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HOME > J. Microbiol > Volume 61(7); 2023 > Article
Journal Article
Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium‑Induced Colitis
Woon-ki Kim 1,2, Sung-gyu Min 1, Heeun Kwon 1, SungJun Park 1,3,4, Min Jung Jo 1, GwangPyo Ko 1,2,3
Journal of Microbiology 2023;61(7):673-682.
DOI: https://doi.org/10.1007/s12275-023-00061-5
Published online: June 14, 2023
1Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea, 2Institute of Health and Environment, Seoul National University, Seoul 08826, Republic of Korea, 3N‑Bio, Seoul National University, Seoul 08826, Republic of Korea, 4KoBioLabs, Inc., Seoul 13488, Republic of Korea
Corresponding author:  Woon-ki Kim ,
GwangPyo Ko ,
Received: 10 February 2023   • Revised: 12 May 2023   • Accepted: 16 May 2023
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Abstract

Ulcerative colitis, a major form of inflammatory bowel disease (IBD) associated with chronic colonic inflammation, may be induced via overreactive innate and adaptive immune responses. Restoration of gut microbiota abundance and diversity is important to control the pathogenesis. Lactobacillus spp., well-known probiotics, ameliorate IBD symptoms via various mechanisms, including modulation of cytokine production, restoration of gut tight junction activity and normal mucosal thickness, and alterations in the gut microbiota. Here, we studied the effects of oral administration of Lactobacillus rhamnosus (L. rhamnosus) KBL2290 from the feces of a healthy Korean individual to mice with DSS-induced colitis. Compared to the dextran sulfate sodium (DSS) + phosphate-buffered saline control group, the DSS + L. rhamnosus KBL2290 group evidenced significant improvements in colitis symptoms, including restoration of body weight and colon length, and decreases in the disease activity and histological scores, particularly reduced levels of pro-inflammatory cytokines and an elevated level of anti-inflammatory interleukin-10. Lactobacillus rhamnosus KBL2290 modulated the levels of mRNAs encoding chemokines and markers of inflammation; increased regulatory T cell numbers; and restored tight junction activity in the mouse colon. The relative abundances of genera Akkermansia, Lactococcus, Bilophila, and Prevotella increased significantly, as did the levels of butyrate and propionate (the major short-chain fatty acids). Therefore, oral L. rhamnosus KBL2290 may be a useful novel probiotic.

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    Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium‑Induced Colitis
    J. Microbiol. 2023;61(7):673-682.   Published online June 14, 2023
    DOI: https://doi.org/10.1007/s12275-023-00061-5
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