- Potential of 2, 2'-dipyridyl diselane as an adjunct to antibiotics to manage cadmium-induced antibiotic resistance in Salmonella enterica serovar Typhi Ty2 strain
-
Praveen Rishi , Reena Thakur , Ujjwal Jit Kaur , Harjit Singh , Kuldip K. Bhasin
-
J. Microbiol. 2017;55(9):737-744. Published online August 5, 2017
-
DOI: https://doi.org/10.1007/s12275-017-7040-0
-
-
1,015
View
-
0
Download
-
8
Crossref
-
 Abstract
 PDF
-
One of the reasons for increased antibiotic resistance in Salmonella
enterica serovar Typhi Ty2 is the influx of heavy
metal ions in the sewage, from where the infection is transmitted.
Therefore, curbing these selective agents could be
one of the strategies to manage the emergence of multidrug
resistance in the pathogen. As observed in our earlier study,
the present study also confirmed the links between cadmium
accumulation and antibiotic resistance in Salmonella. Therefore,
the potential of a chemically-synthesised compound 2,
2-dipyridyl diselane (DPDS) was explored to combat the
metal-induced antibiotic resistance. Its metal chelating and
antimicrobial properties were evidenced by fourier transform
infrared spectroscopy (FTIR), field emission scanning
electron microscopy (FE-SEM), and microbroth dilution
method
. Owing to these properties of DPDS, further, this
compound was evaluated for its potential to be used in combination
with conventional antibiotics. The data revealed
effective synergism at much lower concentrations of both
the agents. Thus, it is indicated from the study that the combination
of these two agents at their lower effective doses
might reduce the chances of emergence of antibiotic resistance,
which can be ascribed to the multi-pronged action of
the agents.
-
Citations
Citations to this article as recorded by  - Breaking the resistance loop via genomics: Unravelling mitigation approaches to heavy metal-mediated antibiotic resistance across molecular dimensions
Bhumika Maharana, Nishant A. Dafale
Ecological Genetics and Genomics.2026; 40: 100506. CrossRef - Assessment of antimicrobial resistant bacteria and antimicrobial resistance genes in hospital, pharmaceutical and agricultural settings in Lagos state, Nigeria
Abraham AJAYI, Emelda CHUKWU, Utibeima U. ESSIET, Jacob YISAU, Kazeem OSUOLALE, Rufai ABUBAKAR, Paschal EZEOBI, Jane OKWUZU, Babatunde ADEWALE, Babatunde SALAKO, Ganiyu O. OYETIBO, Yewande A. TOBUN, Saheed T. ADEOTI, Rasheed MACAULAY, Ayokunle OMILEYE, Ra
Minerva Biotechnology and Biomolecular Research.2025;[Epub] CrossRef - Interference of sodium alginate and 2,2’-bipyridyl on bacterial growth and biofilm produced by Staphylococcus aureus isolates from bovine mastitis
Ana Caroline Batista Nunes, Danillo Sales Rosa, Naiana Braga Freire, Antônio Wilton Cavalcante Fernandes, Renata de Faria Silva Souza, Gisele Veneroni Gouveia, Hugo Colombarolli Bonfá, Mateus Matiuzzi da Costa
Semina: Ciências Agrárias.2025; 46(2): 367. CrossRef - A NiCoT family metal transporter of Mycobacterium tuberculosis (Rv2856/NicT) behaves as a drug efflux pump that facilitates cross-resistance to antibiotics
Anwesha Adhikary, Sarmistha Biswal, Debasmita Chatterjee, Anindya S. Ghosh
Microbiology
.2022;[Epub] CrossRef - Heavy metal-induced selection and proliferation of antibiotic resistance: A review
Prakriti Vats, Ujjwal Jit Kaur, Praveen Rishi
Journal of Applied Microbiology.2022; 132(6): 4058. CrossRef - Potential of 1-(1-napthylmethyl)-piperazine, an efflux pump inhibitor against cadmium-induced multidrug resistance in Salmonella enterica serovar Typhi as an adjunct to antibiotics
Ujjwal Jit Kaur, Adity Chopra, Simran Preet, Khem Raj, Kanthi Kiran Kondepudi, Varsha Gupta, Praveen Rishi
Brazilian Journal of Microbiology.2021; 52(3): 1303. CrossRef - Prophylactic potential of cytolethal distending toxin B (CdtB) subunit of typhoid toxin against Typhoid fever
Reena Thakur, Preeti Pathania, Navneet Kaur, Vattan Joshi, Kanthi Kiran Kondepudi, Chander Raman Suri, Praveen Rishi
Scientific Reports.2019;[Epub] CrossRef - Augmented antibiotic resistance associated with cadmium induced alterations in Salmonella enterica serovar Typhi
Ujjwal Jit Kaur, Simran Preet, Praveen Rishi
Scientific Reports.2018;[Epub] CrossRef
|
MSK
