lagoa, Luís Martins, Maria Cristina Queiroga
Biomedicines.2025; 13(10): 2372. CrossRef - Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation
Seokcheon Song, Jun-Hyeong Kim, Sung Jae Jang, Eun Jung Jo, Sang Kyun Lim, GwangPyo Ko
Journal of Microbiology.2025; 63(10): e2509005. CrossRef - Oral Administration of Lactiplantibacillus plantarum KBL396 Regulates Serum 5-Hydroxytryptamine and Gut Microbiota: Evidence from a Preclinical Mouse Model and a Randomized Controlled Human Trial
Woojae Myung, Sung Jae Jang, Giljae Lee, Cheonghoon Lee, Kiuk Lee, Sung Hyun Moon, Yunsun Jeong, Woon-Ki Kim, SungJun Park, Hyungjin Lee, Yun Seong Park, Sangah Shin, Tae-Wook Nam, Hong Jin Jeon, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2025;[Epub] CrossRef - The Skin Histopathology of Pro- and Parabiotics in a Mouse Model of Atopic Dermatitis
Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Tae Yang Kim, Jeong Woo Park, Byeong Soo Kim, Gon Sup Kim
Nutrients.2024; 16(17): 2903. CrossRef
- Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium‑Induced Colitis
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Woon-ki Kim , Sung-gyu Min , Heeun Kwon , SungJun Park , Min Jung Jo , GwangPyo Ko
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J. Microbiol. 2023;61(7):673-682. Published online June 14, 2023
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DOI: https://doi.org/10.1007/s12275-023-00061-5
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473
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7
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7
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8
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Abstract
PDF
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Ulcerative colitis, a major form of inflammatory bowel disease (IBD) associated with chronic colonic inflammation, may
be induced via overreactive innate and adaptive immune responses. Restoration of gut microbiota abundance and diversity
is important to control the pathogenesis. Lactobacillus spp., well-known probiotics, ameliorate IBD symptoms via various
mechanisms, including modulation of cytokine production, restoration of gut tight junction activity and normal mucosal
thickness, and alterations in the gut microbiota. Here, we studied the effects of oral administration of Lactobacillus rhamnosus
(L. rhamnosus) KBL2290 from the feces of a healthy Korean individual to mice with DSS-induced colitis. Compared to the
dextran sulfate sodium (DSS) + phosphate-buffered saline control group, the DSS + L. rhamnosus KBL2290 group evidenced
significant improvements in colitis symptoms, including restoration of body weight and colon length, and decreases in the
disease activity and histological scores, particularly reduced levels of pro-inflammatory cytokines and an elevated level of
anti-inflammatory interleukin-10. Lactobacillus rhamnosus KBL2290 modulated the levels of mRNAs encoding chemokines
and markers of inflammation; increased regulatory T cell numbers; and restored tight junction activity in the mouse colon.
The relative abundances of genera Akkermansia, Lactococcus, Bilophila, and Prevotella increased significantly, as did the
levels of butyrate and propionate (the major short-chain fatty acids). Therefore, oral L. rhamnosus KBL2290 may be a useful
novel probiotic.
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Citations
Citations to this article as recorded by - Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota
Yue Gao, Binbin Huang, Yunyi Qin, Bing Qiao, Mengfei Ren, Liqing Cao, Yan Zhang, Maozhen Han
Frontiers in Microbiology.2025;[Epub] CrossRef - Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota
Jianlong Lao, Man Chen, Shuping Yan, Han Gong, Zhaohai Wen, Yanhong Yong, Dan Jia, Shuting Lv, Wenli Zou, Junmei Li, Huiming Tan, Hong Yin, Xiangying Kong, Zengyuan Liu, Fucheng Guo, Xianghong Ju, Youquan Li
BMC Microbiology.2025;[Epub] CrossRef -
Lactobacillus rhamnosus MP108 alleviates ulcerative colitis in mice by enhancing the intestinal barrier, inhibiting inflammation, and modulating gut microbiota
Huizhen Li, Yang Chen, Huiting Fang, Xinmei Guo, Xuecong Liu, Jianxin Zhao, Wei Chen, Bo Yang
Food Science and Human Wellness.2025; 14(6): 9250139. CrossRef - Therapeutic Potential of Short-Chain Fatty Acids in Gastrointestinal Diseases
Meng Tong Zhu, Jonathan Wei Jie Lee
Nutraceuticals.2025; 5(3): 19. CrossRef - Probiotics: Shaping the gut immunological responses
Eirini Filidou, Leonidas Kandilogiannakis, Anne Shrewsbury, George Kolios, Katerina Kotzampassi
World Journal of Gastroenterology.2024; 30(15): 2096. CrossRef - Synergistic effects of probiotics with soy protein alleviate ulcerative colitis by repairing the intestinal barrier and regulating intestinal flora
Rentang Zhao, Bingqing Shang, Luyan Sun, Suyuan Lv, Guolong Liu, Qiu Wu, Yue Geng
Journal of Functional Foods.2024; 122: 106514. CrossRef - Lactobacillus gasseri BNR17 and Limosilactobacillus fermentum ABF21069 Ameliorate High Sucrose-Induced Obesity and Fatty Liver via Exopolysaccharide Production and β-oxidation
Yu Mi Jo, Yoon Ji Son, Seul-Ah Kim, Gyu Min Lee, Chang Won Ahn, Han-Oh Park, Ji-Hyun Yun
Journal of Microbiology.2024; 62(10): 907. CrossRef - Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide
Yeji You, Sung-Hwan Kim, Chul-Hong Kim, In-Hwan Kim, YoungSup Shin, Tae-Rahk Kim, Minn Sohn, Jeseong Park
Microorganisms.2023; 11(9): 2312. CrossRef
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